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All Journal Majalah Kedokteran Andalas Health and Medical Journal Jurnal Kesehatan Primer Jurnal Ilmu Kesehatan Indonesia (JIKSI) Jurnal Otorinolaringologi Kepala dan Leher Indonesia (JOKLI) Jurnal Riset Ilmiah Jurnal Sains, Teknologi dan Kesehatan
Yusri, Elfira
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Gambaran lingkar perut, indeks massa tubuh dan kadar asam urat : - Yasri, dwiyulia; Ramadhani, Khairini; Fasrini, Ulya Uti; Desmawati; Yusri, Elfira
JURNAL KESEHATAN PRIMER Vol 8 No 1 (2023): JKP (Jurnal Kesehatan Primer)
Publisher : Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/jkp.v8i1.1056

Abstract

Introduction: Increasing levels of uric acid (hyperuricemia) are associated with the incidence of obesity. Abdominal circumference and body mass index are commonly used indicators for obesity. This study aims to determine the description of abdominal circumference, body mass index, and uric acid levels in the staff of the Faculty of Medicine, Andalas University. Methods: This descriptive study used a cross-sectional design. A total of 41 research subjects from the secondary data obtained were staff at the Faculty of Medicine, Andalas University. The data consisted of age, sex, abdominal circumference, height, weight, and uric acid. The data was processed to see the frequency distribution of the research variables using univariate analysis. Results: The results of this study found that more than half of the research subjects were female, namely 28 (68.3%), and were in the age range of 26-45 years (65.9%). The study subjects who were categorized as central obesity and overweight were 65.85% and 73.17%, respectively. However, most of the research subjects had normal uric acid levels (82.93%).
Pengaruh Ekstrak Etanol Peronema canescens Jack terhadap Ekspresi Gen Tumor Necrosis Factor Alpha pada Sel HeLa Ansharina, Hafiznie; Revilla, Gusti; Kadri, Husnil; Desmawati, Desmawati; Yusri, Elfira; Ali, Hirowati
Health and Medical Journal Vol 7, No 1 (2025): HEME January 2025
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v7i1.1418

Abstract

Latar Belakang: Kanker serviks merupakan kanker yang menduduki peringkat keempat pada wanita di seluruh dunia. Kanker ini disebabkan oleh Human Papillomavirus (HPV) tipe resiko tinggi yang menyerang sel-sel leher rahim. Sel kanker akan mensekresi Tumor Necrosis Factor Alpha (TNF-α) untuk menjadikan lingkungan mikrotumor mendukung bagi kelangsungan hidup sel kanker. Terapi kanker serviks yang umum digunakan adalah pembedahan, radioterapi, dan kemoterapi. Terapi lain yang juga digunakan adalah tanaman herbal, contohnya sungkai. Ekstrak etanol daun sungkai (Peronema canescens J) mengandung senyawa yang berperan sebagai antiinflamasi dan antioksidan. Tujuan: Penelitian ini bertujuan untuk mengetahui pemberian ekstrak etanol daun sungkai dalam menurunkan ekspresi gen TNF-α pada sel HeLa. Metode: Penelitian ini merupakan penelitian true experimental dengan post test only control group design yang menggunakan 24 well plate kultur sel HeLa yang tumbuh secara konfluens. Sampel dibagi menjadi empat kelompok (K, P1, P2, dan P3). Kelompok perlakuan diberikan ekstrak etanol daun sungkai dengan konsentrasi inhibition concentration (IC)25, IC50, dan IC75 yang diinkubasi selama 24 jam. Sel yang telah diberi perlakuan akan dipanen untuk dilakukan isolasi RNA. Pemeriksaan gen TNF-α dilakukan menggunakan PCR Konvensional, kemudian band elektroforesis berukuran 47 bp dianalisis menggunakan ImageJ. Hasil: Data didapatkan dari analisis ketebalan band elektroforesis yang diukur menggunakan ImageJ. Analisis data dilakukan menggunakan uji One Way ANOVA dan Post Hoc Bonferroni, didapatkan rerata ekspresi gen TNF-α pada kelompok K, P1, P2, dan P3 secara berturut-turut adalah 0,32; 0,29; 0,23; dan 0,14. Terdapat perbedaan yang bermakna antara kelompok K terhadap P2 dan P3 dengan nilai p=0,000 (p<0,05), sedangkan kelompok K dengan P1 perbedaannya tidak bermakna (p>0,05). Kesimpulan: Pemberian ekstrak etanol daun sungkai pada konsentrasi IC50 dan IC75 mampu menurunkan ekspresi gen TNF-α pada kelompok sel HeLa.
Hubungan Rasio Neutrofil Limfosit, Rasio Platelet Limfosit, dan Rasio Limfosit Monosit dengan Stadium Klinis Karsinoma Nasofaring di RSUP Dr. M. Djamil Padang Periode 2020-2022 Rahman, Rifna Alya; Rahman, Sukri; Almurdi, Almurdi; Yusri, Elfira; Meinapuri, Malinda; Irawati, Lili
Jurnal Otorinolaringologi Kepala dan Leher Indonesia Vol. 3 No. 1 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jokli.v3i1.56

Abstract

Karsinoma nasofaring merupakan penyakit kanker ke-5 tersering di Indonesia yang berkaitan dengan infeksi Virus Epsteinn-Barr. Rasio neutrofil limfosit (RNL), rasio platelet limfosit (RPL), rasio limfosit monosit (RLM) merupakan biomarker inflamasi yang dapat mewakili respon inflamasi sehingga dapat menggambarkan progresivitas kanker. Stadion klinis juga digunakan untuk menentukan progresivitas kanker. Penelitian ini bertujuan untuk mengetahui hubungan RNL, RPL, dan RLM dengan stadium klinis karsinoma nasofaring. Penelitian ini menggunakan desain penelitian cross sectional dengan menggunakan data rekam medis pasien di RSUP Dr. M. Djamil Padang. Pengambilan sampel dilakukan dengan teknik konsekutif sampling. Total sampel yang digunakan sebanyak 64 sampel. Uji statistik menggunakan uji Chi-square. Hasil penelitian ini diperoleh kasus karsinoma nasofaring lebih banyak terjadi pada jenis kelamin laki-laki (65,6%), kelompok umur 25–49 tahun dan terdiagnosis pada stadium IV A. Hasil pemeriksaan darah rutin berada pada rentang normal yaitu neutrofil (51,5 %), limfosit (76,9%), monosit (57,8%), dan trombosit (54,7%). Nilai RNL, RPL, dan RLM mengalami peningkatan yaitu RNL (85,9%), RPL (68,8%), dan RLM (50%). Hasil uji Chi-square yang diperoleh tidak ada hubungan RNL (p>0,05), RPL (p>0,05), dan RLM (p>0,05) dengan stadion klinis. Dari penelitian ini disimpulkan bahwa tidak terdapat hubungan yang signifikan antara RNL, RPL dan RLM dengan stadion klinis KNF di RSUP Dr. M. Djamil Padang.
Correlation Of Neutrophil Lymphocyte Ratio And Platelet Lymphocyte Ratio With Severity Of COVID-19 Warman, Fadil Ahmadhia; Yulia, Dwi; Kadri, Husnil; Mulyana, Roza; Yusri, Elfira; Putra, Syandrez Prima
Majalah Kedokteran Andalas Vol 46, No 9 (2024): Supplementary Januari 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i9.p1361-1375.2024

Abstract

The neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) tests are simple tests can be done before a COVID-19 patient hospitalized. This examination is useful for determining the diagnosis and prognostic of the patient. The aim of the study was to determine the correlation between NLR and PLR with the severity of COVID-19. This research was an analytical study with a cross-sectional approach using secondary data from 289 medical records of patients with confirmed COVID-19 for the period June-August 2021. The total sampling technique was used and processed with the chi-square test. Most of the research subjects were in the range of 26-45 years (28.4%). More than half of the subjects were female (61.6%). There were 99 patients (34.3%) with severe conditions. Less than half of the patients had abnormal leukocyte and platelet examination results, namely 64 (22.1%) and 56 (19.4%). Patients with abnormal NLR and PLR examinations were 135 (46.7%) and 123 (42.6%). There was a significant correlation between NLR and the severity of COVID-19 inpatients (p<0.001, OR=9.452). There is a significant correlation between PLR and the severity of COVID-19 inpatients (p<0.001, OR=7.268). This study concludes a significant correlation between NLR and PLR with the severity of COVID-19.
PROFIL PASIEN COVID-19 DI RUMAH SAKIT UNIVERSITAS ANDALAS Putri, Azhara Dhiya Yosse; Lestari, Yuniar; Susanti, Restu; Afriant, Rudy; Putra, Syandrea Prima; Yusri, Elfira
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 1 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Maret 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i1.986

Abstract

   Background: Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by SARS- CoV-2 virus. The outcomes of COVID-19 patients were found to be influenced by the presence of comorbidities of the patient. Furthermore, this will affect the healing process in the patient itself. The most common comorbidity in COVID-19 patients is hypertension followed by diabetes mellitus. Hypertension is mentioned as the predominant factor of COVID-19 infection. Objective: This study aims to determine the profile of COVID-19 patients with hypertension. Methods: The type of this research is observational descriptive which was conducted in October 2021 – November 2022 at the Medical Record Installation of Rumah Sakit Universitas Andalas. This study was conducted using a total sampling technique with a total sample of 161 patient. Results: The results showed that the frequency of female was more than male (60.9:39.1). The frequency of >50 years old is almost the same as 50 years old (50.9:49.1). There are more patients without comorbid hypertension than patients with comorbid hypertension (64.6:35.4). Conclusions: There are more COVID-19 patients treated at Andalas University Hospital aged 50 years with female sex and more patients without hypertension comorbid.  
Efektivitas Plasmaferesis Sebagai Terapi Pada Miastenia Gravis: Sebuah Tinjauan Naratif Azzati, Normaida Baizura; Permana, Hendra; Almurdi, Almurdi; Susanti, Lydia; Alioes, Yustini; Yusri, Elfira
Jurnal Ilmu Kesehatan Indonesia Vol. 6 No. 1 (2025): Maret 2025
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v6i1.1390

Abstract

Latar Belakang: Miastenia gravis adalah penyakit neurologi autoimun yang jarang terjadi, namun sangat mempengaruhi kualitas hidup pasien dikarenakan tingkat keparahan yang cukup tinggi. Plasmaferesis digunakan sebagai salah satu pilihan terapi pada kondisi ini. Objektif: Tinjauan Naratif ini bertujuan untuk menilai penelitian terkait efektivitas terapi plasmaferesis terhadap miastenia gravis. Metode: Penelitian ini merupakan tinjauan literatur terhadap 7 artikel penelitian yang dipublikasi pada rentang tahun 2019-2023. Sumber pangkalan data yang digunakan adalah Pubmed, Science Direct, dan ProQuest. Artikel dilakukan penyeleksian berdasarkan kriteria eligibilitas yang telah ditentukan. Hasil: Menurut artikel yang dilakukan tinjauan, diketahui bahwa plasmaferesis dapat memberikan luaran klinis yang baik pada pasien. Plasmaferesis juga mampu meningkatkan kualitas hidup pasien secara signifikan. Kesimpulan: Semua literatur sepakat menyatakan bahwa plasmaferesis efektif digunakan sebagai terapi pada miastenia gravis.
PREVALENSI ANEMIA PADA KEHAMILAN : SEBUAH TINJAUAN LITERATUR SISTEMATIS Azmira, Nazurah; Defrin, Defrin; Burhan, Ida Rahmah; Rustam, Erlina; Antonius, Puja Agung; Yusri, Elfira
SINERGI : Jurnal Riset Ilmiah Vol. 2 No. 9 (2025): SINERGI : Jurnal Riset Ilmiah, September 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v2i9.1374

Abstract

Background : Anemia has become a public health problem that bring many potencial danger to both maternal and neonatal side. Many studies show that there are significant correlation between maternal mortality and anemia during pregnancy.Objective: This review is done to determine the prevalence and risk factors of anemia among pregnant women Methods : This study is a systematic literature review focused on the prevalence of anemia during pregnancy from 2011-2020. Literature search on Pubmed and Proquest databases was carried out to identify studies included in inclusion criteria related to prevalence of anemia during pregnancy. In this review, 60 articles were reviewed after 4105 articles found in both databases were screened using PRISMA guidelines. A total of 49589 participants from 20 developing countries were included. Results : The results showed that the rate of anemia in pregnancy range from 7,4% to 90%, with an average of 36,2%. The most reported risk factors are low economic level/ household income (10,2%), maternal age (9,6), rural residence (7,8%), educational status of the mother (7,2%)and less consumption of iron/folic acid (7,2%). Conclusion : Based on the review, available evidence suggest that prevalence of anemia remain high especially in low and middle income countries. Maximum efforts need to be initiated to help prevent anemia during pregnancies. Public should be educated on early initiation of antenatal care to enhance surveillance, identification and treatment of anemia
Correlation Of Neutrophil Lymphocyte Ratio And Platelet Lymphocyte Ratio With Severity Of COVID-19 Warman, Fadil Ahmadhia; Yulia, Dwi; Kadri, Husnil; Mulyana, Roza; Yusri, Elfira; Putra, Syandrez Prima
Majalah Kedokteran Andalas Vol. 48 No. 2 (2025): MKA April 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i9.p1361-1375.2024

Abstract

The neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) tests are simple tests can be done before a COVID-19 patient hospitalized. This examination is useful for determining the diagnosis and prognostic of the patient. The aim of the study was to determine the correlation between NLR and PLR with the severity of COVID-19. This research was an analytical study with a cross-sectional approach using secondary data from 289 medical records of patients with confirmed COVID-19 for the period June-August 2021. The total sampling technique was used and processed with the chi-square test. Most of the research subjects were in the range of 26-45 years (28.4%). More than half of the subjects were female (61.6%). There were 99 patients (34.3%) with severe conditions. Less than half of the patients had abnormal leukocyte and platelet examination results, namely 64 (22.1%) and 56 (19.4%). Patients with abnormal NLR and PLR examinations were 135 (46.7%) and 123 (42.6%). There was a significant correlation between NLR and the severity of COVID-19 inpatients (p<0.001, OR=9.452). There is a significant correlation between PLR and the severity of COVID-19 inpatients (p<0.001, OR=7.268). This study concludes a significant correlation between NLR and PLR with the severity of COVID-19.
Korelasi Lactate Dehydrogenase dengan Rasio PaO2/FiO2 pada Pasien dengan COVID-19 di Intensive Care Unit Fitriani, Elsa; Rikarni, Rikarni; Yusri, Elfira
Majalah Kedokteran Andalas Vol. 46 No. 3 (2023): Online Juli 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i4.p752-756.2023

Abstract

AbstrakLatar Belakang: Severe Acute Respiratory Syndrome (SARS COV-2) menyebabkan COVID-19  dengan manifestasi klinis bervariasi, terutama menyebabkan kerusakan parenkim paru. Kerusakan parenkim paru menyebabkan peningkatan kadar enzim lactate dehydrogenase (LDH) dan manifestasi berat akan menimbulkan acute respiratory distress syndrome (ARDS). Derajat keparahan gagal nafas dinilai dengan rasio PaO2/FiO2. Tujuan: menganalisis korelasi LDH dan rasio PaO2/FiO2 pada COVID-19. Metode: Penelitian analitik potong lintang terhadap 52    orang pasien COVID-19 di intensive care unit (ICU). LDH diukur dengan alat clinical chemistry analyzer dan rasio PaO2/FiO2 dengan blood gas analyzer. Uji korelasi Pearson bermakna apabila p<0,05. Hasil Subjek penelitian sejumlah 52 orang, 27(51,9%) laki-laki dan 25(48,1%) perempuan dengan rerata usia 56(12,796) tahun. Manifestasi klinis ditemukan ARDS ringan (13,50%), sedang (42,30%), berat (44,20%). Rerata LDH adalah 459,33(203,95) U/L dan rerata rasio PaO2/FiO2 adalah 121,67(58,72) mmHg. Uji korelasi Pearson  menunjukkan r=-0,43 dan p=0,002. Pembahasan: Rerata kadar LDH serum meningkat pada penelitian ini. Kadar LDH dan rasio PaO2/FiO2 pasien COVID-19 di ICU menunjukan korelasi sedang dan bermakna. Simpulan: Hasil penelitian terdapat korelasi LDH dengan rasio PaO2/FiO2 pasien COVID-19. Pemeriksaan LDH  digunakan sebagai parameter untuk menilai kerusakan jaringan parenkim paru pasien COVID-19. Kata kunci: COVID-19; SARS-CoV-2;ARDS, LDH;  Rasio PaO2/FiO 
Co-Authors Almurdi Almurdi Ansharina, Hafiznie Antonius, Puja Agung Azmira, Nazurah Azzati, Normaida Baizura Burhan, Ida Rahmah Defrin, Defrin Desmawati Desmawati Desmawati Erlina Rustam Fitriani, Elsa Gusti Revilla Hendra Permana Hirowati Ali, Hirowati Husnil Kadri Lili Irawati Lydia Susanti, Lydia Malinda Meinapuri Putra, Syandrea Prima Putri, Azhara Dhiya Yosse Rahman, Rifna Alya Ramadhani, Khairini Restu Susanti Rikarni Rikarni Roza Mulyana Rudy Afriant Sukri Rahman Syandrez Prima Putra Ulya Uti Fasrini Warman, Fadil Ahmadhia Yasri, dwiyulia Yulia, Dwi Yuniar Lestari Yustini Alioes