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Puspitasari, Ratih Dyah
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Physics Public Health Social Sciences Other

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Network Pharmacology-Based Evaluation of Sungkai (Peronema canescens J.) Leaf Bioactive Compounds as Potential Therapeutics for Cervical Cancer Puspitasari, Ratih Dyah
Jurnal Sains dan Terapan Kimia Vol 20, No 1 (2026)
Publisher : Program Studi Kimia, Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jstk.v20i1.24974

Abstract

Cervical cancer continues to pose a significant public health challenge, especially in low- and middle-income countries, largely due to persistent Human Papillomavirus (HPV) infection and the limited efficacy and safety of current therapies. Although flavonoid-based anticancer agents such as jaceosidin have shown anticancer activity, their clinical use is limited by low bioavailability and insufficient clinical evidence, underscoring the need for safer, more effective therapeutic options. This study utilized in silico and network pharmacology methods to assess bioactive compounds from Sungkai leaves (Peronema canescens J.). Seven peronemin derivatives were evaluated for drug-likeness, toxicity, and anticancer potential through ADMET predictions, bioactivity profiling, and protein target identification. The findings demonstrated that peronemin C1 and D1 possess activity against cervical cancer cell lines and exhibit favorable pharmacokinetic properties. Network pharmacology analysis identified 115 cancer-associated targets, with STAT3 identified as a central hub regulating cell proliferation, apoptosis, and inflammatory signaling. Functional analyses further indicated that peronemin compounds modulate key oncogenic pathways, supporting their multitarget potential. Collectively, these results indicate that peronemin compounds from Sungkai leaves, particularly C1 and D1, are promising candidates for the development of cervical cancer therapies targeting STAT3.
Perubahan Komponen Utama Pada Minyak Atsiri Selasih Ungu (Ocimum Conum, Sims) Dengan Metode Microwave Assisted Organic Synthesis (MAOS) Menggunakan Katalis KF/Al2O3 Puspitasari, Ratih Dyah; Rubiyanto, Dwiarso; Allwar, Allwar
INDONESIAN JOURNAL OF CHEMICAL RESEARCH VOLUME 1, ISSUE 1, 2014
Publisher : Chemistry Department, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (781.046 KB) | DOI: 10.20885/ijcr.vol1.iss1.art9

Abstract

Penerapan metode MAOS (Microwave Assisted Organic Synthesis) pada minyak atsiri selasih ungu (Ocimum Canum, Sims) telah dilakukan. Dalam penelitian ini KF/AI2O3 digunakan sebagai katalis, gliserol dan etilen glikol sebagai pelarut. Katalis dikarakterisasi dengan FTIR dan hasil menunjukkan penampakan tiga spektra: K3AIF6, KOH dan K2CO3. Hasil optimasi waktu dan konsentrasi yang diperoleh yaitu 6 menit pada KF/Al2O3 10% untuk pelarut gliserol dan 2 menit pada KF/Al2O3 20% untuk pelarut etilen glikol.
Molecular Docking and in Silico Pharmacokinetic Analysis of Peronemin As A Potential 17β-Hsd1 Inhibitor For Estrogen-Dependent Cancer Therapy Puspitasari, Ratih Dyah; Tarigan, Indra Lasmana
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 6 (2025): December 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i6.18780

Abstract

High levels of estradiol (E2) are important in the development of endometrial cancer. This hormone is mostly produced when the enzyme 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) changes estrone (E1) into estradiol (E2). Inhibiting this enzyme can reduce estrogen production in cancers that rely on estrogen. This study examined three Peronemin derivatives (A2, A3, C1) as potential 17β-HSD1 inhibitors through detailed computer analysis. PASS predictions showed these compounds likely have antineoplastic activity (Pa > 0.85). Their physicochemical properties, based on Lipinski's rule, suggest they have good ADME profiles, with high gastrointestinal absorption and a predicted ability to cross the blood-brain barrier.Molecular docking results showed that all three compounds interacted stably with the 17β-HSD1 active site. Peronemin C1 had the strongest binding (ΔG = -6.56 kcal-mol-¹; Ki = 15.56 μM). Mapping the interactions revealed that A2 formed hydrogen bonds with Tyr155, A3 formed hydrogen bonds with Lys159, and C1 exhibited strong hydrophobic interactions. The results suggest that Peronemin A2, A3, and especially C1 could be promising for further development as 17β-HSD1 inhibitors. However, further laboratory studies are needed to confirm the effectiveness of these compounds and determine their practical application.
Co-Authors Allwar Allwar Arnis, Suzi Guci Dewi, Tribuana Tungga Dhian Eka Wijaya Dwiarso Rubiyanto Elis Kartika Endi Adriansyah Faizar Farid Farah, Farah Hariestya Viareco Heriyanti Heriyanti, Heriyanti Indra Lasmana Tarigan Lizawati Lizawati Madyawati Latief Muhaimin Muhaimin Munifilia Ekasari Nelson Nurul Pratiwi Oktariyani, Salmiyah Ramadhan, Iham Ifandi Ramadhan, Ilham Ifandi Restina Bemis, Restina Saharin, Siti Munirah Sarani, Desfira Shella, Ance Pramai Silaban, Desy Vania Sinurat, Julius Alvin Novensius Sowe, Momodou Salieu Susanto, Nindita Clourisa Amaris Sutrisno, Sutrisno Ulvia, Tiara