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All Journal Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Jurnal Agroekoteknologi CHEMPUBLISH JOURNAL Jukung (Jurnal Teknik Lingkungan) Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Jurnal Kartika Kimia PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Hydrogen: Jurnal Kependidikan Kimia Jurnal Abdi Masyarakat Indonesia IJCR (Indonesian Journal of Chemical Research) Jurnal Pengabdian Masyarakat Pinang Masak
Puspitasari, Ratih Dyah
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Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Physics Public Health Social Sciences Other

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Molecular Docking and in Silico Pharmacokinetic Analysis of Peronemin As A Potential 17β-Hsd1 Inhibitor For Estrogen-Dependent Cancer Therapy Puspitasari, Ratih Dyah; Tarigan, Indra Lasmana
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 6 (2025): December 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i6.18780

Abstract

High levels of estradiol (E2) are important in the development of endometrial cancer. This hormone is mostly produced when the enzyme 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) changes estrone (E1) into estradiol (E2). Inhibiting this enzyme can reduce estrogen production in cancers that rely on estrogen. This study examined three Peronemin derivatives (A2, A3, C1) as potential 17β-HSD1 inhibitors through detailed computer analysis. PASS predictions showed these compounds likely have antineoplastic activity (Pa > 0.85). Their physicochemical properties, based on Lipinski's rule, suggest they have good ADME profiles, with high gastrointestinal absorption and a predicted ability to cross the blood-brain barrier.Molecular docking results showed that all three compounds interacted stably with the 17β-HSD1 active site. Peronemin C1 had the strongest binding (ΔG = -6.56 kcal-mol-¹; Ki = 15.56 μM). Mapping the interactions revealed that A2 formed hydrogen bonds with Tyr155, A3 formed hydrogen bonds with Lys159, and C1 exhibited strong hydrophobic interactions. The results suggest that Peronemin A2, A3, and especially C1 could be promising for further development as 17β-HSD1 inhibitors. However, further laboratory studies are needed to confirm the effectiveness of these compounds and determine their practical application.
INOVASI PEMBUATAN DISHWASH DAN SABUN PADAT KULIT NANAS DAN KOPI DI SMA N 4 TANJUNG JABUNG TIMUR Puspitasari, Ratih Dyah
DHARMAKARYA: Jurnal Aplikasi Ipteks untuk Masyarakat Vol 14, No 2 (2025): Dharmakarya Juni 2025
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/dharmakarya.v14i2.58669

Abstract

Kulit kopi dan kulit nanas, memiliki kandungan senyawa kimia yang beragam dan memiliki potensi bioaktivitas salah satunya sebagai antibakteri. Dari aktivitasnya sebagai antibakteri, kulit kopi dan kulit nanas dapat dijadikan sebagai bahan pembuatan dishwash dan sabun. Pentingnya edukasi pemanfaatan limbah dapat diterapkan pada siswa sekolah khususnya sekolah menengah atas (SMA), hal ini bertujuan untuk menumbuhkan jiwa kewirausahaan (enterprenuership) sehingga siswa memiliki bekal berwirausaha dengan memanfaatkan limbah dari lingkungan sekitarnya, dimana kewirausahaan merupakan materi penting dalam Pelajaran P5 pada kurikulum merdeka. Berdasarkan ketersediaan bahan baku limbah kulit kopi dan kulit nanas serta adanya peluang untuk berwirausaha, maka diperlukan adanya pelatihan kepada siswa SMA dalam mengembangkan potensi dan memanfaatkan bahan alam disekitarnya yang dapat dijadikan sebagai produk tepat guna. Pada pelaksanaannnya menggunakan metode pendekatan Pendidikan dan pelatihan. Berdasarkan hasil kuioner diperoleh sebesar 93,3% peserta PPM memahami dan dapat melakukan pembuatan dishwash dan sabun pada
Co-Authors Allwar Allwar Arnis, Suzi Guci Dewi, Tribuana Tungga Dhian Eka Wijaya Dwiarso Rubiyanto Elis Kartika Endi Adriansyah Faizar Farid Farah, Farah Hariestya Viareco Heriyanti Heriyanti, Heriyanti Indra Lasmana Tarigan Lizawati Lizawati Madyawati Latief Muhaimin Muhaimin Nelson Nurul Pratiwi Oktariyani, Salmiyah Ramadhan, Iham Ifandi Ramadhan, Ilham Ifandi Restina Bemis, Restina Saharin, Siti Munirah Shella, Ance Pramai Silaban, Desy Vania Sinurat, Julius Alvin Novensius Sowe, Momodou Salieu Susanto, Nindita Clourisa Amaris Sutrisno, Sutrisno Ulvia, Tiara