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All Journal Majalah Kedokteran Bandung JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) Indonesian Journal of Medicine Buletin Kedokteran dan Kesehatan Prima International Journal of Health and Pharmaceutical (IJHP)
Ferdinand, Sahna
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

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Antioxidant and Antityrosinase Activities of Ethanolic Pachyrhizuserosus Peel and Tuber Extract Siregar, Irma Dolsyeria; Kusuma, Hanna Sari Widya; Widowati, Wahyu; Marpaung, Hans Hotma; Ferdinand, Sahna; Fachrial, Edy; Lister, I Nyoman Ehrich
Majalah Kedokteran Bandung Vol 51, No 2 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (277.515 KB) | DOI: 10.15395/mkb.v51n2.1628

Abstract

Aging process is a physiological process in living organisms caused by, among others, free radicals. One of the free-radical-related aging problems is skin hyperpigmentation (excessive melanin) due to increasing tyrosinase enzyme activities. Natural compounds are widely used as antioxidant and antiaging agents. Bengkuang (Pachyrhizuserosus) is known as a source of various active compounds which can be used against free radicals to reduce the risk of skin aging  through  tyrosinase enzyme inhibition. This study was performed in September 2018 in Aretha Medika Utama, Biomolecular and Biomedical Research Center, Bandung, Indonesia to examine the antioxidant and antityrosinase properties of Pachyrhizuserosus peel extract (PPE) and Pachyrhizuserosus  tuber extract (PTE).The extraction of PPE and PTE was performed using 70% ethanol by maceration method, followed by  phytochemical analysis using modified Farnsworth method. Antioxidant activities were measured through 2,2-Diphenyl-1-picrylhydrazil (DPPH) scavenging activities while antiaging assay were conducted through the  tyrosinase activity inhibition. In this study, PPE contained saponin, tannin, triterpenoid, and terpenoid while the PTE showed the presence of flavonoid, saponin, phenol, tannin, and alkaloid in phytochemical analysis. In the antioxidant assay, PPE presented a higher DPPH scavenging activities (IC50= 84.09 µg/mL) when compared to PTE (IC50= 98.30 µg/mL)(p<0.05). In antiaging assay, PPE showed a higher tyrosinase inhibitory activities when compared to PTE with =97.05µg/mL and 194.51µg/mL,respectively. It can be concluded that PPE has antioxidant and antiaging activities effective for preventing skin aging. Aktivitas Antioksidan dan Antitirosinase Ekstrak Etanol Kulit dan Daging PachyrhizuserosusProses penuaan merupakan suatu proses fisiologis yang terjadi pada makhluk hidup yang dapat disebabkan oleh radikal bebas. Hiperpigmentasi kuli tmerupakan salah satu masalah penuaan yang disebabkan oleh radikal bebas melalui peningkatan aktivitas enzim tirosinase. Bengkuang (Pachyrhizus erosus) diketahui mengandung berbagai senyawa aktif yang dapat menangkal radikal bebas serta mengurangi risiko penuaan kulit. Penelitian dilaksanakan pada September 2018 di Aretha Medika Utama, Biomolecular and Biomedical Research Center, Bandung, Indonesia untuk menguji kemampuan aktivitas antioksidan dan antitirosinase pada ekstrak etanol kulit bengkuang (EEKB) dan ekstrak etanol daging bengkuang (EEDB). Pembuatan ekstrak kulit dan daging bengkuang dilakukan dengan cara mengekstraksi bahan dengan etanol 70% menggunakan metode maserasi, kemudian dilanjutkan dengan analisis fitokimia ekstrak dengan modifikasi metode Farnsworth. Aktivitas antioksidan diuji dengan mengukur pemerangkapan 2,2-Diphenyl-1-picrylhydrazil (DPPH) sedangkan antiaging diuji dengan mengukur aktivitas penghambatan tirosinase. Pada uji fitokimia menunjukkan EEKB memiliki kandungan senyawa saponin, tanin, triterpenoid dan terpenoid, sedangkan EEDB menunjukkan kandungan senyawa flavonoid, saponin, fenol, tanin, dan alkaloid. Pada uji antioksidan, EEKB memiliki aktivitas tertinggi pada pemerangkapan DPPH (IC50=84.09 µg/mL) dibanding dengan EEDB (IC50=98.30 µg/mL) (p≤0.05). Pada pengujian antiaging, EEKB memiliki nilai yang lebih tinggi pada aktivitas penghambatan tirosinase dibandingkan dengan EEDB (IC50=97.05 µg/mL; 194.51 µg/mL (p≤0.05). Simpulan, EEKB memiliki aktivitas antioksidan dan antiaging sehingga efektif dalam mencegah penuaan kulit. 
PENGARUH EKSTRAK KUNYIT PUTIH TERHADAP HISTOPATOLOGI GINJAL PADA TIKUS JANTAN DENGAN MODEL NEPHROPATHY DIABETICUM Aulia, Rumi; Damanik, Marco Frans Hernandes; Tandanu, Erny; Ferdinand, Sahna
(Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) Vol 6, No 1 (2021): JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat)
Publisher : Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37887/jimkesmas.v6i1.16375

Abstract

Abstrak DiabetesXmellitusX (DM) XmerupakanXsuatuXpenyakitXkronisXyangXditandaiXoleh peningkatan kadar guladarah dalam tubuh akibatXgangguanXpadaXsekresiXinsulin, XhormonXinsulinXyangXtidakXbekerja sebagaimanaXmestinyaXatauXkeduanya. XKondisi hiperglikemia yang berlangsung kronis akan menimbulkankomplikasi pada berbagai organ salah satunya adalah organ ginjal. PenelitianXiniXbertujuanXuntuk mengetahuipengaruhXpemberianXekstrak kunyit putih (Curcuma zedoaria) terhadap gambaran histopatologi ginjal padatikus jantan dengan model nephropathy diabeticum. Rancangan penelitian ekperimental ini bersifat OneGroupPretest PostTest Design menggunakan sampel 30 ekor tikus jantan (Rattus norvegicus L.) galur Wistar,dimana tikus diinduksiXdengan penyuntikkan aloksanXdenganXdosis 180mg/KgBBXsecara intraperitoneal.Kemudian tikus dibagi menjadi 6 kelompokXyaitu 1 kelompok normal dan 5 kelompok tikus modelhiperglikemia yang diberi ekstrak kunyit putih denganXdosis 250, 500 dan 750mg/KgBB selama 14 hari,kelompok kontrol positif (glibenclamid 0,45mg/KgBB) dan kelompok kontrol negatif (tikus model hiperglikemiatanpa perlakuan). PadaXhariXke-14 tikus dikorbankan dan diambil darah untuk pemeriksaan kadar gula darahdan ginjalnya untuk pemeriksaanXhistologi denganXpewarnaan menggunakan HematoksilinEosin (H-E). HasilpenelitianXmenunjukanXbahwaXpemberianXekstrakXkunyit putih (Curcuma zedoaria) memiliki aktivitasnefroprotektif.KataXKunciX: Diabetes Melitus, Kunyit Putih, Nefroprotektif
Test The Growth Process of Hair Follicles by Administering Coconut and Candlenut Oil to The Entire Back of White Rats (Rattus Norvegicus) Of the Wistar Strain Mulan, Mulan; Hendrianto, Hendrianto; Ferdinand, Sahna
International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 3 (2024): August 2024
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v3i4.309

Abstract

Hair serves a variety of purposes, including thermoregulation and protection. Hair regulates temperature in nonhuman animals, including primates, by holding heat or preventing cold. Hair can also be used for disguise and as a sexual attractant. Human hair is thinner and lighter than that of primates. The purpose of this study was to determine and test the efficacy of providing a coconut oil and candlenut oil mixture in the process of hair development in Wistar rats (Rattus norvegicus). The study's findings indicate that a combination containing 80% coconut oil and 20% candlenut oil is the most efficient in stimulating hair development in white rats (Rattus norvegicus) of the Wistar strain. This hair growth acceleration is possible because coconut oil contains a high concentration, precisely 80%. Because coconut has a high amount of lauric acid, it has numerous health benefits, including good hair.
Description of Hematological Parameters and Severity Levels of COVID-19 Patients and Disease Progression at Royal Prima Hospital, Medan, North Sumatera, Indonesia Azah, Yunita Wannur; Novalinda Ginting, Chrismis; Chiuman, Linda; Ferdinand, Sahna
Indonesian Journal of Medicine Vol. 8 No. 4 (2023)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.08.04.12.

Abstract

Background: The severity of COVID-19 can be evaluated by checking several routine hematological parameters. Routine hematology examinations have an important role in early detection, diagnosis, disease management and disease progression. This study aims to determine the relationship between hematological parameters and disease progression and severity in COVID-19 patients. Subjects and Method: This was a cross sectional study conducted at Royal Prima Hospital, Medan, North Sumatera, Indonesia, from January to February 2022. A total of 93 patients who had confirmed COVID-19 were selected using a simple random sampling technique according to the inclusion and exclusion criteria. The research was The dependent variables of this research were disease progression and severity of COVID-19 patients. The independent variables are hematological parameters based on hospital medical record data. Data analysis used the Chi-Square test and logistic regression. Results: 75 people (80.6%) COVID-19 sufferers had severe disease. NLR and D-dimer levels were significantly related to disease progression in COVID-19 sufferers (p<0.05). Leukocyte, lymphocyte, NLR, CRP, D-dimer levels are related to the severity of COVID-19 sufferers (p<0.05). Leukocyte levels have the strongest relationship with the severity of COVID-19 with an OR value of 1.798. Conclusion: NLR and D-dimer levels are significantly related to disease progression and leukocyte. Lymphocyte, NLR, CRP, D-dimer levels are related to the severity of COVID-19 sufferers.
Factors influencing the participation of mothers with toddlers in posyandu activities in Kemenangan Tani Village, Medan Tuntungan District Mujahidin, Mujahidin; Wenti Anggraeni, Wenti; Daeli, Elisa Hotmauli Gratia; Sabri, Ihsan; Ivonne, Ivonne; Muchtar, Muhammad Arafat; Riskaldy, Riskaldy; Dewani , Yunita; Ferdinand, Sahna; Mukhtar, Zulfikri; Reza, Faisal
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.7442

Abstract

Posyandu is a type of community-based health effort (UKBM) which is managed and organized by, for, and with the community in the implementation of health development. Empowering the community to obtain essential health services, accelerating the reduction of maternal and child mortality. This study aims to determine the relationship between knowledge and characteristics of mothers under five with visits to posyandu activities in Kelurahan Kemenangan Tani. This research is an analytic survey with a cross-sectional approach. The population in this study were mothers of children under five at the Kelurahan Kemenangan Tani Posyandu. The sample in this study was 60 respondents with the determination of the number of samples using the slovin formula. The sampling technique used is proportional random sampling with inclusion and exclusion criteria. Data was collected through interviews using a questionnaire. This study used the chi-square statistical test (Confidance Interval (CI) 95%; = 0.05). Multivariate analysis using logistic regression. The results of this study indicate that there is a significant relationship between mother's knowledge and mother's characteristics with the visit of mothers under five in posyandu activities (p < 0.05). The dominant independent variable was education (p= 0.011; PR= 14,903, 95% CI = 1,872-118,660). The conclusion of this study is that there is a significant relationship between mother's knowledge and mother's characteristics with the visit of mothers under five in posyandu activities. The dominant independent variable is education.
Co-Authors Aulia, Rumi Azah, Yunita Wannur Chiuman, Linda Daeli, Elisa Hotmauli Gratia Damanik, Marco Frans Hernandes Dewani , Yunita Edy Fachrial faisal Reza Ginting, Chrismis Novalinda Hanna Sari Widya Kusuma, Hanna Sari Widya Hendrianto Hendrianto, Hendrianto Ivonne, Ivonne Lister, I Nyoman Ehrich Marpaung, Hans Hotma Muchtar, Muhammad Arafat Mujahidin Mujahidin Mukhtar, Zulfikri Mulan, Mulan Riskaldy, Riskaldy Sabri, Ihsan Siregar, Irma Dolsyeria Tandanu, Erny WAHYU WIDOWATI Wenti Anggraeni, Wenti