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All Journal Journal of Nutrition and Health Journal of Educational, Health and Community Psychology Journal of Biomedicine and Translational Research Sari Pediatri Paediatrica Indonesiana Medica Hospitalia Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Diponegoro International Medical Journal (DIMJ) Media Publikasi Promosi Kesehatan Indonesia (MPPKI) eJournal Kedokteran Indonesia Indonesian Journal of Biomedicine and Clinical Sciences
Agustini Utari
Bagian Ilmu Kesehatan Anak, Fakultas Kedokteran Universitas Diponegoro Semarang
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Paediatrica Indonesiana

 1 
Insulin-like growth factor-1 and growth in infants 0-6 months of age Bob Kevin Pardede; Agustini Utari; Maria Mexitalia
Paediatrica Indonesiana Vol 61 No 2 (2021): March 2021
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi61.2.2021.89-93

Abstract

Background During infancy, growth is affected by many factors, including hormones. Insulin-like growth factor-1 (IGF-1) is a hormone with an important role in regulating somatic growth and organ development. Objective To analyze for possible correlations between IGF-1 levels and infant growth from 0-6 months of age. Methods A prospective study was conducted on 38 infants from birth to 6 months of age. Inclusion criteria were full-term newborns with normal birth weight and singleton birth. Serum IGF-1 was measured twice, from umbilical cord blood at birth and at 6 months of age. Anthropometric measurements were made every three months. Paired T-test was used to analyze mean IGF-1 among time points, and Pearson’s correlation test was used to analyze IGF-1 levels and growth. Results Mean IGF-1 level decreased from birth to 6 months of age (89.6 ng/mL vs. 48.3 ng/mL, respectively; P<0.001). Delta IGF-1 had positive significant correlations with delta weight at 3 months (r=0.347; P=0.033) and 6 months (r=0.386; P=0.017), as well as delta head circumference at 3 months (r= 0.356; P=0.028) and 6 months (r=0.357; P=0.028). However, there were significant negative correlations between umbilical cord IGF-1 with delta body weight (r= −0.459; P=0.004) and delta length at 6 months (r= −0.414; P=0.010). Conclusions. There iss a decrease in IGF-1 levels at the first 6 months of life. Umbilical cord IGF-1 level has negative correlations with the weight and length increment at the age of 6 months.
Edwards Syndrome and Trisomy 8: a case report of a newborn with multiple congenital anomalies with double aneuploidy Utari, Agustini; Maharani, Nani; Indriyati, Rita; Sihombing, Nydia Rena Benita; Sarosa, Gatot Irawan; Winarni, Tri Indah
Paediatrica Indonesiana Vol. 65 No. 4 (2025): July 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.4.2025.350-6

Abstract

Chromosomal aneuploidy is the most common genetic cause of multiple congenital anomalies (MCA), contributing to high neonatal mortality and morbidity rates in intensive care units. Prevalence of live birth double trisomy is rarely reported, with previous studies reporting the involvement of autosomal aneuploidy combined with sex chromosomal aneuploidy that is a more tolerable or benign phenotype. Mostly, a live-born baby with a double trisomy is associated with mosaicism.  This report aims to present a rare case of a viable baby with non-mosaic double autosomal trisomy involving chromosomes 8 and 18. A term baby from advanced maternal and paternal age with low birth weight and height was born from spontaneous vaginal delivery from unremarkable pregnancy. The phenotype was suitable with Edward syndrome with congenital heart anomalies confirmed by cytogenetic analysis with additional extra chromosome 8 (48, XX,+8,+18). The baby was on and off the mechanical ventilator due to respiratory failures, and her health condition gradually deteriorated, leading to her death at the age of 2.5 months due to neonatal pneumonia.
Co-Authors A, Mahayu Dewi Aman B Pulungan Anindita Soetadji Anindita Soetadji Annastasia Ediati Asikin, Hang Gunawan Asri Purwanti Attika A. Andarie Bob Kevin Pardede Diadra Annisa Donna Hermawati Endang Susilowati Fadia Raihani Aprilia Herenda Fanti Saktini Ferdy Kurniawan Cayami Frida Soesanti Gatot Irawan Sarosa, Gatot Irawan Hertanto W Subagjo I Wayan Bikin Ika Rara Rosita Indriyati, Rita Jessica Juan Pramudita Lestari, Esa Loyallita Madarina Julia Magdalena Sidhartani, Magdalena Mahayu Dewi Ariani Maria Mexitalia Maria Mexitalia meiranny, arum Meita Hendrianingtyas Nani Maharani Nida Hanifah Niken Pritayati Ninung Rose Diana Kusumawati Nydia Rena Benita Sihombing Panunggal, Damianus Galih Pratiwi, Juwita Rina Pratiwi Safira Azzahra Selvia Eva Sabatini Sihombing, Nydia Rena Benita Sultana MH Faradz Sultana MH Faradz Tanjung Ayu Sumekar Tithasiri Audi Audi Rahardjo Tri Indah Winarni Tri Winarni Vynda Ulvyana Widodo Sarjana A.S ‘Aisy, Ghina