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HARMAN AGUSAPUTRA
Universitas Wijaya Kusuma Surabaya
Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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PREVALENSI DAN FAKTOR-FAKTOR RISIKO INFEKSI SALURAN KEMIH PADA IBU HAMIL DI PUSKESMAS DUKUH KUPANG SURABAYA Rukmana, Kresna Aditya; Inawati; Harman Agusaputra; Budhi Setiawan
Prosiding Seminar Nasional COSMIC Kedokteran Vol 3 (2025): Edisi 2025
Publisher : Lembaga Penelitian Dan Pengabdian Kepada Masyarakat Universitas Wijaya Kusuma Surabaya

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Abstract

Infeksi Saluran Kemih (ISK) merupakan salah satu risiko kehamilan berupa kondisi klinis infeksi yang disebabkan oleh bakteri yang apabila tidak dilakukan tatalaksana dengan baik akan memperburuk kondisi kehamilan yang membahayakan ibu dan janin. ISK memiliki multifaktor risiko yang mendasari perjalanan dan keparahan penyakit yang diantaranya meliputi usia, sosioekonomi, tingkat pendidikan, paritas, gravida, frekuensi hubungan seksual, riwayat ISK, volume minum air putih, dan kebersihan vulva. Penelitian ini bertujuan untuk menemukan prevalensi ISK berdasarkan faktor-faktor risikonya pada ibu hamil di Poli KIA Puskesmas Dukuh Kupang Surabaya Periode Maret-Mei 2024. Penelitian ini dirancang menggunakan pendekatan deskriptif dengan desain penelitian cross-sectional pada total sampel dari ibu hamil selama 3 bulan penelitian. Populasi ditemukan sebanyak 40 orang dan besar sampel adalah 40 orang. Analisis data menggunakan metode crosstab analysis diperoleh hasil sebagai kesimpulan prevalensi ISK pada ibu hamil sebesar 12,5% yang seluruhnya berusia 20-35 tahun, berpendidikan SMA, berpenghasilan di bawah gaji UMR kota Surabaya, sebagian besar usia kehamilan di trimester ketiga, sebagian besar belum pernah melahirkan, sebagian besar dengan intensitas kontak seksual 1x/minggu, sebagian besar memiliki riwayat multigravida, sebagian yang lain memilikir riwayat primipara, seluruhnya tidak memiliki riwayat ISK, sebagian besar konsumsi volume minum air ≥8 gelas per hari, dan seluruhnya merawat kebersihan vulva yang baik. Kesimpulan penelitian menyatakan bahwa prevalensi ISK beberapa menjadi faktor risiko yaitu usia muda, usia kehamilan, sosioekonomi, frekuensi hubungan seksual, multigravida, dan multipara. Selain itu, tidak didasari oleh faktor risiko yang diteliti dan diduga disebabkan oleh faktor-faktor lain yang perlu diteliti lebih lanjut diantaranya perilaku kesehatan seksual, immunocompromised, tingkat stres, dan komorbid.
Tingkat Pengetahuan dan Kesadaran Masyarakat Akan Deteksi Kanker Serviks di Lingkungan RW 12 Pondok Wage Indah 2 Sidoarjo Hernanda, Pratika; Wardhani, Mira Kusuma; Rahmawati, Febtarini; Agusaputra, Harman
Calvaria Medical Journal Vol 1 No 2 (2023): Edisi Desember 2023
Publisher : Institute for Research and Community Services (LPPM) of University of Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/cmj.v1i2.22

Abstract

Introduction: Cervical cancer is a malignant tumor that attacks the surface layer of the cervix, called squamous epithelial cells, which are located between the uterus and the vagina. It is important for women to know what factors can cause cervical cancer and have knowledge about preventing cervical cancer because the incidence of cervical cancer is still high in Indonesia, and there are still many women who lack knowledge. Method: A descriptive research design with a sample size of 33 people used total sampling of respondents who underwent pap smear examinations during Early Detection of Cervical Cancer event in RW 12 - Pondok Wage Indah 2 Sidoarjo. The data will be analyzed with a quantity test using SPSS software. Results: This research shows that the average age of respondents iss 48 years, as many as 47.2% of respondents have high education (minimum D3), the majority are housewives (IRT) as many as 25 people (69.4%), and the majority 23 people (63.9%) had good knowledge of cervical cancer risk factors, 9 people (25%) had sufficient/moderate knowledge and 1 person (2.8%) had poor knowledge. Conclusion: Respondents who underwent pap smear examinations mostly had a good level of knowledge about cervical cancer.
Analisis Karakteristik Pasien Diabetes Melitus Tipe 2 di Puskesmas Dukuh Kupang Surabaya Wirayudha, Sri Annung; Inawati Inawati; Agusaputra, Harman; Hernanda, Pratika Yuhyi
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 3 (2025): Desember : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i3.6863

Abstract

Type 2 Diabetes Mellitus is a chronic metabolic disease with a continuously increasing global prevalence. Understanding the characteristics of patients is essential for early detection, clinical management, and prevention of complications. Objective: To identify the characteristics of patients with type 2 diabetes mellitus at Dukuh Kupang Primary Health Center, Surabaya, based on age, gender, routine check-ups, duration of illness, body mass index (BMI), and complications. Methods: This descriptive observational study employed a cross-sectional approach and was conducted from January to February 2025. A total of 30 respondents were selected using purposive sampling. Data were obtained from medical records and supplemented by questionnaires. Results: Most patients were aged >60 years (57%), female (60%), had a normal BMI (50%), and adhered to routine medical check-ups (97%). The majority had been diagnosed for more than 5 years (53%) and experienced complications (83%), with neuropathy being the most common type (73%). Conclusion: Patients with DM type 2 at Dukuh Kupang Health Center were predominantly elderly, female, had a normal BMI, and experienced neuropathic complications.
Survival Pasien Kanker Kolorektal di RSUD Nganjuk dan Ekspresi Gen APC, KRAS dan SMAD4 Pada Tumornya Hernanda, Pratika Yuhyi; Pramugyono, Pramugyono; Wulandari, Ida Septika; Agusaputra, Harman; Sugeng, Maria Wijayanti; Ama, Fuad; Shalsabillah, Nadia Fitri
Majalah Kedokteran Indonesia Vol 75 No 5 (2025): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.75.5-2025-1830

Abstract

Introduction: The survival of colorectal cancer patients is significantly influenced by comorbid factors, including age, smoking, obesity, comorbidities, and genetics. The purpose of this study was to analyze factors affecting colorectal cancer survival in Nganjuk Regional General Hospital and to examine the expression of the APC, KRAS, and SMAD4 genes in tumor tissue.Methods: We analyzed the comorbid factors in 51 colorectal cancer patients and then analyzed their relationship to colorectal cancer survival. Immunohistochemistry (IHC) staining was performed to examine the expression of the KRAS, APC, and SMAD4 genes in colorectal cancer tissue. Data were analyzed using bivariate analysis between variables using the Chi-square test, and survival analysis was performed using Kaplan-Meier statistical analysis.Results: The data shows that colorectal cancer patients with comorbidities tend to have a lower survival rate than those without comorbidities (P-value 0.054), and patients with metastases also have a lower survival rate (P-value 0.748). APC and SMAD4 gene expression in stromal tissue IHC was more dominant than KRAS gene expression in the stroma. Increased gene expression in the stroma indicates its role in tumor invasion and metastasis.Conclusion: Comorbidities and the presence of metastases negatively impact the survival rate of colorectal cancer patients. APC and SMAD4 gene expression in the stromal tissue was more dominant than KRAS gene expression in the stroma, suggesting a role for these genes in tumor invasion and metastasis.
SKRINING KANKER PARU DI POSYANDU LANSIA NIRMALA WAGE SIDOARJO Hernanda, Pratika Yuhyi; Arimbi, Muzaijadah Retno; Sugeng, Maria Widijanti; Agusaputra, Harman; Ama, Fuad; Widayati, Lilis
Prosiding Seminar Nasional COSMIC Kedokteran Vol 4 (2026): Edisi 2026
Publisher : Lembaga Penelitian Dan Pengabdian Kepada Masyarakat Universitas Wijaya Kusuma Surabaya

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Abstract

Latar belakang: Skrining kanker paru adalah pemeriksaan untuk mendeteksi dini kanker paru-paru. Dalam hal ini dilakukan pemeriksaan foto Rontgen dada bagi masyarakat yang beresiko tinggi dan atau bergejala. Skrining ini penting dilakukan karena kanker paru-paru seringkali tidak menimbulkan gejala hingga stadium lanjut. Skrining kanker paru-paru direkomendasikan untuk orang-orang yang berisiko tinggi, seperti: perokok atau mantan perokok, memiliki riwayat keluarga dengan kanker paru dan usia lebih dari 40 tahun. Metode: Pengabdian masyarakat dengan edukasi kanker paru dan Pemeriksaan foto thoraks. Hasil: Setelah dilakukan edukasi tentang kanker Paru di Balai RW 12 Posyandu Lansia Nirmala Wage, 15 pasien yang sesuai kriteria dilakukan pemeriksaan Foto Thoraks dimana masyarakat ini beresiko tinggi atau yang memiliki gejala kanker paru minimal batuk yang tidak kunjung sembuh dan atau penurunan berat badan yang tidak jelas penyebabnya. Sebanyak 3 dari 15 pasien (20%) memiliki gangguan paru pada hasil foto thoraksnya, sehingga pasien bisa dirujuk ke fasilitas kesehatan untuk mendapat penanganan lebih lanjut. Pengetahuan masyarakat akan kanker paru juga meningkat setelah dilakukannya Edukasi di Seminar kanker paru yang kami selenggarakan sehingga harapannya kejadian kanker paru dapat ditekan di masyarakat. Kesimpulan: Deteksi dini kanker paru dapat dilakukan dengan skrining melalui anamnesa, pemeriksaan fisik dan pemeriksaan foto thoraks. Edukasi kanker paru dapat meningkatkan kesadaran dini akan kesehatan paru di masyarakat.
KARAKTERISTIK KANKER PARU DI PRAKTEK SWASTA SURABAYA TAHUN 2017-2020 Agusaputra, Harman; Parengkuan, Irene Lingkan; Hernanda, Pratika Yuhyi; Sugeng, Maria W; Ama, Fuad
Prosiding Seminar Nasional COSMIC Kedokteran Vol 4 (2026): Edisi 2026
Publisher : Lembaga Penelitian Dan Pengabdian Kepada Masyarakat Universitas Wijaya Kusuma Surabaya

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Abstract

Latar Belakang: Kanker paru merupakan kanker yang cukup mengkuatirkan dan menjadi penyebab kematian terbanyak di dunia, Insiden secara keseluruah no 2 setelah kanker payudara. Diantara laki-laki umumnya terjadi peningkatan lebih banyak 2x lipat dibanding perempuan. Indonesia diperkirakan mempunyai resiko tinggi kanker paru, bersamaan dengan china dan negara eropa. Tujuan: penelitian ini ingin memperkuat epidemologi data epidemologi. Metode: Penelitian dilakukan secara cross sectional, diambil data sekunder dari praktek besama di Surabaya. Kriteria inklusi kasus pasien kanker paru didiagnosa dengan mengunakan FNAB CT guiding dalam kurun waktu 2017-2020 dengan total sampel 168 suspek kasus kanker paru. Hasil: Dari 108 kasus kanker paru ditemukan di Surabaya laki-laki lebih banyak 67,5% dengan ratio laki-laki : perempuan 2:1 . usia rerata terdiagnosis 56,4 tahun, usia termuda umur 27 tahun dan tertua umur 84 tahun. Range 61-70 tahun. Lokasi terbanyak paru sebelah kanan 56,4% dan Morfologi tumor terbanyak adalah Adenocarcinoma sebanyak 73 %. Kesimpulan: Karsinoma paru banyak dijumpai pada laki-laki dan kecenderungan pada perempuan akan terjadi peningkatan, dan dapat juga terjadi pergeseran rereta usia 61-70 tahun, paru sebelah kanan tetap menjadi kasus lokasi terbanyak dan tipe adenocarcinoma merupakan trend terbanyak.
Hubungan Kebiasaan Konsumsi Teh Dengan Kadar Hemoglobin Pada Penderita Anemia di Puskesmas Dukuh Kupang Surabaya Ramona Frisca Ariansyah; Inawati Inawati; Harman Agusaputra; Pratika Yuhyi Hernanda
Jurnal Ners Vol. 9 No. 4 (2025): OKTOBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i4.49976

Abstract

Anemia merupakan masalah kesehatan global dengan prevalensi tinggi, terutama pada remaja dan wanita usia subur. Salah satu faktor yang diduga memengaruhi kadar hemoglobin adalah kebiasaan konsumsi teh, karena kandungan tanin di dalamnya dapat menghambat penyerapan zat besi. Penelitian ini bertujuan menganalisis hubungan kebiasaan konsumsi teh dengan kadar hemoglobin pada penderita anemia di Puskesmas Dukuh Kupang Surabaya. Penelitian menggunakan desain observasional analitik dengan pendekatan cross-sectional terhadap 30 responden berusia 17–50 tahun yang memenuhi kriteria inklusi. Data dikumpulkan melalui kuesioner mengenai kebiasaan konsumsi teh, asupan zat besi, serta gejala anemia, sementara kadar hemoglobin diukur menggunakan hemoglobin meter. Hasil analisis Spearman menunjukkan tidak terdapat hubungan signifikan antara konsumsi teh dengan kadar hemoglobin (p=0,936). Namun, ditemukan hubungan signifikan antara asupan zat besi dengan kadar hemoglobin (p=0,044) dan antara jenis anemia dengan gejala klinis (p=0,009). Penelitian ini menyimpulkan bahwa faktor utama yang memengaruhi kadar hemoglobin pada responden adalah asupan zat besi, sedangkan kebiasaan konsumsi teh tidak terbukti berpengaruh signifikan.
In Silico Study: Comparison of Binding Affinity of Quercetin and Tak-285 Against HER2 Malignancy Protein I Putu Widja Putra; Putri, Candra Rini Hasanah; Harman Agusaputra
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol. 15 No. 1 (2026): March 2026
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v15i1.4735

Abstract

Background : Cancer is a leading global health challenge, driven by various proteins that promote malignant cell growth—one of which is HER2, a transmembrane receptor tyrosine kinase in the ErbB family. TAK-285 is a known HER2 inhibitor. Recently, natural compounds like quercetin have gained attention for their ability to suppress HER2 overexpression and offer therapeutic potential. Objective: This study is to compare the binding affinity between quercetin and the reference inhibitor TAK-285 with the HER2 protein, as well as to analyze the molecular interaction patterns of HER2 using In Silico study. Through this, the study seeks the determine the potential similarity in the inhibition mechanisms of HER2 quercetin and TAK-285. Methods: Experimental study using In Silico docking methods, was performed using AutoDock Vina via PyRx 0.8 to evaluate involving docking interactions between quercetin and HER2, as well as TAK-285 and HER2. Results : The results showed that quercetin binds to HER2 with a binding energy of -8.3 kcal/mol, while TAK-285 shows a stronger affinity with -9.0 kcal/mol. Despite having a slightly lower binding affinity, quercetin successfully interacts with key residues in the HER2 binding pocket and demonstrates potential as a natural HER2 inhibitor.Conclusion: These findings suggest that quercetin may serve as a promising lead compound for HER2-targeted therapy and support further investigation through in vitro and in vivo studies.
Kursus Singkat Monitoring Perkembangan Balita Dalam Penanganan Stunting Sebagai Upaya Peningkatan Pengetahuan Kader Surabaya Hebat Inawati Inawati; Titiek Sunaryati; Harman Agusaputra; Putu Oky Ari Tania
Journal of Community Development Vol. 5 No. 2 (2024): December
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/comdev.v5i2.275

Abstract

Undernutrition is responsible for nearly 50% child deaths, especially in poor countries. Approximately 25% of toddlers worldwide experience stunted which is associated with mortality, cognitive impairment and reduced productivity. The mission of the Kementrian Kesehatan is to improve the level of public health through community empowerment (Posyandu). especially in Surabaya with the empowerment of Kader Surabaya Hebat (KSH). Wonokromo District, with an area of ​​8.42 Km2 and occupying 2.55% of the area of ​​Surabaya city, has 3 access to primary health facilities, covering 6 sub-districts (Kelurahan). The ratio of community health centers per Wonokromo sub-district is 1.9, this shows that the coverage of primary health access in Wonokromo is quite good. KSH knowledge needs to be improved through education, short courses and monitoring. The aim of this Pengabdian  activity is to increase knowledge regarding monitoring the toddlers development, especially in handling stunting toddlers. This activity was able to increase the knowledge of KSH as shown by an increase in the highest score of 100, from 10% to 54.2%. Increasing KSH knowledge is a first step so that it can be applied to the community, namely toddlers in the Wonokromo health center area, so that monitoring of stunting toddlers can run and can prevent or even reduce the stunting rate in Wonokromo.
Co-Authors Ama, Fuad Arimbi, Muzaijadah Retno ATIK WULANDARI AYLI SOEKAMTO Budhi Setiawan Candra Rini Hasanah Putri Emilia Devi Emillia Devi D.Rianti, Emillia Devi Febtarini Rahmawati Fuad Ama Fuad Ama Fuad Ama HARYANTO, LOO Hernanda, Pratika I Putu Widja Putra Inawati Inawati Inawati Inawati Inawati Inawati Inawati Inawati Inawati, Inawati Indah Widyaningsih Irene Lingkan Parengkuan Loo Hariyanto Raharjo, Loo Hariyanto MARIA SUGENG Maria Widijanti Sugeng Masfufatun Masfufatun Meivy Isnoviana Ni Luh Narita Vijayanti Niluh Narita Vijayanti Pramugyono, Pramugyono Pratika Yuhyi Hernanda Putu Oky Ari Tania Ramona Frisca Ariansyah Rukmana, Kresna Aditya Shalsabillah, Nadia Fitri SOEKAMTO, AYLY Sugeng, Maria W Sugeng, Maria Wijayanti Titiek Sunaryati Titiek Sunaryati Titiek Sunaryati Titiek Sunaryati, Titiek Wardhani, Mira Kusuma Widayati, Lilis Wirayudha, Sri Annung WULANDARI, ATIK Wulandari, Ida Septika