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All Journal Biomedical Journal of Indonesia Jurnal Riset Kesehatan Poltekkes Depkes Bandung JOURNAL OF COMMUNITY ENGAGEMENT AND EMPOWERMENT Indonesian Journal of Health Science Berita Kedokteran Masyarakat Buletin Ilmu Kebidanan dan Keperawatan Jurnal Medicare Health Care : Journal of Community Service Lontara Journal Of Health Science And Technology Media Penelitian dan Pengembangan Kesehatan Jurnal Teknologi Bank Darah
Kwarta, Cityta Putri
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Nursing Public Health Veterinary Other

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The role of inflammatory biomarkers in adolescent major depressive disorder: a systematic review Kwarta, Cityta Putri; Sari, Mike Permata; Suharti; Sundjaya, Tonny; Novitasari, Prihatini Dini; Taufik, Kumar
Berita Kedokteran Masyarakat Vol 42 No 01 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/bkm.v42i01.23244

Abstract

Purpose: Major Depressive Disorder (MDD) in adolescents is an escalating mental health problem with underlying biological pathways. Increasing evi- dence highlights the role of inflammatory response and immune dysregulation in its development and progression. This study aims to explore the role of inflammatory biomarkers in Major Depressive Disorder (MDD) among adolescent populations, elucidating their potential utility for more effective treatment strategies. Methods: A systematic review was conducted using Ebsco, PubMed, Scopus, Web of Science, and Google Scholar databases. Studies published between 2019 and 2025 that focused on adolescent MDD (aged 10-19 years) and inflammation were included. Study quality was evaluated using the Joanna Briggs Institute (JBI) tool, and narrative analyses were conducted for data synthesis. The PICOS (Population, Intervention, Comparison, Outcome, and Study Design) framework is used to ensure clarity in defining the research question and inclusion criteria. The systematic review was registered in PROSPERO (CRD420251129403). Results: A total of 29 articles met the inclusion criteria for this study. Across the included studies, elevated levels of pro-inflammatory cytokines, particularly inter- leukin-6 (IL-6) and Tumor Necrosis Factor-Alpha (TNF-α), were consistently associated with MDD in adolescents. Dysregulation of the Hypothalamic- Pituitary-Adrenal (HPA) axis and alterations in anti-inflammatory cytokines such as IL-10 were also observed. These biomarkers were linked to changes in stress hormone regulation. Conclusion: Inflammatory biomarkers play a significant role in the pathophysiology of MDD among adolescents, offering promising avenues for early detection and personalised intervention. Integrating biomarker assessment into clinical practice may improve diag- nosis and guide targeted treatments.
Pengabdian kepada Masyarakat melalui Kegiatan Donor Darah di RS Bhayangkara Watukosek Reswari, Putu Ayu Dhana; Amalia, Yustisia; Kwarta, Cityta Putri; Kusumawardani, Lentera Afrida; Samsulhadi, Wiwid; Widuri, Sasi
Health Care : Journal of Community Service Vol. 3 No. 4 (2025)
Publisher : Rena Cipta Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62354/healthcare.v3i4.173

Abstract

The issue of blood availability remains a challenge in healthcare services, particularly in meeting transfusion needs in hospitals. Low participation in voluntary blood donation and limited public understanding, including among university students, regarding the importance of donation contribute to the imbalance between blood demand and supply. This community service activity aims to increase voluntary blood donation participation through the involvement of Universitas Dr. Soetomo students as agents of social awareness at RS Bhayangkara Watu Kosek. The activity was conducted offline through brief education, donor health screening, and blood donation implementation in collaboration with hospital healthcare professionals. The participants consisted of 50 Universitas Dr. Soetomo students, comprising 15 males and 35 females. Results indicated that all eligible participants successfully donated blood, and there was a marked improvement in students' understanding and positive attitudes toward blood donation as a form of social and humanitarian concern. This activity demonstrates that student-based community service is effective in supporting hospital blood availability while simultaneously building students' social character. The outcomes of this service serve as an important model for sustainable collaboration between universities and hospitals in supporting healthcare services.
Peningkatan Literasi Donor Darah dan Pencegahan Anemia Berbasis Edukasi Partisipatif pada Remaja melalui Keterlibatan Mahasiswa Universitas Dr. Soetomo Widuri, Sasi; Amalia, Yustisia; Kwarta, Cityta Putri; Kusumawardani, Lentera Afrida; Samsulhadi, Wiwid; Reswari, Putu Ayu Dhana
Health Care : Journal of Community Service Vol. 3 No. 4 (2025)
Publisher : Rena Cipta Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62354/healthcare.v3i4.174

Abstract

The issues of blood availability and the high prevalence of anemia among adolescents remain major public health challenges in Indonesia. Low health literacy, misconceptions about blood donation, and unbalanced dietary patterns highlight the need for systematic and sustainable educational interventions. This community service activity aimed to improve adolescents’ knowledge, attitudes, and behavioral readiness related to blood donation and anemia prevention through participatory education involving students of Universitas Dr. Soetomo as agents of change. The program was conducted offline through interactive lectures, dialogic discussions, simulations, and evaluations using pre-test and post-test methods. A total of 50 participants were involved, consisting of 15 males and 35 females. The results demonstrated an increase in the average knowledge scores from a moderate category in the pre-test to a high category in the post-test, accompanied by more positive attitudes toward blood donation and increased awareness of nutrition and iron supplementation. These findings indicate that student-based participatory health education is effective in enhancing adolescent health literacy. This community service initiative is important as a model of community empowerment oriented toward health behavior change and the strengthening of the role of higher education institutions in public health development.
Skrining Tekanan Darah sebagai Upaya Deteksi Dini Hipertensi pada Masyarakat Usia Produktif di Kelurahan Menur Pumpungan Samsulhadi, Wiwid; Amalia, Yustisia; Kwarta, Cityta Putri; Kusumawardani, Lentera Afrida; Widuri, Sasi; Reswari, Putu Ayu Dhana
Health Care : Journal of Community Service Vol. 3 No. 4 (2025)
Publisher : Rena Cipta Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62354/healthcare.v3i4.175

Abstract

Hypertension is one of the primary health issues among the productive-age group, often remaining undetected due to low public awareness regarding routine screenings. This community service project aims to conduct blood pressure screenings while simultaneously increasing awareness of hypertension risks among the productive-age population in Menur Pumpungan Village. The activity was conducted offline through blood pressure measurements using standardized digital tensimeters, accompanied by brief education on hypertension and its prevention. The participants consisted of 100 individuals from the general public, including both productive-age men and women. The results indicated that a portion of the participants fell into the prehypertension and hypertension categories, while others maintained normal blood pressure levels. These findings suggest a significant potential for hypertension issues within the productive-age population. This initiative underscores the importance of routine blood pressure checks for early detection and strengthens the role of community service in supporting promotive and preventive health efforts at the village level.
Sosialisasi dan Pemberdayaan Karang Taruna dalam Membangun Ekosistem Donor Darah Berkelanjutan di Kebonsari Surabaya Amalia, Yustisia; Kwarta, Cityta Putri; Kusumawardani, Lentera Afrida; Widuri, Sasi
Health Care : Journal of Community Service Vol. 3 No. 4 (2025)
Publisher : Rena Cipta Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62354/healthcare.v3i4.177

Abstract

Ketersediaan stok darah merupakan komponen krusial dalam sistem pelayanan kesehatan, namun partisipasi masyarakat di wilayah urban seperti Surabaya masih di bawah target 2% populasi. Kelurahan Kebonsari memiliki potensi risiko kesehatan yang tinggi, namun peran Karang Taruna dalam donor darah masih bersifat insidental dan terhambat oleh rendahnya literasi kesehatan. Sebanyak 70% pemuda awalnya memiliki ketakutan terhadap jarum suntik dan mitos kesehatan. Tujuan pengabdian ini adalah membangun ekosistem donor darah berkelanjutan melalui pemberdayaan 20 stakeholder kunci Karang Taruna Kebonsari. Metode yang digunakan adalah Training of Trainers (ToT) dan Focus Group Discussion (FGD) yang meliputi tahap baseline survei, intervensi edukasi intensif, dan pembentukan database digital. Hasil kegiatan menunjukkan peningkatan literasi kesehatan peserta secara signifikan dengan rata-rata kenaikan skor sebesar 48,3%, di mana pemahaman syarat medis meningkat dari 35% menjadi 90%. Seluruh peserta (100%) menyatakan komitmen tertulis sebagai pendonor tetap dan pionir edukasi di tingkat RT/RW. Luaran program berupa Buku Pedoman Mitra dan sistem database "Kartu Donor Rutin" menjadi fondasi kemandirian stok darah di Kelurahan Kebonsari. Kesimpulannya, hambatan utama donor darah adalah masalah persepsi yang dapat dimitigasi melalui edukasi kelompok kecil yang intensif bagi kader kepemudaan.
The Role of Immunity in The Epidemiology of Adolescent Syphilis Kwarta, Cityta Putri; Fathiyyah, Nurul; Ganisia, Ainun; Imeldawati, Rakhmalia
Biomedical Journal of Indonesia Vol. 12 No. 1 (2026): Vol 12, No 1, 2026 (In Press)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i1.233

Abstract

Introduction. Syphilis is a sexually transmitted infection (STI) caused by the bacterium Treponema pallidum and remains a global health problem with a significant increase in prevalence. Adolescents are vulnerable to syphilis because they lack sufficient sexual health information and services. This study aims to explore the role of cellular immune response in the pathogenesis of syphilis in adolescents and the factors that influence it. Methods. This research study adopted a systematic literature review methodology, sourcing data from PubMed, Scopus, Web of Science, and Google Scholar databases. Results. The results demonstrate a crucial involvement of macrophages, dendritic cells, and T lymphocytes in the cellular immune response against Treponema pallidum causes Syphilis. The immune response is principally influenced by variables such as age, nutritional status, and the presence of HIV infection. High infection rates are also attributable to factors such as risky sexual behaviour and socioeconomic conditions. Enhanced interventions, including comprehensive sexual health education and improved access to healthcare services, are crucial for mitigating the adverse effects of syphilis in adolescents. Conclusion. In conclusion, this research underscores the necessity of a deeper understanding of the immunopathogenic mechanisms of syphilis in adolescents to facilitate the development of more effective preventive, diagnostic, and therapeutic strategies.
Seroprevalence of syphilis in reproductive-age female blood donors: a cross-sectional study in Surabaya, Indonesia Badrus, Arkha Rosyaria; Khairoh, Miftahul; Kwarta, Cityta Putri; Anggraeni, Novi; Imeldawati, Rakhmalia; Amalia, Yustisia; Pacheco, Cipriano do Rosario
Berita Kedokteran Masyarakat Vol 42 No 02 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/bkm.v42i02.26788

Abstract

Purpose: Syphilis remains a global public health concern, particularly in developing countries. This study aims to determine the seroprevalence of syphilis and assess its association with sociodemographic factors among female blood donors of reproductive age in Surabaya, Indonesia. Methods: This cross-sectional study analysed secondary data from 186 female blood donors aged 15–49 years at the Indonesian Red Cross (PMI) in Surabaya. Syphilis status was categorized as reactive or non-reactive based on screening results. Sociodemographic variables included age, marital status, education, and occupation. Descriptive and chi-square bivariate analyses were conducted using JASP 0.95.4, with significance set at p < 0.05. Results: The seroprevalence of syphilis among female donors was 25.3%. Significant associations were found between syphilis status and marital status (p = 0.000), age category (p = 0.001), and education level (p = 0.013). Unmarried women, adolescents aged 15–24, and those with lower levels of education had the highest proportions of reactive results. While occupation was not statistically significant (p = 0.228), students and housewives showed the highest infection rates. Conclusion: The high seroprevalence of syphilis among female reproductive-age donors in Surabaya is significantly associated with specific sociodemographic factors. Strengthening STI prevention programs and routine donor screenings is essential to ensure blood safety and improve reproductive health outcomes.
Co-Authors Amalia, Yustisia Anggraeni, Novi Arkha Rosyaria Badrus Eny Widiyasari, Eny Fathiyyah, Nurul Ganisia, Ainun Hubaedah, Annah Imeldawati, Rakhmalia Kusumawardani, Lentera Afrida Lentera Afrida Kusumawardani Miftahul Khairoh Nafiata, Ikrimah Novitasari, Prihatini Dini Nuraenayatin, Nina Pacheco, Cipriano do Rosario Pratiwi, Dessy Putri Rahmadani, Putri Reswari, Putu Ayu Dhana Rochmayanti, Shinta Nur Samsulhadi, Wiwid SARI, MIKE PERMATA Suharti Sundjaya, Tonny Susila, Ida Taufik, Kumar Ummah, Kholifatul Wahyuni, Nuris Sobriyanti Widuri, Sasi Wuru, Maria Yolanda