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THE EFFECTIVENESS OF LEMON JUICE (Citrus limon) ON PURKINJE CELL OF WHITE MALE MICE (Mus musculus) CEREBELLAR CORTEX THAT EXPOSED BY MONOSODIUM GLUTAMATE (MSG) Afsari, I Gusti Ayu Novita; Fitriani, Hikmah; Suroso, Triono Adi
Proceedings of the International Conference on Applied Science and Health No 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Abstract

Introduction: A number of studies have indicated that excessive MSG (Monosodium glutamate) consumption can lead to the formation of free radicals that can have a negative effect on purkinje cells in the cerebellar cortex. Lemon fruit is a plant that has benefits as a natural antioxidant because it contains compounds such as flavonoids, vitamin C, citric acid and other substances. This study aims to examine the effect of lemon juice (Citrus limon) to purkinje cells of the cerebellum cortex on male white mice (Mus musculus) which exposed of monosodium glutamate.Method: This research is an experimental laboratory with a post test only control group design. The research  subjects were 30 white male mice divided into 5 groups: normal control given standard  feed, negative control  given MSG dose 4mg / grBW, group of dose I , dose II , and dose III that were each given lemon juice with doses 3.33ml / kgBW, 6.67ml / kgBW, 13.33ml/ kgBW respectively. The number of purkinje cells is calculated in the cerebellar cortex by HE staining. The results of the study were analyzed by One Way ANOVA followed by the Bonferroni Post hoc test.Results: The average number of purkinje cells in administration of lemon juice with dosages of 3.33 ml/kgBW, 6.67 ml/kgBW and 13.33 ml /kgBW were 14.10 cells, 16.73 cells and 17.50 cells respectively. Based on the Post Hoc test, the average number of purkinje cells at the dose of 13.33 ml / kgBW was higher than the negative control (p = 0.021)Conclusion: Lemon juice could be used to reduce negative effect of MSG on purkinje cells of white male mice. Moreover, this finding could be used as reference on further research of benefit of lemon juice.
GAMBARAN KARAKTERISTIK PENYAKIT HIRSCHSPRUNG’S DI RSUD GUNUNG JATI CIREBON PERIODE 2020–2022 Andini, Maryzka; Kusumo, Dimas Aryo; Hermawan, Iwan; Nopita, Ineu; Ahmad, Zulkifli; Suroso, Triono Adi
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 11 No 1 (2025): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
Publisher : Fakultas Kedokteran UGJ Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33603/tumed.v11i1.10044

Abstract

ABSTRAK Latar Belakang: Penyakit Hirschsprung’s adalah terjadinya pembesaran usus yang tipikal sepanjang bagian proksimal yang mengalami aganglionosis coli. Insiden penyakit Hirschsprung’s di dunia adalah 1:5000 kelahiran hidup dengan angka kematian berkisar antara 1–10%. Tujuan: Mengetahui gambaran jenis kelamin, usia, usia gestasi, usia saat dilakukan Tindakan, gambaran gejala klinis, Tindakan operasi dan komplikasi pasien penderita Hirschsprung’s di RSUD Gunung Jati Kota Cirebon Metode: Desain penelitian ini deskriptif retrospektif. Data yang digunakan adalah data sekunder berupa rekam medis pasien Hirschsprung’s di RSUD Gunung Jati periode 2020-2022. Teknik pengambilan sampel yang digunakan adalah total sampling. Hasil: Berdasarkan uji univariat didapatkan kejadian penyakit Hirschsprung’s terbanyak pada kategori usia 0-6 bulan (37,1%) dengan jenis kelamin laki-laki (60,0%), pasien berdasarkan usia gestasi preterm (8,6%), usia saat operasi 0-6 bulan (37,1%), gambaran klinis yang terbanyak konstipasi (55,7%), Tindakan operasi yang paling sering dilakukan yaitu operasi Swenson (77,1%) dan pasien dengan komplikasi infeksi luka operasi (7,1%). Simpulan: Gambaran penyakit Hirschsprung’s yang didominasi paling banyak berdasarkan karakteristik penyakit yaitu pada kategori usi 0-6 bulan (37,1%) dengan jenis kelamin laki-laki (60,0%) ABSTRACT Background: Hirschsprung's disease is the typical occurrence of intestinal enlargement along the proximal part which has aganglionosis coli. The incidence of Hirschsprung's disease in the world is 1:5000 live births with a mortality rate ranging from 1–10%. Aim: Knowing the description of gender, age, gestational age, age at the time of action, description of clinical symptoms, surgical procedures and complications of patients with Hirschsprung's at Gunung Jati Hospital, Cirebon City. Methods: This research design is descriptive retrospective. The data used is secondary data in the form of medical records of Hirschsprung's patients at Gunung Jati Regional Hospital for the 2020-2022 period. The sampling technique used is total sampling. Results: Based on the univariate test, the highest incidence of Hirschsprung's disease was found in the age category 0-6 months (37.1%) with male sex (60.0%), patients based on preterm gestational age (8.6%), age at surgery 0-6 months (37.1%), the most clinical picture is constipation (55.7%), the most frequently performed surgery is Swenson surgery (77.1%) and patients with surgical wound infection complications (7.1%) %). Conclusion: The most dominant description of Hirschsprung's disease is based on disease characteristics, namely in the 0-6 month age category (37.1%) with male sex (60.0%)
The Influence of Nutritional Education and Reproductive Health of Pregnant Women on the Knowledge and Attitudes of Pregnant Women in Talun District Using a Quasi Experimental Study Putri, Nena Bidari; Fauzah, Shofa Nur; Suroso, Triono Adi
Journal of Social Research Vol. 4 No. 9 (2025): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v4i8.2703

Abstract

The prevalence of SEZs in Indonesia was 35.5% in 2018. Data from West Java Province in 2020 reported 55,629 cases of pregnant women experiencing SEZs across 27 districts and cities in the province. Specifically, based on data from West Java Province, there were 4,696 cases of pregnant women experiencing SEZs in Cirebon Regency. The factor of knowledge about nutrition and reproductive health is related to the incidence of SEZs, which are a cause of fetal growth and development disorders. For this reason, this research was carried out. The research aims to determine the influence of nutrition education and reproductive health of pregnant women on the knowledge and attitudes of pregnant women in Talun District. This study is Quasi Experimental research with a Separate Sample Pretest-Posttest design. The population consisted of pregnant women undergoing antenatal care at the Talun Health Center, Cirebon Regency, West Java, totaling 32 respondents who met the inclusion criteria. Quota sampling was used as the sampling method. A T-test analysis was conducted to determine the influence of nutrition education and reproductive health of pregnant women on their knowledge and attitudes in Talun District. The T-test analysis found a significant influence of nutrition education and reproductive health of pregnant women on their knowledge and attitudes in Talun District (P < 0.05). The provision of nutrition and reproductive health education has a positive effect on improving the knowledge and attitudes of pregnant women.
Hubungan Kunjungan Antenatal Care Dengan Tingkat Pengetahuan Tentang Preeklamsia Pada Ibu Hamil Di Puskesmas Sedong Aprila, Bela; Wirandoko, Ignatius Hapsoro; Suroso, Triono Adi
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i10.61685

Abstract

Latar Belakang : Preeklamsia merupakan salah satu penyebab utama kematian ibu dan janin di Indonesia, ditandai dengan hipertensi dan proteinuria setelah usia kehamilan 20 minggu. Kurangnya pengetahuan ibu hamil mengenai preeklamsia berkontribusi terhadap keterlambatan deteksi dan penanganan kondisi ini. Kunjungan antenatal care (ANC) secara teratur merupakan upaya penting dalam meningkatkan pengetahuan ibu hamil mengenai tanda bahaya kehamilan, termasuk preeklamsia. Berdasarkan data WHO tahun 2020, preeklamsia menyumbang sekitar 25% dari penyebab kematian ibu di dunia, dan di Indonesia tercatat 412 kasus kematian ibu akibat preeklamsia pada tahun 2023. Prevalensi hipertensi dalam kehamilan di Jawa Barat mencapai 10,57%, tertinggi di Indonesia. Tujuan : Menganalisis hubungan kunjungan antenatal care dengan tingkat pengetahuan tentang preeklamsia pada ibu hamil di puskesmas sedong. Metode : Penelitian ini merupakan penelitian observasional analitik dengan pendekatan cross sectional. Teknik pengambilan sampel menggunakan accidental sampling dengan jumlah sampel sebanyak 97 ibu hamil. Instrumen yang digunakan adalah kuesioner terstruktur yang telah diuji validitas dan reliabilitasnya. Analisis data dilakukan menggunakan uji Spearman. Hasil : Terdapat hubungan yang signifikan antara hubungan kunjungan antental care dengan tingkat pengetahuan tentang preeklamsia pada ibu hamil (p=0,006). Kesimpulan: Penelitian menunjukkan adanya hubungan signifikan antara kunjungan antenatal care dan pengetahuan tentang preeklamsia di Puskesmas Sedong. Ibu hamil yang rutin melakukan kunjungan antenatal cenderung memiliki pemahaman yang lebih baik mengenai preeklamsia. Hal ini menyimpulkan bahwa pentingnya peningkatan akses dan kepatuhan terhadap kunjungan ANC guna meningkatkan pengetahuan serta pencegahan terhadap preeklamsia.
HUBUNGAN RUJUKAN KASUS OBSTETRI DENGAN SECTIO CAESAREA DI RUMAH SAKIT UMUM DAERAH GARUT PERIODE 2018-2020 Permanawati, De’is Putra; Ahmad, Zulkifli; Nurbaniwati, Nunung; Suroso, Triono Adi; Fachrudin, Duddy
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 10 No 4 (2024): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
Publisher : Fakultas Kedokteran UGJ Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33603/tumed.v10i4.9643

Abstract

Latar belakang: Sectio Caesarea (SC) merupakan jenis persalinan buatan yang dilakukan pada saat kondisi ibu dan janin tidak memungkinkan untuk melakukan persalinan secara pervaginam atau normal. Perlu adanya rujukan dengan beberapa indikasi terkait terlebih dahulu untuk melakukan persalinan secara Sectio Caesarea. Penggunaan tindakan sectio caesarea saat ini semakin meningkat diatas standar yang ditetapkan WHO. Tujuan: Penelitian ini dilakukan untuk mengetahui hubungan rujukan kasus obstetric dengan kejadian persalinan secara section caesarea. Metode: Penelitian ini merupakan studi observasional dengan metode cross-sectional dengan jumlah sampel sebanyak 387 subyek. Data yang digunakan adalah data sekunder, yang kemudian dilakukan analisis. Untuk analisis bivariat, digunakan uji korelasi Spearman, sedangkan untuk analisis multivariat diterapkan uji regresi logistik Hasil: Didapatkan sebesar 58,7% pasien melahirkan dengan caesar dan 41,3% melahirkan dengan persalinan normal. Faktor dengan indikasi medis adalah 57,1% pada indikasi ibu dan 42,9% pada indikasi janin, faktor dengan resiko paritas 17,1%, resiko umur ibu 30,5%, resiko usia kehamilan 60,2%, resiko respon time 36,2%. Berdasarkan perhitungan analisa data peneliti didapatkan hasil dari faktor kejadian persalinan caesar yaitu kejadian indikasi rs=0,184, paritas rs=0,171, umur ibu rs=0,248, usia kehamilan rs=0,207, waktu respon rs=0.=,335. Variabel paling berpengaruh dalam kejadian sectio caesarea adalah umur ibu yang dengan Exp(B) tertinggi dibandingkan variabel yang lain. Kesimpulan: Dari hasil analisis 5 variabel tersebut membuktikan adanya hubungan yang signifikan antara rujukan kasus obstetri dengan kejadian SC di Rumah Sakit Umum Daerah Garut periode 2018-2020. Kata Kunci: Sectio Caesarea, Rujukan Persalinan, Proses Persalinan ABSTRACT Introduction : Sectio Caesarea (SC) is a type of artificial childbirth that is carried out when the condition of the mother and fetus does not allow for pervaginal or normal birthing. There needs to be a referral with several related indications in advance to childbirth by Caesarean sectio. The use of caesarean section is currently increasing and has even exceeded the maximum limit of WHO standards. Aim : This study was conducted to determine the relationship between obstetric case referrals and the incidence of delivery by caesarean sectio. Method This study is an observational research using a cross-sectional method with a sample size of 387 subjects. The data used is secondary data, which was then analyzed. For bivariate analysis, the Spearman correlation test was used, while multivariate analysis employed logistic regression. Result : Researchers got the percentage results of 58.7% of patients gave birth by caesarean section and 41.3% gave birth by normal delivery. Factors with medical indications were 57.1% for maternal indications and 42.9% for fetal indications, factors with parity risk 17.1%, maternal age risk 30.5%, gestational age risk 60.2%, risk response time 36 ,2%. Based on the calculation of the research data analysis, the results obtained from the incidence of cesarean delivery, namely the incidence of indications rs=0.184, parity rs=0.171, maternal age rs=0.248, gestational age rs=0.207, response time rs=0.=.335. The most influential on the incidence of sectio caesarea is the age of the mother who has the highest Exp (B) value compared to other variables. Conclusion : The analysis of the five variables demonstrates a significant relationship between obstetric referrals and the occurrence of cesarean sections at Garut Regional General Hospital during the period of 2018-2020.. Keywords: Section Caesarea, Labor Referral, Delivery Process
Hubungan Sindrom Metabolik Dengan Preeklampsia di Puskesmas Majasem Husnaa, Farah Syaufika; Suroso, Triono Adi; Ahmad, Zulkifli
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v7i9.14860

Abstract

Preeclampsia is a pregnancy-induced hypertension accompanied by proteinuria or other organ system disturbances. The incidence of preeclampsia in Indonesia is 128,273 per year or around 5.3%, with no apparent decrease in cases over the last two decades. Several risk factors can contribute to the development of preeclampsia, one of which is obesity, a metabolic disorder in the body and a clinical manifestation of metabolic syndrome. This study aims to determine the incidence of metabolic syndrome in postpartum mothers with a history of preeclampsia, understand the incidence of preeclampsia, and analyze the relationship between metabolic syndrome and preeclampsia at Majasem Community Health Center in 2022. The study utilizes an analytical observational method with a cross-sectional approach. Data used are medical records of postpartum mothers in 2022 at Majasem Community Health Center. The total sampling method was employed, resulting in 40 research samples. Bivariate analysis using Spearman's correlation test indicates that the number of postpartum mothers experiencing metabolic syndrome is 16. The total number of preeclampsia cases at Majasem Community Health Center is 40. The Spearman test results show a significant relationship between metabolic syndrome and preeclampsia, with a p-value of 0.018 < 0.05.
HUBUNGAN SINDROM METABOLIK DENGAN PREEKLAMPSIA DI PUSKESMAS MAJASEM Husnaa, Farah Syaufika; Suroso, Triono Adi; Ahmad, Zulkifli; Syah, Pangeran Akbar; Nopita, Ineu; Herwindo, Taufan; Primanagara, Risnandya
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 11 No 2 (2025): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
Publisher : Fakultas Kedokteran UGJ Cirebon

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Abstract

LATAR BELAKANG: Preeklampsia merupakan hipertensi kehamilan yang terjadi disertai dengan adanya proteinuria atau gangguan sistem organ lainnya. Insiden preeklampsia di Indonesia adalah 128.273/tahun atau sekitar 5,3% dimana tidak tampak adanya penurunan kasus dalam dua dekade terakhir. Terdapat beberapa faktor risiko yang dapat menimbulkan preeklampsia, salah satunya adalah obesitas yang merupakan gangguan metabolisme pada tubuh sebagai salah satu manifestasi klinis dari sindrom metabolik METODE: Observasional analitik dengan pendekatan cross sectional. Data yang digunakan merupakan data rekam medis ibu post partum pada tahun 2022 di Puskesmas Majasem. Teknik pengambilan sampel menggunakan metode total sampling dan didapatkan sebanyak 40 sampel penelitian. Analisis bivariat yang digunakan adalah uji korelasi Spearman. HASIL: Didapatkan jumlah ibu post partum yang mengalami sindrom metabolik sebanyak 16 orang. Jumlah total kasus preeklampsia di Puskesmas Majasem adalah 40 kasus. Hasil uji spearman menunjukana adanya hubungan antara sindrom metabolik dengan preeklampsia. SIMPULAN: Terdapat hubungan antara sindrom metabolik dengan preeklampsia di Puskesmas Majasem dengan p-value 0,018 < 0,05. Kata kunci: sindrom metabolik, obesitas, preeklampsia ABSTRACT BACKGROUND: Preeclampsia is a gestasional hypertension that present with proteinuria or others organ damages. Every year in Indonesia, the incident of preeclampsia is 128.273 cases or approximately 5,3% which had not shown a decrement from the number of the cases for two decades. There are some risk factors that can cause preeclampsia, one of it is obesity which is the component of metabolic disorders as a clinical manifestation of metabolic syndrome. METHOD: This study is an analytical observational study with a cross-sectional approach. The data that used in this study is a secondary data that achieved from Majasem Community Health Centre medical records in 2022. The sampling method used in this study is a total sampling method and as much 40 sample were included to this study. The bivariate analysis that used in this study is the Spearman correlation test RESULT: the incidence of metabolic syndrome in post partum woman in Majasem Community Health Centre is 16 cases. The incidence of preeclampsia in in Majasem Community Health Centre at 2022 is 40 cases. The Spearman analytical test shows a correlation between metabolic syndrome and preeclampsia in Majasem Community Health Centre. CONCLUSION: the Spearman test showed a p-value of 0,018 < 0,05 which means there is a correlation between metabolic syndrome and preeclampsia at Majasem Community Health Centre. Keywords: metabolic syndrome, obesity, preeclampsia