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PHARMACIST COUNSELING EFFECT TO THE LEVEL OF PATIENT KNOWLEDGE WITH TYPE 2 DIABETES MELLITUS IN “KIMIA FARMA KAWI” PHARMACY, MALANG CITY Hakim, Abdul; Atmaja, Ria Ramadhani Dwi; Sugihantoro, Hajar; Mufidah, Fahda Dina
Journal of Islamic Pharmacy Vol 2, No 2 (2017): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v2i2.4507

Abstract

Diabetes mellitus is a carbohydrates, fats, protein metabolism disorder that caused by impaired insulin secretion, insulin disruption or both. Diabetes mellitus sufferer need a special care to make the blood glucose level always in normal condition and no complications in various organs. Type 2 diabetes mellitus is inception of disease begins with development of key metabolic abnormality, insulin resistance. Causes of type 2 diabetes mellitus is obesity, age over 40, lifesyle, genetic suscetibility. Pharmacist counseling to the patients of type 2 diabetes mellitus is very important because it can improve patient knowledge, patient compliance to the treatment and the quality of patients life. The purpose of this study is to determine the effect of counseling by pharmacists to the level of patient’s knowledge of type 2 diabetes mellitus in “Kimia Farma Kawi” Pharmacy, Malang City.This research is a quantitative study with Pre-Experimental design in the form of pretest – post-test design. Number of samples was taken during one month by using consecutive sampling method. The result of this study was using through Wilcoxon test that there was difference of value before and after the pharmacist counseling the patients of type 2 diabetes mellitus with significance value equal to 0.000 (p value 0,05). The conclusion of this research is the pharmacist counseling can improve patient knowledge of type 2 diabetes mellitus. Keywords : pharmacist counseling, knowledge, type 2 diabetes mellitus 
Pengaruh Variasi Konsentrasi Propilen Glikol Sebagai Enhancer Terhadap Sediaan Transdermal Patch Ibuprofen In Vitro Misnamayanti, Misnamayanti; Sugihantoro, Hajar; Fauziyah, Begum
Journal of Islamic Pharmacy Vol 4, No 2 (2019): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v4i2.8029

Abstract

Ibuprofen is an anti-inflammatory class of non-steroidal propionic acid used in the treatment of osteoarthritis, analgesics, and antipyretics. Ibuprofen made in a transdermal patch to avoid side effects of irritation to the stomach, first pass effect on application oral. This aims of the research to determine the physical characteristics of the patch, the effect of propylene glycol concentration (150 mg, 200 mg, 250 mg) on the thickness patch, pH, and the rate of penetration as increase in penetration of the ibuprofen transdermal patch. Patch preparations were made in 3 draft formulas with varying concentrations of propylene glycol 150 mg, 200 mg, and 250 mg. The method used for penetration testing is Franz diffusion cells. The results of physical characteristics are clear, odorless, dry, not cracked, 300 folds, thickness ranges from 0.142 to 0.184. The concentration of propylene glycol effects (p-value 0.05) the penetration and no effect (p-value 0.05) the pH test. Increasing the concentration of propylene glycol causes an increase medicine that penetrate the skin.Keywords: Ibuprofen, transdermal patch, propylene glycol
Analisis in Silico Senyawa Fitokimia dari Fraksi n-Heksana Daun Semanggi (Marsilea crenata Presl.) sebagai Agen Neuroprotektif Ma'arif, Burhan; Jatmiko, Ricky Arie; Megawati, Dewi Sinta; Annisa, Rahmi; Sugihantoro, Hajar; Muchlisin, Muhammad Artabah; Laswati, Hening; Agil, Mangestuti
Journal of Islamic Pharmacy Vol 5, No 1 (2020): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v5i1.9180

Abstract

Estrogen deficiency causes various health problems in postmenopausal women, including neurodegenerative disease. Phytoestrogens emerged as a group of compounds that can replace the estrogen function in the body, and prevent the neurodegenerative disease to occur. Semanggi (Marsilea crenata Presl.) is a typical plant in Surabaya, Indonesia, that contain phytoestrogens. The aim of this research was to determine the metabolite profile of n-hexane fraction of Semanggi leaves using UPLC-QToF-MS/MS, and then to predict the neuroprotective activity of compounds with in silico study using PyRX 0.8 software. The 100 ppm of n-hexane fraction of Semanggi leaves in DCM and methanol were injected 5 µl each into the UPLC-QToF-MS/MS, and then analyzed by Masslynx 4.1 software to determine the compounds. The compounds from metabolite profiling then prepared with SwissADME webtool and Avogadro 1.90.0 software, molecular docking was done using Autodock Vina and Biovia Discovery Studio Visualizer 2016 to 3OLS protein. Metabolite profiling process shows a total of 34 predictable compounds and 28 unknown compounds. From in silico study, it shows a total of 7 compounds that are predicted to have activities similar to estrogen. This result indicate that n-hexane fraction of Semanggi leaves has potential as a neuroprotective agent for treatment for postmenopausal women who experience estrogen deficiency.Keywords: Marsilea crenata Presl., phytoestrogens, metabolite profiling, in silico, neuroprotective
Tingkat Kepuasan Konsumen terhadap Pelayanan Kefarmasian di Apotek Ganesha Farma Kabupaten Lamongan Nisa', Zahrotun; Sugihantoro, Hajar; Syahrir, Ach; Wijaya, Dhani
Journal of Islamic Pharmacy Vol 6, No 1 (2021): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v6i1.11273

Abstract

Pharmaceutical service is a form of health service in pharmacy as an inseparable unit that plays a significant role in improving the quality of life of patients and also increasing patient satisfaction. Based on the preliminary study, the services whose provided by the Ganesha Farma Pharmacy staff are less satisfying to consumers, related to the friendliness of the pharmacy staff and the lack of provision of drug information by pharmacy staff. Therefore, in this study, it is expected to know the level of customer satisfaction at the Ganesha Farma Pharmacy, Lamongan Regency. The purpose of this study was to determine the level of customer satisfaction with pharmaceutical service at Ganesha Farma Pharmacy in Lamongan Regency.  The type of research was descriptive with a quantitative approach.  The sampling method was non-probability sampling with the purposive sampling technique. The samples obtained were 100 respondents.  The method of calculating the level of customer satisfaction was the Customer Satisfaction Index (CSI) method.  The results showed that the level of satisfaction at the reliability dimension of 70.8% (satisfied), responsivenesss 68.8% (satisfied), assurance 69% (satisfied), empathy 69.8 (satisfied), tangible 69.4% (satisfied). The conclusion of this study is the level of customer satisfaction towards pharmaceutical services at Ganesha Farma Pharmacy, Lamongan Regency is 69.56% with the satisfied category.Keywords: Level of customer satisfaction, Pharmacy, Pharmaceutical services
Evaluasi Kuantitatif Penggunaan Antibiotik di Ruang Perawatan Airlangga dan Peta Kuman RSUD Kanjuruhan Malang Periode Juli-Desember 2018 Wirda Anggraini; Hajar Sugihantoro; Firda Ludfiyah
Indonesian Journal of Clinical Pharmacy Vol 10, No 2 (2021)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2021.10.2.90

Abstract

Antibiotik merupakan salah satu obat yang paling banyak dikonsumsi secara luas di tempat layanan kesehatan. Tingginya jumlah penggunaan antibiotik yang tidak tepat dapat mengakibatkan terjadinya resistensi, efek samping dan biaya rumah sakit yang meningkat. Salah satu upaya untuk mengendalikan resistensi antibiotik di rumah sakit adalah pelaksanaan evaluasi penggunaan antiobiotik. Penelitian ini bertujuan untuk mengetahui profil penggunaan antibiotik dan peta kuman, serta melakukan evaluasi kuantitatif. Penelitian ini merupakan penelitian observasional deskriptif menggunakan desain cross-sectional melalui data rekam medik pasien Ruang Perawatan Airlangga bulan Juli–Desember 2018 dan data peta kuman tahun 2018 RSUD Kanjuruhan Malang yang diambil secara retrospektif. Didapatkan 75 sampel rekam medis yang kemudian dianalisis secara kuantitatif menggunakan metode ATC/DDD. Hasil penelitian ini menunjukkan bahwa golongan antibiotik terbanyak yang digunakan adalah golongan Cephalosporin (86%) dengan tiga antibiotik tertinggi adalah Cefoperazone (43,90%), Ceftriaxone (18,29%), dan Cefotaxime (13,41%). Dari hasil analisis kuantitatif penggunaan antibiotik dengan metode ATC/DDD, didapatkan nilai total DDD/100 patient days sebesar 66,44 dengan antibiotik tertinggi adalah Cefoperazone (20,72), dan Ceftriaxone (20,18). Antibiotik yang masuk dalam segmen 90% antara lain Cefoperazone (parenteral) 31,19%, Ceftriaxone (parenteral) 30,37%, Cefotaxime (parenteral) 12,45%, Levofloxacin (parenteral) 5,19%, Levofloxacin (oral) 4,88%, dan Metronidazole (parenteral) 4,73%. Isolat bakteri yang diperoleh dari laboratorium mikrobiologi berjumlah 120 isolat dengan distribusi bakteri gram positif (49,17%) dan bakteri gram negatif (50,83%). Isolat bakteri gram positif terbanyak adalah Staphylococcus aureus (30%) dan bakteri gram negatif terbanyak adalah Escherichia coli (15%) dengan sensitivitas antibiotik terbaik untuk bakteri gram positif adalah Clarithomicyn (81,8%) dan untuk bakteri gram negatif adalah Amikacin (77,8%).Kata kunci: Antibiotik, DDD/100 patient days, DU 90%, peta kuman  A Quantitative Evaluation of the Antibiotic Use in Airlangga Ward and Microorganism Pattern in Kanjuruhan Regional General Hospital Malang, between July and December 2018AbstractAntibiotics are the most widely used class of drugs in health care, however, the abuse of these drugs leads to resistance, side effects, and increased hospital costs. The evaluation of antibiotics use is a possible attempt to control antibiotic resistance in hospitals. Therefore, this study aimed to determine the profile of antibiotic use, microorganism pattern, and perform a quantitative evaluation. Using an observational descriptive method study with a cross-sectional design, data were retrospectively retrieved from medical records of patients admitted in Airlangga Ward between July and December 2018, as well as the microorganism pattern in Kanjuruhan Region General Hospital Malang 2018. A total of 75 medical record samples were obtained and these were further analyzed using the ATC/DDD method. According to the results, the most used antibiotics group was Cephalosporin (86%), particularly Cefoperazone (43.90%), Ceftriaxone (18.29%), and Cefotaxime (13.41%). In addition, the quantitative analysis of antibiotics use showed the total DDD/100 patient days was 66.44 with Cefoperazone (20.72) and Ceftriaxone (20.18). The antibiotics included in the 90% segment were Cefoperazone (parenteral) 31.19%, Ceftriaxone (parenteral) 30.37%, Cefotaxime (parenteral) 12.45%, Levofloxacin (parenteral) 5.19%, Levofloxacin (oral) 4.88%, and Metronidazole (parenteral) 4.73%. Meanwhile, a total of 120 bacterial isolates (49.17% gram-positive and 50.83% gram-negative) were obtained from the microbiology laboratory, with the most prevalent gram-positive and negative isolates being Staphylococcus aureus (30%) and Escherichia coli (15%), respectively. Also, the best antibiotic sensitivity for gram-positive and negative bacteria was recorded for Clarithomicyn (81.8%) and Amikacin (77.8%), respectively.    Keywords: Antibiotics, DDD/100 patient days, DU 90%, microorganism pattern
HUBUNGAN PENGETAHUAN DAN PERILAKU PENGGUNAAN ANTIBIOTIK (STUDI KASUS PADA KONSUMEN APOTEK-APOTEK KECAMATAN GLAGAH KABUPATEN LAMONGAN) Hajar Sugihantoro
Jurnal Ilmiah Farmasi Farmasyifa Vol 3, No 2 (2020)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiff.v3i2.5655

Abstract

ABSTRAKKetidaktepatan penggunaan antibiotik banyak ditemukan di masyarakat luas. Hal ini dapat menjadi penyebab terjadinya resiko buruk seperti resistensi antibiotik. Studi awal yang dilakukan pada 15 warga Kecamatan Glagah menunjukkan sebanyak 73% menggunakan antibiotik untuk penyakit non infeksi atau membelinya tanpa resep dokter. Tujuan penelitian ini untuk mengetahui tingkat pengetahuan dan perilaku penggunaan antibiotik serta meneliti hubungan antara pengetahuan dan perilaku penggunaan antibiotik. Penelitian ini merupakan penelitian dalam bentuk survey dengan pendekatan cross sectional. Pengambilan sampel dilakukan dengan metode purposive sampling. Alat ukur yang digunakan berupa kuesioner tertutup. Analisis data dilakukan dengan analisis Spearman. Penelitian dilakukan pada 96 konsumen Apotek-apotek di Kecamatan Glagah Kabupaten Lamongan. Hasil yang didapat yakni mayoritas responden berjenis kelamin perempuan (64%), berusia antara 18-40 tahun (75%). Pendidikan terakhir mayoritas responden adalah SMA (55%).  Mayoritas responden adalah ibu rumah tangga (32%). Antibiotik yang banyak digunakan oleh responden adalah amoxicillin (63%). Tingkat pengetahuan responden dengan kategori pengetahuan baik sebanyak 8%, kategori cukup sebanyak 35%, dan kategori kurang sebanyak 57%. Adapun kategori perilaku baik sebanyak 22%, kategori cukup sebanyak 66%, dan kategori kurang sebanyak 12%. Hasil uji spearman didapatkan nilai sig. 0,000, nilai koefisien korelasi sebesar 0,431, dan arah korelasi positif (+). Penelitian ini menunjukkan adanya hubungan yang bermakna antara pengetahuan dan perilaku penggunaan antibiotik pada konsumen Apotek-apotek Kecamatan Glagah Kabupaten Lamongan.
Evaluasi Kualitatif Penggunaan Antibiotik pada Pasien Infeksi Saluran Kemih dengan Metode Gyssens Wirda Anggraini; Tifany Maulida Candra; Siti Maimunah; Hajar Sugihantoro
KELUWIH: Jurnal Kesehatan dan Kedokteran Vol. 2 No. 1 (2020): Keluwih: Jurnal Kesehatan dan Kedokteran (December)
Publisher : Direktorat Penerbitan dan Publikasi Ilmiah, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/kesdok.V2i1.2876

Abstract

Abstract—Urinary Tract Infection (UTI) was the presence of the large number of microorganisms in the urine that can cause urinary tract infections. UTIs were infection whose incidence is still high in Indonesia. The main therapy of UTIs was using antibiotics. The immense of antibiotic use can cause irrationality. This irrationality would give some negative effects such as allergic reaction, physiological changes, and antibiotic resistance. The purpose of this study was to know the quality of antibiotic use in UTI patients in Kanjuruhan Region General Hospital. The type of research was observational by the cross-sectional design. The data were taken retrospectively during September-November 2019 and used the medical records of 27 UTI inpatients. The results of this study determined 20% including category 0 (approriate use of antibiotic), 2,86% category I (antibiotic use not correct timing); 28,57% category II A (antibiotic use not correct dose); 34,29% category II B (antibiotic use not correct interval); 11,42% category III B (antibiotic use is too short) and 2,86% category IV A (there is more effective alternative). Keywords: antibiotic, gyssens, urinary tract Abstrak—Infeksi Saluran Kemih (ISK) merupakan suatu keadaan dimana terdapat mikroorganisme dalam urin yang jumlahnya sangat banyak dan mampu mengakibatkan infeksi pada saluran kemih. ISK tergolong penyakit infeksi yang angka kejadiannya masih tinggi di Indonesia. Terapi utama ISK adalah terapi dengan menggunakan antibiotik. Meluasnya penggunaan antibiotik dapat menyebabkan tidak rasionalnya penggunaan antibiotik. Penatalaksanaan terapi antibiotik yang tidak rasional dapat menimbulkan risiko antara lain adalah reaksi alergi, toksisitas, perubahan fisiologi, dan resistensi antibiotik. Tujuan penelitian ini adalah untuk mengetahui kualitas penggunaan antibiotik pada pasien ISK di RSUD Kanjuruhan Kabupaten Malang. Jenis penelitian adalah observasional dengan menggunakan desain penelitian cross-sectional. Pengambilan data dilakukan secara retrospektif selama bulan September-November 2019 dan menggunakan 27 data rekam medik pasien ISK Rawat Inap. Hasil evaluasi kualitatif menunjukkan, sebesar 20% termasuk kategori 0 (penggunaan antibiotik tepat/bijak); 2,86% kategori I (penggunaan antibiotik tidak tepat waktu); 28,57% kategori II A (penggunaan antibiotik tidak tepat dosis); 34,29% kategori II B (penggunaan antibiotik tidak tepat interval pemberian); 11,42% kategori III B (penggunaan antibiotik terlalu singkat); dan 2,86% kategori IV A (ada antibiotik lain yang lebih efektif). Kata kunci : antibiotik, gyssens, infeksi saluran kemih
Evaluasi Rasionalitas Penggunaan Obat Antihipertensi di Instalasi Rawat Jalan RSUD dr. Soegiri Lamongan Periode Tahun 2017 Dian Sa'idah; Hajar Sugihantoro; Abdul Hakim; Siti Maimunah
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (440.059 KB) | DOI: 10.35814/jifi.v17i1.650

Abstract

Hypertension is a non-communicable disease characterized by increased blood pressure that reaches > 140/90 mmHg. The incidence of hypertension and its complications continues to increase every year so the potential for irrational use of drugs is also increasing. The purpose of this study was to determine the rationality of the use of antihypertensive drugs at the outpatient installation of Hospital Dr. Soegiri Lamongan in the 2017 period, which reviews the exact indication, the right patient, the right drug, and the right dosage. This study is an observational study conducted by descriptive method and uses retrospective data, namely medical record sheets of hypertensive patients in 2017. The sampling method used was proportional stratified random sampling. The study population was 451 medical records of hypertensive patients, the number of samples used was 82 medical records where there were 269 prescription sheets in it. The data obtained are then compared using the 2013 American Society of Hypertension (ASH) literature and 2017 Hypertension Clinical Guidelines. The results showed that the rationality of the use of antihypertensive drugs in Dr. Soegiri Lamongan Hospital in 2017 period is 100% accurate on indications, 91,82 % right on patients, 88,85% right on drugs, and 98,14% right on dosages.
Pengetahuan, Persepsi, dan Sikap Masyarakat Muslin di Kabupaten Magetan terhadap Obat Halal Nurista Safa Normasilla; Abdul Hakim; Hajar Sugihantoro
Journal of Islamic Pharmacy Vol 7, No 1 (2022): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v7i1.14739

Abstract

Indonesia merupakan negara yang memiliki jumlah penduduk muslim terbesar di dunia. Sehingga masalah kehalalan suatu produk merupakan hal yang sangat penting di Indonesia. Adanya UU tentang Jaminan Produk Halal maka akan menjamin kehalalan produk yang beredar di masyarakat. Akan tetapi, kenyataannya jumlah obat halal yang beredar dalam masyarakat masih sedikit sehingga mempengaruhi tingkat kesadaran konsumsi dan minat beli  masyarakat terhadap obat halal. Tingkat kesadaran masyarakat ini berhubungan dengan tingkat pengetahuan, persepsi, dan sikap masyarakat terhadap obat halal. Tingginya tingkat pengetahuan, persepsi, dan sikap masyarakat maka akan meningkatkan kesadaran masyarakat terhadap obat halal. Kesadaran masyarakat muslim di Kabupaten Magetan terhadap obat halal khususnya vaksin masih tergolong rendah. Maka dari itu, penelitian ini dilakukan dengan tujuan untuk mengetahui tingkat pengetahuan, persepsi dan sikap masyarakat muslim di Kabupaten Magetan tentang obat halal. Penelitian ini merupakan penelitian deskriptif dengan metode kuantitatif. Teknik pengambilan sampel yang digunakan adalah purposive sampling dan menggunakan instrumen kuesioner. Hasil penelitian ini menunjukkan tingkat pengetahuan, persepsi dan sikap masyarakat terhadap obat halal secara berturut-turut yaitu 61% berada kategori sedang, 69% berada pada kategori sangat baik, dan 72% beradap pada kategori sangat baik. Berdasarkan hal tersebut, dapat disimpulkan bahwa tingkat pengetahuan masyarakat tentang obat halal di Kabupaten Magetan adalah sedang. Tingkat persepsi dan sikap masyarakat tentang obat halal di Kabupaten Magetan adalah sangat baik. Kata Kunci : obat, halal, pengetahuan, persepsi, sikap
EVALUASI KUALITAS PENGGUNAAN ANTIBIOTIKA PADA PASIEN PASCA BEDAH DENGAN METODE GYSSENS DI RSUD BDH SURABAYA PERIODE 2016 Hajar Sugihantoro; Abdul Hakim; Nur Miya Zakiya
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 17, No 01 (2020): Jurnal Ilmu Farmasi & farmasi Klinik Vol 17 No. 01, Juni 2020
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (362.555 KB) | DOI: 10.31942/jiffk.v17i01.3481

Abstract

ABSTRACT The rational use of antibiotics is prescribing antibiotics, dosage, duration, safe and affordable interval of medicine use by the patient. The purpose of this research is to know the quality of antibiotics use to the post-surgery patients in BDH Surabaya for 2016. This is a cross-sectional design, collecting the data from the medical records of post-surgery patients who received antibiotics in BDH Surabaya during 2016. The sample was taken by proportional stratified sampling. The quality of antibiotics use was analyzed by using Gyssens. The result showed that from reviews those 97 medical records, the total of the rational use of antibiotics in BDH Public Hospital Surabaya were 59.7% (category 0) and 40.3% included to the category II-IV. The use of antibiotics with incorrect dosages (category IIA) 4.8%, inappropriate administration intervals (category IIB) 7.7%, too long use (category IIIA) 16.3%, too short use (category IIIB) 1.9%, there was more effective antibiotics (category IVA) 2.9%, and there was other cheaper antibiotics (category IVC) 6.7%. Based on the quality of the use of antibiotics in post-surgical patients in BDH Hospitals at 2016 period, that appropriate Gyssens category rational antibiotic use was 59.7% and the results are not rational as much as 40.3%. Keywords: antibiotic, rational, quality, Gyssens