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All Journal Jurnal Ilmiah Farmasi Jurnal Kimia (Journal of Chemistry) Buletin Udayana Mengabdi Indonesia Medicus Veterinus Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Farmasi Kryonaut Prosiding Workshop dan Seminar Nasional Farmasi (WSNF)
Putu Oka Samirana
Program Studi Farmasi Fakultas MIPA Universitas Udayana Bali
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Veterinary

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Kandungan Fitokimia dan Aktivitas Farmakologi dari Ulva lactuca Ni Luh Linda Sukrawati; Putu Oka Samirana; Anak Agung Gede Rai Yadnya Putra
Prosiding Workshop dan Seminar Nasional Farmasi Vol. 3 (2024): Prosiding Workshop dan Seminar Nasional Farmasi 2024
Publisher : Program Studi Farmasi Fakultas MIPA Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/WSNF.2024.v03.p15

Abstract

Ulva lactuca adalah salah satu alga laut yang termasuk ke dalam genus Ulva dan keluarga Ulvaceae. Ulva lactuca memiliki komposisi kimia bernilai ekonomis tinggi yang dapat membuka peluang pemanfaatan dalam aplikasi kosmetik, farmasi, kimia, makanan, dan energi. Artikel ulasan ini bertujuan untuk memeriksa profil fitokimia dan aktivitas farmakologi dari Ulva lactuca. Pencarian data diperoleh dari jurnal internasional dan nasional melalui website dan database berbasis ilmiah yaitu PubMed dan Google Scholar. Berdasarkan literatur yang telah dikumpulkan, terdapat sebanyak 7 artikel yang memenuhi kriteria inklusi. Hasilnya menunjukkan Ulva lactuca memiliki berbagai metabolit sekunder meliputi alkaloid, terpenoid, steroid, saponin, dan flavonoid. Beberapa senyawa seperti asam sinapik, naringin, rutin, dan quercetin diisolasi dari rumput laut ini. Aktivitas farmakologi dari Ulva lactuca yang paling umum ditemukan dalam literatur adalah antioksidan, antibakteri, antijamur, anticancer, dan antidiabetes. Meskipun alga laut ini menawarkan sumber yang menjanjikan dalam dunia farmakologi dan fitokimia, namun perlu dilakukan penelitian lebih lanjut untuk mengeksplorasi potensi Ulva lactuca sebagai produk alami yang bermanfaat bagi kesehatan manusia. Mengingat bahwa penelitian terkait kandungan fitokimia dan aktivitas farmakologi Ulva lactuca masih sangat terbatas.
Studi Antibakteri, Antioksidan, dan Potensi Alga Merah Genus Gracilaria sebagai Pewarna Alami Valentina Ayu Hapsari; Putu Oka Samirana
Prosiding Workshop dan Seminar Nasional Farmasi Vol. 3 (2024): Prosiding Workshop dan Seminar Nasional Farmasi 2024
Publisher : Program Studi Farmasi Fakultas MIPA Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/WSNF.2024.v03.p22

Abstract

Gracilaria merupakan salah satu genus alga merah yang melimpah di perairan Indonesia dan telah mendapatkan perhatian luas dalam penelitian karena berbagai potensi biologisnya. Artikel ini merangkum 25 artikel terkait aktivitas antibakteri, antioksidan, dan potensi sebagai pewarna alami dari beberapa spesies Gracilaria. Penelusuran pustaka dilakukan menggunakan Google Scholar dari 2014 hingga Juli 2024. Ekstrak etil asetat dari Gracilaria sp. menunjukkan aktivitas antibakteri sangat kuat terhadap Escherichia coli dan Staphylococcus aureus, sedangkan Gracilaria fisheri juga menunjukkan efektivitas tinggi dengan nilai IC50 rendah dalam pengujian antioksidan. Senyawa bioaktif seperti flavonoid, tanin, dan saponin berkontribusi pada potensi antibakteri, sementara polifenol dan flavonoid berperan dalam aktivitas antioksidan. Temuan ini menunjukkan bahwa genus Gracilaria memiliki potensi sebagai sumber agen antibakteri dan antioksidan alami, dengan variasi efektivitas tergantung pada spesies dan metode ekstraksi. Pigmentasi alami dari genus Gracilaria terutama fikoeritrin dan karotenoid, menunjukkan potensi sebagai pewarna alami yang aman dan ramah lingkungan dalam industri pangan dan kosmetik. Artikel ini menyimpulkan bahwa alga merah genus Gracilaria memiliki potensi besar untuk dikembangkan lebih lanjut sebagai sumber bahan bioaktif dengan aplikasi luas dalam bidang kesehatan dan industri.
Kandungan Fitokimia dan Aktivitas Antibakteri dari Alga Merah Genus Halymenia Prasti Yuniarni; Putu Oka Samirana
Prosiding Workshop dan Seminar Nasional Farmasi Vol. 3 (2024): Prosiding Workshop dan Seminar Nasional Farmasi 2024
Publisher : Program Studi Farmasi Fakultas MIPA Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/WSNF.2024.v03.p24

Abstract

Alga merah dari genus Halymenia adalah jenis alga yang telah menarik perhatian para peneliti karena kandungan fitokimianya yang berpotensi sebagai agen antibakteri. Artikel ini bertujuan untuk mengkaji literatur mengenai kandungan fitokimia dan aktivitas antibakteri dari alga merah genus Halymenia, serta mengevaluasi potensi terapeutiknya berdasarkan penelitian yang telah dilakukan. Pengkajian ini menggunakan pendekatan literature review dengan melakukan penelusuran pustaka menggunakan PubMed dan Google Scholar. Berdasarkan tinjauan literatur, alga merah dari genus Halymenia mengandung berbagai senyawa fitokimia termasuk flavonoid, alkaloid, saponin, triterpenoid, tanin dan fenolik. Studi menunjukkan bahwa ekstrak alga merah memiliki potensi antibakteri yang signifikan terhadap berbagai patogen bakteri seperti Escherichia coli dan Staphylococcus aureus. Aktivitas antibakteri ini berkaitan dengan kemampuannya dalam mengganggu dinding sel bakteri dan menghambat sintesis protein, sehingga menyebabkan kematian sel bakteri. Alga merah dari genus Halymenia menunjukkan potensi yang besar sebagai sumber senyawa antibakteri alami. Literatur yang ada mendukung penggunaan alga ini dalam pengembangan agen antimikroba baru.
TYROSINASE INHIBITORS FROM HALOPHILIC AND MARINE-DERIVED FUNGI: ACTIVE METABOLITES, INHIBITORY ACTIVITIES, AND POTENTIAL APPLICATIONS IN HYPERPIGMENTATION Maurayanti, Putu Ristanaya; Nursid, Muhammad; Dewi, Luh Putu Mirah Kusuma; Samirana, Putu Oka
Jurnal Farmasi Kryonaut Vol 5 No 2 (2026): JFK
Publisher : LPPM STIKES BULELENG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59969/jfk.v5i2.219

Abstract

Skin hyperpigmentation is a dermatological problem associated with increased melanin production, in which tyrosinase plays an important role in melanogenesis. Halophilic and marine-derived fungi can adapt to extreme environmental conditions and may produce secondary metabolites with biological activities, including tyrosinase inhibition. This review aimed to evaluate the potential of halophilic and marine-derived fungi as sources of tyrosinase inhibitors by examining fungal origin, species, sample type, active metabolites, assay methods, and reported inhibitory activity. A literature search was conducted using Google Scholar with keywords related to marine fungi, endophytic fungi, halophilic fungi, and tyrosinase. Original research articles published in English that reported tyrosinase inhibitory activity of halophilic or marine-derived endophytic fungi were considered. Eleven articles were selected for further analysis. The findings showed that fungi associated with sponges, algae, sediments, and marine environments produced metabolites with varying tyrosinase inhibitory activities. Several isolated compounds exhibited strong activity, with lower IC50 values than kojic acid, whereas crude extracts generally showed lower activity. Azaphilone, polyketide, and related metabolites were reported among several active isolates. However, most studies were limited to in vitro enzyme assays, with insufficient validation of mechanisms, toxicity, and efficacy in cellular or in vivo models. Halophilic and marine-derived fungi have potential as sources of novel tyrosinase inhibitors, but standardized assays, mechanistic characterization, and safety and efficacy validation are needed to support further development as potential skin-lightening agents.
EXPLORING THE ANTIBACTERIAL POTENTIAL OF HALOPHILIC FUNGI AND THEIR SECONDARY METABOLITES: AN EVIDENCE-BASED PERSPECTIVE ON NOVEL ANTIBIOTIC CANDIDATE DEVELOPMENT Mahadewi, Ni Kadek Wiwik; Nursid, Muhammad; Dewi, Luh Putu Mirah Kusuma; Samirana, Putu Oka
Jurnal Farmasi Kryonaut Vol 5 No 1 (2026): JFK
Publisher : LPPM STIKES BULELENG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59969/jfk.v5i1.223

Abstract

Antibiotic resistance has emerged as a major global health threat, creating an urgent need for alternative antibacterial sources. Halophilic fungi, which inhabit hypersaline environments, are known to produce unique secondary metabolites with potential antibacterial activity. This review aimed to evaluate the antibacterial potential of halophilic fungi and their secondary metabolites through a structured literature review approach. Relevant articles published between 2015 and 2025 were collected from the Scopus and Google Scholar databases using the keywords “halophilic fungi” and “antibacterial”. Article selection was conducted based on predefined inclusion and exclusion criteria following the PRISMA guidelines. A total of 10 eligible original research articles were analyzed descriptively. The findings show that halophilic fungi produce diverse antibacterial metabolites, including alkaloids, gramicidin S, bisvertinolone, epicoracine, alterperylenol, and (Z)-18-octadec-9-enolide, which exhibit inhibitory activity against both Gram-positive and Gram-negative bacteria. Several metabolites demonstrate antibacterial activity comparable to or higher than standard antibiotics, while low Minimum Inhibitory Concentration (MIC) values indicate strong therapeutic potential. Overall, halophilic fungi represent an underexplored biological resource with significant potential for the development of novel antibacterial agents against bacterial resistance.
BIOACTIVE POTENTIAL OF RED AND GREEN ALGAE AS ANTIOXIDANT AND PHOTOPROTECTIVE SOURCES AGAINST OXIDATIVE STRESS AND ULTRAVIOLET RADIATION Cahyani, Ni Kadek Angga Rusnita; Puspawati, Ni Made; Dewi, Luh Putu Mirah Kusuma; Samirana, Putu Oka
Jurnal Farmasi Kryonaut Vol 5 No 1 (2026): JFK
Publisher : LPPM STIKES BULELENG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59969/jfk.v5i1.227

Abstract

Excessive exposure to ultraviolet (UV) radiation promotes the formation of reactive oxygen species (ROS), contributing to photoaging, hyperpigmentation, and skin cancer. Therefore, natural alternatives to synthetic sunscreens are increasingly explored due to potential health and environmental concerns. Seaweeds are promising sources of natural photoprotective agents because they produce bioactive compounds to survive high UV exposure. Among them, Eucheuma cottonii (red algae) and Ulva sp. (green algae) contain phenolics, carotenoids, and mycosporine-like amino acids (MAAs) with antioxidant and UV-protective properties. This narrative review aimed to compare the antioxidant and UV-protective activities of E. cottonii and Ulva sp. by analyzing original research articles published between 2015 and 2025. Quantitative data, including IC50 values for antioxidant activity and SPF or UV transmittance for photoprotection, were extracted and evaluated. The results show that extraction methods, solvent polarity, and formulation concentration significantly affect the observed bioactivities. Overall, E. cottonii consistently demonstrated stronger antioxidant capacity and higher UV-protection potential than Ulva sp., likely due to differences in phytochemical composition. These findings highlight the potential of red and green seaweeds as natural active ingredients for safer, eco-friendly, and sustainable sunscreen formulations.
Co-Authors A. A. G. R. Y. Putra A. Indyayani, I G A. N. Mahendra Amin, Amirul Anak Agung Gede Rai Yadnya Putra Ariadi, K. A. Cahyani, Ni Kadek Angga Rusnita Cokorda Istri Sri Arisanti D. A. A. Andhini D. M. N. Pratiwi Dewa Ayu Angghy Andhini Dewa Ayu Swastini Dewi P.E.M.U Dewi, Luh Putu Mirah Kusuma Eka Indra Setyawan I G A. Indyayani I Gusti Ngurah Agung D.P. I Made Agus Gelgel Wirasuta I P. R. Ardinata I P. S. D Suarka I P. W. Kusuma I Wayan Juli Sumadi I. D. M. R Taradipta I.A.D. Wiryanthini Indyayani I.G.A K. W Astuti K. Widnyani Astuti Karso, F. P. Kusuma, Lalu Angga Sadi Luh Made Sudimartini Mahadewi, Ni Kadek Wiwik Mahadewi, S. A. Mahamuni, L.P.K Mariani sembiring Maurayanti, Putu Ristanaya Milawati Milawati Muhammad Nursid N. P. A. Y. Pratiwi N. P. E Sari N. W. Satriani N. W. Satriani N.P.A.D. Wijayanthi N.W. Musdwiyuni Ni Kadek Warditiani Ni Luh Linda Sukrawati Ni Made Pitri Susanti Ni Made Puspawati Ni Putu Ariantari Ni Putu Eka Leliqia P. A. S. Putra P. R. Harfa Padmanaba I.G.P. Padmanaba, I.G.P. Pinangkaan, C. Prasti Yuniarni Putra, I. G. N. R. Putra, P. A. S. Putu Dessy Wilantari Putu Eka Masmita U.D. Putu Siska Angelina Pramesti S. Ainnurrahmah S. P. P. Dewi Sarasmitha M.A Setyaawan E.I. Setyawan E.I. Shaswati, Gusti Ayu Prianka Adi Subratha I D. G. P. Y. Taradipta, I. D. M. R. V. A. Setiawan Valentina Ayu Hapsari Widhiastuti, K.A.P. Widnyana, I Putu Sudiatmika Wijayanti, N.L.P.D