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All Journal Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Teknologi Sistem Informasi dan Aplikasi Jurnal Sistem Komputer & Kecerdasan Buatan Law Research Review Quarterly Yumary: Jurnal Pengabdian kepada Masyarakat Jurnal Ilmiah Pharmacy Asian Australasian Neuro and Health Science Journal (AANHS-J) Pharmademica: Jurnal Kefarmasian dan Gizi Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Sains Medisina Jurnal Pengabdian Masyarakat Wadah Publikasi Cendekia
Ramadhan, Hafiz
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Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Journal : Jurnal Farmasi Sains dan Komunitas

 1 
Formulation of Wound Healing Hydrogel from 70% Ethanol Extract of Kelakai Roots (Stenochlaena palustris (Burm. F.) Bedd) with Polymer Combination of PVA/HPMC Forestryana, Dyera; Pebrianie, Shilpa; Ramadhan, Hafiz; Restapaty, Ratna
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.005291

Abstract

Kelakai root contains alkaloids, saponins, tannins, and flavonoids. This compound is known to have medicinal properties such as wound healing. The effectiveness of wound healing increased by using hydrogel to deliver the active substance. The use of polymers played a role in delivering the active substance. This study aimed to formulate hydrogels for wound healing with various concentrations of polyvinyl alcohol (PVA) and hydroxy propyl methyl cellulose (HPMC) K4M. Preparation of hydrogel by the solvent casting method used 0.2% Kelakai root extract. The physical characteristics of hydrogel investigated before and after the stability test included organoleptic, weight uniformity, thickness, pH, moisture content, and hedonic test of Kelakai roots extract hydrogel.  The optimum formula was tested for wound healing activity. The data obtained were then analyzed using Wilcoxon testswith p0.05 considered significant. Physically, Kelakai root extract hydrogel met the test requirements. The results of the wound-healing activity showed that the hydrogel extract of the Kelakai root was able to heal the wounds within seven days. There was a significant difference in wound healing time with p=0.014. The optimum formula obtained based on the stability test was F4 with a 1:4 ratio of PVA and HPMC. 
Co-Authors Achmad Udin Zailani Ade Kurniawan Adinda Syafitri, Adinda Akbar, Depy Oktapian Alfi, Muhammad Amalia Khairunnisa, Amalia Andy Chandra, Muhammad Arsyad, Zyrzasya Sofia Nara Febriani, Reva Aura Forestryana, Dyera Hadi, Ahmad Nur Hasymi, Liana Fitriani Hermawan Saputra Ibrahim, Sabri Irsyad, Muhammad Ari Jamaludin, Wahyudin Bin Kurdiansyah Maharani, Nessa Astika Nasution, Muhammad Deni Niki Ratama Pambudi, Didik Rio Pangestu, Rico Alfian Pebrianie, Shilpa Putri Indah Sayakti Rahmayanti Fitriah Rahmi Muthia Ramadhani, Syahrizal Raudatunnisa Restapaty, Ratna Ridwan Arifin Saefudin, Yusuf Rizky Siregar, Salman Siti Anisa Sri Mulyati Subareng, Ahmad Rizal Maulana Sutomo Sutomo Vebruati Vebruati, Vebruati Wicaksono, Andri Aditya Wiwin Tyas Istikowati Yanie, Akhmad