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All Journal Journal of Natural Product and Pharmaceutical Chemistry Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Pharmaceutical and Clinical Research International Journal Of Science, Technology & Management (IJSTM)
Masfria
Departemen Kimia Farmasi, Fakultas Farmasi, Universitas Sumatera Utara
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Journal : International Journal Of Science, Technology

 1 
Antibacterial Activity of Ethanol Extract and Fraction of Daemonorops draco (Willd.) Blume. Fruit Samaniyah, Siti; Masfria; Sitorus, Panal
International Journal of Science, Technology & Management Vol. 3 No. 4 (2022): July 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i4.544

Abstract

Daemonorops draco is a type of draco (Willd.) Blume fruit is well-known as an antiseptic, increases blood circulation, anti-microbial, anti-viral, anti-tumor, wound medicine, diarrhea, fractures, gonorrhea, mild burns, and other traditional medicines. Daemonorops draco is a type of draco (Willd.) Blume belongs to the Arecaceae family and contains alkaloids, flavonoids, tannins, saponins, steroids / triterpenoids, and glycosides, among other chemical components. Chemical compounds such as flavonoid compounds, saponins, and tannins have antibacterial and antiviral properties. Simplicia features, phytochemical screening, and antibacterial activity testing of ethanol extract and fruit fractions of Daemonorops draco (Willd.) Blume are all part of this study. Organoleptic, macroscopic, and microscopic tests were performed on the simplicia, as well as water content measurement on ethanol extracts. Maceration with ethanol as the solvent was followed by fractionation with n-hexane and ethylacetate as solvents. The phytochemical screening was done on Daemonorops draco (Willd.) Blume simplicia powder, extract, and fruit fraction. The antibacterial activity of each fraction was determined by examining the zone of inhibition against different test species, including Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), and Salmonella typhi (ATCC 25923). (ATCC 6539). The water content of the simplicia was 4.65 percent, and the ethanol extract was 5.98 percent, according to the results of the characterisation. Alkaloids, flavonoids, glycosides, saponins, tannins, and steroids/triterpenoids were found in the phytochemical screening test of the ethanol extract. At a concentration of 25 mg/ml, Staphylococcus aureus had the highest antibacterial activity with an effective inhibitory diameter of 15.3 mm, Escherichia coli had the highest antibacterial activity with an effective inhibitory diameter of 14.2 mm, and Salmonella typhi had the highest antibacterial activity with an effective inhibitory diameter of 14.5 mm.
Antibacterial Activity Of Daemonorops Draco (Willd) Blume Fruit Ethanol Extract Against Some Bacterial Pathogens Apriani, Aida; Masfria, Masfria; Sitorus, Panal
International Journal of Science, Technology & Management Vol. 3 No. 4 (2022): July 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i4.545

Abstract

Daemonorops draco (Willd.) Blume fruit has been used as a traditional medicine which is well-known as an antiseptic, stimulates blood circulation, anti-microbial, anti-viral, anti-tumor, wound medicine, diarrhea, fractures, gonorrhea, minor burns and others. Daemonorops draco (Willd.) Blume belonging to the Arecaceae tribe contains a class of chemical compounds such as alkaloids, flavonoids, tannins, saponins, steroids/triterpenoids, and glycosides. Flavonoid compounds, saponins and tannins are chemical compounds that have potential as antibacterial and antiviral. This study aims to determine the characteristics of simplicia, phytochemical screening, antibacterial activity test of the ethanol extract of Daemonorops draco (Willd.) Blume fruit.Simplicia characterization includes organoleptic, macroscopic, microscopic examination, determination of water content. Extraction was carried out by maceration using ethanol as a solvent. Phytochemical screening was carried out on simplicia powder, fruit ethanol extract Daemonorops draco (Willd.) Blume, assay of antibacterial activity of extract using diffusion methodagar by observing the zone of inhibition against several test bacteria: Staphylococcus aureus, Escherichia coli, Salmonella thypi. The results of simplicia characterization obtained water content of 4.65%. The results of the phytochemical screening test of simplicia and ethanolic extracts contained groups of alkaloids, flavonoids, glycosides, saponins, tannins, steroids/triterpenoids. Having the highest antibacterial activity was ethanol extract from Gram positive Staphylococcus aureus bacteria followed by Gram negative bacteria Escherichia coli and Salmonella thypi at a concentration of 500 mg/ml with an effective inhibitory diameter of 15.5 mm, Escherichia coli at 14.3 mm, Salmonella typhi at 14, 8 mm.
Synthesis Of Silver Nanoparticles (Agnp) From The Extract Of Kemloko Fruit (Phyllantus Emblica L.) Mukhlisa, Ida; Masfria, Masfria; Sumaiyah, Sumaiyah
International Journal of Science, Technology & Management Vol. 3 No. 5 (2022): September 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i5.620

Abstract

Nanoparticles are nano-sized materials that are widely used because they have many advantages and very beneficial benefits. One method of making nanoparticles biologically. In the process of chemically synthesizing silver nanoparticles, nanomaterials are toxic and not environmentally friendly. So, other options are used, such as biological synthesis with natural materials as reducing catalysts and plant extract bioreductors that can reduce the amount of dangerous materials in the waste. This study aims to make nanoparticles from kemloko ethanol extract with biological methods. Extraction was carried out by the maceration method and synthesis of silver nanoparticles by a biological method with functional group analysis characteristics using FTIR. The results of this study indicate that these nanoparticles indicate that silver nanoparticles can be synthesized biologically for silver nanoparticles and the FTIRcharacteristic results show that silver nanoparticles contain OH, C=O, N=O, C-O, and C-H groups.
Phytochemical Screening and Antibacterial Activity Ethanolic Extract of Solanum mauritianum Scop Leaves Against Staphylococcus aureus and Pseudomonas aeruginosa BR PA, Ayu Meta Sari; Masfria; Sitorus, Panal
International Journal of Science, Technology & Management Vol. 3 No. 6 (2022): November 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i6.648

Abstract

According to the Karo people, Solanum mauritianum Scop leaves are widely used as traditional medicine, which is used topically to treat sprains, wounds, and bruises because of their high phenol content. The purpose of this study was to identify the content of secondary metabolites (alkaloids, flavonoids, saponins, tannins, steroids, triterpenoids, and glycosides) that inhibit the antibacterial activity of Staphylococcus aureus and Pseudomonas aeruginosa by the diffusion method using paper discs from the ethanolic extract of Solanum mauritianum Scop leaves. The results of phytochemical screening showed that Solanum mauritianum Scop leaves were positive for alkaloids, flavonoids, glycosides, saponins, tannins, and steroids. Results The antibacterial activity test of the ethanolic extract of Solanum mauritianum Scop leaves showed effective results at a concentration of 80 mg/mL on Staphylococcus aureus with an inhibition zone diameter of 14.54 ± 0.13 mm. Meanwhile, Pseudomonas aeruginosa showed effective results at a concentration of 300 mg/mL with an inhibition zone diameter of 15.70 ± 0.09 mm. Both bacteria showed activity in the strong category. Conclusion The ethanolic extract of Solanum mauritianum Scop leaves has antibacterial activity against both test bacteria with a strong category
Characterization, Phytochemical Screening of Phyllanthus emblica L. Fruit Nanoherbal and Determination of the Estrus Cycle of Female Rats Nurul Suci; Masfria; Aminah Dalimunthe; Hafid Syahputra
International Journal of Science, Technology & Management Vol. 4 No. 1 (2023): January 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i1.727

Abstract

One of a plant that is thought to have quite high antioxidant activity is kemloko (Phyllanthus emblica L.). This plant is a material that is often used by the community as a traditional medicine. This plant in India has been used to treat cancer, diabetes, liver (liver), heart problems and anemia. This biological activity is thought to be caused by the presence of bioactive compounds from secondary metabolites contained therein, especially compounds from the phenolic and flavonoid groups. The short length of the estrus cycle of rats makes them ideal for investigation of changes occurring during the reproductive cycle. The estrus cycle lasts four days and is characterized as: proestrus, estrus, metestrus and diestrus, which may be determined according to the cell types observed in the vaginal smear. Since the collection of vaginal secretion and the use of stained material generally takes some time, the aim of the present work was to provide researchers with some helpful considerations about the determination of the rat estrus cycle phases in a fast and practical way. This study began with macroscopic examination, examination of water content, examination of water-soluble extract levels, examination of ethanol-soluble extracts, examination of total ash content, and also an examination of acid-insoluble ash levels, phytochemical screening of Phyllanthus emblica L. fruit nanoherbal and determination of the estrus cycle of female rats. The results of phytochemical screening showed that the compound of Phyllanthus emblica L. Fruit nanoherbal contained a class of secondary metabolites of alkaloids, flavonoids, tannins, saponins, steroids/triterpenoids, and glycosides. And the estrus cycle of female rats can be determined by observing changes in vaginal epithelial cells.
Co-Authors Aida Apriani Amana, Meuthia Rizka Aminah Dalimunthe Aminah Dalimunthe BR PA, Ayu Meta Sari Deni OS Simbolon Ginda Haro Ginda Haro Hafid Syahputra Haro, Ginda Iksen, Iksen Julia Reveny Juwita, Nur Aira Maulidar, Nanda Putri Muchlisyam Muhammad Rivai Mukhlisa, Ida Nanda Putri Maulidar Nurul Suci Permata, Yade Metri Prayoga, Tedy Rehulina Gultom Rohani, Ade Sri Samaniyah, Siti Sitorus, Panal Sudarmi Sudarmi Sumaiyah Sumaiyah, Sumaiyah