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All Journal Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Dinamisia: Jurnal Pengabdian Kepada Masyarakat Martabe : Jurnal Pengabdian Kepada Masyarakat Jurnal Abdimas Madani dan Lestari (JAMALI) Indonesian Journal of Pharmaceutical and Clinical Research Jurnal Nusa Akuntansi Jurnal Sains dan Teknologi Pangan
Prasetyo, Bayu Eko
Department Of Pharmaceutical Technology, Faculty Of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
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Journal : Indonesian Journal of Pharmaceutical and Clinical Research

 1 
Formulation and Characterization of Nanoemulsion of Tread leave Ethanol Extract (Catharanthus roseus (L.) G. Don) as Antihyperglycemic Mariadi; Prasetyo, Bayu Eko; Adela, Hanny; Wiladatika, Winda
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 2 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (881.744 KB) | DOI: 10.32734/idjpcr.v2i2.3204

Abstract

Nanoemulsion technology has been widely developed and applied on natural extract to enhance bioavailability and drug effects. The tread plant (Catharanthus roseus (L.) G. Don) is commonly known in traditional medicine for lowering blood sugar levels. This study aimed to make and characterize nanoemulsion of tread leaf extract as antihyperglycemic using sesame oil and olive oil as carriers. Nanoemulsion formulations were made using ethanol extract of tread leaves, and additives such as Tween 80, isopropyl myristate in varying ratios and some of vegetable oils. The nanoemulsion was physically evaluated tests including the pH, the type of emulsion, homogeneity and size distribution which measured by the Particle Size Analyzer (PSA). Antihyperglycemic testing was carried out on 4 groups of male mice (5 mice/ group) induced with glucose and treated with extract, nanoemulsion, and distilled water. The results showed that the nanoemulsion preparation had a pH of 6.4 to 6.5; o/w type of emulsion and it was stable on storage for 1 month. The particle size distribution of the nanoemulsion was 85.8% with size <500 nm. Nanoemulsion could reduce the blood glucose levels in mice to normal level after 60 minutes. It also showed the decreae for 43-46% of the blood glucose level after 2 hours. The Nanoemulsion of tread leaf extract has a faster ability and a greater percentage in reducing blood glucose levels compared to extract and control. Keywords: Nanoemulsion, Catharanthus roseus, sesame oil, olive oil, Antihyperglikemic
Development of Oral Thin Film Strip Contained Ethanol Extract of Clove Leaves (Syzygium aromaticum (L.) Merr. & Perry) Bayu Eko Prasetyo; Mariadi; Emil Salim
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 5 No. 2 (2022): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v5i2.17919

Abstract

Halitosis or bad breath can occur due to poor oral hygiene care, dental caries or infections in the oral cavity. The use of mouth fresheners is one of the solution product to overcome the problem. Oral Thin Film Strip (OTFS) is an alternative mouth freshener. The preparation of OTFS was carried out using the solvent casting method. Five film formula were made with varying concentrations of gelatin and HPMC, namely F1 (0:3), F2 (1:3), F3 (1:1), F4 (3:1), and F5 (3:0). Evaluation of the preparation included organoleptic test, weight uniformity, thickness, disintegration time, pH, and folding resistance. Stability testing was carried out for 3 months at 25±2°C and 40±2°C. Antibacterial activity test against Streptococcus mutans (S. mutans) on the preparation was done using disc diffusion method. The OTFS preparation produced gave a homogeneous colour, aroma and taste of the extract. The resulting preparation had weight between 0.345-0.180 grams, thickness between 0.148-0.247 mm, disintegration time of 44-60 seconds, a pH between 6.06-6.33, and a film folding resistance between 339.83-673.67 times. The preparation was stable in storage for 3 months at a temperature of 25±2℃ and 40±2℃. The preparation showed antibacterial activity against S. mutans with zone of inhibition between 8.0-9.1 mm. Clove leaf ethanol extract can be formulated into OTFS preparations with good physical characteristics, stable in 3 months storage and had antibacterial activity against S. mutans so that it has the potential to overcome bad breath.
Co-Authors . Marianne Adela, Hanny Anayanti Arianto Angelyne, Metha De Lux Putra, Effendy Diah Nuky Rahani Effendy De Lux Putra, Effendy De Lux Emil Salim Emil Salim Henny Sri Wahyuni Lainy Rafiqah Lia Laila Lia Laila, Lia Mariadi Mariadi Mariadi Muhammad Daffa Al-Khairi Napitupulu, Pinastiara Nazliniwaty Nazliniwaty* Nilsya Febrika Zebua, Nilsya Febrika Shafiyah, Miranda Tanaka, Gracelyn Thomi Baihaki Hijriyan Vanessa Angkasa Vivian Victoria Wahidah Ramadhani Manurung Wahyuni*, Henny Sri Widya Sari Madina Hasibuan Wiladatika, Winda Yade Metri Permata Yuliasmi, Sri Yusuf, Nur’aini