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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Mandala Pharmacon Indonesia Jurnal Mandala Pengabdian Masyarakat Jurnal DiMas (Jurnal Pengabdian Kepada Masyarakat) Sciences of Pharmacy AMMA : Jurnal Pengabdian Masyarakat
Alaydrus, Syafika
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Formulation, Evaluation And Antibactery Activity Test Of Gastroretentive Mukoadhesive Granul Matrix Earthworm Extract (Lumbricus rubellus) Magfirah, Magfirah; Alaydrus, Syafika; Tandi, Joni; Utami, Indah Kurnia; Dewi, Niluh Puspita
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.503

Abstract

Background: Earthworm extract (Lumbricus rubellus) has antimicrobial activity because it produces high levels of the lumbricine compound but is easily denatured in the stomach so that its solubility and biological activity change. Therefore its Application can be developed in the form of gastrorentetif mucoadhesive preparation. Objectives: The purpose of this study was to optimize and evaluate the antibacterial activity of gastroretentive mucoadhesive preparation matrix of earthworm extract (Lumbricus rubellus). Material and Methods: The matrix utilized a preparatory technique of applying wet granulation mucoadhesive polymers such as chitosan, HPMC, and sodium CMC with concentrations determined based on simple lattice design resulting in 7 granule formulas. The granule formulas obtained were then evaluated including flow time and dwell angle tests, particle size distribution tests, compressibility tests, dissolution tests, and antibacterial activity tests. Results: The results showed that the flow rate on the F3 granule formulation met the requirements of flow rate >10 g/s, a consequence of measuring the angle of repose in the F1-F5 formula had good flowability which was below 30o, in contrast to F6 and F7 which had an angle of repose of 30-40o favorable to flowability. The F1-F7 formula was mostly preserved in mesh number 20 sieve with a size of 426-850 ?m, according to the results of particle size distribution utilizing the multistage sieve method, the compressibility index of the F1-F7 granule formula was 10% and the measurement results at the 30 minute showed that the average dissolution of the F1-F3 granules was 97.77%, 97.77%, and 101.22% respectively while the F4-F7 granule formulas did not show slow drug release because at the 30th minute the drug released ranged and the antibacterial activity test of Formula 1-Formula 7 granules is respectively 6 mm, 5.5 mm, 8 mm, 3.5 mm, 4.7 mm, 2.1 mm and 3.3 mm. Conclusions: The results of the evaluation of the characteristics of earthworm extract mucoadhesive gastroretentive granule preparation demonstrated that the preparation met the requirements for granule preparation and exhibited antibacterial properties. Among the seven formulas tested, formula 3 had the highest efficacy of antibacterial activity.
Cegah Stunting Dengan Tanaman Obat Keluarga: Cegah Stunting Dengan Tanaman Obat Keluarga Alaydrus, Syafika; Rianto, Rianto; Rusliyana, Rusliyana; Dewi, Niluh Puspita; Anwarudin, Wawang
Jurnal Mandala Pengabdian Masyarakat Vol. 5 No. 1 (2024): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpm.v5i1.369

Abstract

Indonesia has quite a serious nutritional problem which is characterized by many cases of malnutrition. Malnutrition is an impact of nutritional status. 2016 National Health Service data recorded that the prevalence of stunting reached 33.6%, this is an important health problem because the stunting problem is above the 20% threshold. Meanwhile, stunting in children under five is caused by multifactors, such as nutritional consumption during pregnancy, maternal knowledge about nutrition, limited access to services, inadequate access to sanitation and clean water. This counseling aims to help increase public knowledge, about preventing stunting in toddlers and is a form of the Tri Dharma of Higher Education. Counseling is provided using an interactive lecture method through distributing leaflets, health checks, providing nutritious food, providing TOGA books and social service. The effectiveness of the extension was tested by administering a questionnaire on community satisfaction with the activities carried out. The results of this service activity provide the Sejahtera village community with knowledge about what stunting is, the causes of stunting, the dangers of stunting in the long term and how to overcome the impact of stunting so that stunting can be minimized in children.
Enzymatic virgin coconut oil effect on urea and creatinine levels of hypercholesterolemia-diabetics induced Wistar male rats Dewi, Niluh Puspita; Alaydrus, Syafika; Nadila, Nadila; Magfirah, Magfirah; Tandi, Joni; Anggi, Viani; Astria, Nani
Pharmaciana Vol. 14 No. 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.27489

Abstract

Coconut (Cocos nucifera) is an Indonesian commodity that has high economic value tall. Virgin Coconut Oil (VCO) is one of the processed coconut products whose selling value is very high, because The composition of VCO consists of medium-chain fatty acids that can maintain a healthy body and prevent various diseases. The process of making VCO used in This research is an enzymatic method using pineapple weevil as a bromelain enzyme. This study aims to determine the effect of enzymatic administration of VCO and an enzymatic dose of VCO which is effective in reducing urea and creatinine levels in hypercholesterolemic-diabetic male white rats (Rattus norvegicus). This study was an experimental laboratory with a modified pretest and posttest randomized controlled group design using 30 test animals which were divided into 6 treatment groups. Each group consisted of 5 test animals, namely normal control, negative control, and positive control, with doses of 0.2, 0.4, and 0.8 mL/kg BW. The data obtained were analyzed using a One Way Anova and non- parametric statistical test by Kruskal Wallis. test and followed by a further Mann Whitney test to determine differences between treatments. The results showed that enzymatic VCO at a dose of 0.8 mL/kg BW was an effective dose in reducing urea and creatinine levels with an average decrease of 17.40 mg/dL and 0.36 mg/dL. The novelty in this study showed that the enzymatic VCO had an effect on reducing urea and creatinine levels in diabetic hypercholesterolemic male white rats.
Antioxidant, analgetic, and anti-inflammatory activity test of purple leaf ethanol extract (Graptophyllum pictum L. Griff) in vitro and in vivo Ocvinta, Sisca; Dewi, Niluh Puspita; Utami, Indah Kurnia; Darmayanti, Darmayanti; Alaydrus, Syafika; Anwarudin, Wawang
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.29070

Abstract

Purple leaves are one of the plants that are widely used as medicine. Purple leaves have 3 types of plant varieties, namely purple leaves, green leaves, and white mottled leaves.  Purple leaves have pharmacological activities that can be used as medicine, including antioxidants (improving the deterioration of cells in the body), anti-inflammatory (reducing or suppressing inflammation), antidiabetic (lowering blood glucose levels), analgesics (relieving pain), immunomodulators (increasing the work of the immune system in the body), antihemorrhoids (treating symptoms and complaints of hemorrhoids), and antibacterial (as an antiseptic). The purpose of this study was to determine the antioxidant activity of purple leaf ethanol extract (Graphtophyllum pictum (L.) Griff) in vitro using the DPPH method and to determine its effectiveness as an analgesic and anti-inflammatory against Wistar rats.The results showed that antioxidant activity showed an IC50 value of 72.31 ppm (strong antioxidant). Meanwhile, in the analgetic test, the highest percentage of analgesic effectiveness was found at a dose of 100 mg/kg BW (129.64%) and showed anti-inflammatory activity at a dose of 100 mg/kgBW with a percentage decrease in edem volume of 28.73% at the sixth hour.
SWAMEDIKASI PENGGUNAAN OBAT ALERGI SEBAGAI UPAYA MENINGKATKAN PENGETAHUAN MASYARAKAT DI DESA SEJAHTERA KECAMATAN PALOLO: SWAMEDIKASI PENGGUNAAN OBAT ALERGI SEBAGAI UPAYA MENINGKATKAN PENGETAHUAN MASYARAKAT DI DESA SEJAHTERA KECAMATAN PALOLO kurnia utami, indah; Ika Yususf, Ratna; puspita dewi, niluh; Alaydrus, Syafika
AMMA : Jurnal Pengabdian Masyarakat Vol. 1 No. 06 (2022): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Self-medication or what is known as self-medication is one of the actions that are often taken by the community to treat skin disorders. Based on a systematic review, it is known that the prevalence of self-medication in skin diseases ranges from 6-44%. Research in Togo, Africa found that 91.1% of people with skin disorders who seek treatment at health services have self-medicated before going to health services, while research conducted in Jakarta showed 44.64% of people were self-medicating for skin diseases with modern or traditional medicines. Allergies are reactions of the human immune system to certain objects, which should not cause reactions in other people's bodies. The reaction can appear in the form of a runny nose, itchy skin rash, or even shortness of breath. The drugs used by the public in self-medication of skin diseases are oral and topical drugs, including preparations containing corticosteroids, antibiotics and antifungals, a combination of salicylic acid and benzoic acid. Self-medication behavior can be influenced by knowledge, sociodemographic characteristics, family and advertising. Based on research, knowledge is the most significant factor influencing self-medication behavior.
Penyuluhan Stunting : Upaya Meminimalisir Tingginya Angka Stunting di Desa Sawidago: Penyuluhan Stunting : Upaya Meminimalisir Tingginya Angka Stunting di Desa Sawidago Puspita Dewi, Niluh; mariyani, mariyani; Alaydrus, Syafika; Anggi, Viani; Magfirah, Magfirah; Kurnia Utami, Indah
Jurnal Dimas Vol 5 No 2 (2023): Jurnal Pengabdian Kepada Masyarakat
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/dimas.v5i2.69

Abstract

Indonesia has quite a serious nutritional problem which is characterized by many cases of malnutrition. Malnutrition is an impact of nutritional status. Stunting is a condition of malnutrition that is related to past nutritional deficiencies, so it is a chronic nutritional problem. Many factors can cause stunting in toddlers, such as toddler characteristics and socio-economic factors. Community outreach activities are carried out with the aim of providing education to the public regarding the risk factors for stunting and its prevention. This counseling was carried out in order to increase the knowledge of the residents of Sawidago Village, especially mothers, because the mother is the person who is always with the child from pregnancy to 24 months of age. So that the baby's development will continue to be assisted by the mother. Counseling is provided using an interactive lecture method through posters and distribution of leaflets as well as social service. The effectiveness of the extension was tested by administering a partner satisfaction questionnaire with the activities carried out. The results of activity observations showed that Partners were satisfied with the outreach activities carried out.
Subchronic Toxicity Test of Purple Leaves Ethanol Extract (PLEE) on the Histopathological Picture of the Pancreas of Wistar Rats Wardani, Yunira; Dewi, Niluh Puspita; Alaydrus, Syafika; Rachmawati, Meike
Jurnal Penelitian Pendidikan IPA Vol 10 No 6 (2024): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i6.8069

Abstract

Medicinal plants are considered a rich source of bioactive metabolites and have the potential for the discovery and development of new drugs, one of which is the purple leaf plant which is known to treat various diseases. The aim of this research was to determine the effect of administering purple leaf ethanol extract over a certain period of time at doses of 500 mg/kgBB, 2.000 mg/kgBB and 5.000 mg/kgBB on the histopathology of the Wistar rat pancreas. In this study, an experimental method was used with a randomized block design, using 20 male Wistar rats which were divided into 4 research groups, 1 control group which was given Na-CMC. and 3 treatment groups were given purple leaf ethanol extract at a dose of 500 mg/kgBB (P1), dose of 2.000 mg/kgBB (P2) and  dose of 5.000 mg/kgBB (P3). The test preparation was administered orally, for 28 days. The results of subchronic toxicity testing of purple leaf ethanol extract on Wistar rats carried out for 28 days, up to a dose of 5.000 mg/kg BB, showed that at a dose of 2.000 mg/kg BB – 5.000 mg/kg BB it was toxic to the histopathology of the Wistar rats pancreas, which was characterized by the presence of cell degeneration, increased organ index and the presence of symptoms of toxicity
Prostate Anticancer Activity Testing α Mangostin Invitro Study on Sel DU 145 Using WST 8 Method Dewi, Rai Chika; Alaydrus, Syafika; Wahyuhandayani, Tien
Jurnal Penelitian Pendidikan IPA Vol 10 No 8 (2024): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i8.8517

Abstract

Prostate cancer is a cancer that has a high risk of death. Prostate cancer, specifically prostate adenocarcinoma, arises from the cells in the prostate gland or its peripheral zone. Chemotherapy, radiation therapy, and surgery are the main treatments for prostate cancer today. Empirical evidence shows that α-mangostin is used as a cancer therapy. At every stage of carcinogenesis, including cell division, proliferation, apoptosis, inflammation, and metastasis, α-mangostin can inhibit it. This study aims to evaluate the activity of α-mangostin against the DU145 prostate cancer cell line, and compare the %survival rate between cisplatin and α-mangostin. The method used is cytotoxicity testing in vitro with the WST-8 method. The research results showed that α-mangostin had an IC50 value of 16.89 ppm, in the active category, IC50 of cisplatin was 4.69 in the active category. Then statistical analysis was carried out using GraphPad Prism versi9.0.0 The results obtained were no significant differences between %survival rate cisplatin and α-mangostin at a concentration of 12.5 ppm. The conclusion of this study is The IC50 values of α-Mangostin and cisplatin against DU 145 cells were 16.89 ppm and 4.65 ppm, respectively. At a concentration of 12.5 ppm, there was no significant difference in their effects.
Anti-Cancer Activity Of The Combination Of Marine Mineral Consentrates And α Mangostin On Prostate Cancer Line DU 145 And HEK 293 By WST-8 Method Agustina, Giska Putri; Alaydrus, Syafika; Dewi, Niluh Puspita
Jurnal Penelitian Pendidikan IPA Vol 10 No 8 (2024): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i8.8518

Abstract

Marine mineral concentrates have good activity against normal cells, but are less effective against cancer cells. This research was carried out by combining concentrations of sea minerals with natural ingredients that have anti-cancer potential, one of which is α-mangostin. This study aims to determine the IC50 of the combination of α-mangostin, marine mineral concentrate, the combination of α-mangostin & marine mineral concentrate when compared cisplatin and evaluate the activity of α-mangostin, KML and the combination of α-mangostin and KML compared with ciplatin against the DU 145 cancer cell line and HEK 293. The method used is cytotoxicity testing using the WST-8 method. The results of the test materials were α-Mangostin 16.89 ppm, the combination of α-Mangostin-KML with a concentration of 12.5 ppm, namely 1,732 ppm, the combination of α-Mangostin-KML with a concentration of 25 ppm, namely 4,930 ppm, the combination of α-Mangostin-KML with concentration of 50 ppm 5,194 ppm, and cisplatin 4,649 ppm. The results of data analysis show significant differences for all samples. Conclusion α-Mangostin helps KML increase the cytotoxic effect on DU 145 cancer cells and sea mineral concentrate helps reduce the cytotoxic effect of α-Mangostin on normal HEK-293 cells.
Determination of specific and non-specific standardization parameters for ethanol extract of purple leaves (Graptophyllum pictum (L) Griff ) Tampang, Rivani; Alaydrus, Syafika; Dewi, Niluh Puspita; Tandi, Joni
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8812

Abstract

this study aims to determine the standardization of specific parameters (organoleptic and chemical content) and non-specific parameters (ash content, water content, drying loss, heavy metal contamination, Yeast Mold Number (AKK), microbial contamination / Total Plate Count (ALT)). The results showed that the specific parameters of the organoleptic properties of 96% ethanol extract of purple leaves (Grapthophyllum pictum (L) Griff) were black, shaped like a paste, a distinctive purple leaf odor and a bitter taste. The results of phytochemical screening of 96% purple leaf ethanol extract contained alkaloids, flavonoids, and tannins. However, the saponin test was negative for saponins. Non-specific parameters of 96% ethanol extract of cherry leaves were water content of 5.96%, total ash content of 16.86%, drying loss of 17.26%, heavy metals As and Cd were not detected, the presence of metals in Pb was 0.12 mg / kg, microbial contamination (Alt) and yeast mold numbers (Akk) were not found colonies. Based on these results, it can be concluded that the standardization test of specific and non-specific parameters, the ethanol extract of purple leaves has met the quality standards of simple drugs.
Co-Authors Agustina, Giska Putri Astria, Nani Darmayanti Darmayanti Dewi, Rai Chika Ika Yususf, Ratna Joni Tandi, Joni Kurnia Utami, Indah Lestari, Widya Ayu Magfirah, Magfirah Mariyani, Mariyani Meike Rachmawati Nadila, Nadila Niluh Puspita Dewi, Niluh Puspita Ocvinta, Sisca Polontalo, Nani Astria Puspita Dewi, Niluh Rianto Rianto Rusliyana, Rusliyana Tampang, Rivani Tuldjanah, Muthmainah Utami, Indah Kurnia Viani Anggi Wahyuhandayani, Tien Wardani, Yunira Wawang Anwarudin