Garuda - Garba Rujukan Digital

Activity Test of Cassia alata L. Leaf Extract on Kidney Histopathology Damage Score of Diabetes Mellitus Model Patala, Recky; Praypelisa, Ipa; Tandi, Jony; Utami, Indah Kurnia
Majalah Obat Tradisional Vol 29, No 1 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.86199

Diabetic nephropathy is a disease experienced by diabetic patients. In this disease, damage to the glomerulus occurs. The administration of antidiabetic drugs tends to cause unwanted side effects, so there is a need for alternative treatment from herbs, one of which is Cassia alata L. Cassia alata L. leaves have chemical content such as flavonoids, alkaloids, tannins, and saponins. Flavonoids reduce blood glucose levels by increasing insulin secretion and mimetic agents, tannins slow carbohydrate digestion and saponins repair pancreatic beta cells and increase glycogen in the liver. This study aims to determine the effect of Cassia alata L. ethanol on the histopathology damage score of male white rat kidney (Rattus norvegicus) induced by streptozotocin. The test animals used were 30 male white rats divided into six treatment groups, each group consisting of five male white rats, namely the normal control group, negative control group, positive control group, treatment group with doses of 500 mg/kg BW, 600 mg/kg BW, and 700 mg/kg BW. The parameters evaluated were kidney tissue damage score and histopathology image analysis. The results showed that the ethanol extract of Cassia alata L. leaves contain alkaloids, flavonoids, saponins, and tannins. The ethanol extract of Cassia alata L. leaves in doses of 500 mg/kg BW, 600 mg/kg BW and 700 mg/kg BW has the activity of reducing the score of kidney tissue damage in male white rats and a dose of 700 mg/kg BW is the best dose in reducing the score of kidney tissue damage in diabetes mellitus models with a score of 2.

Antioxidant, analgetic, and anti-inflammatory activity test of purple leaf ethanol extract (Graptophyllum pictum L. Griff) in vitro and in vivo Ocvinta, Sisca; Dewi, Niluh Puspita; Utami, Indah Kurnia; Darmayanti, Darmayanti; Alaydrus, Syafika; Anwarudin, Wawang
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.29070

Purple leaves are one of the plants that are widely used as medicine. Purple leaves have 3 types of plant varieties, namely purple leaves, green leaves, and white mottled leaves. Purple leaves have pharmacological activities that can be used as medicine, including antioxidants (improving the deterioration of cells in the body), anti-inflammatory (reducing or suppressing inflammation), antidiabetic (lowering blood glucose levels), analgesics (relieving pain), immunomodulators (increasing the work of the immune system in the body), antihemorrhoids (treating symptoms and complaints of hemorrhoids), and antibacterial (as an antiseptic). The purpose of this study was to determine the antioxidant activity of purple leaf ethanol extract (Graphtophyllum pictum (L.) Griff) in vitro using the DPPH method and to determine its effectiveness as an analgesic and anti-inflammatory against Wistar rats.The results showed that antioxidant activity showed an IC50 value of 72.31 ppm (strong antioxidant). Meanwhile, in the analgetic test, the highest percentage of analgesic effectiveness was found at a dose of 100 mg/kg BW (129.64%) and showed anti-inflammatory activity at a dose of 100 mg/kgBW with a percentage decrease in edem volume of 28.73% at the sixth hour.

Pembuatan Permen Herbal (Gummy Candy) Kunyit Sebagai Penambah Nafsu Makan Di Desa Powelua, Kabupaten Donggala, Sulawesi Tengah: Turmeric Gummy Candy to Increase Appetite in Powelua Village, Donggala Regency, Central Sulawesi magfirah; Utami, Indah Kurnia; Polakitan, Grace; Afdal, Faidil
Jurnal Mandala Pengabdian Masyarakat Vol. 5 No. 2 (2024): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpm.v5i2.391

Desa Powelua Kec. Banawa Tengah Kab. Donggala adalah salah satu desa dengan kategori 3T (terdepan, terluar, tertinggal) dan merupakan salah satu penyumbang terhadap tingginya angka stunting di kabupaten donggala. Dalam upaya percepatan penurunan stunting, Salah satu cara yang dapat dilakukan adalah dengan memanfaatkan bahan alam yaitu kunyit yang dapat menambah nafsu makan karena Rimpang kunyit memiliki kandungan kimia yaitu zat kurkuminoid sebagai penambah nafsu makan dalam bentuk permen herbal (gummy candy) yang lebih enak rasanya. Metode yang digunakan berupa sosilisasi dengan memberikan penyuluhan menggunakan banner yang dilanjutkan dengan sesi diskusi, tanya jawab dan pretest postest. Kegiatan PKM bertempat di balai Desa powelua yang dihadiri oleh masyarakat setempat dan perangkat desa guna memfasilitasi jalannya kegiatan. Hasil dari kegiatan, Masyarakat sangat antusias dan dapat menambah pengetahuan melalui kuisionor posttest yang dibagikan. Dari hasil perhitungan pre-test sebesar 30,95% dan hasil posttest yang didapatkan 75,24% Masyarakat mengetahui cara pencegahan stunting dengan pemanfaatan kunyit sebagai herbal penambah nafsu makan. Dapat disimpulkan bahwa kegiatan PKM ini sangat bermanfaat bagi Masyarakat Desa Powelua.

Tahfizh Online : Sebuah Strategi Era Digital dalam Memotivasi dan Menjaga Hafalan Utami, Indah Kurnia; Zahruddin; Maftuhah
Jurnal Inovasi Pendidikan MH Thamrin Vol. 8 No. 2 (2024): Jurnal Inovasi Pendidikan MH Thamrin
Publisher : LPPM Universitas Mohammad Husni Thamrin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37012/jipmht.v8i2.2443

Kegiatan masyarakat yang awalnya bertatap muka kini bergeser ke serba online atau daring, tak terkecuali dunia pendidikan. Pembelajaran tahfidz atau menghafal al-Qur’an juga demikian, hal yang umumnya secara langsung dari murid kepada gurunya kini harus dilakukan secara daring, yang mana tidak lazim dilakukan mengingat kegiatan tersebut membutuhkan bimbingan langsung secara tatap muka dari guru. Tujuan dari penelitian ini adalah untuk mengetahui strategi proses pelaksanaan hafalan al-Qur’an secara daring, termasuk di dalamnya proses pelaksanaan dan hambatan yang ditemui. Metode yang digunakan dalam penelitian ini adalah metode penelitian kualitatif. Teknik pengambilan datanya menggunakan observasi, wawancara, dan studi pustaka. Sebagai sebuah strategi dalam mempertahankan target hafalan mahasiswi IIQ Jakarta, tahfizh online memiliki kekurangan, yaitu instruktur kurang puas atau kurang merasa nyaman menyimak hafalan secara daring, susah mengetahui apakah ada yang curang dalam menyetorkan hafalan, kendala sinyal dan kuota internet, dan dikhawatirkannya kualitas bacaan yang kurang pas karena pada saat menyetorkan hafalan secara daring pelafalan menjadi tidak jelas karena terkendala sinyal, dan sebagainya. Sisi positif tahfizh online yaitu fleksibel dan bisa dilakukan kapan pun tanpa harus khawatir terbentur jadwal, bisa mendekatkan jarak sehingga tidak menghalangi proses menyetorkan hafalan, dll.

COST MINIMIZATION ANALYSIS OF ANTIHYPERTENSIVE DRUG USE IN CHRONIC KIDNEY DISEASE PATIENTS UNDERGOING HEMODIALYSIS Utami, Indah Kurnia; Rakanita, Yasinta; Dewi, Niluh Puspita
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1655

Hypertension is the primary cause of Chronic Kidney Disease (CKD), as it damages blood vessels in the kidneys. The most commonly used management for hypertension as monotherapy includes Calcium Channel Blockers (CCB) such as Amlodipine and Angiotensin Receptor Blockers (ARB) such as candesartan. Patients with CKD undergoing hemodialysis depend on dialysis machines, which impacts their economic burden. Therefore, a cost analysis review of drugs with the same therapeutic goals is necessary. This was a non-experimental study with a descriptive design. Data were collected through retrospective purposive sampling from January to December 2023 using medical records and payment data for inpatient treatments with hemodialysis that met the inclusion criteria. Direct medical costs included antihypertensive, other medication, service and facility fees, and medical support costs. Of the 100 samples that met the inclusion criteria from January to December 2023, amlodipine was the most commonly used antihypertensive (56%), followed by candesartan (38%). The average direct medical costs were IDR 184.350 for Amlodipine and IDR 561,339 for candesartan. The patient characteristics by gender showed a higher percentage of males (52%) than of females (48%). By age, the majority were in the late adult group (67%), whereas the elderly accounted for (33%). The Amlodipine group achieved more significant cost minimization than the candesartan group. Future studies should examine the potential of amlodipine in reducing the economic burden of limited resources. Keywords: antihypertensive, CMA, CKD

COST MINIMIZATION ANALYSIS OF ANTIHYPERTENSIVE DRUG USE IN CHRONIC KIDNEY DISEASE PATIENTS UNDERGOING HEMODIALYSIS Utami, Indah Kurnia; Rakanita, Yasinta; Dewi, Niluh Puspita
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1655

Hypertension is the primary cause of Chronic Kidney Disease (CKD), as it damages blood vessels in the kidneys. The most commonly used management for hypertension as monotherapy includes Calcium Channel Blockers (CCB) such as Amlodipine and Angiotensin Receptor Blockers (ARB) such as candesartan. Patients with CKD undergoing hemodialysis depend on dialysis machines, which impacts their economic burden. Therefore, a cost analysis review of drugs with the same therapeutic goals is necessary. This was a non-experimental study with a descriptive design. Data were collected through retrospective purposive sampling from January to December 2023 using medical records and payment data for inpatient treatments with hemodialysis that met the inclusion criteria. Direct medical costs included antihypertensive, other medication, service and facility fees, and medical support costs. Of the 100 samples that met the inclusion criteria from January to December 2023, amlodipine was the most commonly used antihypertensive (56%), followed by candesartan (38%). The average direct medical costs were IDR 184.350 for Amlodipine and IDR 561,339 for candesartan. The patient characteristics by gender showed a higher percentage of males (52%) than of females (48%). By age, the majority were in the late adult group (67%), whereas the elderly accounted for (33%). The Amlodipine group achieved more significant cost minimization than the candesartan group. Future studies should examine the potential of amlodipine in reducing the economic burden of limited resources. Keywords: antihypertensive, CMA, CKD

Formulation, Evaluation And Antibactery Activity Test Of Gastroretentive Mukoadhesive Granul Matrix Earthworm Extract (Lumbricus rubellus) Magfirah, Magfirah; Alaydrus, Syafika; Tandi, Joni; Utami, Indah Kurnia; Dewi, Niluh Puspita
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.503

Background: Earthworm extract (Lumbricus rubellus) has antimicrobial activity because it produces high levels of the lumbricine compound but is easily denatured in the stomach so that its solubility and biological activity change. Therefore its Application can be developed in the form of gastrorentetif mucoadhesive preparation. Objectives: The purpose of this study was to optimize and evaluate the antibacterial activity of gastroretentive mucoadhesive preparation matrix of earthworm extract (Lumbricus rubellus). Material and Methods: The matrix utilized a preparatory technique of applying wet granulation mucoadhesive polymers such as chitosan, HPMC, and sodium CMC with concentrations determined based on simple lattice design resulting in 7 granule formulas. The granule formulas obtained were then evaluated including flow time and dwell angle tests, particle size distribution tests, compressibility tests, dissolution tests, and antibacterial activity tests. Results: The results showed that the flow rate on the F3 granule formulation met the requirements of flow rate >10 g/s, a consequence of measuring the angle of repose in the F1-F5 formula had good flowability which was below 30o, in contrast to F6 and F7 which had an angle of repose of 30-40o favorable to flowability. The F1-F7 formula was mostly preserved in mesh number 20 sieve with a size of 426-850 ?m, according to the results of particle size distribution utilizing the multistage sieve method, the compressibility index of the F1-F7 granule formula was 10% and the measurement results at the 30 minute showed that the average dissolution of the F1-F3 granules was 97.77%, 97.77%, and 101.22% respectively while the F4-F7 granule formulas did not show slow drug release because at the 30th minute the drug released ranged and the antibacterial activity test of Formula 1-Formula 7 granules is respectively 6 mm, 5.5 mm, 8 mm, 3.5 mm, 4.7 mm, 2.1 mm and 3.3 mm. Conclusions: The results of the evaluation of the characteristics of earthworm extract mucoadhesive gastroretentive granule preparation demonstrated that the preparation met the requirements for granule preparation and exhibited antibacterial properties. Among the seven formulas tested, formula 3 had the highest efficacy of antibacterial activity.

Edukasi Pengunaan Suplemen Vitamin dan Mineral Dalam Pencegahan Stunting Bagi Masyarakat Desa Sejahtera Sulawesi Tengah Magfirah, Magfirah; Utami, Indah Kurnia; Marzuki, Sitti Aisyah; Letana, Trace Chintia
Jurnal Mandala Pengabdian Masyarakat Vol. 5 No. 1 (2024): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpm.v5i1.379

Stunting is a national health problem that is a global health priority that can affect the quality of human resources (HR) as the future generation of the Indonesian nation. One of the efforts to deal with the stunting problem is to increase communication through community service activities in the form of education about stunting, which is one embodiment of the stunting reduction strategy in accordance with presidential regulation number 72 of 2021 concerning the acceleration of stunting reduction in Indonesia. Sejahtera Village, Palolo District, Sigi Regency, Central Sulawesi was chosen as a place for community service because it is one of the villages with a high incidence of stunting in Sigi Regency. Community service activities aim to invite the community and provide education so that the community can use vitamin and mineral supplements properly and correctly as a step to support government programs in reducing the number of stunting incidents in children with a focus on pregnant women. The method used is socialization by providing counseling using leaflets followed by discussion sessions, question and answer and pretest posttest. PKM activities take place at the Sejahtera Village office and are attended by the local community and village officials to facilitate the running of the activities. As a result of the activity, the community was very enthusiastic and were able to increase their knowledge through the posttest questionnaires that were distributed. From the pretest calculation results, it was 24,95% and the posttest results showed that 65,24 % of the public knew how to prevent stunting. It can be concluded that this PKM activity is very beneficial for the people of Sejahtera Village.

Antioxidant, analgetic, and anti-inflammatory activity test of purple leaf ethanol extract (Graptophyllum pictum L. Griff) in vitro and in vivo Ocvinta, Sisca; Dewi, Niluh Puspita; Utami, Indah Kurnia; Darmayanti, Darmayanti; Alaydrus, Syafika; Anwarudin, Wawang
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.29070

Purple leaves are one of the plants that are widely used as medicine. Purple leaves have 3 types of plant varieties, namely purple leaves, green leaves, and white mottled leaves. Purple leaves have pharmacological activities that can be used as medicine, including antioxidants (improving the deterioration of cells in the body), anti-inflammatory (reducing or suppressing inflammation), antidiabetic (lowering blood glucose levels), analgesics (relieving pain), immunomodulators (increasing the work of the immune system in the body), antihemorrhoids (treating symptoms and complaints of hemorrhoids), and antibacterial (as an antiseptic). The purpose of this study was to determine the antioxidant activity of purple leaf ethanol extract (Graphtophyllum pictum (L.) Griff) in vitro using the DPPH method and to determine its effectiveness as an analgesic and anti-inflammatory against Wistar rats.The results showed that antioxidant activity showed an IC50 value of 72.31 ppm (strong antioxidant). Meanwhile, in the analgetic test, the highest percentage of analgesic effectiveness was found at a dose of 100 mg/kg BW (129.64%) and showed anti-inflammatory activity at a dose of 100 mg/kgBW with a percentage decrease in edem volume of 28.73% at the sixth hour.

Tahfizh Online : Sebuah Strategi Era Digital dalam Memotivasi dan Menjaga Hafalan Utami, Indah Kurnia; Zahruddin; Maftuhah
Jurnal Inovasi Pendidikan MH Thamrin Vol. 8 No. 2 (2024): Jurnal Inovasi Pendidikan MH Thamrin
Publisher : LPPM Universitas Mohammad Husni Thamrin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37012/jipmht.v8i2.2443

Kegiatan masyarakat yang awalnya bertatap muka kini bergeser ke serba online atau daring, tak terkecuali dunia pendidikan. Pembelajaran tahfidz atau menghafal al-Qur’an juga demikian, hal yang umumnya secara langsung dari murid kepada gurunya kini harus dilakukan secara daring, yang mana tidak lazim dilakukan mengingat kegiatan tersebut membutuhkan bimbingan langsung secara tatap muka dari guru. Tujuan dari penelitian ini adalah untuk mengetahui strategi proses pelaksanaan hafalan al-Qur’an secara daring, termasuk di dalamnya proses pelaksanaan dan hambatan yang ditemui. Metode yang digunakan dalam penelitian ini adalah metode penelitian kualitatif. Teknik pengambilan datanya menggunakan observasi, wawancara, dan studi pustaka. Sebagai sebuah strategi dalam mempertahankan target hafalan mahasiswi IIQ Jakarta, tahfizh online memiliki kekurangan, yaitu instruktur kurang puas atau kurang merasa nyaman menyimak hafalan secara daring, susah mengetahui apakah ada yang curang dalam menyetorkan hafalan, kendala sinyal dan kuota internet, dan dikhawatirkannya kualitas bacaan yang kurang pas karena pada saat menyetorkan hafalan secara daring pelafalan menjadi tidak jelas karena terkendala sinyal, dan sebagainya. Sisi positif tahfizh online yaitu fleksibel dan bisa dilakukan kapan pun tanpa harus khawatir terbentur jadwal, bisa mendekatkan jarak sehingga tidak menghalangi proses menyetorkan hafalan, dll.

Title

Found 12 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 12 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 12 Documents
Search