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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Biologi Tropis Jurnal Abdi Insani Jurnal Pengabdian kepada Masyarakat Nusantara Rambideun : Jurnal Pengabdian Kepada Masyarakat Sciences of Pharmacy Indonesian Journal of Jamu
Tuldjanah, Muthmainah
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Determination of Secondary Metabolite Levels in Ethanol Extract of Clove leaves (Syzygium aromaticum L.) Using LC-HRMS Methods Tuldjanah, Muthmainah; Sasdila, Sasdila; Yanuarty, Rezky; Wulandari, Ayu; Tandi, Joni
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.7975

Abstract

The use of plants as raw materials for medicinal purposes has become increasingly prevalent due to the diverse secondary metabolites they can produce. Clove leaves (Syzigium aromaticum L.) are known for their antimicrobial, antioxidant, anti-inflammatory, analgesic, anticancer, anesthetic, aphrodisiac, and antipyretic properties. This study aims to determine the levels of secondary metabolites in clove leaves using the LC-HRMS method. The results showed that the ethanol extract of clove leaves contained 34 compounds, with the compounds (-)-Caryophyllene oxide and Miquelianin having the highest chromatogram peaks at 9.714195% and 8.712299% of the compound composition, respectively.
Pemanfaatan Kulit Buah Kelor Sebagai Antibakteri Desa Sejahtera Kecamatan Palolo, Kabupaten Sigi, Sulawesi Tengah Tuldjanah, Muthmainah; Adriansyah, Putra; Heldayanti, Heldayanti
Jurnal Pengabdian kepada Masyarakat Nusantara Vol. 5 No. 1 (2024): Jurnal Pengabdian kepada Masyarakat Nusantara (JPkMN)
Publisher : Lembaga Dongan Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55338/jpkmn.v5i1.2678

Abstract

Pemanfaatan bahan alam sebagai obat merupakan hal tepat yang dapat menunjang kehidupan, dimana beberapa keuntungan dari bahan-bahan alami yaitu salah satunya memiliki efek samping rendah apabila dibandingkan dengan obat dari bahan sintetik. Desa Sejahtera, Kecamatan Palolo, Kabupaten Sigi Sulawesi Tengah merupakan salah satu desa dimana masyarakatnya mengkonsumsi daun kelor dan buah kelor. Masyarakat desa ini, pada umumnya sering mengkonsumsi buah kelor sebagai sayur, namun kulit dari buah kelor hanya dijadikan sebagai limbah, sehingga dilakukan penelitian terkait uji aktivitas antibakteri kulit buah kelor. Tujuan dilaksanakannya kegiatan ini agar Masyarakat desa Sejahtera mengetahui manfaat dari kulit buah kelor dan cara pemanfaatannya. Metode yang digunakan saat melakukan pengabdian masyarakat berupa ceramah tentang swamedikasi sediaan herbal untuk melihat pemahaman peserta terhadap materi yang disajikan, presenter membagikan kuisioner keberhasilan kegiatan yang harus dilengkapi oleh masyarakat yang berpartisipasi dalam kegiatan ini. Hasil kegiatan penggabdian pada masyarakat ini meningkatkan pengetahuan masyarakat tentang manfaat kulit buah kelor sebagai antibakteri dan bagaimana cara pengolahannya.
Edukasi Pemanfaatan Potensi Daun Kelor Sebagai Upaya Pencegahan Stunting Pada Masyarakat Desa Powelua Kabupaten Donggala Sulawesi Tengah Tuldjanah, Muthmainah; Budiawan, Erick; Sasdila; Natalia, Putri; Tudaan, Leligrafela
RAMBIDEUN : Jurnal Pengabdian Kepada Masyarakat Vol. 7 No. 3 (2024): Rambideun: Jurnal Pengabdian Kepada Masyarakat
Publisher : LPPM Universitas Al Muslim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51179/pkm.v7i3.2730

Abstract

Stunting is a disorder where the growth and development of toddlers is hampered due to malnutrition during pregnancy and this condition is known by looking at the child's body condition which is smaller than other children of the same age. Overcoming stunting is one of the programs of the Donggala Regency Government because of the large number of stunted children in the district, one of which is Powelua Village. Many factors can cause delays in the growth and development of toddlers, including toddler characteristics and socio-economic factors. The number of families at risk of stunting in Powelua Village in 2023 reached 58 children with a total of 150 Heads of Families. This community service activity aimed to educate the public that Moringa leaves have a very high nutritional content, especially their potential in preventing stunting. One way to prevent stunting is to provide education related to the potential use of Moringa leaves in preventing stunting which wass delivered in the form of lectures with material, as well in the form of leaflets, followed by a questions-and-answers session. Evaluation of achievement was carried out by providing pre-tests and post-tests to the community on the material presented with a success indicator of 74.27% of parents understanding the education provided. The results of implementing this community service activity showed an increase in knowledge of 88.67% with a very good category.
Characterizations of Swelling Granule of Clove Leaf (Syzygium aromaticum L.) Ethanol Extract Wulandari, Ayu; Chintya, Gita; Tuldjanah, Muthmainah; Yanuarty, Rezky
Sciences of Pharmacy Volume 3 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0301182

Abstract

Cloves, scientifically known as Syzygium aromaticum L., hold promise as a potential antiulcer remedy due to their rich composition of compounds, including high levels of phenolic compounds such as eugenol, eugenol acetate, and gallic acid. To improve bioavailability in the gastric environment, this study focuses on optimizing and evaluating a swelling granule system derived from clove leaf extract. The granules were produced using wet granulation with Carbopol, HPMC, and their combination as polymer matrices. Results indicated favorable properties in the swelling granules, with the optimal composition of 210 mg Carbopol, 36 mg PVP, and 404 mg Avicel pH 101. These granules exhibited a uniform particle size distribution, with 90.1% below 149 µm and 9.9% distributed across mesh numbers 100, 80, and 40. The formula with Carbopol polymer showed superior flow rate, compressibility, and swelling capacity compared to other formulations. The interaction between Carbopol's C=O groups and HPMC's hydroxyl groups significantly influenced parameters, especially swelling capacity. Thus, when combining polymers, potential chemical or physical reactions should be considered. The wet granulation process effectively preserved secondary metabolite levels from clove leaf. Further tests are recommended to evaluate the granulation's effectiveness as a delivery system for clove leaf extract.
Suspension of Sonchus arvensis L Leaves Ethanolic Extract Affects Blood Creatinine and Urea Levels in Streptozotocin-Induced Wistar Male Rats Dewi, Niluh Puspita; Alaydrus, Syafika; Lestari, Widya Ayu; Magfirah, Magfirah; Utami, Indah Kurnia; Polontalo, Nani Astria; Tuldjanah, Muthmainah
Sciences of Pharmacy Volume 3 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0301173

Abstract

The study focused on analyzing the secondary metabolites present in the ethanol extract of Sonchus arvensis L. leaves (SALEE) and their impact on creatinine and urea levels when administered in suspension form at different doses. Phytochemical screening of SALEE identified alkaloids, flavonoids, phenols, saponins, and tannins. In the experiment, twenty-five white male rats were divided into five groups: a healthy control group (Group I), a negative control group (Group II), and three test groups (Groups III, IV, and V) receiving SALEE at doses of 200, 300, and 400 mg/kg BW, respectively. After inducing diabetes with streptozotocin and a 21-day follow-up period, creatinine and urea levels were assessed. The results demonstrated that SALEE administration significantly reduced creatinine levels and increased urea levels. Notably, the 200 mg/kg BW dose of SALEE exhibited a consistent and long-term effect. It was observed that blood urea levels fluctuated even in healthy and negative control groups during the 21-day observation period. In the group receiving the highest dose of SALEE (400 mg/kg BW), blood urea levels increased significantly on days 14 and 21, indicating a potential increase in the rats' appetite rather than renal function failure. Overall, the findings suggest that SALEE has promising potential to regulate creatinine and urea levels in the blood of individuals with diabetes, highlighting its potential for therapeutic and supplemental use.
PEMANFAATAN DAUN JUWET SEBAGAI ANTIOKSIDAN (SYZYGIUM CUMINI L.) PADA MASYARAKAT RT 09, KELURAHAN LAMBARA, KECAMATAN TAWEILI SULAWESI TENGAH tuldjanah, Muthmainah; Budiawan, Erick; Paga, Fajria Rezky Priyanti Amara; Vegyn, Vegyn; Mu’min, Nur Hijrah
Jurnal Abdi Insani Vol 12 No 10 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i10.2961

Abstract

Juwet leaves (Syzygium cumini L.) are plants with antioxidant content that can protect the body from free radicals that cause degenerative diseases. The community of RT 09, Lambara Village has access to juwet plants that grow naturally in the surrounding environment, but their level of knowledge and understanding of the benefits of juwet leaves as a source of natural antioxidants is still low. This community service activity aims to increase the knowledge and understanding of the community of RT 09, Lambara Village, Taweili District regarding the benefits of juwet leaves as a source of natural antioxidants for health. Education was carried out through a lecture method with posters and brochures, followed by a question and answer session. Evaluation of the program's success was carried out by providing a pre-test before education and a post-test after education to 45 participants from the RT 09 community using a 4-question instrument related to knowledge about juwet leaves and antioxidants. The community service activity carried out on November 30, 2024, was attended by 45 participants and ran smoothly. The evaluation results showed a very significant increase in community knowledge. In the pre-test, the community's understanding level ranged from 32-44% for the four aspects measured (knowledge of the benefits of juwet leaves, the definition of antioxidants, the importance of antioxidants, and dosage). After providing educational materials, post-test results showed an increase in understanding to 90-98%. The participants' enthusiasm was evident in their active participation in the question and answer session and their positive appreciation for the program. The educational program on the use of juwet leaves as an antioxidant succeeded in significantly increasing the knowledge of the community in RT 09, Lambara Village, as indicated by an increase in the understanding score from 32-44% (pre-test) to 90-98% (post-test).
Specific and Non-Specific Safety Testing of Red Gedi Leaf Ethanol Extract (Abelmoschus manihot L. Medik) Tandi, Joni; Susanto, Yuliet; Handayani, Tien Wahyu; Magfirah, Magfirah; Tuldjanah, Muthmainah
Jurnal Jamu Indonesia Vol. 11 No. 1 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i1.417

Abstract

Red gedi leaves (Abelmoschus manihot (L.) Medik) are traditionally used for their antidiabetic, antioxidant, and hepatoprotective properties. This study aimed to characterize the specific and non-specific quality parameters of red gedi leaf ethanol extract based on Herbal Pharmacopoeia standards. Extraction was performed by maceration using 96% ethanol, yielding 6.72%. Phytochemical screening confirmed the presence of flavonoids, saponins, tannins, quinones, and steroids, with a high total flavonoid content of 56.97 ± 3.75 mg/g. Non-specific parameters, including water content, drying loss, ash values, microbial contamination, and heavy metal levels (Pb and Cd), complied with the required standards. Organoleptic evaluation showed a viscous extract with brownish color, slightly astringent taste, and characteristic odor. These results indicate that red gedi leaf ethanol extract meets Herbal Pharmacopoeia quality requirements and has potential for development as a standardized antioxidant herbal product.
Acute Toxicity Nanoemultion of Ethanol Extract of Clove Leaves (Syzygium aromaticum L.) Tuldjanah, Muthmainah; Ladjeba, Putri Natalia Laurenza; Yanuarty, Rezky; Wuladari, Ayu; Tandi, Joni; Sudarman, Muaadzatul Izzah
Jurnal Penelitian Pendidikan IPA Vol 12 No 2 (2026)
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i2.12783

Abstract

Clove leaves have been widely used as traditional medicine. Clove leaves are rich in saponins, flavonoids, tannins, sterols, and essential oils. To improve the function of clove leaves, one of them is by reducing the sample size into nanoemulsion form. Nanoemulsions were prepared using the sonication method and exhibited an average droplet size of 13.3 nm. The purpose of this study was to determine the toxic properties, the dose that can cause toxic effects, and the LD50 value of nanoemulsion administration of ethanol extract of clove leaves. This study used 25 male white rats which were divided into five groups, namely a control group (nanoemulsion base) and four treatment groups receiving oral doses of 5, 50, 300, and 2000 mg/kg BW. The LD50 value was calculated using AOT425 StatPgm in accordance with OECD TG 425 (Up and Down Procedure). Mortality summary: control 0/5; 5 mg/kg BW 0/5; 50 mg/kg BW 0/5; 300 mg/kg BW 0/5; 2000 mg/kg BW 5/5. The results showed an LD50 of 798.5 mg/kg BW and, based on the GHS, it falls under Acute Toxicity (Oral) Category 4 (300–2000 mg/kg BW). Clinical signs such as piloerection, grooming, and weakness appeared mainly in the early observation phase (from 30 minutes to 4/8/12 hours) in each dose group and were reversible.
Co-Authors Adriansyah, Putra Alaydrus, Syafika Ayu Wulandari Budiawan, Erick Chintya, Gita Handayani, Tien Wahyu Heldayanti, Heldayanti Joni Tandi, Joni Ladjeba, Putri Natalia Laurenza Lestari, Widya Ayu Magfirah, Magfirah Mu’min, Nur Hijrah Niluh Puspita Dewi, Niluh Puspita Paga, Fajria Rezky Priyanti Amara Polontalo, Nani Astria Putri Natalia Sasdila Sasdila, Sasdila Sudarman, Muaadzatul Izzah Tudaan, Leligrafela Utami, Indah Kurnia Vegyn, Vegyn Wuladari, Ayu Yanuarty, Rezky Yuliet Yuliet