Article Per Year (5 Year)
p-Index From 2021 - 2026
1.347
P-Index
This Author published in this journals
All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Mandala Pharmacon Indonesia Jurnal Abdi Insani Jurnal Mandala Pengabdian Masyarakat Jurnal DiMas (Jurnal Pengabdian Kepada Masyarakat) Indonesian Journal of Jamu
Alaydrus, Syafika
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Public Health Social Sciences Other

Published : 7 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 7 Documents
Search

 1 
Formulation, Evaluation And Antibactery Activity Test Of Gastroretentive Mukoadhesive Granul Matrix Earthworm Extract (Lumbricus rubellus) Magfirah, Magfirah; Alaydrus, Syafika; Tandi, Joni; Utami, Indah Kurnia; Dewi, Niluh Puspita
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.503

Abstract

Background: Earthworm extract (Lumbricus rubellus) has antimicrobial activity because it produces high levels of the lumbricine compound but is easily denatured in the stomach so that its solubility and biological activity change. Therefore its Application can be developed in the form of gastrorentetif mucoadhesive preparation. Objectives: The purpose of this study was to optimize and evaluate the antibacterial activity of gastroretentive mucoadhesive preparation matrix of earthworm extract (Lumbricus rubellus). Material and Methods: The matrix utilized a preparatory technique of applying wet granulation mucoadhesive polymers such as chitosan, HPMC, and sodium CMC with concentrations determined based on simple lattice design resulting in 7 granule formulas. The granule formulas obtained were then evaluated including flow time and dwell angle tests, particle size distribution tests, compressibility tests, dissolution tests, and antibacterial activity tests. Results: The results showed that the flow rate on the F3 granule formulation met the requirements of flow rate >10 g/s, a consequence of measuring the angle of repose in the F1-F5 formula had good flowability which was below 30o, in contrast to F6 and F7 which had an angle of repose of 30-40o favorable to flowability. The F1-F7 formula was mostly preserved in mesh number 20 sieve with a size of 426-850 ?m, according to the results of particle size distribution utilizing the multistage sieve method, the compressibility index of the F1-F7 granule formula was 10% and the measurement results at the 30 minute showed that the average dissolution of the F1-F3 granules was 97.77%, 97.77%, and 101.22% respectively while the F4-F7 granule formulas did not show slow drug release because at the 30th minute the drug released ranged and the antibacterial activity test of Formula 1-Formula 7 granules is respectively 6 mm, 5.5 mm, 8 mm, 3.5 mm, 4.7 mm, 2.1 mm and 3.3 mm. Conclusions: The results of the evaluation of the characteristics of earthworm extract mucoadhesive gastroretentive granule preparation demonstrated that the preparation met the requirements for granule preparation and exhibited antibacterial properties. Among the seven formulas tested, formula 3 had the highest efficacy of antibacterial activity.
Cegah Stunting Dengan Tanaman Obat Keluarga: Cegah Stunting Dengan Tanaman Obat Keluarga Alaydrus, Syafika; Rianto, Rianto; Rusliyana, Rusliyana; Dewi, Niluh Puspita; Anwarudin, Wawang
Jurnal Mandala Pengabdian Masyarakat Vol. 5 No. 1 (2024): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpm.v5i1.369

Abstract

Indonesia has quite a serious nutritional problem which is characterized by many cases of malnutrition. Malnutrition is an impact of nutritional status. 2016 National Health Service data recorded that the prevalence of stunting reached 33.6%, this is an important health problem because the stunting problem is above the 20% threshold. Meanwhile, stunting in children under five is caused by multifactors, such as nutritional consumption during pregnancy, maternal knowledge about nutrition, limited access to services, inadequate access to sanitation and clean water. This counseling aims to help increase public knowledge, about preventing stunting in toddlers and is a form of the Tri Dharma of Higher Education. Counseling is provided using an interactive lecture method through distributing leaflets, health checks, providing nutritious food, providing TOGA books and social service. The effectiveness of the extension was tested by administering a questionnaire on community satisfaction with the activities carried out. The results of this service activity provide the Sejahtera village community with knowledge about what stunting is, the causes of stunting, the dangers of stunting in the long term and how to overcome the impact of stunting so that stunting can be minimized in children.
Enzymatic virgin coconut oil effect on urea and creatinine levels of hypercholesterolemia-diabetics induced Wistar male rats Dewi, Niluh Puspita; Alaydrus, Syafika; Nadila, Nadila; Magfirah, Magfirah; Tandi, Joni; Anggi, Viani; Astria, Nani
Pharmaciana Vol. 14 No. 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.27489

Abstract

Coconut (Cocos nucifera) is an Indonesian commodity that has high economic value tall. Virgin Coconut Oil (VCO) is one of the processed coconut products whose selling value is very high, because The composition of VCO consists of medium-chain fatty acids that can maintain a healthy body and prevent various diseases. The process of making VCO used in This research is an enzymatic method using pineapple weevil as a bromelain enzyme. This study aims to determine the effect of enzymatic administration of VCO and an enzymatic dose of VCO which is effective in reducing urea and creatinine levels in hypercholesterolemic-diabetic male white rats (Rattus norvegicus). This study was an experimental laboratory with a modified pretest and posttest randomized controlled group design using 30 test animals which were divided into 6 treatment groups. Each group consisted of 5 test animals, namely normal control, negative control, and positive control, with doses of 0.2, 0.4, and 0.8 mL/kg BW. The data obtained were analyzed using a One Way Anova and non- parametric statistical test by Kruskal Wallis. test and followed by a further Mann Whitney test to determine differences between treatments. The results showed that enzymatic VCO at a dose of 0.8 mL/kg BW was an effective dose in reducing urea and creatinine levels with an average decrease of 17.40 mg/dL and 0.36 mg/dL. The novelty in this study showed that the enzymatic VCO had an effect on reducing urea and creatinine levels in diabetic hypercholesterolemic male white rats.
Antioxidant, analgetic, and anti-inflammatory activity test of purple leaf ethanol extract (Graptophyllum pictum L. Griff) in vitro and in vivo Ocvinta, Sisca; Dewi, Niluh Puspita; Utami, Indah Kurnia; Darmayanti, Darmayanti; Alaydrus, Syafika; Anwarudin, Wawang
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.29070

Abstract

Purple leaves are one of the plants that are widely used as medicine. Purple leaves have 3 types of plant varieties, namely purple leaves, green leaves, and white mottled leaves.  Purple leaves have pharmacological activities that can be used as medicine, including antioxidants (improving the deterioration of cells in the body), anti-inflammatory (reducing or suppressing inflammation), antidiabetic (lowering blood glucose levels), analgesics (relieving pain), immunomodulators (increasing the work of the immune system in the body), antihemorrhoids (treating symptoms and complaints of hemorrhoids), and antibacterial (as an antiseptic). The purpose of this study was to determine the antioxidant activity of purple leaf ethanol extract (Graphtophyllum pictum (L.) Griff) in vitro using the DPPH method and to determine its effectiveness as an analgesic and anti-inflammatory against Wistar rats.The results showed that antioxidant activity showed an IC50 value of 72.31 ppm (strong antioxidant). Meanwhile, in the analgetic test, the highest percentage of analgesic effectiveness was found at a dose of 100 mg/kg BW (129.64%) and showed anti-inflammatory activity at a dose of 100 mg/kgBW with a percentage decrease in edem volume of 28.73% at the sixth hour.
Penyuluhan Stunting : Upaya Meminimalisir Tingginya Angka Stunting di Desa Sawidago: Penyuluhan Stunting : Upaya Meminimalisir Tingginya Angka Stunting di Desa Sawidago Puspita Dewi, Niluh; mariyani, mariyani; Alaydrus, Syafika; Anggi, Viani; Magfirah, Magfirah; Kurnia Utami, Indah
Jurnal Dimas Vol 5 No 2 (2023): Jurnal Pengabdian Kepada Masyarakat
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/dimas.v5i2.69

Abstract

Indonesia has quite a serious nutritional problem which is characterized by many cases of malnutrition. Malnutrition is an impact of nutritional status. Stunting is a condition of malnutrition that is related to past nutritional deficiencies, so it is a chronic nutritional problem. Many factors can cause stunting in toddlers, such as toddler characteristics and socio-economic factors. Community outreach activities are carried out with the aim of providing education to the public regarding the risk factors for stunting and its prevention. This counseling was carried out in order to increase the knowledge of the residents of Sawidago Village, especially mothers, because the mother is the person who is always with the child from pregnancy to 24 months of age. So that the baby's development will continue to be assisted by the mother. Counseling is provided using an interactive lecture method through posters and distribution of leaflets as well as social service. The effectiveness of the extension was tested by administering a partner satisfaction questionnaire with the activities carried out. The results of activity observations showed that Partners were satisfied with the outreach activities carried out.
Cytotoxic Effect of Brazilin on DU145 Prostate Cancer Cells Using the WST-8 Assay Alaydrus, Syafika; Niluh Puspita Dewi; Pratiwi, Dinda
Jurnal Jamu Indonesia Vol. 11 No. 1 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i1.423

Abstract

Prostate cancer is characterized by abnormal growth of prostate gland cells due to uncontrolled cellular proliferation. Brazilin, a homoisoflavonoid compound derived from Caesalpinia sappan L., is known for its anticancer activity. This study aimed to evaluate the cytotoxic effect of brazilin on DU145 prostate cancer cells through an in vitro assay employing the WST-8 method. The results showed that both brazilin and cisplatin significantly reduced the cancer cell survival rate compared to the negative control group (p < 0.05). Although no significant difference was observed between the two compounds at the highest concentration (ns), their IC₅₀ values differed significantly (p < 0.05), recorded at 18.92 ppm for brazilin and 0.03569 ppm for cisplatin; both were classified as highly active. These findings suggest that brazilin possesses cytotoxic potential comparable to cisplatin at elevated concentrations and may be developed further as a naturally derived anticancer agent.
EDUKASI PEMANFAATAN SEDUHAN DAUN TEH HIJAU SEBAGAI ANTIKARIES DI DESA BOSA KEC. TAWAELI, SULAWESI TENGAH R, Sririzqi Muthmainnah A.; Alaydrus, Syafika; Mariyani, Mariyani; Utami, Faikah Dyah; Djumiran, Sandra Sri Dewi; Tamuntuan, Annisa Fitria
Jurnal Abdi Insani Vol 13 No 1 (2026): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v13i1.2775

Abstract

Bosa Village is categorized as a 3T priority area (Frontier, Outermost, and Disadvantaged), resulting in a lack of dental health facilities and limited public knowledge regarding the dangers of dental caries, as well as a lack of understanding of utilizing plants for disease prevention. Shredded green tea leaves (Camellia sinensis) are a widely available commercial product that can be utilized for dental caries prevention due to their antibacterial properties. Therefore, the objective of this community service is to educate the public on dental caries prevention, specifically through the formulation of mouthwash from steeped green tea leaves to enhance knowledge of dental health maintenance using accessible products. The method employed was the lecture method, complemented by the distribution of brochures. This was followed by a recall of the material through a Q&A session. The results showed a significant improvement in the participants' competence between the pre-test and post-test. Although participants initially lacked understanding in several aspects, there was a substantial increase in comprehension following the post-test. This improvement was evident after the community of Bosa, Hamlet II, received education on utilizing green tea leaves as a mouthwash for dental caries prevention. Consequently, the community has begun to understand the prevention and maintenance of oral health, including the use of shredded green tea leaves as an anti-caries mouthwash.
Co-Authors Astria, Nani Darmayanti Darmayanti Djumiran, Sandra Sri dewi Joni Tandi, Joni Kurnia Utami, Indah Lestari, Widya Ayu Magfirah, Magfirah Mariyani, Mariyani Nadila, Nadila Niluh Puspita Dewi Niluh Puspita Dewi, Niluh Puspita Ocvinta, Sisca Polontalo, Nani Astria Pratiwi, Dinda Puspita Dewi, Niluh R, Sririzqi Muthmainnah A. Rianto Rianto Rusliyana, Rusliyana Tamuntuan, Annisa Fitria Tuldjanah, Muthmainah Utami, Faikah Dyah Utami, Indah Kurnia Viani Anggi Wawang Anwarudin