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All Journal Jurnal Kedokteran Hewan Molekul: Jurnal Ilmiah Kimia Buletin Pengabdian Infolitika Journal of Data Science Jurnal Farmasi Galenika
BAKRI, TEDY KURNIAWAN
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Engineering Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Veterinary

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Advanced Anemia Classification Using Comprehensive Hematological Profiles and Explainable Machine Learning Approaches Noviandy, Teuku Rizky; Idroes, Ghifari Maulana; Suhendra, Rivansyah; Bakri, Tedy Kurniawan; Idroes, Rinaldi
Infolitika Journal of Data Science Vol. 2 No. 2 (2024): November 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/ijds.v2i2.237

Abstract

Anemia is a common health issue with serious clinical effects, making timely and accurate diagnosis essential to prevent complications. This study explores the use of machine learning (ML) methods to classify anemia and its subtypes using detailed hematological data. Six ML models were tested: Gradient Boosting, Random Forest, Naive Bayes, Logistic Regression, Support Vector Machine, and K-Nearest Neighbors. The dataset was preprocessed using feature standardization and the Synthetic Minority Oversampling Technique (SMOTE) to address class imbalance. Gradient Boosting delivered the highest accuracy, sensitivity, and F1-score, establishing itself as the top-performing model. SHapley Additive exPlanations (SHAP) analysis was applied to enhance model interpretability, identifying key predictive features. This study highlights the potential of explainable ML to develop efficient, accurate, and scalable tools for anemia diagnosis, fostering improved healthcare outcomes globally.
Education on clean and healthy living behavior and wise use of medicine at the Al-Qur'an Tahfidz Boarding School Jami' Baitusshalihin [Edukasi perilaku hidup bersih dan sehat serta bijak menggunakan obat di Pesantren Tahfidz Al-Qur'an Jami' Baitusshalihin] Bakri, Tedy Kurniawan; Suryawati, S; Suardi, Hijra Novia; Fahlevi, Heru; Adella, Shylvana; Dharma, Rudi; Meriyana, Cut Melda; Raihanah, R
Buletin Pengabdian Vol 4, No 3 (2024): Bull. Community. Serv.
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/bulpen.v4i4.41329

Abstract

A healthy and clean environment can be created starting from self-awareness and the surrounding community. A clean environment fosters a healthy life and is free from various diseases. Clean and Healthy Living Behavior (PHBS) is an action to prevent the occurrence of diseases and improve health levels. Disease disorders caused by poor sanitation in the boarding school environment certainly require further treatment, one of which is by consuming certain drugs. The steps in obtaining, using, storing, and disposing of drugs need to be known by students in order to maximize the healing of their illnesses. The purpose of this service is to increase awareness among students about the importance of maintaining personal and environmental hygiene, as well as to provide the right knowledge about the use of drugs. The methods used in this community service include lectures, discussions, educational videos, and simulations. The results of this community service indicate an increase in the understanding and knowledge of students regarding clean living patterns. Boarding school managers also gained a better understanding of the importance of proper sanitation in the boarding school environment and how to use drugs properly and correctly. In conclusion, there is an increase in students' understanding of clean-living patterns and knowledge of how to use drugs appropriately.
THE IMPACT OF ADVERSE DRUG REACTION OCCURRENCE TO DRUG ADHERENCE LEVEL: A CROSS-SECTIONAL STUDY IN PATIENTS WITH TUBERCULOSIS Bakri, Tedy Kurniawan; Akmal, Raihanul; Vonna, Azizah; Sari, Fitrah
JURNAL FARMASI GALENIKA Vol 8 No 2 (2021): Jurnal Farmasi Galenika Vol 8 No 2
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v8i2.194

Abstract

Tuberculosis is well-known as an ancient disease that remains a global challenge until this era. The main goals of the treatment are to eradicate the colonization of acid-resistant basil and to prevent the occurrence of drug resistance. However, the accomplishment of this multi-drugs therapy is not always achieved due to several obstacles, one of is patient adherence to the treatment. Patient adherence is a considerable determinator that influenced by a number factors including the adverse drug reaction (ADR) which appeared to the patients. This study aimed to examine the correlation between adverse drug reaction and patients’ adherence to the anti-tuberculosis category 1 regimen during the intensive phase. This observational analytic study used cross sectional method and involved 35 subjects. Drug adherence level was measured using Medication Adherence Scale-8 (MMAS-8) questionnaire, the characteristics of ADR were collected using check list sheet of ADR, and the probability of ADR was analyzed using Naranjo Algorithm. The results showed that the majority of patients in this study were adherence to anti tuberculosis drugs (62,8%) and experienced ADR (74,3%). Bivariate analysis using chi-square statistical test showed there was significant correlation between adverse drug reaction and adherence to anti-tuberculosis drugs during the intensive phase treatment (P-value = 0,02288).
Hubungan Pengetahuan Dan Laporan Ibu Terkait Kejadian Ikutan Pasca Imunisasi Pada Bayi 0-24 Bulan Di Puskesmas Batoh Banda Aceh Bakri, Tedy Kurniawan; Fitria, Nanda; Desiyana, Lydia Septa; Vonna, Azizah; Sari, Fitrah
JURNAL FARMASI GALENIKA Vol 8 No 3 (2021): Jurnal Farmasi Galenika Vol 8 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v8i3.195

Abstract

Kejadian Ikutan Pasca Imunisasi (KIPI) merupakan semua kejadian medis yang tidak diinginkan terjadi dalam satu bulan setelah imunisasi dan belum tentu memiliki hubungan kausalitas dengan vaksin. Data laporan KIPI dicatat apabila ibu dari anak yang mengalami KIPI melapor ke pelayanan kesehatan. Salah satu hal yang mempengaruhi penanganan dan sikap ibu terkait KIPI pada anak adalah pengetahuan ibu. Tujuan penelitian ini adalah untuk mengetahui reaksi KIPI yang dialami oleh bayi 0-24 bulan, mengetahui proporsi tingkat pengetahuan ibu yang melaporkan KIPI atau tidak melaporkan KIPI serta hubungan antara pengetahuan ibu dan laporan ibu terkait KIPI pada anak. Penelitian ini merupakan jenis penelitian observasional analitik dengan menggunakan metode cross-sectional. Dilakukan wawancara terhadap 68 responden yang diperoleh berdasarkan teknik quota sampling. Data pengetahuan ibu diperoleh dengan menggunakan kuesioner pengetahuan ibu dan data terkait KIPI diperoleh dari formulir KIPI yang diterbitkan oleh Menteri Kesehatan RI. Hasil penelitian menunjukkan bahwa semua reaksi KIPI termasuk dalam reaksi KIPI ringan diantaranya demam (85,2%), bengkak (29,4%) dan kemerahan di lokasi penyuntikan (22%), diare (4,4%), muntah (4,4%), alergi (1,4%), sesak napas (1,4%), dan abses (1,4%). Ibu yang tidak melaporkan KIPI sebanyak 86,7% didominasi oleh ibu dengan tingkat pengetahuan cukup yaitu 47%, sedangkan ibu yang melaporkan KIPI sebanyak 13,2% didominasi oleh ibu dengan tingkat pengetahuan baik yaitu 5,8%. Berdasarkan hasil analisis menggunakan Fisher’s Exact sebagai uji alternatif menunjukkan bahwa tidak terdapat hubungan yang signifikan antara pengetahuan ibu dengan laporan ibu terkait KIPI pada anak (p-value = 0,231).
Development of Fourier Transform Infrared Spectrophotometric Method for Quantification of Simvastatin, Atorvastatin, and Rosuvastatin in Marketed Tablet Preparations Nerdy, Nerdy; Zebua, Nilsya Febrika; Nadia, Syarifah; Putra, Effendy De Lux; Bakri, Tedy Kurniawan
Molekul Vol 20 No 2 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.2.8635

Abstract

ABSTRACT. Marketed pharmaceutical dosage forms must be checked to ensure that the drug in distribution meets the quality requirements. The Fourier transform infrared spectrophotometric method will provide new innovations which are low cost, environmental friendly, simple, and rapid for analysis. The aim of this research was to develop a single analytical method that can be used to determine levels of three different statin derivatives (simvastatin, atorvastatin, and rosuvastatin) in tablet preparations. The method used in this study was Fourier transform infrared spectrophotometric, a very simple sample preparation stage by solvent extraction with minimal solvent extraction without potassium bromide and without pellet press. The specific wave numbers of simvastatin, atorvastatin, and rosuvastatin were determined between 4000 cm–1 to 650 cm–1. The Fourier transform infrared spectrophotometric method had been successfully developed and successfully applied to the determination of levels of simvastatin, atorvastatin, and rosuvastatin in marketed tablet preparations containing single active pharmaceutical ingredient. The specific wave numbers of simvastatin, atorvastatin, and rosuvastatin obtained was 1712.7 cm–1; 1660.5 cm–1; and 965.4 cm–1, respectively. The results obtained in the content determination based on the peak height and peak area fulfill the requirements for active pharmaceutical ingredient assay ranging from 90.00% to 110.00%. The developed method has also been validated for accuracy, precision, specificity, linearity, range, limit of detection, and limit of quantitation. Thus, this method can be a valid alternative method, cheap, green, easy, and fast in determination of the levels of simvastatin, atorvastatin, and rosuvastatin in tablet preparations. Keywords : atorvastatin, FTIR, rosuvastatin, simvastatin, tablet
EFFECT OF HESPERETIN TREATMENT ON BLOOD GLUCOSE LEVEL, SPERMATOZOA QUALITY, AND SPERMATOZOA QUANTITY IN ALLOXAN-INDUCED DIABETIC MICE Nerdy, Nerdy; Meliala, Linta; Barus, Bunga Rimta; Lestari, Puji; Ginting, Selamat; Ariani, Peny; Mierza, Vriezka; Bakri, Tedy Kurniawan
Jurnal Kedokteran Hewan Vol 15, No 1 (2021): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v15i1.18406

Abstract

Male infertility has occurred rapidly in the last few decades, primarily in developing countries. An antioxidant, hesperetin is a flavonoid that is found in abundance in orange peels. The aims of this research were to determine the effect of hesperetin on blood sugar levels, spermatozoaquality, and spermatozoa quantity. The research structure included induction of diabetes mellitus and treatment for 8 weeks, followed bydetermination of blood sugar levels, spermatozoa quality, and spermatozoa quantity. Hesperetin has the ability to restore blood sugar levels, spermatozoa quantity, seminiferous tubules diameter, and testicular weight, volume, and germinal epithelial layer thickness with significant difference from the normal control group. Hesperetin did not fully restore spermatozoa motility, viability, and morphology with significant difference from the normal control group, nor from the positive control group. However, overall, hesperetin decreased blood glucose levels, increased spermatozoa quantity, and improved the spermatozoa quality in alloxan-induced diabetes mellitus mice. Dose-dependent activity was observed with the optimum dose at 200 mg/kg body weight.
Co-Authors Adella, Shylvana Akmal, Raihanul Ariani, Peny Barus, Bunga Rimta Dharma, Rudi Effendy De Lux Putra, Effendy De Lux Fitria, Nanda GINTING, SELAMAT Heru Fahlevi, Heru Hijra Novia Suardi Idroes, Ghifari Maulana Lydia Septa Desiyana, Lydia Septa Meliala, Linta Meriyana, Cut Melda Mierza, Vriezka Nadia, Syarifah Nerdy, Nerdy Nilsya Febrika Zebua, Nilsya Febrika PUJI LESTARI Raihanah, R Rinaldi Idroes Sari, Fitrah Suhendra, Rivansyah Suryawati, S Teuku Rizky Noviandy VONNA, AZIZAH