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Fioni, Fioni
Universitas Prima Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Physics Public Health Social Sciences Transportation Veterinary

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Effectiveness of green betel leaf extract cream in healing cut wounds Aulia, Hilda Rafni; Wienaldi, Wienaldi; Fioni, Fioni
Jurnal Prima Medika Sains Vol. 5 No. 2 (2023): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v5i2.4399

Abstract

Green betel leaf (Piper betle L.) is widely used in the healing of cut wounds. The aim of this study was to investigate the efficacy of green betel leaf extract cream in the healing of cut wounds on the skin of white Wistar rats. The design employed was a pre-test post-test with a control group design and a sample size of 20 white rats divided into four groups. Betel leaf extract was prepared using the maceration method, while a cream preparation of betel leaf extract was prepared using the oil-in-water emulsion type (M/A). Macroscopic histopathological evaluation was performed by examining fibroblast growth. A one-way analysis of variance (ANOVA) test (p < 0.05) was used to determine the difference between groups, and a post hoc least significant difference (LSD) test was used to analyze which treatment group had the greatest efficacy. Technical terms were explained upon first use, and the language used was clear, objective, and value-neutral to improve academic quality. The text was free from grammatical errors, spelling mistakes, and unnecessary jargon. A one-way analysis of variance (ANOVA) test (p < 0.05) was used to determine the difference between groups, and a post hoc least significant difference (LSD) test was used to analyze which treatment group had the greatest efficacy. The study revealed a substantial difference in the average wound healing rates between the control group (P0) and treatment groups P1, P2, and P3. This is due to the lack of active substances in the control group (P0), which aids in accelerating the wound healing process. Notably, the 15% green betel leaf extract cream demonstrated superior efficacy in healing wounds in white rats compared to the 10% and 25% green betel leaf extract creams. The results indicated no significant difference between the application of 15% and 25% green betel leaf extract cream. This is due to the fact that secondary metabolite compounds present in the extract produce a healing effect on wounds at these particular levels. However, lower concentrations only act as microorganism inhibitors, rendering them less effective for promoting wound healing.
FAKTOR-FAKTOR YANG MEMENGARUHI RETURN SAHAM PADA PERUSAHAAN SUBSEKTOR FOOD AND BEVERAGE 2016-2024 FIONI, FIONI; ARILYN, ERIKA JIMENA
E-Jurnal Manajemen Trisakti School of Management (TSM) Vol. 5 No. 1 (2025): E-Jurnal Manajemen Trisakti School of Management (TSM)
Publisher : Pusat Penelitian dan Pengabdian kepada Masyarakat Sekolah Tinggi Ilmu Ekonomi Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34208/ejmtsm.v5i1.2904

Abstract

This study aims to analyze the effect of the current ratio (CR), debt to equity ratio (DER), net profit margin (NPM), price to earnings ratio (PER), and return on equity (ROE) on stock returns. The population of the study consists of companies in the Food and Beverages subsector during the period 2016–2024. The sample was obtained using a purposive sampling method, resulting in a total of 90 samples from 10 companies over a 9-year period. Secondary data were obtained from the official website of the Indonesia Stock Exchange (IDX) and analyzed using multiple regression with the help of the E- Views 12 application. The results of the study indicate that the return on equity (ROE) has a significant effect on stock returns. Meanwhile, the current ratio (CR), debt to equity ratio (DER), net profit margin (NPM), and price to earnings ratio (PER) do not have a significant effect on stock returns.
Efektivitas madu sebagai gastroprotektif pada tikus putih yang diinduksi aspirin bedasarkan hasil histopatologi Meutia, Rena; Razoki, Razoki; Halim, Binarwan; Nasution, Chairul Radjab; Tarigan, Antje Irmella; Fioni, Fioni; Nardi, Leo
Buletin Kedokteran & Kesehatan Prima Vol. 1 No. 2 (2022): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v1i2.2689

Abstract

Tukak lambung merupakan kerusakan jaringan mukosa, sub mukosa sampai lapisan otot lambung. Salah satu penyebabkan tukak lambung yaitu hipersekresi asam lambung sehingga terjadi kerusakan mukosa. Madu memiliki efek gastroprotektif, karena di dalam madu terdapat senyawa flavonoid, vitamin E, asam askorbat, dan katalase, Tujuan penelitian ini adalah untuk mengetahui aktivitas gastroprotektif akibat pemberian madu pada tikus yang diinduksi aspirin. Metode yang digunakan madu pada masing-masing pemberian tunggal diberikan 3 variasi kosentrasi yaitu madu 0,5; 0,75; dan 1 ml/kgbb. Parameter pengamatan meliputi biometrik makroskopis (jumlah tukak, pH tukak dan indeks tukak) dan mikroskopis (uji histopatologi). Bedasarkan hasil yang diperoleh bahwa bedasarkan pengamatan makroskopis terhadap perlakuan tunggal menunjukkan bahwa pemberian madu sebesar 1 ml/kgbb menunjukkan efek gastroprotektif dari kosentrasi lainnya. Kesimpulan: uji histopatologi pada dosis yang memiliki efek gastroprotektif dapat mengembalikan kohesi sel mukosa yang sebelumnya telah rusak akibat erosi.
The effect of gelagah stem extract on blood glucose levels in male white rats induced with alloxan Simatupang, Veronica Triwindari; Lubis, Asyrun Alkhairi; Nasution, Ali Napiah; Lumbantobing, Christina JRE; Fioni, Fioni; Rahimi, Armon
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 1 (2024): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i1.5218

Abstract

Diabetes mellitus is a metabolic disorder characterized by elevated blood glucose levels due to insulin deficiency, insulin resistance, or both. This study aimed to investigate the effects of gelagah stem extract (Saccharum spontaneum L.) on blood glucose levels in male Sprague-Dawley rats induced with alloxan. Experimental rats were divided into six groups: a normal control group, a negative control group (administered 100 mg/kg body weight alloxan), a positive control group (administered 5 mg/kg body weight glibenclamide), and three treatment groups administered gelagah stem extract at doses of 100, 200, and 400 mg/kg body weight. Results showed that all doses of gelagah stem extract significantly reduced blood glucose levels in alloxan-induced diabetic rats. Statistical analysis (Post hoc LSD) confirmed that the decrease in blood glucose levels was significantly different between the treatment groups and the negative control group (p < 0.05).
The Potential of Tamarillo (Solanum betaceum) Peel as an Antioxidant by Radical Scavenging DPPH and Antiaging by Collagenase Inhibition Liena, Liena; Fioni, Fioni; Siregar, Lidya; Girsang, Ermi
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 4: Desember 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v8i4.2504

Abstract

Background: The skin aging process, which is impacted by various variables, including genetics, advancing age, environmental conditions, and lifestyle choices, has emerged as a significant concern in skincare. Signs of skin aging, such as decreased firmness and elasticity and the appearance of fine lines and discoloration, have raised significant concerns. The link between free radicals and skin aging has been the subject of in-depth research, while collagenase activity has also been found to influence skin aging. The natural antiaging potential of herbal plants has been widely studied to overcome this problem, one of which is tamarillo (Solanum betaceum). Objectives: This study aimed to examine the antioxidant and antiaging properties of S. betaceum Peel Extract (SBPE). Method: Tamarillo peel was extracted using the maceration method. The antioxidant test was analyzed by trapping 2,2-diphenyl-1-picrylhydrazyl (DPPH), and the antiaging test was analyzed by collagenase inhibitory activity. Results: SBPE showed vigorous DPPH scavenging activity (IC50: 60.91 ± 0.36 ?g/mL), while SBPE also showed moderate collagenase inhibitory activity (IC50: 121.47 ± 2.32 ?g/mL). Conclusion: SBPE has high antioxidant activity and moderate antiaging activity.
The antioxidant and anti-elastase activities of tamarillo fruit extract (Solanum betaceum) Fioni, Fioni; Liena, Liena; Siregar, Lusyana; Girsang, Ermi
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 4: Desember 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v8i4.2508

Abstract

Skin aging is a complex process characterized by structural and functional loss of skin tissue. Aging is triggered by reactive oxidative stress (ROS), which activates enzymes involved in the aging process, such as elastase. Tamarillo is one of the natural plants that has various chemical compounds that have the potential to be antioxidants and anti-aging. The objective was to examine the antioxidant and antiaging activity of Tamarillo Fruit Extract (TFE). The H2O2 scavenging assay and anti-elastase assay were used. The result shows that TFE has a high antioxidant activity, as evaluated by H2O2 scavenging activity. The highest scavenging activity was found in a TFE concentration of 500 µg/mL (72.96%). Meanwhile, TFE shows its highest anti-elastase activity at a concentration of 66.67 µg/mL (32.33%). TFE's activity in both antioxidant and antiaging assays was concentration-dependent. The IC50 of the H2O2 assay was 278.20 µg/mL, and the IC50 of the anti-elastase assay was 110.67 µg/mL. Therefore, TFE shows its antioxidant and antiaging activities and has the potential to be used in further studies, both in vivo and clinical studies.
Tests of Burn Wound Healing with Nanogel Preparations from Ethanol Extract of Andaliman Fruit Janice, Janice; Erwina Putri, Riri; Fioni, Fioni
Jurnal EduHealth Vol. 14 No. 04 (2023): Jurnal eduHealt, 2023, December
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Andaliman (Zanthoxylum acanthopodium DC) is a plant known for its diverse bioactive compounds, including antimicrobial and anti-inflammatory properties. Nano-gel formulations were prepared using appropriate techniques, and their physicochemical properties, including particle size, pH, viscosity, and centrifugation stability, were evaluated. Additionally, organoleptic tests were conducted to assess the sensory characteristics of the nano-gels. Furthermore, an irritation test was performed to ensure the formulation's safety when applied to the skin. The percentage of wound closure was evaluated at various time points, including days 2, 4, 6, 8, 10, 12, and 14, comparing it to a commercially available wound healing product, Bioplacenton. Initial findings showed that the nano gel formulations exhibited favorable physicochemical properties, including appropriate particle size within the nano-scale range. The pH values were within an acceptable range, and the formulations demonstrated suitable viscosity and stability during centrifugation. Organoleptic tests indicated good sensory characteristics, and the irritation test showed the formulation's safety without significant skin irritation. The percentage of wound closure increased over time for all three concentrations (F1: 5%, F2: 10%, F3: 20%). In conclusion, nano gel formulations containing various concentrations of Andaliman extract exhibited good physicochemical properties, favorable sensory characteristics, and safe application on the skin. Moreover, they demonstrated promising wound healing effects, potentially comparable to commercial wound healing agents.
An Investigation on The Impact of Orally Administered Celery and Orange Juices on The Production of Collagen in Rats Exposed to Ultraviolet-B Light Arhani, Adli; Fioni, Fioni; Pratama , Irza Haicha
Jurnal EduHealth Vol. 14 No. 04 (2023): Jurnal eduHealt, 2023, December
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

At the correct dosage, ultraviolet (UV) radiation has many positive health effects and is essential for the body. The flip side is that exposure to excessive amounts of ultraviolet light (UV) can be harmful. Repetitive exposure to UVB light causes reactive oxygen species (ROS) to be produced, reducing the production of antioxidant enzymes, increasing oxidative protein modification, and causing glycation and lipid peroxidation products to accumulate. Because of this, it's essential to take precautions to guard the skin from free radical damage and slow the aging process by employing antioxidants in various forms. In this study, rats were exposed to UVB light and then given either celery juice (Apium graveolens) or orange juice (Citrus) orally to see if it would increase the quantity of collagen in the rats. True experimentation, or study in a controlled laboratory setting, is the method of choice. Each of the three groups consisted of eight white rats, for a total of twenty-four rats. Due to their high concentrations of antioxidant components, the phytochemicals found in celery and orange juices were determined to have therapeutic potential in the study's conclusions. With a collagen density value of 3+ and a density of collagen fibers in the skin ranging from 50 to 90% per field of view, the group given orange juice had a more substantial impact on the collagen growth of rat skin tissue after exposure to UVB light compared to the group given celery juice.
Oral Red Pomegranate (Punica granatum) Extract Administration to Elevate Blood Glutathione Peroxidase Levels in Female Wistar Rats (Rattus Norvegicus) Following Maximum Physical Activity Liena, Liena; Rahma Sari; Fioni, Fioni
Jurnal EduHealth Vol. 14 No. 04 (2023): Jurnal eduHealt, 2023, December
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

There is a significant danger to human health from oxidative stress. This disorder does not have any apparent symptoms. However, it is linked to the start and progression of many diseases. There are also no established medical procedures for detecting oxidative stress. Finding out how oral administration of red pomegranate (Punica granatum) extract increases blood glutathione peroxidase levels in female rats (Rattus norvegicus) strains is the goal of this experimental quantitative study, which employs a pre-test-post-test control group design. Maximum physical activity was induced in Wistar rats. Twenty-four animals were used in the experiments, with six in each group. Three, four, and five milliliters of red pomegranate extract were used in this experiment. With an antioxidant value of 8.33 ppm, pomegranate extract (Punica granatum) was determined to have a very robust action, according to the research. In terms of composition, the 5-milliliter dose of red pomegranate (Punica granatum) extract outperforms the others when compared to average levels of glutathione peroxidase. Researchers discovered that supplementing with red pomegranate extract (Punica granatum) considerably raised glutathione peroxidase levels, suggesting that this fruit may aid in the body's antioxidant defenses against free radicals generated by strenuous exercise.
Co-Authors Arhani, Adli ARILYN, ERIKA JIMENA Aulia, Hilda Rafni Binarwan Halim Chen Wei Dewi Riastawaty Edy Fachrial Erwina Putri, Riri Fibrini, Dewi Florenly Florenly Florenly Florenly Florenly Florenly Girsang, Ermi Janice Janice Ji Junfeng Jiang Fan Johannes Bastira Ginting Khainir Akbar, Khainir Li Sha Li Wei Liana Liana Liena Liena Liena, Liena Lister, I Nyoman Ehrich Lubis, Asyrun Alkhairi Lumbantobing, Christina JRE Meutia, Rena Nardi, Leo Nasution, Ali Napiah Nasution, Chairul Radjab Pratama , Irza Haicha Rahimi, Armon Rahma Sari Razoki, Razoki Reh Malem br Karo Rizal Rizal Simatupang, Veronica Triwindari Sinurat, Jhon Patar Siregar, Lidya Siregar, Lusyana Tarigan, Antje Irmella WAHYU WIDOWATI Wienaldi, Wienaldi