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All Journal Medical Journal of Indonesia Indonesian Journal of Medicine Indonesian Journal of Cancer Jurnal Online Skripsi Manajemen Rekayasa Konstruksi (JOS-MRK)
Muhammad, Faizal
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Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Engineering Immunology & microbiology Medicine & Pharmacology Public Health Transportation

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Association between vaspin rs2236242 gene polymorphism and atherosclerosis in ischemic stroke patients with diabetes mellitus in the Indonesian population Danuaji, Rivan; Suroto; Purwanto, Bambang; Indarto, Dono; Muhammad, Faizal; Mirawati, Diah Kurnia; Widyaningsih, Vitri; Soetrisno; Subandi; Budianto, Pepi; Hambarsari, Yetty; Hamidi, Baarid Luqman; Prabaningtyas, Hanindia Riani; Hutabarat, Ervina Arta Jayanti; Ristinawati, Ira; Tejomukti, Teddy; Tedjo, Raden Andi Ario
Medical Journal of Indonesia Vol. 33 No. 4 (2024): December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247566

Abstract

BACKGROUND Stroke is the third leading cause of morbidity and second in mortality worldwide. Diabetes mellitus (DM) is a risk factor for stroke. Vaspin and single nucleotide polymorphism (SNP) rs2236242 involved DM pathogenesis. This study aimed to explore the correlation between SNP rs2236242, serum vaspin levels, and atherosclerosis in patients with ischemic stroke and DM. METHODS This study was conducted in Dr. Moewardi Hospital from 2022 to 2023. The case group included patients with ischemic stroke and DM, while the controls were those with ischemic stroke only. Tetra-primer amplification refractory mutation system-polymerase chain reaction was used to determine the genotypes. RESULTS There were 31 cases and 33 control. SNP rs2236242 showed that odds ratio (OR) (95% confidence interval [CI]) for AA-TT was 0.273 (0.241–0.305) and for TA-TT was 0.315 (0.298–0.341). The OR (95% CI) for allele A to T was 0.789 (0.373−1.669). The mean (standard deviation) serum vaspin level in the case group compared to the control was 1,570 (2,108) ng/ml versus 1,630 (1,428) ng/ml (p = 0.064). Higher vaspin levels were found in T allele of the TT (1,523 [2,269] ng/ml, p = 0.021) and TA (1,760 [1,349] ng/ml, p = 0.004) genotype groups than the A allele of the AA genotype group (0.914 [0.329] ng/ml). CONCLUSIONS Vaspin gene polymorphism AA genotype or A allele significantly reduces vaspin levels in patients with ischemic stroke with DM.
EVALUASI KINERJA SIMPANG BERSINYAL DI JALAN AHMAD YANI – JALAN RAYA BUDURAN, SIDOARJO Muhammad, Faizal; Muhamad Fajar Subkhan; Marjono
Jurnal Online Skripsi Manajemen Rekayasa Konstruksi (JOS-MRK) Vol. 3 No. 1 (2022): MARET 2022
Publisher : Jurusan Teknik Sipil Politeknik Negeri Malang

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Abstract

Penelitian ini bertujuan untuk mengevaluasi kinerja simpang bersinyal pada kondisi eksisting dengan menerapkan beberapa alternatif penyelesaian dan menghitung biaya akibat tundaan. Data yang dibutuhkan antara lain data primer dan data sekunder. Data primer didapat dari pengukuran geometrik jalan, survei arus lalu lintas, hambatan samping dan panjang antrian pada tanggal 25, 27 dan 29 Mei 2021. Data sekunder didapat dari Dinas Perhubungan Sidoarjo berupa rekaman CCTV, rata – rata kecepatan, data jumlah penduduk Kabupaten Sidoarjo, PDRB dan UMR Kabupaten Sidoarjo. Pengolahan data kinerja simpang bersinyal pada penelitian ini menggunakan metode Pedoman Kapasitas Jalan Indonesia (PKJI) 2014. Dari hasil analisis kinerja simpang bersinyal eksisting didapat nilai DJ lebih dari 0,85; Tundaan simpang rata-rata T = 522,70 det/skr dan Tingkat pelayanan = F. Alternatif solusi pada simpang bersinyal dilakukan dengan pengalihan semua jenis kendaraan bermotor dari lengan Timur dan beberapa jenis kendaraan bermotor dari Utara, Selatan dan Barat. Dari perhitungan alternatif tersebut didapatkan hasil DJ < 0,85; Tundaan simpang rata-rata T = 58,82 det/skr dan Tingkat pelayanan = E. Dari hasil perhitungan BOK akibat tundaan waktu pada simpang didapat selisih yang cukup besar antara eksisting dan adanya alternatif sebesar Rp 8.709.193,00 /jam. Biaya akibat tundaan eksisting dengan alternatif didapatkan selisih total kerugian per hari sebesar Rp 90.359.243,15 (PDRB) dan Rp 49.256.191,29 (UMR) dengan penggunaan alternatif 4 menghasilkan biaya akibat tundaan lebih murah ketimbang kondisi eksisting simpang bersinyal ini.
A Rare Case of Newly Acquired Hemophilia Following Diabetic Ketoacidosis in A Male Patient with IL-2 (Rs2069762) Polymorphism Muhammad, Faizal; Arthareza, Adhelia Galuh Permatasari; Marwanta, Sri
Indonesian Journal of Medicine Vol. 10 No. 3 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.3.832

Abstract

Background: Diabetes is commonly linked to autoimmune processes, but acquired hemophilia A (AH)—a rare bleeding disorder due to factor VIII (FVIII) inhibitors—remains uncommon, particularly during diabetic ketoacidosis (DKA). Recent studies have suggested a role of IL-2 (rs2069762) polymorphism in FVIII inhibitor development. This study aims to highlight a rare case of newly acquired hemophilia coinciding with DKA and the presence of IL-2 gene polymorphism. Case Presentation: A 40-year-old male presented with dyspnea, abdominal pain, and signs of DKA. He had a history of drug-induced rash due to sulfasalazine. Initial management with IV fluids and insulin resolved the metabolic crisis. However, on day two, he developed spontaneous bruising and gross hematuria. Laboratory tests revealed a low FVIII inhibitor titer (1.2 BU) and positive insulin antibodies. Genetic testing showed TT homozygous polymorphism of IL-2 (rs2069762), potentially contributing to FVIII inhibitor formation. Results: The patient was treated with low-dose cyclophosphamide and methylprednisolone, followed by rituximab due to poor initial response. Intensive insulin therapy was also administered. After five weeks, clinical remission of AH was achieved, although the patient remains at risk for relapse due to the IL-2 polymorphism. Conclusion: This case illustrates a rare interplay between DKA and acquired hemophilia, potentially mediated by IL-2 (rs2069762) polymorphism. Prompt diagnosis and individualized immunosuppressive therapy are essential. The findings support further investigation into genetic predispositions in AH pathogenesis during autoimmune or metabolic stress events like DKA.
Sensitivity and Specificity of Ultrasonography for Assessing Axillary Lymph Nodes in Breast Cancer Patients in Surakarta, Indonesia Bellynda, Monica; Yarso, Kristanto Yuli; Rosati, Ari; Kamil, Muhammad Rizki; Muhammad, Faizal
Indonesian Journal of Cancer Vol 19, No 3 (2025): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i3.1339

Abstract

Background: Breast cancer is the most common malignancy in women worldwide. Early detection is effective in reducing breast cancer mortality by 25–30%. Staging assessment with sentinel lymph node biopsy (SLNB) is the gold standard for patients with clinically negative axillae. Ultrasound examination of the axillae is often performed as a preoperative treatment for breast cancer patients to determine the stage of the cancer, where regional axillary lymph node assessment can be related to the prognostic factors of breast cancer, as well as assessing the prognosis for distant metastases. This study aims to evaluate the sensitivity of ultrasound examination of the axillary lymph nodes in breast cancer.Method: This study employs a descriptive research method with a retrospective approach, utilizing secondary data and comprising 283 samples. Inclusion criteria included patients diagnosed with cervical carcinoma confirmed by histopathological evaluation and complete medical records documenting age, primary complaints, histopathological classification, and TNM staging. Data were processed and presented using descriptive statistics. The study was conducted at the Surakarta Hospital between 2020 and 2022. Inclusion criteria were breast cancer patients with stage T1-2 N0 M0 confirmed by histopathological examination who underwent axillary lymph node ultrasound examination in Surakarta. Data was taken from the medical records. Patient's initial, age, date of examination, clinical diagnosis, expertise of the ultrasound, and histopathology of the axillary lymph node were recorded. The gold standard is SLNB. The calculation of diagnostic validity was carried out using a 2x2 table, and then the sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of ultrasound were calculated.Results: 176 cases met the inclusion criteria, with 59.10% patients aged over 50 years old. Seventeen cases had positive ultrasound but negative histopathology examinations. Meanwhile, the remaining 15 cases had negative ultrasound but positive histopathology examinations. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy results are as follows: 82%, 83%, 80%, 83%, 4.89, 0.21, and 82%, respectively.Conclusion: Ultrasound examination for assessing axillary lymph nodes is easy, inexpensive, effective, and safe. The results can be increased with better radiological methods and experience from higher-level operators.
Co-Authors Arthareza, Adhelia Galuh Permatasari Bambang Purwanto Bellynda, Monica Budianto, Pepi Diah Kurnia Mirawati Dono Indarto Hambarsari, Yetty Hamidi, Baarid Luqman Hutabarat, Ervina Arta Jayanti Kamil, Muhammad Rizki Marjono Marwanta, Sri Muhamad Fajar Subkhan Prabaningtyas, Hanindia Riani Ristinawati, Ira Rivan Danuaji Rosati, Ari Soetrisno SUROTO Tedjo, Raden Andi Ario Tejomukti, Teddy Vitri Widyaningsih Yarso, Kristanto Yuli