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Prihatina, Lale Maulin
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Prevalensi Gangguan Refraksi pada Mahasiswa Baru Universitas Mataram Angkatan 2014 Nintyastuti, Isna Kusuma; Geriputri, Ni Nyoman; Prihatina, Lale Maulin; Syari, Mayuarsih Kartika; Wilmayani, Ni Ketut
Jurnal Kedokteran Vol 5 No 4 (2016)
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Latar Belakang: Gangguan refraksi merupakan salah satu penyebab kebutaan di dunia. World Health Organization (WHO) menyatakan 45 juta orang menjadi buta di seluruh dunia, dan 135 juta dengan low vision. Dari 66 juta anak usia sekolah (5-19 tahun) di Indonesia, sekitar 10% menderita kelainan refraksi. Sampai saat ini angka pemakaian kaca mata koreksi masih sangat rendah sekitar 12,5% dari prevalensi tersebut. Apabila kondisi ini tidak ditangani secara menyeluruh akan berdampak negatif pada perkembangan kecerdasan anak dan proses pembelajaran yang akan mempengaruhi produktivitas dan mutu angkatan kerja (15-55 tahun). Tujuan Penelitian: Penelitian ini bertujuan untuk mengetahui prevalensi gangguan refraksi pada mahasiwa baru Universitas Mataram angkatan 2014, mengetahui distribusi karakteristik subjek yang diteliti, meliputi: jenis kelamin, usia, pendidikan orang tua, penghasilan rumah tangga, adanya gangguan refraksi pada keluarga inti, waktu yang dihabiskan untuk membaca dan bermain game komputer di rumah, riwayat pemeriksaan ketajaman pengelihatan dan pemakaian kacamata koreksi sebelumnya, dan gejala gangguan pengelihatan serta untuk mengetahui frekuensi kejadian pada berbagai tipe gangguan refraksi. Metode: Penelitian ini menggunakan metode cross-sectional dengan pengambilan sampel secara kluster sesuai dengan fakultas pada mahasiswa baru Universitas Mataram angkatan 2014. Pengambilan data dilakukan dengan menggunakan kuisioner, pemeriksaan tajam penglihatan, pemeriksaan autorefraktokeratometer dan koreksi subjektif pada penderita gangguan refraksi. Hasil: Penelitian dilakukan pada 183 responden, 67 laki–laki dan 115 perempuan, dengan rerata umur 18,76±1,66 tahun. Responden terbanyak berasal dari fakultas keguruan dan ilmu pendidikan (33%). Sebagian besar memiliki orang tua dengan tingkat pendidikan terakhir SMA/sederajat (33% dan 31%) dan penghasilan kurang dari 2 juta per bulan (79%). Riwayat pemeriksaan tajam pengelihatan sebelumnya hanya didapatkan pada 27% responden. Diagnosis terbanyak Myopia Simpleks (OD 8,74%, OS 12,02%) dan terjarang Astigmat Myopia Simpleks (0,55%). Dua puluh empat responden sudah menggunakan kacamata dengan rerata umur mulai berkacamata 16,58±3,55 tahun. Tidak didapatkan perbedaan yang bermakna pada riwayat keluarga (p=0,4023). Lama penggunaan gadget memiliki signifikansi terhadap risiko terjadinya gangguan refraksi (p=0,0177). Kesimpulan: Myopia Simpleks merupakan diagnosis kelainan refraksi yang paling banyak ditemukan. Tidak terdapat perbedaan bermakna pada faktor risiko riwayat keluarga dan didapatkan perbedaan bermakna pada risiko lama penggunaan gadget.
Antioxidant Effect in Nasopharyngeal Cancer Histopathology Degree on 40 PPM Formaldehyde-Inducted Rattus novergicus Wibawa, Putu Arta; Wedayani, Anak Agung Ayu Niti; Prihatina, Lale Maulin; Yuliani, Eka Ari; Pratiwi, Sekar
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.8805

Abstract

Formaldehyde exposure, implicated on the development of nasopharyngeal cancer (NPC), remains a significant concern worldwide, with increasing incidence, morbidity, and mortality cases. This study eager to investigate the antioxidant effect on degree of histopathology from formaldehyde exposure, assessing nasopharyngeal dysplasia progression toward malignancy. Rattus norvegicus divided equally into four groups: control, placebo, formaldehyde-induced (40 PPM), and formaldehyde-induced with antioxidant, followed by dysplasia degree examination under light microscope. The result revealed severe dysplasia in the formaldehyde group, indicating non-keratinizing squamous cell carcinoma. Additionally, antioxidant-treated group presented reduced severity, with lower degree of dysplasia. This result is indicating positive improvement of antioxidant effect toward NPC malignancy, supporting previous studies and further confirming genotoxicity and irritability of formaldehyde. Nevertheless, limitations, existed with lack of sample studied and dose-response analysis, were demanding deeper study need to be done.
Relationship Between S100 Protein Expression and Grading Meningioma Prihatina, Lale Maulin; Rohadi; Priyanto, Bambang; Zulkarnaen, Decky Aditya; Syukur, Abdul
Jurnal Penelitian Pendidikan IPA Vol 11 No 7 (2025): July
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i7.11529

Abstract

Meningioma is the most common type of benign brain tumor in adults and mostly originates from the meningeal layer of the brain and spinal cord. The prevalence of meningioma in the world is estimated to be about 24-30% of intracranial primary brain tumors. This tumor is classified into three groups based on grade, grade I (benign), grade II (atypical), and grade III (anaplastic). The S100 protein is not specific to meningiomas but some studies have shown that the expression of S100 protein is stronger in grade I meningiomas than in grade II and III meningiomas. Based on these findings, the authors are interested in analyzing whether there is a relationship between S100 expression and meningioma grading. The determination of S100 protein expression is very necessary as a reference in determining the prognosis and selection of the best therapy for patients. This research was carried out in the period from January 2021 to December 2021. 9 samples were included in this study according to the inclusion and exclusion criteria. The data was analyzed using SPSS version 26. The results of this study: A normality test was carried out with the Shapiro Wilk test and a value of p=0.34 (CI 95%) was obtained using Spearman analysis.
Histopathological Comparison of Nasopharyngeal and Lung Tissue on Wistar Rats Induced with Formaldehyde Abdiman, I Made Tobias; Wedayani, Anak Agung Ayu Niti; Prihatina, Lale Maulin; Restuningdyah, Novia Andansari Putri
Jurnal Biologi Tropis Vol. 24 No. 1 (2024): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1.6456

Abstract

Formaldehyde is a toxic substance commonly found in everyday life. Formaldehyde is also a carcinogenic exposure that often occurs in industrial areas. Formaldehyde itself is genotoxic and cytotoxic to tissues that can cause dysplasia to carcinoma. Inhalation of formaldehyde will expose the respiratory tract, which includes the nasopharynx and lung tissue to formaldehyde. Therefore, it is important to know the differences in tissue susceptibility to formaldehyde exposure related to the ability to cause dysplasia and carcinoma. Six Wistar rats were induced with formaldehyde through the inhalation method at a dose of 40 ppm for 16 weeks, and then terminated and subjected to histopathological examination. The degree of dysplasia will be assessed in both tissues, and then compared and tested statistically. The Mann-Whitney U statistical test showed a P value of 0.818, meaning that there was no significant difference between the degree of dysplasia in nasopharyngeal tissue and lung tissue. However, there was a difference in the rate of dysplasia progression between the two tissues, with nasopharyngeal tissue having a faster rate of progression. This difference in the rate of progression is related to the higher amount of formaldehyde deposition in the upper airway.
The Relathionship Between CD31 Immunohistochemical Expression and Meningioma Grading Differences Febriana, Nanggi Qoriatul; Rosyidi, Rohadi Muhammad; Januarman, Januarman; Rahim, Adelia Riezka; Prihatina, Lale Maulin
Jurnal Biologi Tropis Vol. 25 No. 1 (2025): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i1.8539

Abstract

The proper management of meningioma patients requires a definitive diagnosis of the meningioma grade by examining the expression of CD31 in tumor blood vessels using immunohistochemical staining. This study aims to determine the relationship between CD31 immunohistochemical expression and the grading differences of meningiomas. Nine paraffin block samples from the surgical tissue of meningioma patients were used, with three samples each from grade I, grade II, and grade III meningiomas. Immunohistochemical staining for CD31 was then performed on each meningioma slide, and the samples were observed under a binocular light microscope with 200x magnification. The results showed CD31 expression in grade I as 90%, 40%, and 80%; in grade II as 80%, 80%, and 60%; and in grade III as 40%, 20%, and negative (0%). The statistical test results of this study indicate a strong negative correlation between CD31 immunohistochemical expression and meningioma grading differences. The higher the meningioma grade, the lower the CD31 expression found, and vice versa. This research is important to assist neurosurgeons in the proper management of meningioma patients, potentially preventing poor prognosis and complications. It is hoped that future studies will analyze the relationship between CD31 immunohistochemical expression with subtypes of each meningioma grade and their respective locations.
PENGENALAN KESEHATAN REPRODUKSI DAN PENCEGAHAN INFEKSI MENULAR SEKSUAL DI SMPN 2 DAN SMPN 6 MATARAM Octora, Metta; Danianto, Ario; Adni, Azizatul; Prihatina, Lale Maulin; Lasiaprillianty, Intan Wahyu; Wicaksono, Teguh Budi
Jurnal Abdi Insani Vol 11 No 2 (2024): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v11i2.1275

Abstract

Teenager reproductive health is a health problem that concerns the nation's next generation, with high vulnerability to sexually transmitted infections (STIs). About 1 million transmissions of STIs, such as chlamydia, gonorrhea, syphilis and trichomoniasis occur every day worldwide, and the majority are asymptomatic. Every year, it is estimated 374 million cases are predominantly of reproductive age. This program is based on the trend increasing of promiscuous sexual relations among junior high school teenagers which results in early pregnancy and transmission of STIs. This program has purpose to increase the knowledge of junior high school students and teachers regarding sexually transmitted infections and reproductive health as well as preventing free sex. Counseling regarding reproductive health and sexually transmitted infections is carried out at SMPN 2 and SMPN 6 in Mataram. Extension activities include providing outreach materials, interactive question and answer sessions, Instagram competitions on related topics. The mean post-test score of participants was significantly higher than the pre-test (p <0.05). The scores of SMPN 6 students were found to have a significant increase in the mean during the post-test compared to the pre-test (p <0.05). There was a change in the knowledge of SMPN 2 and SMPN 6 Mataram students regarding reproductive health and STIs after the counseling
The Relationship Between BRCA1 Expression and Grade in Breast Cancer Patients in NTB Mikailla, Romy Healthy; Padauleng, Novrita; Lestari, Rizka Vidya; Prihatina, Lale Maulin; Priyanto, Bambang; Kumaladewi, Baiq Ratna
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10860

Abstract

Breast cancer is the malignancy with the highest incidence among women in West Nusa Tenggara (NTB). The Breast Cancer 1 (BRCA1) gene is a tumor suppressor gene that plays a crucial role in DNA repair and genome stability. A decrease in BRCA1 expression is theoretically associated with more aggressive tumor characteristics, such as a low degree of differentiation (high grade). However, data regarding the relationship between BRCA1 protein expression and the degree of cell differentiation in the patient population in NTB remains limited. This study employed a cross-sectional design with an observational analytic approach on 50 paraffin block samples from Invasive Breast Carcinoma patients at the NTB Provincial General Hospital from 2022-2023. BRCA1 protein expression was assessed using immunohistochemistry with a positive cut-off defined as staining in >20% of tumor cell nuclei. Data on the degree of differentiation (Grade 1, 2, and 3) were obtained from medical records. The relationship between the two variables was analyzed using the Lambda, Pearson’s R, and Spearman Correlation tests with a significance level of p < 0.05. The majority of samples (84%) were grade 3 tumors. The distribution of BRCA1 expression in the total sample was balanced, with 25 cases (50%) showing positive expression and 25 cases (50%) showing negative expression. In the grade 3 subgroup, this distribution remained balanced. Statistical analysis consistently showed no significant relationship between BRCA1 expression and the degree of cell differentiation (p > 0.05).
Studi Perbandingan Imunohistokimia NeuN dan NSE untuk Penilaian Neuroprotektif Kombinasi Centella asiatica, Kayu Manis, dan Spirulina pada Cedera Otak Traumatis Rohadi, Rohadi; Priyanto, Bambang; Januarman, Januarman; Prihatina, Lale Maulin
JURNAL SAINS TEKNOLOGI & LINGKUNGAN Vol. 11 No. 3 (2025): JURNAL SAINS TEKNOLOGI & LINGKUNGAN
Publisher : LPPM Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jstl.v11i3.968

Abstract

Background: Traumatic brain injury (TBI) is a major cause of morbidity and mortality globally, often resulting in cognitive and functional impairment. Effective neuroprotective strategies are needed to mitigate secondary injuries following TBI. This study evaluated the neuroprotective effects of combined Centella asiatica, cinnamon, and spirulina using NeuN and neuron-specific enolase (NSE) immunohistochemical staining in a rat model of TBI. Methods: Ten male Sprague-Dawley rats (200–400 g, 10–12 weeks) were subjected to TBI using the modified Marmarou model and treated orally with a combination extract of Centella asiatica, cinnamon, and spirulina for 10 days. On day 11, brain tissues were collected for histopathological examination and immunohistochemical staining using NeuN and NSE markers to evaluate neurogenesis and neuronal survival. Results: Immunohistochemical analysis revealed a mean positive expression of 71.66% in the NeuN group, indicating increased neuronal survival and neurogenesis, while the NSE group consistently showed 0% positive staining across all samples. The NeuN staining provided a clear depiction of neuronal preservation in the brain tissue, whereas NSE did not demonstrate detectable neurogenesis or neuronal protection in this model. Conclusion: The administration of a combined extract of Centella asiatica, cinnamon, and spirulina demonstrated neuroprotective effects in a rat model of subacute traumatic brain injury, as indicated by increased NeuN immunohistochemical expression, reflecting enhanced neurogenesis and neuronal survival. NeuN staining provided a clearer and more sensitive depiction than NSE, supporting its reliability as an immunohistochemical marker for evaluating neuroprotection and neurogenesis during the subacute phase of TBI in models treated with herbal-based interventions.
Co-Authors Abdiman, I Made Tobias Abdul Syukur Anak Agung Ayu Niti Wedayani Ario Danianto, Ario Azizatul Adni Bambang Priyanto, Bambang Decky Aditya Zulkarnaen Febriana, Nanggi Qoriatul Geriputri, Ni Nyoman Intan Wahyu Lasiaprillianty, Intan Wahyu Januarman, Januarman Kumaladewi, Baiq Ratna Lestari, Rizka Vidya Metta Octora Mikailla, Romy Healthy Nintyastuti, Isna Kusuma Padauleng, Novrita Pratiwi, Sekar Rahim, Adelia Riezka Restuningdyah, Novia Andansari Putri Rohadi Rohadi Rohadi Rosyidi, Rohadi Muhammad Syari, Mayuarsih Kartika Teguh Budi Wicaksono Wibawa, Putu Arta Wilmayani, Ni Ketut Yuliani, Eka Ari