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PENGARUH BUTYLATED HYDROXYANISOLE TERHADAP STABILITAS DAN KARAKTERISTIK EMULGEL KOMBINASI EKSTRAK JAHE MERAH DAN MINYAK PEPPERMINT Rismawati, Dewi; Aji, Nur; Herdiana, Irvan
Pharmaqueous: Jurnal Ilmiah Kefarmasian Vol. 2 No. 1 (2020): Volume 2, Nomor 1, Mei 2020
Publisher : Universitas Al-Irsyad Cilacap

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36760/jp.v1i2.119

Abstract

Emulgel ekstrak jahe merah dan minyak peppermint tanpa penambahan antioksidan dapat menyebabkan perubahan warna. Maka perlu adanya pengembangan formula dengan penambahan butylated hydroxyanisole sebagai antioksidan. Penelitian ini bertujuan untuk mengetahui pengaruh penambahan butylated hydroxyanisole dalam formulasi emulgel kombinasi ekstrak jahe merah dan minyak peppermint. Konsentrasi butylated hydroxyanisole yang digunakan dalam formulasi adalah 0,01% pada formula 1 yaitu 0,02% pada formula 2 yaitu 0,03% pada formula 3, dan formula 4 tanpa menggunakan butylated hydroxyanisole. Evaluasi fisik dilakukan terhadap beberapa parameter uji karakteristik sedian antara lain organoleptik, pengukuran pH, daya sebar, viskositas, homogenitas, dan sineresis. Evaluasi fisik dilakukan pada sediaan yang disimpan di suhu 4°±2°C, suhu ruang, 40°±2°C pada minggu ke-0 sampai minggu ke-12. Hasil menunjukan bahwa seluruh formula pada penyimpanan suhu 40°±2°C dan suhu ruang, emulgel mengalami perubahan warna menjadi kecoklatan dan kuning. Homogenitas dan nilai pH emulgel seluruh formula selama penyimpanan menunjukan hasil yang homogen dan stabil pada pH 6. Semua formula selama penyimpanan mengalami peningkatan daya sebar dan penurunan viskositas. Pada formula 4 (tanpa BHA) menunjukan angka sineresis paling tinggi sebesar 41,75% pada jam ke-72. Hasil ini menunjukan bahwa penggunaan BHA tidak berpengaruh dalam formulasi emulgel kombinasi ekstrak jahe merah dan minyak peppermint.
Formulation and Characterization of Instant Powder Combination of Ginger, Bangle, and Lemon Extract as an Antioxidant Aji, Nur; Sutiswa, Shandra Isasi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 3 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i32023.331-346

Abstract

Background: Degenerative disease is a  decreasing organ function; clinical manifestations can affect the whole body, which is caused by oxidative stress. Ginger, bangle, and lemon have antioxidant properties. The combination of the three is expected to increase antioxidant activity. Objective: This study aimed to determine the potential antioxidant activity of the mixture of the three samples formulated as instant powder. Methods: This research is an experimental laboratory. This study will examine the effect of variations in extract concentration and PEG-40 HCO concentration on instant powder's characteristics and antioxidant activity. Results: Individually, ginger extract has extreme antioxidant activity (IC50 = 23.57 ± 0.13 µg/mL) and bangle strong (IC50 = 64.89 ± 0.15 µg/mL), while lemon has weak antioxidant activity (IC50 >500 µg/mL). Combining ginger, bangle, and lemon with a simplex axial method obtained the combination of ginger: bangle: lemon with the ratio of 4/6: 1/6: 1/6. Adding a mixture of extracts affects the solubility and antioxidant activity of the extracts. The greater the amount of extract, the lower the solubility, and the antioxidant activity did not increase with addition. The addition of PEG-40 HCO increases the solubility of the extract in the instant powder. Antioxidant activity increased to the "medium” category (121.90 µg/mL) after adding PEG-40 HCO at a concentration of 2.70%. The unfavourable impact of PEG-40 HCO addition on instant powders is the angle of repose, flow time, and compressibility. Conclusion:  The ginger, bangle, and lemon can be combined and made into instant powder with potential antioxidant activity in the moderate category.
Liquid Hand Soap Formulation of Java Citronella (Cymbopogon winterianus) Oil Using Surfactant Combination as Foaming Agent Martihandini, Nooryza; Aminah, Mimin; Aji, Nur
Interest : Jurnal Ilmu Kesehatan INTEREST: Jurnal Ilmu Kesehatan Volume 13 Number 2 November 2024
Publisher : Poltekkes Kemenkes Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37341/interest.v13i2.600

Abstract

Background: Unhygienic hands can cause microorganism infection. Citronella oil contains citronellal, citronellol, and geraniol, which have antibacterial activity. Liquid hand soap removes the dirt and microorganisms; however, it commonly uses sodium lauryl sulphate (SLS) as a foaming agent that may irritate the skin. Lauryl glucoside is a non-ionic, non-irritating surfactant. This study aimed to formulate and characterise liquid hand soaps from citronella oil using a combination of SLS and lauryl glucoside as surfactants. Methods: The research was conducted using an experimental laboratory method. Three liquid hand soap formulas were developed from 15% citronella oil with different weight ratios of SLS and lauryl glucoside: F1 (1:2), F2 (1:1), and F3 (2:1). Then, all liquid hand soaps were evaluated for organoleptic properties, homogeneity, viscosity, pH, and foam height. Then the foam stability test was conducted after the formed foam was left for 5 minutes. Results: The results showed that all liquid hand soaps were homogeneously distributed, clear viscous liquids having a distinctive odour of citronella oil. The liquid hand soap preparations had a viscosity range of 549.7–565.8 cps, a pH in the range of 7.39–7.89, a foam height of 74–85 mm, and a stability foam of 63.52–68.91%. All formulas complied with SNI 2588:2017 criteria for liquid hand soap. Conclusion: This study presented that citronella oil could be formulated into liquid hand soap using a combination of SLS and lauryl glucoside. The optimal formula was F1 with a 1:2 ratio of SLS and lauryl glucoside. F1 had the most stable foam due to the higher concentration of lauryl glucoside, which enhances foam stability.