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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Althea Medical Journal Jurnal Gizi dan Pangan Soedirman (JGPS) Hearty : Jurnal Kesehatan Masyarakat Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Medika Malahayati YARSI Medical Journal Sumatera Medical Journal Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan PREPOTIF : Jurnal Kesehatan Masyarakat Indonesian Journal of Global Health research Jurnal Info Sains : Informatika dan Sains International Journal of Civil Engineering and Infrastructure (IJCEI) Jurnal Sosial dan Sains Jurnal Indonesia Sosial Sains Buletin Pengabdian Jurnal Ruhul Islam Holistik Jurnal Kesehatan
Marsiati, Himmi
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UTILIZATION OF ARTIFICIAL AQUIFERS BY ADDING ZEOLITE AND CARBON TO IMPROVE WATER QUALITY Imamuddin, Mohammad; budiman, budiman; Marsiati, Himmi; Dewi, Firda Rachma; Mahdiani, Nila Sekar
International Journal of Civil Engineering and Infrastructure Vol. 5 No. 1 (2025): IJCEI Volume 5 No. 1
Publisher : University Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Water is the most important component of life. The function of water for living beings cannot be replaced by any other substance. One of the main issues currently faced regarding waterresources is the declining quality of water for both domestic and non-domestic purposes.According to the Regulation of the Minister of Health of the Republic of Indonesia No.492/Menkes/PER/IV/2010 concerning drinking water requirements, it states that safe andhealthy drinking water for consumption must meet requirements that include physical,chemical, and bacteriological criteria. Strict requirements are imposed on drinking waterbecause they are directly related to the biological processes of the body that determine humanquality of life. The consumption rate of drinking water is very high in tropical regions. This isdue to the high humidity, and people in tropical areas require a large amount of drinkingwater to quench their thirst. Therefore, high-quality drinking water is necessary to maintainhealth. The dangers or health risks resulting from the decline in the physical quality of watercan have negative impacts on health. The utilization of groundwater remains a mainstay forcommunities in meeting their domestic and non-domestic water needs. The increasingpopulation has led to a decline in the quality of clean water due to human activities that causeenvironmental pollution. Sources of groundwater pollution include industrial activities, wastedisposal sites, mining areas, residential areas, salt industries, agricultural activities, andlivestock farming.
Effect of Vitamin D Supplementation on Irisin, Telomerase, Klotho, and Tumor Necrosis Factor-alpha (TNF-α) in Elderly: A Quasi-Experimental Study Mukhtar, Diniwati; Rahmah, Nunung Ainur; Wuryanti, Sri; Marsiati, Himmi; Haddad, Desi Ariyani; Manik, Sabarina Elfrida; Weni, Linda; Nursabur, Bistamy Muhammad; Hutabarat, Andrea Ivana Allicia; Puspita, Switania Putri
Althea Medical Journal Vol 12, No 3 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n3.4286

Abstract

Background: Vitamin D plays a crucial role in aging by regulating mitochondrial function, inflammation, oxidative stress, and telomere stability. Vitamin D deficiency is common among the elderly and is linked to accelerated aging. Biomarkers such as irisin, telomerase, klotho, and tumor necrosis factor-alpha (TNF-α) are associated with aging processes. This study aimed to evaluate the effect of vitamin D supplementation on these biomarkers in elderly individuals.Methods: This quasi-experimental pretest-posttest study was conducted in Kadugadung Village, Banten, Indonesia from Maret to September 2024.  A total of 47 healthy elderly individuals (≥60 years) were recruited using purposive sampling. The treatment group (n=25) received 800 IU/day of vitamin D for 20 days, whereas the control group (n=22) received none. Blood samples were collected before and after the intervention to measure serum irisin, telomerase activity, klotho, and TNF-α. Baseline variables included body mass index (BMI), blood pressure, hemoglobin, hematocrit, blood glucose, cholesterol, and uric acid. Data were analyzed using paired and independent statistical tests.Results: Vitamin D supplementation significantly increased serum irisin levels (p=0.016), meanwhile no significant changes were observed in telomerase activity (p=0.128), klotho (p=0.819), or TNF-α (p=0.098). In the treatment group, blood glucose was correlated positively with TNF-α (r=0.423, α<0.05), whereas cholesterol was correlated negatively with TNF-α (r=-0.51, α<0.01). Furthermore, telomerase activity was correlated positively with irisin (r=0.348, α<0.05).Conclusion: Vitamin D supplementation at 800 IU/day significantly enhances serum irisin, but does not affect telomerase, klotho, or TNF-α. These findings suggest a potential role of vitamin D in modulating aging-related biomarkers.
TINGKAT PENGETAHUAN DAN STATUS SOSIAL EKONOMI ORANG TUA DI RW. 01 KELURAHAN SUKAPURA TERKAIT BALITA GIZI KURANG DAN TINJAUANNYA MENURUT PANDANGAN ISLAM Samudra, Galih Jati Bintang; Marsiati, Himmi; Arifandi, Firman; Wuryanti, Sri
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 1 (2024): APRIL 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i1.24329

Abstract

Gizi kurang merupakan salah satu masalah yang masih banyak terjadi dikalangan masyarakat Indonesia. Sukapura adalah kelurahan yang berada di wilayah kecamatan Cilincing, Jakarta Utara. Berdasarkan pengamatan yang telah dilakukan peneliti, terdapat lokasi yang cenderung kumuh dan memiliki tempat tinggal yang cukup padat, sehingga hal tersebut dapat mempengaruhi kesehatan khususnya bagi balita. Untuk menganalisis tingkat pengetahuan orang tua dan status sosial ekonomi terkait balita gizi kurang di Kelurahan Sukapura, Jakarta Utara. Penelitian menggunakan metode cross sectional dengan data primer dan sekunder. Sampel penelitian adalah orang tua yang memiliki balita berumur 1-59 bulan, dengan ukuran sampel minimal 55 orang. Proses pengumpulan data melalui kertas kuesioner, yang bisa diisi oleh responden. Kemudian data akan dikumpulkan dan diukur secara kuantitatif, menggunakan skala ukur rasio Penelitian menunjukan bahwa terdapat hubungan yang signifikan antara tingkat pengetahuan orang tua dengan status gizi pada balita dengan P-value = 0,001. Sedangkan untuk hubungan status sosial ekonomi dengan status gizi pada balita tidak terdapat hubungan yang signifikan, didapatkan P-value = 0,909. Studi  tersebut  menyimpulkan  bahwa  tingkat  pengetahuan berperan penting untuk mengetahui gizi pada balita, sedangkan status sosial ekonomi tidak berpengaruh signifikan dengan gizi pada balita. Dari perspektif Islam, sebagai orang tua sudah sepatutnya memiliki pengetahuan untuk memenuhi gizi anak dan dapat memberikan apa yang dibutuhkan oleh anaknya.
Edukasi tatalaksana awal pada luka bakar di Kecamatan Cempaka Baru, Jakarta Pusat (Education on early management of burns in Cempaka Baru Sub-District, Central Jakarta) Mukhtar, Diniwati S; Ridwan, Karina A; Qomariyah, Q; Marsiati, Himmi; Luthfiah, Hasna
Buletin Pengabdian Vol 2, No 3 (2022): Bull. Community. Serv.
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/bulpengmas.v2i3.27328

Abstract

Burns can occur anywhere and anytime. However, until now there is no data on burn mortality. This activity aims to provide education on the initial management of burns in the community of Cempaka Baru Sub-District, Central Jakarta. The methods used are seminars and discussions using Powerpoint slides, as well as pre-test and post-test questionnaire instruments. Results: there were 3 groups of participants, consisting of 4 people (13.3%) young adults (age 15-30 years), 9 middle adults (age 31-50 years), or 30%, and 17 older adults (age 50 years). years) or 56.7%. There was a significant increase in participants' knowledge after the seminar, the lowest pre-test score was 20 and the lowest score was 40 in the post-test. There was an increase in the mode value or the majority value of the participants from the pre-test, which was 80 to 100 in the post-test. Then there was an increase in the average score of participants from 75.12 in the pre-test to 87.94 in the post-test (p = 0.00). After being given education, the results of data analysis still showed an increase in knowledge with significant results, namely the value of p = 0.00 (p 0.05). In conclusion, the increase in participants' knowledge about burns is better than before.
Antioxidant and Cytotoxic Activity Test of Srikaya (Annona squamosa L.) Leaves and Matoa (Pometia pinnata) Leaves Extract Combination on Oral Squamous Carcinoma Cells (HSC-3) Izzati, Putri Arifa; Marsiati, Himmi
Jurnal Indonesia Sosial Sains Vol. 6 No. 2 (2025): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v6i2.1608

Abstract

Oral cancer, particularly oral squamous cell carcinoma, is a prevalent and lethal disease that often metastasizes to surrounding tissues. Traditional treatments such as surgery, radiotherapy, and chemotherapy present various side effects, necessitating the exploration of alternative therapies. This study aims to determine the antioxidant value of the combination of ethanol extracts of srikaya leaves (Annona squamosa L) and matoa leaves (Pometia pinnata) against HSC-3 cell cytotoxicity. The antioxidant test on the combination of ethanol extracts of srikaya leaves and matoa leaves using DPPH assay to obtain IC50. HSC-3 cell lines were treated with a combination of ethanol extracts of srikaya leaves (Annona squamosa L) and matoa leaves (Pometia pinnata) with concentrations of 12.5 µl/ml, 25 µl/ml, 50 µl/ml, 100 µl/ml, and 200 µl/ml for 24 hours and tested with the CCK-8 assay method to calculate cell viability and obtain IC(50.The results of the antioxidant test of the combination of ethanol extracts of srikaya leaves (Annona squamosa L) and matoa leaves (Pometia pinnata) in the regression analysis results, obtained a significant value of p-Value = 0.033 <0.050, so it is stated that the concentration has a significant effect on inhibition. In the results of IC 50 obtained 7.62 µl / ml shows antioxidant activity is classified as very strong which is characterized by the value of IC 50 < 50 µl / ml. Statistical analysis using ANOVA followed by Tukey's HSD post hoc test obtained (p-Value = 0.000 with a correlation value of r = 0.599) means that the treatment given does not have a significant effect on the observation results. Ethanol extracts of srikaya leaves (Annona squamosa L) and matoa leaves (Pometia pinnata) have the potential to be made as a therapy using natural ingredients on anticancer HSC-3 cancer cells.
Efek Proteksi Mendengarkan, Membaca, dan Menghafal Al-Qur'an terhadap Demensia Royhan, Aan; Muhammad Astiwara, Endy; Mukhtar, Diniwati; Samsul Mustofa, Muhammad; Marsiati, Himmi
Jurnal Ruhul Islam Vol 2 No 1 (2024): Jurnal Ruhul Islam
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jri.v2i1.179

Abstract

Demensia merupakan penyakit dengan penurunan fungsi kognitif yang dapat memengaruhi memori dan tingkah laku. Sampai saat ini, pengobatan demensia belum menunjukkan hasil yang memuaskan, sehingga terapi pencegahan primer menjadi alternatif terbaik. Pencegahan primer difokuskan pada pemeliharaan kesehatan mental dan fungsi kognitif, salah satunya dengan kegiatan menghafal, membaca dan mendengarkan Al-Qur’an. Kajian ini bertujuan untuk mengkaji efek proteksi Al-Qur’an terhadap demensia dalam perspektif ilmu kesehatan, ilmu biomedik, dan hukum Islam. Kajian ini menggunakan metode studi literatur dengan mengumpulkan data dari berbagai sumber, seperti jurnal ilmiah, buku, dan artikel ilmiah. Hasil dari studi literatur menunjukkan bahwa kebiasaan rutin menghafal Al-Qur’an berpengaruh terhadap fungsi memori jangka pendek, kecerdasan intelektual dan emosional. Rutinitas membaca Al-Qur’an menurunkan tekanan darah, menurunkan tingkat stres dan meningkatkan kebahagiaan, menjaga kestabilan emosi, menurunkan tingkat depresi, dan meningkatkan kecerdasan emosional. Memperdengarkan atau memberikan paparan murottal Al-Qur’an pada orang sehat maupun orang sakit telah menjadi terapi tambahan di beberapa negara muslim karena secara signifikan dapat menurunkan stres, derajat hipertensi, skala nyeri, meningkatkan sistem imun dan hormon β-endorphin. Suara Al-Qur’an yang dipaparkan pada hewan coba dan kultur sel dilaporkan secara signifikan dapat menurunkan tingkat stres oksidatif, meningkatkan proliferasi neuron dan volume otak, sehingga dapat dijadikan alternatif pencegahan primer terhadap demensia.
ANTIOXIDANT ACTIVITY AND CYTOTOXICITY TEST OF EXTRACT COMBINATION OF JAMBU BOL LEAF (Syzygium malaccense L.), MANILA SAPODILLA LEAF (Manilkara zapota L.) AGAINST HSC-3 CELL LINE Mazer, Aryadita Ramadhani; Marsiati, Himmi
HEARTY Vol 13 No 6 (2025): DESEMBER
Publisher : Fakultas Ilmu Kesehatan, Universitas Ibn Khaldun, Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/hearty.v13i6.18599

Abstract

In the herbal plants of jambu bol (Syzygium malaccense L.) and manila sapodilla (Manilkara zapota L.), especially in the leaves of the plant, it contains very strong antioxidants. According to research by Zaen Devi Maulani and Ekayanti Meiliza, the antioxidant activity value of ethanol extract of jambu bol leaves (Syzygium malaccense L.) is 3.297 ± 2.595 ppm and for ethanol extract of manila sapodilla leaves (Manilkara zapota L.) is 8.2786 μg/mL. The antioxidant activity of a compound is said to have very strong antioxidants if the IC₅₀ value is less than 50 ppm, strong IC₅₀ if the IC₅₀ value ranges from 50-100 ppm, moderate if the IC₅₀ value ranges from 100-150 ppm, and weak if the IC₅₀ value ranges from 150-200 ppm. This study is an experimental laboratory by measuring the antioxidant activity value (IC₅₀) using different solvents in the combination of the two simplicia and the toxicity concentration of the combination of the two simplicia using the CCK-8 assay method. The samples used were tested for determination to determine and ensure that the materials used were the correct samples to be tested and made into extracts. Furthermore, the extraction of samples with solvents was concentrated with a rotary evaporator to separate the active substances and solvents. The results of this study indicate that there is no significant difference in the antioxidant activity of the combination of jambu bol leaf extract (Syzygium malaccense L.) and manila sapodilla leaf extract (Manilkara zapota L.) in the positive control (ascorbic acid). There is a significant difference in the cytotoxicity of jambu bol leaf extract (Syzygium malaccense L.) and manila sapodilla leaf extract (Manilkara zapota L.) in the positive control (DMSO) on the viability of HSC-3 cells. The combination of jambu bol leaf extract (Syzygium malaccense L.) and sapodilla leaf extract (Manilkara zapota L.) at a concentration of 5-160 µg/mL did not show any cytotoxic effect on the viability of HSC-3 cells.
Model nekrosis fibroblast terinduksi iskemia sebagai fondasi krusial untuk memahami dan mengatasi cedera vaskular pada jaringan kulit: Sebuah kajian pustaka Hardaningtyas, Kishanty; Marsiati, Himmi; Sobarna, Nenden; Dewi, Dian Andriani Ratna
Holistik Jurnal Kesehatan Vol. 19 No. 10 (2025): Volume 19 Nomor 10
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/hjk.v19i10.2136

Abstract

Background: Vascular injury in skin tissue represents a significant clinical challenge in aesthetic and regenerative medicine and is often manifested as ischemia-induced necrosis of human dermal fibroblasts (HDF). This condition is characterized by cell and tissue death resulting from impaired perfusion and may occur as a complication of dermal filler injections, trauma, or other pathological conditions. To accurately elucidate the underlying pathophysiological mechanisms and to evaluate regenerative therapeutic strategies, an in vitro model capable of replicating ischemia-induced necrosis is required. Purpose: To review the literature related to the ischemia-induced fibroblast necrosis model as a crucial foundation for understanding and addressing vascular injury in skin tissue. Method: Literature searches were conducted using PubMed, Scopus, Web of Science, and Google Scholar with relevant keywords. Results: Indicate that HDF necrosis is commonly induced by exposure to hydrogen peroxide (H₂O₂), cobalt chloride (CoCl₂), and hypoxic culture conditions to simulate oxidative stress and ischemia. Model validation is typically performed using cell viability assays (MTT), lactate dehydrogenase (LDH) release, and morphological analysis. Conclusion: Integrating hypoxia, nutrient deprivation, and oxidative stress in in vitro models offers a solid basis for studying ischemia-induced HDF necrosis and improving skin regenerative therapies, with standardized protocols boosting translational relevance.   Keywords: Fibroblast Necrosis Model; Ischemia; Skin Tissue; Vascular Injury.   Pendahuluan: Cedera vaskular pada jaringan kulit merupakan tantangan klinis penting dalam kedokteran estetik dan regeneratif, yang sering bermanifestasi sebagai nekrosis fibroblas dermal manusia (Human Dermal Fibroblasts/HDF) terinduksi iskemia. Kondisi ini ditandai oleh kematian sel dan jaringan akibat gangguan perfusi, dan dapat terjadi sebagai komplikasi injeksi dermal filler, trauma, maupun kondisi patologis lainnya. Untuk memahami mekanisme patofisiologis yang mendasari kondisi tersebut serta mengevaluasi potensi terapi regeneratif secara akurat, diperlukan model in vitro yang mampu mereplikasi kondisi nekrosis akibat iskemia. Tujuan: Untuk menelaah literatur terkait model nekrosis fibroblast terinduksi iskemia sebagai fondasi krusial untuk memahami dan mengatasi cedera vaskular pada jaringan kulit. Metode: Penelusuran literatur dilakukan menggunakan basis data PubMed, Scopus, Web of Science, dan Google Scholar dengan kata kunci yang relevan. Hasil: Induksi nekrosis HDF umumnya dilakukan melalui paparan hidrogen peroksida (H₂O₂), kobalt klorida (CoCl₂), serta kondisi lingkungan hipoksia untuk mensimulasikan stres oksidatif dan iskemia. Validasi model dilakukan menggunakan uji viabilitas sel (MTT), pelepasan laktat dehidrogenase (LDH), dan analisis morfologi sel. Simpulan: Integrasi hipoksia, deprivasi nutrisi, dan stres oksidatif dalam model in vitro memberikan dasar kuat untuk mempelajari nekrosis HDF terinduksi iskemia serta meningkatkan terapi regeneratif kulit, dengan protokol terstandarisasi yang memperkuat potensi translasi.   Kata Kunci: Cedera Vascular; Iskemia; Jaringan Kulit; Model Nekrosis Fibroblast.
Co-Authors Aan Royhan Arifandi, Firman Awairaro, Tirsa Persila Budiman Budiman Budiman, Dicky Dewi, Dian Andriani Ratna Dewi, Firda Rachma Dicky Wahyudi Diniwati Mukhtar Endy Muhammad Astiwara Faizar, Fathia Azzahra Haddad, Desi Ariyani Hardaningtyas, Kishanty Hutabarat, Andrea Ivana Allicia Imamuddin, Mohammad Izzati, Putri Arifa J, Suherman Kusuma Dewanti, Velisa Linda Armelia Linda Weni Luthfiah, Hasna Mahdiani, Nila Sekar Manik, Sabarina Elfrida Mazer, Aryadita Ramadhani Mukhtar, Diniwati S Nunung Ainur Rahmah Nursabur, Bistamy Muhammad Nurwijayanti O, Fauziah Parwanto, Edy Puspita, Switania Putri Putri, Dhea Angela Qomariyah, Q R, Asmah Restu Syamsul Hadi Reza Aditya Digambiro Ridwan, Karina A Samsul Mustofa, Muhammad Samudra, Galih Jati Bintang Sembiring, Rinawati Sobarna, Nenden Sri Wuryanti Susi Endrini Tjandra Yoga Aditama