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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Althea Medical Journal Jurnal Gizi dan Pangan Soedirman (JGPS) Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Medika Malahayati YARSI Medical Journal Sumatera Medical Journal Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Indonesian Journal of Global Health research Jurnal Info Sains : Informatika dan Sains International Journal of Civil Engineering and Infrastructure (IJCEI) Jurnal Sosial dan Sains
Marsiati, Himmi
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Astronomy Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Neuroscience Nursing Physics Public Health Transportation

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AKTIVITAS ANTIOKSIDAN DAN EFEK SITOTOKSIK EKSTRAK KOLA (COLA NITIDA) PADA KULTER SEL KANKER HATI (HEPG-2) Endrini, Susi; Marsiati, Himmi; J, Suherman; O, Fauziah; R, Asmah
Jurnal Kedokteran YARSI Vol 17, No 1 (2009): JANUARI - APRIL 2009
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (247.103 KB) | DOI: 10.33476/jky.v17i1.195

Abstract

Liver cancer is one among cancers with increasing incidence in the world. Cola fruit (Cola nitida) is a fruit that is rich in properties and has been known since the Dutch colonial era. This fruit contains ingredients such as those contained in tea and chocolate such as methylxanthine and its derivatives. This study aims to determine the content of antioxidants and cytotoxic effects of cola fruit extracts obtained from Indonesia and Malaysia on liver cancer cell lines. Antioxidant content of fruit extracts of cola was assessed using DPPH (2,2-diphenyl-2-picrylhydrazyl hydrate) and cytotoxic effects were studied using MTT (3 - (4,5-Dimethylthiazol-2-Yl)diphenyltetrazolium bromide -2.5) on human liver cancer cell lines (HepG2). The results showed that cola fruit from Malaysia contained high antioxidant with the IC50 value of 37.2 ?g/mL whereas IC50 of value of its Indonesia?s cola fruit was 66.0 ug / mL. The similar results have been shown in the cytotoxic test using HepG-2 liver cancer cell lines. Malaysia?s cola fruit extract has a smaller IC50 value of 6.5 ?g / mL while the fruit extract of Indonesia?s cola showed IC50 value of 39.5 ?g / mL. These values indicates that the fruit extract of cola is a potential anticancer activities especially on liver cancer. Further studies are required to clarify this hypothesis.
HUBUNGAN TINGKAT PENGETAHUAN TENTANG ANEMIA PADA STATUS GIZI DAN KADAR HEMOGLOBIN REMAJA PUTRI DI DESA BANTARSARI, BOGOR, JAWA BARAT Wuryanti, Sri; Asiah, Nur; Marsiati, Himmi
Jurnal Gizi dan Pangan Soedirman Vol 8 No 1 (2024): JURNAL GIZI DAN PANGAN SOEDIRMAN
Publisher : Program Studi Ilmu Gizi, Jurusan Kesmas Fakultas Ilmu-Ilmu Kesehatan Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jgipas.2024.8.1.11497

Abstract

Based on Basic Health Research (Riskesdas) in 2018, the prevalence of anemia in adolescent was 32%. Anemia in teenage girls have negative impacts on pregnancy in the future. This study was to find out the knowledge of anemia and nutrition, the percentage of anemia, whether there were relationship between the knowledge about anemia and nutritional status, and the relationship between the knowledge about anemia and hemoglobin levels in teenage girls in Bogor. This research was a cross sectional study. Data were collected by filling out questionnaires, anthropometric measurements and hemoglobine levels. The subjects were female students, 12 to 20 years from 2 schools at Bantarsari Village, Bogor, December 2022. It was found that 25 subjects (22.1%) had poor nutritional status, 23 subjects (20.4%) suffered from anemia and the majority of research subjects had fairly good knowledge (92.9%). In the Bivariate test, a significant relationship was found between the level of knowledge of research subjects and the level of anemia (P = 0.009) and a significant relationship was obtained between the level of knowledge of research subjects and nutritional status (P = 0.003). Therefore it is important to increase the knowledge of teenage girls about anemia.
Blood glucose levels in chronic kidney disease patients with diabetes mellitus at the internist poly of RSUD Dr. H Abdul Moeloek Bandar Lampung Faizar, Fathia Azzahra; Marsiati, Himmi; Arifandi, Firman; Armelia, Linda
Jurnal Info Sains : Informatika dan Sains Vol. 14 No. 01 (2024): Informatika dan Sains , Edition March 2024
Publisher : SEAN Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: High blood glucose levels in Diabetes Mellitus patients can harm renal capillaries. Chronic Kidney Disease caused by Diabetes Mellitus begins with microalbuminuria. Chronic Kidney Disease patients with Diabetes Mellitus at RSUD Dr. H. Abdul Moeloek Bandar Lampung from July 202 to December 2022 there were 127 patiens.Purpose : The aim of this study was to determine blood glucose levels ini Chronic Kidney Disease patients suffering from Diabetes Mellitus at RSUD Dr. H. Abdul Moeloek Bandar Lampung.Method : This research is an observational analytical research with a cross- sectional approach. The sample in this study was calculated using the Slovin formula so that the number of samples used was 99. Data analysts used univariate analysis.Result : from the research result, it was found that 127 patients with Chronic Kidney Disease suffered from Diabetes Mellitus. Chronic Kidney Disease with Diabetes Mellitus was most often found in men, 64 patients (50.4%), in the age group, Chronic Kidney Disease with Diabetes Mellitus was most often found in patients aged 51-60 years, 56 patients (44.1%), while the blood glucose levels of patients with Chronic Kidney Disease with Diabetes Mellitus were most often found in patients with blood glucose levels >180 mg/DL, 76 patients (59.8%). Conclussion : The blood glucose level most often found was >180 mg/DL, namely 76 patients were called the hyperglycemia category and the lowest blood glucose level found was <74 mg/DL, namely 2 patinents were calles the hypoglycemia category.
Peran Melanocortin Receptor (MCR) Tipe 3 Sebagai Faktor Protektif Pada Pneumonia Geriatri : Studi Literatur Wahyudi, Dicky; Mukhtar, Diniwati; Aditama, Tjandra Yoga; Marsiati, Himmi
Jurnal Ilmu Kedokteran dan Kesehatan Vol 11, No 12 (2024): Volume 11 Nomor 12
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v11i12.17608

Abstract

Usia lanjut menjadi salah satu faktor risiko paling penting untuk pneumonia. Pada kelompok lanjut usia yang menderita pneumonia, tanda-tanda klinis seringkali tidak khas, dan terdapat risiko lebih besar untuk mengalami kegagalan organ (pernapasan, ginjal atau jantung), kehilangan fungsi yang lebih besar dan, akibatnya, prognosis yang lebih buruk. Hal ini didasari oleh adanya mikroaspirasi patogen yang akan menginduksi pertahanan host. Sejumlah modulator peradangan endogen termasuk melanokortin terbukti dapat menghambat proses inflamasi dan membantu mencegah kerusakan jaringan. Peptida melanokortin telah terbukti menurunkan regulasi aktivasi nukleus faktor-kappa beta dan akibatnya sintesis sitokin pada fase awal akan menginduksi protein anti-inflamasi. Diketahui keberadaan reseptor MC3R pada makrofag alveolar menunjukkan aktif secara fungsional. MC3R terutama terlibat dalam efek imunomodulator. Aktivasi MC3R tidak hanya mengurangi produksi mediator pro-inflamasi, namun dapat mengatur diferensiasi sel serta kemotaksis leukosit. Melanokortin saat ini dapat ditambahkan ke sebagian besar mediator pro-resolusi melalui kemampuannya untuk meningkatkan fagositosis dan eferositosis. Namun, sejauh ini belum ada data terkait MC3R pada pasien pneumonia geriatri. Diperkirakan sifat MC3R akan menentukan fungsi lain/sifat biologis melanokortin dalam aspek resolusi inflamasi pada kasus pneumonia geriatrik
Alpha Klotho: Peran Biomolekuler dan Potensinya Sebagai Biomarker Luaran Klinis Dalam Pneumonia Geriatri Wahyudi, Dicky; Mukhtar, Diniwati; Aditama, Tjandra Yoga; Marsiati, Himmi
Jurnal Medika Malahayati Vol 8, No 4 (2024): Volume 8 Nomor 4
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jmm.v8i4.18882

Abstract

Pada populasi geriatri, pneumonia menjadi lebih berisiko karena dikaitkan dengan perubahan fisiologis yang mengakibatkan penurunan fungsi paru, berkurangnya regenerasi, remodeling saluran napas, melemahnya respons imun bawaan dan adaptif, peningkatan kerentanan hingga adanya kemungkinan komorbid yang mempersulit pemulihan. Salah satu protein sitoprotektif yang esensial dalam mencegah kerusakan paru adalah α-klotho. α-Klotho utamanya diproduksi pada ginjal merupakan salah satu hormon endokrin yang sangat penting untuk pemeliharaan dan perlindungan jaringan. α-Klotho berperan dalam mencegah penuaan, memperlambat tingkat degenerasi multi-organ prematur, menurunkan stres oksidatif, dan menekan kerusakan jaringan yang diperantarai oleh inflamasi. Efek tersebut diperoleh melaui inhibisi pada jalur transforming growth factor β (TGF-β), insulin-like growth factor 1 (IGF-1), Wnt dan NF-κB. Ekspresi α-klotho menurun seiring bertambahnya usia. Penurunan ekspresi α-klotho pada paru dikaitkan dengan peningkatan stres oksidatif, inflamasi, dan apoptosis serta penurunan fungsi pembersihan mukosiliar dan peningkatan laju pelebaran alveolus. Hingga saat ini belum ada penelitian khusus yang meneliti ekspresi ɑ-klotho pada pneumonia geriatri. Namun, penelitian terbaru mengungkap potensi protein ini sebagai biomarker. Ditemukan bahwa kadar ɑ-klotho memiliki hubungan negatif yang signifikan terhadap berbagai biomarker inflamasi akut yang merupakan komponen penting dalam patogenesis pneumonia. Potensi α-klotho sebagai modulator respon inflamasi menunjukkan kemungkinan untuk digunakan sebagai biomarker yang mewakili kondisi pneumonia pada populasi lanjut usia dalam memprediksi luaran klinis.
ANALISIS KOMPARATIF ATROFI SEREBRAL PADA GANGGUAN KOGNITIF NON-ALZHEIMER DAN PENYAKIT ALZHEIMER DI INDONESIA Digambiro, Reza Aditya; Marsiati, Himmi; Hadi, Restu Syamsul; Hastuty, Dewi; Parwanto, Edy
Medika Alkhairaat: Jurnal Penelitian Kedokteran dan Kesehatan Vol 6 No 3 (2024): Desember
Publisher : Fakultas Kedokteran Universitas Alkhairaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31970/ma.v6i3.245

Abstract

Abstrak Penelitian ini menganalisis pola atrofi serebral pada pasien gangguan kognitif non-Alzheimer dan penyakit Alzheimer (AD) di Indonesia. Atrofi otak terjadi lebih cepat pada pasien AD dibandingkan penuaan normal, dan percepatan atrofi hipokampus ditemukan pada subjek dengan gangguan kognitif ringan (MCI) yang berkembang menjadi AD. Data diperoleh dari 710 subjek yang menjalani MRI di Rumah Sakit Cipto Mangunkusumo dan Rumah Sakit Hasan Sadikin. Analisis laju atrofi otak keseluruhan, hipokampus, dan pembesaran ventrikel menunjukkan perbedaan signifikan antara kelompok kontrol, MCI, dan AD. Rata-rata percepatan atrofi hipokampus pada subjek MCI mencapai 0,44% per tahun kuadrat (p < 0,05). Temuan ini menggarisbawahi pentingnya deteksi dini dan intervensi terapeutik pada tahap MCI. Penelitian ini juga menunjukkan bahwa pola atrofi serebral di Indonesia serupa dengan temuan global, meskipun terdapat perbedaan faktor risiko lokal. Penelitian lanjutan perlu mencakup analisis longitudinal jangka panjang untuk pemahaman yang lebih baik tentang progresi AD di Indonesia. Kata Kunci: Atrofi serebral, Alzheimer, gangguan kognitif ringan, Indonesia, hipokampus, MRI Abstract This study analyzes cerebral atrophy patterns in patients with non-Alzheimer cognitive impairment and Alzheimer's disease (AD) in Indonesia. Brain atrophy progresses faster in AD patients compared to normal aging, with accelerated hippocampal atrophy observed in mild cognitive impairment (MCI) subjects who progress to AD. Data were obtained from 710 subjects who underwent MRI at Cipto Mangunkusumo Hospital and Hasan Sadikin Hospital. Analysis of overall brain atrophy rates, hippocampal atrophy, and ventricular enlargement revealed significant differences between control, MCI, and AD groups. The average acceleration of hippocampal atrophy in MCI subjects was 0.44% per year squared (p < 0.05). These findings emphasize the importance of early detection and therapeutic intervention at the MCI stage. This study also indicates that cerebral atrophy patterns in Indonesia are similar to global findings, despite local risk factor variations. Further research should include long-term longitudinal analysis to gain a better understanding of AD progression in Indonesia. Keywords: Cerebral atrophy, Alzheimer’s disease, mild cognitive impairment, Indonesia, hippocampus, MRI
Antioxidant activity and phytochemical profiling of peaches, Arabica coffee, and their combination Putri, Dhea Angela; Marsiati, Himmi
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 2 (2024): December 2024
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v15i2.33505

Abstract

Antioxidant compounds scavenge unstable free radical reactions and are abundant in certain plants. Peaches (Prunus persica L.) are rich in phytochemicals such as carotenoids, anthocyanins, phenolic acids, and flavonoids, while Arabica coffee (Coffea arabica) contains alkaloids, flavonoids, tannins, steroids, and terpenoids. This study evaluated the antioxidant activity and phytochemical profile of peaches, Arabica coffee, and their combination using ethanol, ethyl acetate, and water as solvents. Extraction was performed via maceration with 96% ethanol and fractionation using water and ethyl acetate. Antioxidant activity was assessed using the DPPH (1,1-Diphenyl-2-picrylhydrazyl) assay, and phytochemical tests evaluated secondary metabolites such as alkaloids, flavonoids, phenolics, steroids/terpenoids, tannins, and saponins. Results indicated that the ethyl acetate extract of peaches showed moderate antioxidant activity (IC50 = 141.91 ppm), while the water extract of Arabica coffee exhibited robust activity (IC50 = 22.30 ppm). Notably, combining water extracts from both sources demonstrated enhanced antioxidant capacity (IC50 = 37.85 ppm), improving peach extract activity by over threefold. These findings underscore the potential synergistic effects of combining these natural sources for health-promoting antioxidants.
Uji Aktivitas Antioksidan dan Sitotoksik Ekstrak Daun Kersen (Muntingia Calabura) dan Daun Rendeu (Hemigraphis Alternata) Serta Kombinasi Keduanya Terhadap Sel Karsinoma Skuamosa Mulut (Hsc-3) dan Tinjauannya Menurut Pandangan Islam Kusuma Dewanti, Velisa; Marsiati, Himmi
Jurnal sosial dan sains Vol. 5 No. 3 (2025): Jurnal Sosial dan Sains
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/jurnalsosains.v5i3.32080

Abstract

Penelitian ini bertujuan untuk menguji aktivitas antioksidan dan sitotoksik ekstrak daun kersen (Muntingia calabura) dan daun rendeu (Hemigraphis alternata), serta kombinasi keduanya terhadap sel karsinoma skuamosa mulut (HSC-3). Metode yang digunakan dalam penelitian ini meliputi uji aktivitas antioksidan dengan metode DPPH serta uji sitotoksik menggunakan metode MTT assay. Hasil penelitian menunjukkan bahwa ekstrak tunggal dan kombinasi dari kedua daun tersebut memiliki aktivitas antioksidan yang signifikan, dengan nilai IC₅₀ yang menunjukkan potensi sebagai agen antioksidan alami. Selain itu, uji sitotoksik menunjukkan bahwa ekstrak memiliki efek toksik terhadap sel HSC-3, dengan kombinasi ekstrak yang menunjukkan sinergisme dalam menghambat pertumbuhan sel kanker. Dari perspektif Islam, penelitian ini relevan dengan konsep thibbun nabawi dan pemanfaatan bahan alami dalam pengobatan, yang sejalan dengan prinsip menjaga kesehatan sebagai bagian dari ibadah. Oleh karena itu, ekstrak daun kersen dan rendeu berpotensi dikembangkan sebagai agen terapi alami dalam pengobatan kanker, dengan kajian lebih lanjut untuk mendukung efektivitas dan keamanan penggunaannya
Borassus flabellifer Effectively Reduces MDA Levels in High Oxidative Stress Population in Jakarta, Indonesia Digambiro, Reza Aditya; Marsiati, Himmi; Hadi, Restu Syamsul; Parwanto, Edy
Sumatera Medical Journal Vol. 8 No. 2 (2025): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v8i2.18966

Abstract

Background: Malondialdehyde (MDA) is commonly used to assess oxidative stress levels. Objective: This study aimed to investigate the effect of Borassus flabellifer  fruit consumption on MDA levels in individuals with high oxidative stress, providing insights into the fruit’s potential as a natural antioxidant therapy. Methods: A prospective interventional study was conducted in Jakarta, recruiting fifty participants aged 30–60 years with baseline MDA levels >10 nmol/L. Participants consumed 150 grams of Borassus flabellifer fruit daily for 30 days. Blood samples were collected at baseline and post-intervention to assess MDA levels. Results: The average MDA level decreased significantly from 14.35 ± 2.43 nmol/L to 12.00 ± 1.74 nmol/L after 30 days of fruit consumption (p < 0.0001). The Cohen’s d value of 2.92 indicated a large effect size, demonstrating the intervention’s substantial impact. A strong positive correlation (r = 0.91, p < 0.0001) between baseline MDA levels and reduction was observed, suggesting that participants with higher baseline oxidative stress benefited more from the intervention. Conclusion: Borassus flabellifer fruit consumption effectively reduces MDA levels in individuals with high oxidative stress. The results support the inclusion of this fruit in recommendations for managing oxidative stress-related conditions.
Molecular Biomarkers in Pneumonia: Therapeutic Potential of Traditional Plant Medicine Awairaro, Tirsa Persila; Mukhtar, Diniwati; Budiman, Dicky; Marsiati, Himmi
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6671

Abstract

Pneumonia causes 2.56 million global deaths annually, with current therapies limited by antimicrobial resistance and adverse effects. Traditional medicinal plants offer multi-target potential through anti-inflammatory, antioxidant, and immunomodulatory mechanisms. This review synthesizes knowledge on molecular biomarkers in pneumonia pathogenesis and evaluates therapeutic potential of medicinal plants, particularly Coleus amboinicus. A comprehensive literature search was conducted across PubMed/MEDLINE, Scopus, and Web of Science covering publications from January 2000 to June 2025. Inclusion criteria encompassed studies investigating molecular biomarkers, pneumonia therapeutic pathways, or medicinal plants with respiratory therapeutic properties. Narrative synthesis was employed due to study heterogeneity. Of 1,247 articles identified, 10 studies met inclusion criteria and were utilized in the analysis. Key inflammatory biomarkers included IL-6, TNF-α, and IL-1β, increasing from 5.05 mg/dL (controls) to 25.30 mg/dL in bacterial pneumonia. Neutrophil extracellular trap (NET) formation emerged as a central mechanism (47.36% of protein targets). Coleus amboinicus demonstrated 139 bioactive compounds with broad-spectrum antimicrobial activity and antioxidant properties (DPPH EC₅₀ 32.67-152.8 µg/mL). Traditional medicinal plants, particularly Coleus amboinicus, modulate key molecular pathways in pneumonia through sophisticated multi-target mechanisms, supporting integration of biomarker-guided approaches in contemporary respiratory care.
Co-Authors Arifandi, Firman Awairaro, Tirsa Persila Budiman Budiman Budiman, Dicky Dewi, Firda Rachma Dicky Wahyudi Diniwati Mukhtar Faizar, Fathia Azzahra Haddad, Desi Ariyani Hutabarat, Andrea Ivana Allicia Imamuddin, Mohammad J, Suherman Kusuma Dewanti, Velisa Linda Armelia Linda Weni Mahdiani, Nila Sekar Manik, Sabarina Elfrida Nunung Ainur Rahmah Nursabur, Bistamy Muhammad Nurwijayanti O, Fauziah Parwanto, Edy Puspita, Switania Putri Putri, Dhea Angela R, Asmah Restu Syamsul Hadi Reza Aditya Digambiro Sembiring, Rinawati Sri Wuryanti Susi Endrini Tjandra Yoga Aditama