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All Journal JURNAL FARMASIMED (JFM) Mejuajua Jurnal Pengmas Kestra (JPK) Medistra Medical Journal (MMJ)
Pranata, Chandra
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Humanities Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Other

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TRANSPARENT SOAP FORMULATION WITH VARIOUS LEVELS OF CONCENTRATION OF TEAK LEAF EXTRACT (TECTONA GRANDIS L.F.)AS ANTIBACTERIAL SOAP Pranata, Chandra; Irwanto, Reno; .S, Aminah
Jurnal FARMASIMED (JFM) Vol 5 No 2 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v5i2.1401

Abstract

The purpose of this study was to examine the organoleptic, homogeneity and antibacterial properties of transparent soap. The treatment used is; F1 (3% teak leaf extract), F2 (6% teak leaf extract), F3 (9% teak leaf extract), and F4 (12% teak leaf extract). The implementation of the research begins with product optimization in advance of the proportion of the use of raw material components. The results of the homogeneity test experiment showed that all formulas were homogeneous and in accordance with SNI standards, then the results of the water content obtained from each preparation proved to meet the requirements set by SNI ( Indonesian National Standard). The results of the pH measurements showed that at pH F0 it remained at 8. The results for measuring pH F1 showed results with a pH of 8. Meanwhile, pH F2 had a pH of 8. The last measurement for pH at pH F3 showed the same pH results as the other formula, namely at pH 8. So that F0, F1, F2, and F3 have the same pH, namely pH 8, where pH 8 is the pH of the positive control, namely soap on the market. Staphylococcus aureus with a concentration of 3% by 13 mm, 6% by 15 mm, 9% by 17 mm, 12% by 20 mm. The greater the concentration of teak leaf extract in transparent solid coir, the greater the inhibition of bacterial growth.
ANTIBACTERIAL ACTIVITY TEST OF CELERY LEAF ETHANOL EXTRACT (APIUM GRAVEOLENS L.) AGAINST BACTERIA STREPTOCOCCUS SANGUINIS Pranata, Chandra; Renty Monica; Asti Pratiwi; Yosi Darmirani
Jurnal FARMASIMED (JFM) Vol 6 No 1 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

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Abstract

Health is a very important part of human life, especially oral health. Diseases that occur due to lack of oral hygiene include gingivitis caused by Streptococcus sanguinis bacteria. Chlorhexidine is a solution that is used to clean the oral cavity and prevent plaque formation on the teeth. An alternative mouthwash that comes from nature is celery leaves (Apium graveolens L.) with secondary metabolites, namely alkaloids, flavonoids, saponins and tannins. This study was conducted to determine the antibacterial activity of celery leaf ethanol extract against Streptococcus sanguinis bacteria at concentrations of 12.5%, 25%, 50% and 100% using the disc diffusion method with chlorhexidine as a positive control and Aquadest as a negative control. The celery leaf extraction method was carried out by maceration method using 96% ethanol solvent. The results of the inhibition test with a concentration of 12.5%, 25%, 50% and 100% celery leaf ethanol extract can inhibit the growth of Streptococcus sanguinis bacteria with an average diameter of the inhibition zone in the negative control group (aquadest) is 0 mm, 12.5% concentration is 8.15 mm, at 25% concentration is 7.95 mm, 50% concentration is 9.05 mm, 100% concentration is 9.9 mm, while in chlorhexidine (positive control) an average of 17.83 mm is obtained. From these results, it can be concluded that there is activity of celery leaf ethanol extract against the growth of Streptococcus sanguinis bacteria with a concentration that effectively inhibits the growth of Streptococcus sanguinis bacteria is 100% concentration. Keywords: Celery Leaf, Gingivitis, Streptococcus sanguinis
Antibacterial activity test of dragon scale leaf ethanol extract (drymoglossum piloselloides) againts bacteria Staphyloccocues epidermidis Pranata, Chandra
Jurnal FARMASIMED (JFM) Vol 6 No 2 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v6i2.2041

Abstract

Daun Sisik Naga (Drymogglossum Piloselloides) merupakan salah satu tumbuhan alami yang paling mudah ditemukan di indonesia. Secara tradisional daun sisik naga merupakan salah satu tanaman herbal yang mampu digunakan untuk pengobatan antikanker, antioksidan kuat dan anti peradangan. Tumbuhan ini memiliki senyawa metabolit sekunder berupa flavonoid, tanin, saponin yang memiliki efek sebagai antibakteri karena dapat menghambat pertumbuhan bakteri Staphyloccocus Epidermidis penyebab jerawat. Staphyloccocus Epidermidis adalah salah satu spesies bakteri dari genus Staphyloccocus yang termasuk gram positif. Tujuan : Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri ekstrak etanol daun sisik naga terhadap pertumbuhan bakteri Staphyloccocus Epidermidis. Penelitian ini merupakan penelitian Eksperimental. Metode: Metode yang digunakan untuk pengujian aktivitas antibakteri adalah metode agar menggunakan kertas cakram dengan menggunakan 3 sampel dengan konsentrasi 10%, 15% dan 20%. Kontrol Positif berupa Tetrasiklin dan Kontrol Negatif berupa aquadest. Hasil: Penelitian ini menunjukkan bahwa ekstrak etanol daun sisik naga konsentrasi 20 % dengan diameter zona hambat 18,53 mm (kategori kuat), pada konsentrasi 15 % dengan diamter zona hambat 16,46 mm (kategori kuat) dan pada konsentrasi 10 % diameter zona hambat 14,41 mm (kategori kuat). Kesimpulan: Penelitian ini membuktikan bahwa ekstrak etanol daun sisik naga memiliki daya antibakteri terhadap bakteri Staphyloccocus Epidermidis dengan konsentrasi efektif 20 % dengan kategori kuat sebesar 18,53 mm.
PENYULUHAN TAMAN TANAMAN OBAT KELUARGA (TOGA) DI PEKARANGAN UPT PUSKESMAS PADANG LAWAS UTARA sumardi, Sumardi; Samran, Samran; Suprianto, Suprianto; Pranata, Chandra; Siregar, Riwandi
Mejuajua: Jurnal Pengabdian pada Masyarakat Vol. 3 No. 3 (2024): April 2024
Publisher : Yayasan Penelitian dan Inovasi Sumatera (YPIS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/mejuajuajabdimas.v3i3.113

Abstract

Tumbuhan obat tradisional memiliki peran penting dalam penyembuhan penyakit dan pencegahan di masyarakat Indonesia termasuk Kabupaten Padang lawas Utara. Upaya peningkatan peran UPT Puskesmas menjadi kebutuhan dalam suksesi program kesehatan dari pemerintah. Tujuan dari pengabdian ini adalah meningkatkan pemahaman petugas puskesmas tentang jenis, fungsi dan penggunaan tumbuhan obat di pekarangan puskesmas. Metode pengabdian yang digunakan dengan menggali pengetahuan dan informasi dari peserta sebelum dan setelah kegiatan. Respon dan pengetahuan peserta meningkat baik jenis dan jumlah tumbuhan obat untuk pengobatan ringan dan komplementer. Sejalan dengan program Pemerintah Daerah dalam peningkatan derajad kesehatan masyarakat. Diharapkan kegiatan ini meningkatkan pemahaman dan ketrampilan petugas kesehatan di masing-masing Puskesmas sehingga menjadi kader yang handal dalam penyuluhan kepada masyarakat.
Test of the Anti-Inflammatory Effectiveness of Ethanol Extract of Cat's Whiskers Leaves (Orthisiphon Aristatus) on Paw Edema in Male Mice (Mus Musculus) Pranata, Chandra; Darmirani, Yosi; Limbing, Reida
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2289

Abstract

Cat's whisker leaves contain secondary metabolite compounds, flavonoids and essential oils. The chemical compounds contained in cat's whisker leaves have antioxidant, antibacterial, anti-inflammatory and antifungal properties. Flavonoids are known to function as anti-inflammatories by inhibiting pro-inflammatory enzymes, namely by blocking cyclooxygenase or lipoxygenase, can influence cellular signaling pathways such as NF-kB which can inhibit the migration of inflammatory cells to areas of inflammation. Objective: to test the anti-inflammatory effectiveness of ethanol extract of cat's whisker leaves in-vivo. Method: Anti-inflammatory effectiveness testing was carried out on male mice (Mus musculus) by inducing edema on the soles of their feet using 0.1 ml of 1% carrageenan. This research was an experimental study with 5 treatments and 5 replications. The parameters observed were edema volume, edema percentage, and edema inhibition percentage. Edema volume measurements were taken every 60 minutes for 6 hours. The results of measuring the volume of edema were used to calculate the percentage of edema, which was then used to calculate the percentage of edema inhibition. Data on the percentage of edema inhibition were statistically analyzed using the One Way ANOVA test. Result: the results of statistical tests showed significant differences in data on the percentage of edema inhibition and the percentage of edema between treatment groups showing p<0.05. From the results of the percentage of edema inhibition, it shows that cat's whisker leaf extract with a concentration of 15% has the best anti-inflammatory effect, namely inhibition of 88.42% is the concentration with the optimum dose.
Socialization of the Benefits of Cat's Whiskers Leaf Extract (Orthisiphon Aristatus) in Healing Wounds Pranata, Chandra; Darmirani, Yosi
JURNAL PENGMAS KESTRA (JPK) Vol. 4 No. 2 (2024): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jpk.v4i2.2431

Abstract

Inflammation or wounds are a response to disruption of body tissue due to physical, chemical, or biological factors. Wounds often occur in the layers of the skin, muscles, tissues, and organs of the body. Wounds cause various conditions such as pain, bleeding, and swelling. Cat's whiskers leaves contain flavonoid, polyphenol, and terpenoid compounds that can be useful as antioxidants, antibacterials, and anti-wound agents. The purpose of this socialization is to increase public knowledge about plants around them that can be used for health, such as treating wounds using cat's whiskers leaves. The Community Service activity was carried out through a socialization attended by 25 participants who were residents around the Lubuk Pakam sub-district. The material that was socialized was about the benefits of cat's whiskers leaves in healing wounds, chemical compound content, and the process of extracting cat's whiskers leaves. The level of knowledge of participants was measured based on the pre-test and post-test scores filled in by the Community Service participants to assess the success of the implementation of this socialization activity. The results showed that cat's whiskers leaves can be used as an anti-wound medicine because they are rich in secondary metabolites such as flavonoids, polyphenols, and terpenoids. The process of extracting cat's whiskers leaves can be done through soaking or boiling techniques. After the PkM material was socialized, there was an increase in participant knowledge into the good and very good knowledge categories with percentages of 52% and 28% respectively, where previously knowledge was more dominant in the less and sufficient categories with percentages of 48% and 40%. This PkM activity provides benefits to the community in the form of new knowledge about the benefits of cat's whiskers leaves which can act as an anti-wound medicine.
The Effectiveness of Cupping Therapy in Reducing Blood Pressure in Hypertensive Patients at Citra Medika 3 Limau Manis Clinic H, Herlina; Yana, Sri Nur; Pranata, Chandra
Medistra Medical Journal (MMJ) Vol 2 No 1 (2024): Medistra Medical Journal (MMJ)
Publisher : Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/mmj.v2i1.2378

Abstract

Hypertension, a medical condition characterized by chronically elevated blood pressure, is one of the most prevalent cardiovascular diseases. Although asymptomatic in its early stages, hypertension can lead to serious complications in the cardiovascular system and other vital organs. Cupping therapy is a complementary treatment modality that has been used as an alternative approach to manage hypertension. This study aims to evaluate the effectiveness of wet cupping therapy in lowering blood pressure. The method employed involves the application of wet cupping therapy on patients with hypertension. The study results indicate that cupping therapy significantly lowers blood pressure in hypertensive patients, as evidenced by the Wilcoxon test showing a significant difference before and after the intervention. Based on the effectiveness of wet cupping therapy in lowering blood pressure, it shows potential for development as an alternative treatment for hypertension.
The Effect of Giving Green Apple (Malus Domestica) Juice on the Histopathology of White Rat Pulmonary Organs Induced by Cigarette Smoke Pranata, Chandra; Asti Pratiwi
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2437

Abstract

Background: Cigarette smoke contains oxidants or free radicals and around 4700 dangerous chemicals. The high level of free radicals in the body triggers the emergence of Reactive Oxygen Species (ROS) which results in oxidative stress, this can occur if there is an imbalance between the amount of oxidants and antioxidants. In this process, there is a leak of O2 which will turn into superoxide radicals (*O2) which can form pro-inflammatory cytokines such as IL-6. Objective: to identify the effect of exposure to cigarette smoke on the histopathological appearance of rat lungs. Method: This research uses Post Test Only Control Group Design. Samples were taken from 20 male rats that met the inclusion criteria and were randomly divided into 4 groups, namely K1, K2, K3, and K4. K3 was given standard feed plus green apple juice at a dose of 13.5 grams/day. Meanwhile, the K4 group was given standard feed plus green apple juice at a dose of 27 grams/day. However, both were given exposure to cigarette smoke for 14 days. On the 15th day, blood was taken from male Wistar rats to carry out a histopathological examination of the rats' lungs using Hematoxillin-Eosin staining. Results: The results showed that there was damage in the negative group when compared with the normal group and the highest improvement in lung tissue was found at a dose of 27 grams/day when compared with the negative and normal groups. Conclusion: There is an effect of giving green apple juice on IL-6 and SOD levels in mice exposed to cigarette smoke.
Community Education on the Effects of Cigarette Smoke on Lung Tissue and the Preventive Role of Green Apple (Malus domestica) Juice Pranata, Chandra; Darmirani, Yosi; Pratiwi, Asti
JURNAL PENGMAS KESTRA (JPK) Vol. 5 No. 1 (2025): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/fm823d94

Abstract

Cigarette smoke contains a large number of oxidants or free radicals, along with approximately 4,700 harmful chemical substances. An increase in free radical levels in the body can trigger the formation of Reactive Oxygen Species (ROS), which contributes to oxidative stress, especially when there is an imbalance between oxidants and antioxidants. During this process, oxygen (O?) may leak and convert into superoxide radicals (O??), which can stimulate The synthesis of pro-inflammatory mediators like interleukin-6 (IL-6). In this research aims To assess the impact of cigarette smoke exposure on the histological structure of lung tissue in laboratory rats. A Community Service Activity (PkM) involving 70 residents of Pantai Labu Subdistrict Aimed at promoting public awareness regarding the importance of adopting a safe and healthy lifestyle. During the activity, participants received education regarding The damaging influence of cigarette smoke on the body, particularly on, as well as potential of green apple juice as a natural alternative to support lung health. The educational materials included information on the safety and stability of green apple juice consumption, and the importance of maintaining an appropriate acidity level (pH) that aligns with lung health. Through pre-test and post-test assessments, there was a 50% and 30% increase in participants' knowledge, respectively, indicating that the program was effective in improving public understanding of the dangers of cigarette smoke on lung health. In addition, green apple juice was introduced as a promising natural alternative to support the histopathological repair of organs. The PkM team also encouraged the community to adopt a healthier lifestyle, be more selective, and remain cautious about exposure to cigarette smoke in their environment.
Effect of Green Apple Juice on SOD And IL-6 in Cigarette Smoked Rats Pranata, Chandra; Pratiwi, Asti
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/ardvgn81

Abstract

Cigarette smoke contains oxidants or free radicals and approximately 4,700 hazardous chemicals. Elevated levels of free radicals in the body can trigger the generation of Reactive Oxygen Species (ROS), leading to oxidative stress. This condition arises when there is an imbalance between oxidants and antioxidants. During this process, oxygen (O2) leakage occurs, resulting in the formation of superoxide radicals (*O2), which can subsequently induce the production of pro-inflammatory cytokines such as IL-6. The objective of this study was to evaluate the effect of green apple juice supplementation on superoxide dismutase (SOD) and IL-6 levels in male Wistar rats exposed to cigarette smoke. The study employed a Post-Test Only Control Group Design. A total of 20 male rats that met the inclusion criteria were randomly assigned to four groups: K1, K2, K3, and K4. Group K3 received standard feed supplemented with green apple juice at a dose of 13.5 grams per day, while group K4 received standard feed supplemented with green apple juice at a dose of 27 grams per day. Both groups were exposed to cigarette smoke for 14 consecutive days. On the 15th day, blood samples were collected from the male Wistar rats to measure SOD and IL-6 levels using the ELISA method. Data were analyzed using a One-Way ANOVA test, followed by Tukey's Post Hoc test. The results showed that the highest average SOD level was observed in group K2 (1.76 ng/L), while the highest IL-6 level was recorded in group K1 (4.08 ng/L). The One-Way ANOVA test indicated significant differences in SOD and IL-6 levels among the groups, with a p-value of <0.05.
Co-Authors ., Evi ., Muriati ., Yuandani .S, Aminah Asti Pratiwi Cintya, H Darmirani, Yosi Dicky Yuswardi Wiratma Harahap, Hasni Yaturramadhan Herlina H Jansen Silalahi Limbing, Reida Nasution, Muhammad Hamim Novidawati Boru Situmorang Octora, Debi Dinha Pratiwi, Asti Ramadhani, Lili Ratih Anggraeni Reno Irwanto Renty Monica Samran, Samran Santika, Rimma Siahaan, Safrika Juliana Sihombing, Yanna Rotua Siregar, Riwandi Suci Wulandari Sumardi . sumitra, Jhoti Sundara, Putri Suprianto Suprianto Syarifuddin, Aminah Tarihoran, Sartika Noviani Yana, Sri Nur Yosi Darmirani