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All Journal Jurnal Kesmas dan Gizi (JKG) JURNAL FARMASIMED (JFM) Mejuajua Jurnal Pengmas Kestra (JPK) Medistra Medical Journal (MMJ)
Pranata, Chandra
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Humanities Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Other

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The Potential of Durian (Durio zibethinus) Fruit Peel Extract on Blood Pressure, SOD, and hsCRP Levels in Male Wistar Rats Harahap, Hasni Yaturramadhan; Pranata, Chandra
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/6fhzjm83

Abstract

Hypertension remains a major global health problem and is recognized as a leading risk factor for cardiovascular disease. Its pathogenesis involves complex mechanisms, particularly oxidative stress and chronic inflammation. An imbalance between free radical production and endogenous antioxidant defense, especially the enzyme Superoxide Dismutase (SOD), leads to endothelial dysfunction and elevated blood pressure. In parallel, inflammatory mediators such as interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) play important roles in the progression of hypertension. Although conventional therapies are effective, they are often associated with side effects and long-term costs, prompting interest in alternative treatments derived from natural resources. Durian peel (Durio zibethinus), usually considered waste, is rich in bioactive compounds such as flavonoids, alkaloids, tannins, and saponins with potential antioxidant and anti-inflammatory effects. This study employed a true experimental design with a post-test control group using male Wistar rats induced with hypertension by L-NAME administration. Animals were randomized into five groups: negative control, positive control (captopril), and three treatment groups with different extract doses. Assessments included blood pressure measurement, SOD activity, IL-6, and hs-CRP levels. Results demonstrated that durian peel extract contained an average flavonoid level of 16.27 mg QE/g with moderate antioxidant activity (IC50 88.90 µg/mL). The highest dose (800 mg/kgBW) reduced blood pressure by 14.2 ± 3.90 mmHg, approaching the effect of captopril (15.03 ± 6.30 mmHg). Moreover, SOD activity increased, IL-6 levels declined at medium to high doses, and hs-CRP levels decreased significantly, nearly comparable to the positive control. In conclusion, durian peel extract shows potential as an antihypertensive agent through mechanisms involving enhanced antioxidant defense and reduced systemic inflammation.
Analysis of the Relationship between Risk Management of Laboratory Test Errors and the Quality of Laboratory Personnel Services at GrandMed Lubuk Pakam Hospital manullang, Selda; Aritonang, Barita; Pranata, Chandra
JURNAL KESMAS DAN GIZI (JKG) Vol. 8 No. 2 (2026): Jurnal Kesmas dan Gizi (JKG)
Publisher : Fakultas Kesehatan Masyarakat Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/753ef675

Abstract

Risk management is an essential component of a laboratory quality system to prevent errors in examination results and to improve service quality. This study aimed to analyze the relationship between risk management of laboratory result errors and the service quality of laboratory personnel at GrandMed Hospital Lubuk Pakam. This study employed a quantitative method with a cross-sectional design. A total of 30 respondents were recruited using a total sampling technique. Data were collected using questionnaires and analyzed using the Spearman Rank correlation test. The results show that the type of error is significantly associated with service quality (r = 0.389; p = 0.034), risk identification has a very strong and significant association (r = 0.752; p = 0.000), and risk analysis is significantly associated with service quality (r = 0.382; p = 0.037). However, risk control is not significantly associated (r = 0.156; p = 0.410), and user satisfaction is also not significantly associated (r = 0.052; p = 0.784). Overall, risk management of laboratory errors shows a very strong positive correlation with the service quality of laboratory personnel (r = 0.823; p = 0.000). In conclusion, risk identification and risk analysis are the main factors associated with improving the service quality of laboratory personnel. Therefore, strengthening standard
Effectiveness Test of a 96% Ethanolic Extract Cream of Sambung Nyawa Leaves (Gynura procumbens L.) on Incision Wounds in Male White Rats Pranata, Chandra; Harahap, Hasni Yaturramadhan; Herlina, Herlina; Silitonga, Anissa Jelita
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/fh42gn18

Abstract

Background: A major challenge in wound care is the high risk of infection and the relatively prolonged healing process. Synthetic antiseptics such as povidone iodine remain widely used as first-line therapy; however, prolonged use has been reported to cause adverse effects, including tissue irritation and the potential to delay epithelialization under certain conditions. Therefore, alternative therapies that are safer, more effective, and accessible to the community are needed. One promising approach involves the use of traditional medicinal plants known to possess antiseptic, anti-inflammatory, astringent, and antibacterial properties. Sambung Nyawa leaves (Gynura procumbens L.) have been empirically used in Indonesia to treat various health conditions, including skin wounds. This study aimed to evaluate the wound healing effect of an ethanol extract cream of Sambung Nyawa leaves and to determine the most effective concentration for incision wound healing. Methods: A true experimental method with a post-test only control group design was employed. The study subjects were male white rats (Rattus norvegicus) with standardized incision wounds. The animals were treated with Sambung Nyawa leaf extract cream at concentrations of 5%, 10%, and 20%, along with a positive control group (povidone iodine) and a negative control group. The observed parameter was wound diameter following treatment. Results: The findings indicated that the 20% cream concentration demonstrated the fastest healing time, followed by the 10% and 5% concentrations, the positive control, and the negative control. Differences in wound diameter among treatment groups suggest that Sambung Nyawa leaf extract has the potential to accelerate the wound healing process. Conclusion: Cream formulations containing 5%, 10%, and 20% extract exhibited effectiveness relatively comparable to povidone iodine, indicating their potential for development as a natural alternative therapy for incision wounds.
Co-Authors ., Evi ., Muriati ., Yuandani .S, Aminah Aritonang, Barita Asti Pratiwi Cintya, H Darmirani, Yosi Dicky Yuswardi Wiratma Harahap, Hasni Yaturramadhan Herlina H Herlina Herlina Jansen Silalahi Limbing, Reida manullang, Selda Nasution, Muhammad Hamim Novidawati Boru Situmorang Octora, Debi Dinha Pratiwi, Asti Ramadhani, Lili Ratih Anggraeni Reno Irwanto Renty Monica Samran, Samran Santika, Rimma Siahaan, Safrika Juliana Sihombing, Yanna Rotua Silitonga, Anissa Jelita Siregar, Riwandi Suci Wulandari Sumardi . sumitra, Jhoti Sundara, Putri Suprianto Suprianto Syarifuddin, Aminah Tarihoran, Sartika Noviani Yana, Sri Nur Yosi Darmirani