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All Journal JURNAL FARMASIMED (JFM) Science Midwifery Jurnal Pengmas Kestra (JPK) Jurnal Pengabdian Masyarakat Ilmu Kesehatan
Sihombing, Yanna Rotua
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Test to Determine The Quercetin Content of Tenggiang (Polystichum setiferum) Using the High Performance Liquid Chromatography (HPLC) Method and Its Antifungal Activity Against Pityrosporum ovale Turnip, Nur Ulina M. Br.; Ratih Anggraeni; Sihombing, Yanna Rotua; Suci Wulandari
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2361

Abstract

Background: Indonesia is a country with high temperature and humidity, which are supporting factors for the development of microbes. One of the microbes that causes infection is the fungus Pityrosporum ovale which can cause dandruff, especially on the scalp. Treatment is usually done using shampoo containing an antidandruff formula. Synthetic chemicals used in hair care have been widely known and used to treat various infections caused by fungi. Tenggiang, a shrub originating from the Toba Samosir area, is used empirically as a wound medicine. In previous studies, Tenggiang has been shown to have antimicrobial, antioxidant, and anti-inflammatory effects. This is related to the content of secondary metabolites found in tenggiang, such as flavonoids, terpenoids/steroids, saponins, and phenolics. Flavonoids, which are secondary metabolites of the polyphenol group. Objective: to measure the levels of quercetin in tenggiang using the HPLC method and to evaluate its antifungal activity against Pityrosporum ovale. Method: measurement of quercetin using the HPLC method and measurement of antifungal activity using the Kirby-bauer method. Results: The measurement results were then calculated as quercetin equivalents, the extract contained a total of 1.33% flavonoids. The retention time data of the standard quercetin was 5.405 minutes and the retention time of the ethanol extract of mackerel was 5.332. The ethanol extract of mackerel was  said to contain quercetin because it had a retention time that was relatively the same as the retention time of the standard quercetin. The extract also showed potential as an antimicrobial agent, where an increase in extract concentration was directly proportional to an increase in the diameter of the inhibition zone. In addition, when compared to the blank, the resulting difference was statistically significant (p <0.05). Conclusion: Tenggiang, extract has antifungal activity and antioxidant potential.
Socialization and Education of Maggot Extract Nanogel Preparations (Hermatia illucens) for Wound Healing Marbun, Romauli Anna; Sihombing, Yanna Rotua; Anggraeni, Ratih
JURNAL PENGMAS KESTRA (JPK) Vol. 5 No. 1 (2025): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/m4d3b664

Abstract

Background: Wounds are damage to skin tissue that can disrupt the body's protective function and are susceptible to infection. Based on data from the 2017 Basic Health Research, the prevalence of wounds in Indonesia reached 8.2% and showed an increasing trend. One alternative method of wound healing that is known to be effective is maggot therapy using Hermetia illucens. However, the use of live larvae often causes disgust, thus inhibiting public acceptance. Objective: to provide socialization and education regarding the use of maggot extract nanogel preparations as an innovative, safe, and more acceptable form of wound treatment for the public. Method: The method used was to conduct direct socialization to pharmacy students at the Medistra Lubuk Pakam Health Institute. The tool used in data measurement was a questionnaire with a pre-test and post-test design. Results and discussion: Nanogel is formulated from maggot extract with various concentrations and has undergone laboratory tests, showing that the formulation with a concentration of 7.5% has the best particle size and high effectiveness in wound healing. These results are presented and each question item in the questionnaire will be answered by participants. The results of the socialization understanding are 90% of students understand the benefits of maggot extract nanogel preparations (Hermatia illucens) for wound healing. The indicator of the success of this socialization is > 80% of students are correct in filling out the questionnaire with a value above > 75. Conclusion: formula III concentration of 7.5% is a recommendation as the best dose for wounds because it meets the standards of preparation evaluation tests and effectiveness tests. Pharmacy students understand and can conduct further research for wound healing from the biomolecular level
Sosialisasi dan Evaluasi Penggunaan Obat Antihipertensi pada Mahasiswa Farmasi Institut Kesehatan Medistra Lubuk Pakam Marbun, Romauli Anna Teresia; Sihombing, Yanna Rotua; Dalimunthe, Juliana; Wahyuni, Siti; Situmorang, Novidawati Br
Jurnal Pengabdian Masyarakat Ilmu Kesehatan Vol 5, No 1 (2024): Edisi Januari
Publisher : LPPM Institut Kesehatan Helvetia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33085/.v5i1.5992

Abstract

Hipertensi didefinisikan dengan tekanan darah lebih dari atau sama dengan 130/80 mmHg. Sekitar 80-95% kasus mengalami hipertensi esensial, sehingga tidak ada penyebab spesifiknya. Keadaan hipertensi biasanya hanya memunculkan sedikit gejala juga seringkali luput dari perhatian, sehingga dapat memicu penyakit lain, contohnya gagal jantung, hipertrofi ventrikel kiri, stroke, penyakit ginjal stadium akhir, hingga kematian. Peran mahasiswa kesehatan khususnya farmasi dapat menjadi penyaluran informasi pada keluarga mengenai bahaya hipertensi dan cara penanganannya melalui pemberian obat. Metode pengabdian yang dilakukan dalam bentuk Komunikasi, Informasi dan Edukasi (KIE) terkait penggunaan obat antihipertensi. Sosialisasi dan evaluasi penggunaan obat antihipertensi kepada peserta dilaksanakan secara online dengan menggunakan zoom meeting. Sebelum pemaparan materi dilakukan pretest terlebih dahulu. Setelah selesai pemaparan materi, para peserta diberikan posttest untuk mengetahui pengetahuan peserta atas materi yang disampaikan. Kegiatan pengabdian masyarakat ini dilaksanakan pada hari Rabu tanggal 25 Oktober 2023 pukul 09.00-12.00 WIB. Peserta kegiatan aktif dalam diskusi dan memberikan pertanyaan. Hasil posttest menunjukkan bahwa pemahaman dan peningkatan pengetahuan mahasiwa terkait penggunaan obat antihipertensi sudah baik yang terlihat dari peningkatan poin dari pretest sebelumnya. Secara khusus mahasiswa farmasi yang spesifik belajar terapi hipertensi menjadi lebih mendalami kendala yang didapat oleh masyarakat. Perlu adanya kegiatan-kegiatan serupa yang rutin dilakukan untuk mencegah kesalahan penggunaan obat antihipertensi
Activity Test of Daun Jati Belanda (Guazuma ulmifolia Lamk.) on Lymphocyte Proliferation and Immunoglobulin G Expressionas an Immunostimulatory Agent Sihombing, Yanna Rotua; Fitri Siska
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/7mw45p98

Abstract

Background: Infections that attack the immune system have become a major global health issue, including in Indonesia. In 2019, the emergence of Coronavirus created an urgent need for immediate therapy, followed by increased attention to other diseases such as tuberculosis (TB), PCP pneumonia (Pneumocystis jirovecii), candidiasis, and toxoplasmosis. If left untreated, infections can damage tissues and organs. Although immune-boosting drugs are available in healthcare settings, their side effects and potential drug interactions highlight the need for complementary therapies derived from natural ingredients. Indonesia’s biodiversity offers great potential for the development of natural immunostimulants. One such plant is Jati Belanda (Guazuma ulmifolia Lamk.), which is widely found in Deli Serdang, North Sumatra. Empirically, its leaves have been used to treat diarrhea, cough, abdominal pain, and as a tonic and astringent. Research has shown that Guazuma ulmifolia contains alkaloids, tannins, and flavonoids with antihyperlipidemic, antiviral, and anti-inflammatory properties, as well as potential immune-enhancing effects.Objective: This study aimed to analyze the immunostimulatory activity of Guazuma ulmifolia leaf extract on lymphocyte proliferation and IgG expression using male rats. Methods: The experimental method was applied, including a lymphocyte proliferation assay using the MTT method and serum IgG measurement using the ELISA technique. Results: The results showed that the extract significantly increased lymphocyte proliferation and IgG levels. The EC50 value of the extract (4.720 µg/mL) was comparable to that of Imboost (4.282 µg/mL), indicating similar effectiveness. Increased absorbance at various extract concentrations reflected enhanced cell proliferation. A dose of 400 mg/kg body weight effectively elevated IgG levels, strengthening the humoral immune response. The presence of flavonoids, tannins, and saponins is thought to play a role by activating B cells, promoting plasma cell differentiation, and modulating the NF-κB signaling pathway. Conclusion: Therefore, Guazuma ulmifolia leaf extract has potential as a natural immunostimulant that supports the body’s defense against pathogens.
Co-Authors Dalimunthe, Juliana Fatima, Nurdilla Fitri Siska Friska Novita Pasaribu Juliana, Iga Kristian Cahayani Zebua Lenni Rismayanti Lestari, Dayana Maharani, Anisa Marbun, Romauli Anna Nainggolan, Hotdoriska Nasution, Dina Wahyuni Nasution, Muhammad Hamim Novidawati Boru Situmorang Novidawati Br Situmorang Nur Ulina M. Br. Turnip Octavian Ashido Nababan Parinduri, Anggi Isnani Pranata, Chandra Ratih Anggraeni Ratih Anggraeni Romauli Anna Teresia Marbun S, Aminah. Sinaga, Falentina Siska, Fitri Siti Wahyuni Situmorang, Novidawati Br Suci Wulandari Suci Wulandari Syarifuddin, Aminah Zebua, Kristian Cahayani