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All Journal Pharmaciana: Jurnal Kefarmasian Andalas obstetrics and gynecology journal Jurnal Kedokteran STM (Sains dan Teknologi Medik)
Suhandri, Wiwin
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Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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KOMBINASI AKUPUNTUR DENGAN METFORMIN ATAU CLOMIPHENE CITRATE TERHADAP POLYCYSTIC OVARY SYNDROME DALAM MENINGKATKAN KEHAMILAN: COMBINATION OF ACUPUNCTURE WITH METFORMIN OR CLOMIPHENE CITRATE FOR POLYCYSTIC OVARY SYNDROME IN PROMOTING PREGNANCY Alparisi, Bima Diokta; Muzhaffar, Teuku Adib Bariq; Suhandri, Wiwin; Hutagaol, Imelda Baktiana E.; Amanda, Samira
Jurnal Kedokteran STM (Sains dan Teknologi Medik) Vol. 8 No. 2 (2025): Juli 2025
Publisher : Fakultas Kedokteran Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/stm.v8i2.877

Abstract

Polycystic Ovary Syndrome (PCOS) is one of the diseases that can cause infertility for women. Pharmacological therapy given is either metformin or clomiphene citrate while non-pharmacological is acupuncture. Both therapies have been shown to be beneficial in increasing pregnancy. Therefore, the purpose of this review is to determine the effect of the combination of acupuncture against metformin or clomiphene in increasing pregnancy rates. The method used was a literature review sourced from Google Scholar, Pub Med, Science Direct. Then identification, screening, adjustment of inclusion and exclusion variables were carried out and then selected titles, abstracts and contents so that only 6 articles were discussed. The results obtained that the combination therapy of acupuncture with metformin has better clinical effectiveness than clomiphene citrate because of minimal side effects and satisfactory outcomes in increasing pregnancy. Thus, it is hoped that further research will be carried out in the use of a combination of acupuncture therapy with metformin or clomiphene citrate. AbstrakPolycystic Ovary Syndrome (PCOS) merupakan salah satu penyakit yang dapat mengakibatkan infertilitas bagi wanita. Terapi farmakologi yang diberikan yaitu baik metformin atau clomiphene citrate sedangkan non farmakologi berupa akupuntur. Kedua terapi tersebut terbukti bermanfaat dalam meningkatkan kehamilan. Oleh sebab itu, tujuan tinjauan ini adalah untuk mengetahui efek kombinasi akupuntur terhadap metformin atau clomiphene dalam meningkatkan tingkat kehamilan. Metode yang digunakan berupa kajian literatur yang bersumber dari Google Scholar, Pub Med, Science Direct. Kemudian dilakukan identifikasi, skrining, penyesuaian terhadap variabel inklusi dan eksklusi lalu dilakukan seleksi judul, abstrak dan isi maka yang hanya dibahas berjumlah 6 artikel. Hasil yang didapatkan bahwasannya terapi kombinasi akupuntur dengan metformin memiliki efektifitas klinis yang lebih baik dibandingkan clomiphene citrate sebab efek samping yang lebih minim serta outcomes yang cukup memuaskan dalam meningkatkan kehamilan. Dengan demikian, diharapkan dilakukannya penelitian lebih lanjut dalam pemanfaatan kombinasi terapi akupuntur dengan metformin atau clomiphene citrate.
Repurposing drugs in endometrial cancer using genomic variants database Darmawi, Darmawi; S, Donel; Suhandri, Wiwin; Winarto, Winarto; Adikusuma, Wirawan; Irham, Lalu Muhammad; Fidiawati, Wiwit Ade; Razali, Renardy Reza; Nathania, Auren; Zahra, Leina Putri
Pharmaciana Vol. 13 No. 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.27201

Abstract

Endometrial cancer (EC) is the fourth most frequent gynecological cancers, and its incidence and mortality rates have increased over the last decade. Cytotoxic therapy with carboplatin and paclitaxel is the recommended first-line treatment for EC patients. However, the options for following therapy are limited. The latest advances in molecular studies have uncovered the nature of genetic alterations in EC, compelling methods for further research into the treatment of EC since they may disclose to tailored pharmacological therapy. The aim of this study to identify novel drug candidates in treating EC using genomics variants and biological pathway. The genomic variants of  EC were downloaded from cBioportal database. We established connection between the biological EC risk genes from cBioportal database and the DrugBank database. Finally, we used Connectivity Map (CMap) analysis to identify possible drugs whose mechanisms coincided with therapeutic targets and rank them based on the scoring system. We identified novel potential candidate drugs for EC, they are Bosutinib and Nilutamide which exhibit robust scores in the CMap analysis compare to paclitaxel. We also discovered BCR-ABL1 and AR as potential biomarker-driven therapy in EC. This study demonstrates the possibility of using genetic network analysis combined with bioinformatics to repurpose drugs for the treatment of EC. Further study will investigate the mechanisms of using BCR-ABL1 and AR targeting in the treatment of EC.
Diagnostic Value of Cyclooxygenase-2 Serum Levels in Predicting Preterm Labor Suhandri, Wiwin; Djanas, Dovy
Andalas Obstetrics And Gynecology Journal Vol 4, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.4.1.28-34.2020

Abstract

Objective: To determine the value of serum cyclooxygenase 2 in predicting preterm laborMethod: Examination of serum COX-2 levels by ELISA method in pregnant women with 28 weeks to 36 weeks of pregnancy compared with pregnant women with ≥37 weeks of gestation at the time of first stage of active phaseResults: It is known that the average COX-2 level in preterm labor is 21.88 ± 18.22 higher than in term labor which is 4.88 ± 2.35 ng / ml, the statistical test results obtained p = <0.001 serum Cyclooxygenase 2 at preterm deliveries and term deliveries. The value of serum cyclooxygenase 2 levels in predicting preterm labor is at a cut point of 7.0.0 ng / ml with a sensitivity of 86.1% and a specificity of 86.1%Conclusion: There were significant differences in serum cyclooxygenase 2 levels in preterm labor and term delivery Keywords: cyclooxygenase 2, memprediksi persalinan preterm, persalinan preterm.
Co-Authors Alparisi, Bima Diokta Amanda, Samira Darmawi . Djanas, Dovy Hutagaol, Imelda Baktiana E. Lalu Muhammad Irham Muzhaffar, Teuku Adib Bariq Nathania, Auren Razali, Renardy Reza S, Donel Winarto Winarto Wirawan Adikusuma Wiwit Ade Fidiawati Zahra, Leina Putri