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All Journal Biomedical Journal of Indonesia SRIWIJAYA JOURNAL OF MEDICINE Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Biomedika
Pasaribu, Rouly Pola
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Humanities Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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RELATIONSHIP OF MUTATION OF KODON S 315 T KATG MYCOBATERIUM TUBERCULOSIS GENE WITH MULTIDRUG RESISTANCE TUBERCULOSIS IN SOUTH SUMATERA Syafriani, Diah; Pasaribu, Rouly Pola; Ahmad, Zen
Biomedical Journal of Indonesia Vol 6, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i1.10187

Abstract

MDR TB is a condition of M. tuberculosis that is resistant to isoniazid and rifampicin. This occurs because of certain genomic mutations in certain Mtb specific genes. Some of the genes that play a role in the INH mutation are the katG gene, the inhA gene, the ahpC gene, the ndh gene and the kasA gene. The most frequent mutation gene is the katG gene, around 50-80%, and the most mutations (64%) are found in the S 315T codon. The aim was to determine the relationship of S315T genotype in the M. tuberculosis katG gene with the incidence of Mtb resistance in MDR TB patients in South Sumatra. This type of research is an observational cross sectional study approach, conducted in Palembang RSMH in collaboration with the Clinical Microbiology Laboratory of FK UNSRI Palembang from January - July 2019. The sample of the case group (MDR TB) was 50 people while the control group (TB SO) was 21 people. Each group was tested for S315T genotype katG M. tuberculosis gene using the PCR-RFLP method with the Mspl enzyme. Visualization of the katG gene in codon 315 in this study was only found in 40 samples, 26 samples in the case group (MDR TB) and 14 samples in the control group (TB SO). Results Genetic frequency distribution in the case group (MDR TB) was 65.38% wildtype and 34.62% mutant, whereas in the control group (TBSO) it was 92.86% wildtype and 7.14% mutant. The 315 coded KatG gene mutation in this study was not related to the incidence of MDR TB, with p = 0.07, an odds ratio of 6.8 (0.77 - 61.40, 95% CI). The conclusions of this study found 315G katG M. tuberculosis codon mutation mutations of 34.62% but not significantly related to the incidence of MDR TB in South Sumatra.
Affinity of Chlorogenic Acid as COVID-19 Antiviral with Molecular Docking Method Bagaskara, Surya; Parisa, Nita; Pasaribu, Rouly Pola; Tamzil, Nia Savitri; Kamaluddin, Muhammad Totong
Biomedika Vol 16, No 1 (2024): Biomedika Februari 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v16i1.4622

Abstract

Due to the continued presence of and impact of COVID-19 on our modern world, the benefit and necessity of alternative treatment options and effective antiviral compounds is readily apparent. This study seeks to explore the utility of chlorogenic acid as a COVID-19 antiviral. The in-silico experimental study was conducted using a laptop and publicly-available freeware. Key compounds used in this study are the comparative drugs favipiravir (CID 492405), oseltamivir (CID 65028), nafamostat (CID 4413), and spironolactone (CID 5833), to be tested against our subject, chlorogenic acid (CID 1794427). Compunds used in this study were docked with specific target proteins, such as ACE2, TMPRSS2, RdRp, dan 3Clpro, using AutoDock Vina. The visualization of molecular interactions was performed with Discovery Studio v21. Our results showed that chlorogenic acid has one Lipinski’s Rule of Five violation in H-bond Donor parameter. Chlorogenic acid had a higher affinity towards ACE2 and 3CLpro and lower affinity towards TMPRSS2 and RdRp, if compared to competing drugs, with a binding energy of -7.8, -6.9, -7.0, and -7.4 kcal/mol respectively, for ACE2, TMPRSS2, RdRp, and 3CLpro. We conclude that chlorogenic acid shows promise as oral drug candidate based on these results, and that further studies into the realm of molecular dynamics, in-vitro, or in-vivo studies are warranted in order to explore this underutalized compound and possibly bring it to human trials.
PERAN RASIO LACTATE DEHIDROGINASE DAN LIMFOSIT SEBAGAI PENANDA EFUSI PLEURA MALIGNANSI: THE ROLE OF LACTATE DEHYDROGENASE AND LYMPHOCYTE RATIO AS MARKERS OF MALIGNANT PLEURAL EFFUSION Pasaribu, Rouly Pola; Damayanti, Lia
Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Vol. 24 No. 2 (2025): Juli 2025
Publisher : Faculty of Medicine Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/ibnusina.v24i2.913

Abstract

Pendahuluan: Efusi pleura merupakan salah satugejala dari patologi yang mendasarinya. Pemeriksaan biokimia yang umumnya dilakukan untuk membedakan patologi tersebut adalah kadar laktat dehydrogenase, adenosine deaminase, dan limfosit. Tujuan: mengevaluasi penggunaan rasio LDH cairan pleura/limfosit dalam cairan pleura sebagai parameter baru untuk membedakan antara efusi pleura maligna dan bukan. Metode: Penelitian cross sectional di RSUP Dr. Mohammad Hoesin (RSMH) Palembang menggunakan rekam medis. Pasien dewasa dengan diagnosa efusi pleura eksudatif yang dilakukan pemeriksaan analisa cairan pleura libatkan dalam penelitian ini. Uji hipotesis dilakukan dengan menggunakan uji T tidak berpasangan atau uji Mann Whitney U. Hasil: Penelitian ini melibatkan 206 pasien, dimana 43,21% didiagnosis dengan efusi pleura non-malignansi, sedangkan 56,79% dengan efusi pleura malignansi. Pemeriksaan LDH cairan pleuradan limfosit cairan pleura menunjukkan perbedaan yang signifikan antara kelompok pasien dengan dan tanpa malignansi (LDH cairan pleurakelompok malignansi: 593,5 U/L [32 – 1.940] vs kelompok non-malignansi: 198 U/L [104 – 811], p < 0,001; limfosit kelompok non-malignansi: 87% [21-95] vs kelompok malignansi: 38% [30-93], p < 0,001). Rasio LDH cairan pleura terhadap limfosit juga menunjukkan perbedaan yang signifikan (kelompok malignansi: 15,18 [0,81-60,03] vs non-malignansi: 2,84 [1,15-22,87], p < 0,001). Kesimpulan: Terdapat perbedaan yang signifikan antara LDH cairan pleura, limfosit cairan pleura, dan rasio antara kedua antara pasien dengan efusi pleura maligna dan non-maligna.
Association Between LENT Score and Survival in Patients with Malignant Pleural Effusion at Dr. Mohammad Hoesin General Hospital, Palembang Rizkyani Sariza, Fania; Ahmad, Zen; Kurniati, Nova; Yusri, Muhammad; Irfannudin; Sudarto; Andriani, Raden Ayu Linda; Pasaribu, Rouly Pola; Rachman, Alif Fathur
Sriwijaya Journal of Medicine Vol. 8 No. 2 (2025): Vol 8, No 2, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i2.352

Abstract

The presence of a malignant pleural effusion (MPE) indicates advanced stage of malignancy, which severely compromises in a poor prognosis. LENT score has been developed as a prognostic tool for MPE, yet its association with survival has not been thoroughly evaluated in Indonesia. This study aims to examine the association between LENT score and 3-month survival in patients with MPE at Dr. Mohammad Hoesin General Hospital, Palembang. This prospective cohort study included 35 patients with MPE. Survival analysis using Kaplan-Meier curves. In this study cohort, the most frequent primary malignancy observed was lung cancer (62,8%). Kaplan-Meier analysis showed a median survival of 22 days for the high-risk LENT scores and 85 days for the moderate-risk group (p < 0,001). LENT score is significantly associated with three-month mortality in EPG patients. LENT score remains a robust tool for risk stratification in MPE management.
Co-Authors Ahmad, Zen Andriani, Raden Ayu Linda Bagaskara, Surya Irfannudin Kamaluddin, Muhammad Totong kurniati, nova Lia Damayanti Muhammad Yusri Nita Parisa Rachman, Alif Fathur Rizkyani Sariza, Fania Sudarto Syafriani, Diah