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All Journal Majalah Farmaseutik PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PREPOTIF : Jurnal Kesehatan Masyarakat Prosiding University Research Colloquium IJF (Indonesia Jurnal Farmasi)
Julia Megawati Djamal
Universitas Muhammadiyah Kudus
Humanities Computer Science & IT Environmental Science Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : Majalah Farmaseutik

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In Vitro Antihypercholesterol Activity Test of Chocolate (Theobroma cacao L) Peel Kusumaningtyas, Febrianika Ayu; Kadir, Sudirman A.; Djamal, Julia Megawati; Mantali, M. Fathurrachman
Majalah Farmaseutik Vol 21, No 3 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v21i3.108795

Abstract

Cholesterol is a lipid found in the blood and is not hydrolyzed, until now it has become a risk factor for Coronary Heart Disease (CHD). Reducing cholesterol levels is assisted by the use of antihypercholesterol drugs and natural medicines. The by-product of cocoa plantations (Theobroma cacao L) is skin containing secondary metabolites, including flavonoids, alkaloids, tannins and saponins. This study aims to identify the antihypercholesterol activity of cocoa fruit skin extract in vitro with the Liebermann-Burchard method using a UV-Vis spectrophotometer at a wavelength of 669nm. The test results showed that the ethanol extract of cocoa fruit skin obtained through maceration at concentrations of 10, 20, 40, 80 and 100ppm had the activity to lower cholesterol levels with an EC50 value of 67.785ppm. This activity is indicated based on the difference in color intensity of the test solution compared with control negative solution. The conclusion from the results obtained is that cocoa skin extract has activity as a natural cholesterol-lowering agent.
Co-Authors Besan, Emma Jayanti Emma Jayanti Besan Etikasari, Ria Fitri Apriliani Fitri Apriliani H Hasriyani Hasriyani, H Ismari, Dwi Andriyani Tonny Jason Merari Peranginangin Kadir, Sudirman A. Korompot, Nayla Salshabila Krisgiantara, Novita Kusumaningtyas, Febrianika Ayu Mariama, Astari Aprillia Muhammad Fathurrachman Mantali Muhammad Nurul Fadel Murharyanti, Rika Nihayatus Sholekhah Noor Cholifah Noor Hidayah Novita Krisgiantara Rahmat Ismail Ria Etikasari Rika Murharyanti Rizal Maarif Rukmana, Rizal Maarif Sabaan, Wahid Sholekhah, Nihayatus Vivin Rosvita Zaenal Fanani