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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Fitofarmaka Indonesia Jurnal Medika Malahayati Lumbung Farmasi : Jurnal Ilmu Kefarmasian INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Pharmacy Reports Jurnal Farmasi SYIFA Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai
Meiliana, Made Laksmi
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : Pharmacy Reports

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Effect of adjunctive corticosteroid therapy on length of hospital stay and clinical outcomes in community-acquired pneumonia patients Rostalina, Irma; Meiliana, Made Laksmi; Kusniawati, Mega Ayu
Pharmacy Reports Vol. 5 No. 2 (2025): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.111

Abstract

Community-acquired pneumonia remains a major cause of morbidity and mortality despite antibiotic therapy. Corticosteroids may modulate excessive inflammatory responses by suppressing pro-inflammatory cytokines, but their clinical utility remains controversial. To evaluate the effect of adjunctive corticosteroid therapy on length of hospital stay and clinical parameters in community-acquired pneumonia patients. This retrospective observational study analyzed medical records of 59 community-acquired pneumonia patients at Hospital X, Bandar Lampung, during 2023. Patients were categorized into steroid (n=39) and non-steroid (n=20) groups. Clinical parameters including fever, cough, dyspnea, respiratory rate, and length of hospital stay were compared using chi-square analysis. Significant differences were observed in length of stay (p=0.044), dyspnea resolution (p=0.022), and respiratory rate normalization (p=0.042), with the steroid group showing longer durations. No significant differences were found in fever (p=0.653) and cough resolution (p=0.679). Adjunctive corticosteroid therapy did not demonstrate clinical benefit in this population and was associated with prolonged hospital stay, suggesting the need for careful patient selection and standardized protocols.
Concentration-dependent antibacterial activity of Ruellia tuberosa L. leaf extract against Propionibacterium acnes Yani, Indri; Hamidu, La; Meiliana, Made Laksmi
Pharmacy Reports Vol. 5 No. 3 (2025): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.112

Abstract

Acne vulgaris, primarily caused by Propionibacterium acnes, affects millions globally, yet current antibiotic treatments face increasing resistance. This study evaluated the antibacterial activity of Ruellia tuberosa L. leaf ethanol extract against P. acnes ATCC 6919 using the disc diffusion method. Phytochemical screening confirmed the presence of alkaloids, flavonoids, tannins, saponins, and terpenoids. Five extract concentrations (15%, 20%, 25%, 30%, and 35% w/v) were tested alongside negative control (distilled water) and positive control (0.1% clindamycin) in quadruplicate. Results demonstrated concentration-dependent antibacterial activity, with inhibition zones increasing from 5.00 ± 1.30 mm (15%, weak) to 11.81 ± 0.84 mm (35%, strong), compared to 22.05 ± 0.27 mm for clindamycin. One-way ANOVA revealed significant differences among groups (p < 0.001), with Tukey post-hoc analysis confirming progressive activity increases from 15% to 30%, but no significant difference between 30% and 35% (p > 0.05). These findings provide preliminary evidence that Ruellia tuberosa leaf extract possesses antibacterial potential against P. acnes, warranting further investigation for botanical anti-acne formulation development.
Co-Authors Amalia, Riyanti Ardhianto, Denny Didik Hasmono Hamidu, La Indri Yani, Indri Ismayati, Dwi Kusniawati, Mega Ayu Lestari, Yovita Endah Masykuro, Nihayatul Muzammil, A. Novita Sari Oktafany Pulungan, Yulianasari Puspita, Okta Risanti, Yumna Dwi Rostalina, Irma Suri, Nurma Suwartini Ulandari, Syaripah