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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Fitofarmaka Indonesia Jurnal Medika Malahayati Lumbung Farmasi : Jurnal Ilmu Kefarmasian INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Pharmacy Reports JKMP (Jurnal Kebijakan dan Manajemen Publik) Jurnal Farmasi SYIFA Indonesian Journal of Science and Pharmacy Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai
Meiliana, Made Laksmi
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Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : Pharmacy Reports

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Adjunctive corticosteroid therapy and clinical recovery in hospitalized community-acquired pneumonia patients: a retrospective comparative study Rostalina, Irma; Meiliana, Made Laksmi; Kusniawati, Mega Ayu
Pharmacy Reports Vol. 5 No. 2 (2025): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.111

Abstract

Dysregulated inflammation in community-acquired pneumonia (CAP) has prompted investigation of corticosteroids as adjunctive therapy; however, their clinical utility remains contested, particularly in non-severe presentations and resource-limited settings. This study aims to evaluate the effect of adjunctive corticosteroid therapy on length of hospital stay and key clinical parameters in adult CAP patients at a secondary referral hospital in Bandar Lampung, Indonesia. This retrospective comparative study analyzed medical records of 59 eligible CAP patients admitted during 2023. Patients were categorized into steroid (n = 39) and non-steroid (n = 20) groups. Time to clinical improvement in temperature, cough, dyspnea, and respiratory rate, as well as length of hospital stay, were compared using chi-square and Fisher's exact tests. Steroid-treated patients had significantly longer hospital stays (28.2% vs. 5.0% with stays ≥5 days; p = 0.044), slower dyspnea resolution (p = 0.022), and delayed respiratory rate normalization (p = 0.042). No significant differences were observed for temperature (p = 0.653) or cough resolution (p = 0.679). Adjunctive corticosteroid therapy was not associated with clinical benefit in this cohort and was associated with prolonged hospitalization. Severity-based patient selection and standardized protocols are essential before routine corticosteroid use can be recommended in similar settings.
Concentration-dependent antibacterial activity of Ruellia tuberosa L. leaf ethanol extract against Propionibacterium acnes ATCC 6919 Yani, Indri; Hamidu, La; Meiliana, Made Laksmi
Pharmacy Reports Vol. 5 No. 3 (2025): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.112

Abstract

Rising antibiotic resistance in Propionibacterium acnes necessitates alternative anti-acne agents. Ruellia tuberosa L. (Acanthaceae) possesses documented antibacterial potential, yet its activity against P. acnes remains unevaluated. This study investigated the concentration-dependent antibacterial activity of R. tuberosa leaf ethanol extract against P. acnes ATCC 6919. Leaves were extracted by maceration using 96% ethanol. Phytochemical classes were identified by thin-layer chromatography. Antibacterial activity was assessed using the Kirby-Bauer disc diffusion method in triplicate (n = 3) at concentrations of 15%, 20%, 25%, 30%, and 35% (w/v), with 0.1% clindamycin and distilled water as positive and negative controls, respectively. Data were analyzed by one-way ANOVA with Tukey's HSD post-hoc test. TLC confirmed alkaloids, flavonoids, tannins, saponins, and terpenoids. Inhibition zones increased from 5.00 ± 1.30 mm (15%, weak) to 11.82 ± 0.84 mm (35%, strong), compared to 22.05 ± 0.27 mm for clindamycin. Significant differences were detected among all groups (p < 0.0001). The 30% concentration was the lowest to achieve strong inhibitory activity, with no significant advantage conferred by increasing to 35%. R. tuberosa leaf ethanol extract exhibits concentration-dependent antibacterial activity against P. acnes, with 30% identified as the optimal concentration, warranting further investigation for botanical anti-acne formulation development.
Co-Authors Amalia, Riyanti Ardhianto, Denny Didik Hasmono Hamidu, La Indri Yani, Indri Ismayati, Dwi Kusniawati, Mega Ayu Lestari, Yovita Endah Masykuro, Nihayatul Muzammil, A. Novita Sari Oktafany Oktaviana, Rena Pulungan, Yulianasari Puspita, Okta Risanti, Yumna Dwi Rostalina, Irma Suri, Nurma Suwartini Ulandari, Syaripah