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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Fitofarmaka Indonesia Jurnal Medika Malahayati Lumbung Farmasi : Jurnal Ilmu Kefarmasian INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL JKMP (Jurnal Kebijakan dan Manajemen Publik) Jurnal Farmasi SYIFA Indonesian Journal of Science and Pharmacy Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai
Meiliana, Made Laksmi
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences

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Efficacy and Safety of Antihypertensive Drugs in Chronic Kidney Disease Patients at Menggala Regional General Hospital Ardhianto, Denny; Meiliana, Made Laksmi; Ismayati, Dwi; Ulandari, Syaripah; Puspita, Okta; Oktaviana, Rena
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 1 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i1.14983

Abstract

Chronic kidney disease (CKD) is a progressive condition characterized by a gradual decline in glomerular filtration rate, often accompanied by hypertension, necessitating antihypertensive therapy. This study aimed to evaluate the effectiveness of antihypertensive drugs in achieving blood pressure targets (<140/90 mmHg or a mean arterial pressure reduction of ≥20 mmHg) and to identify the incidence of adverse effects in CKD patients at Menggala Regional General Hospital during 2024. A retrospective observational study was conducted using medical records from 199 CKD inpatients selected via purposive sampling. Data analysis employed descriptive statistics, paired t-tests for effectiveness, and chi-square tests for associations between drug types. Results indicated that combination therapy with furosemide IV, candesartan, and amlodipine was the most common (77.4%) and demonstrated effectiveness in 50.8% of cases (p=0.01). Adverse effects occurred in only 1.0% of patients, primarily peripheral edema. The findings underscore the efficacy of combination therapies involving diuretics, ARBs, and CCBs in managing hypertension in CKD, with minimal adverse events. This research provides valuable insights for optimizing antihypertensive regimens in similar settings.
Effectiveness of Vitamin D Supplementation in Children with Attention-Deficit/Hyperactivity Disorder: A Systematic Review Puspita, Okta; Meiliana, Made Laksmi; Ardhianto, Denny; Ulandari, Syaripah
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 11, No 1 (2026)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v11i1.9367

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder that significantly affects functioning and quality of life. Emerging evidence suggests that vitamin D may contribute to neurodevelopment and behavioral regulation, and children with ADHD have been reported to exhibit lower serum 25(OH)D concentrations. However, findings regarding the clinical effectiveness of vitamin D supplementation remain inconsistent. This study systematically reviewed the effectiveness of vitamin D supplementation in children with ADHD. A systematic review was conducted in accordance with PRISMA guidelines by searching PubMed, ScienceDirect, and Scopus for randomized controlled trials (RCTs) published between January 2016 and February 2026. Eligible studies included children aged ≤18 years diagnosed with ADHD who received oral vitamin D supplementation. Study quality was assessed using the Joanna Briggs Institute Critical Appraisal Checklist, and a qualitative synthesis was performed. Six RCTs met the inclusion criteria. Across studies, vitamin D supplementation consistently increased serum 25(OH)D concentrations. However, clinical effects were heterogeneous. Although some trials reported modest improvements in specific symptom domains, particularly inattention, consistent reductions in overall ADHD severity were not observed. In conclusion, vitamin D supplementation effectively improves serum 25(OH)D levels but demonstrates variable clinical benefits in children with ADHD. Current evidence does not support its use as a definitive standalone treatment, although potential adjunctive benefits cannot be excluded. Further high-quality, large-scale RCTs are needed to clarify its clinical role. 
Impact of Empirical Antibiotic Therapy on Infection-Related Parameters in Burn Patients at Abdul Moeloek Regional General Hospital, Bandar Lampung Puspita, Okta; Meiliana, Made Laksmi
Indonesian Journal of Science and Pharmacy Vol. 3 No. 3 (2026): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v3i3.167

Abstract

Burn injuries increase the risk of infection due to disruption of the skin barrier. Therefore, empirical antibiotics are commonly administered during the early phase of treatment. However, evidence regarding changes in inflammatory parameters following therapy remains limited. This study aimed to analyze the effect of empirical antibiotic administration on inflammatory parameters in burn patients at Abdul Moeloek Regional General Hospital, Bandar Lampung. This retrospective observational study utilized medical record data from 79 burn patients, predominantly adult males. The parameters analyzed included leukocyte, neutrophil, lymphocyte, and platelet counts following empirical antibiotic therapy. All patients showed improvement in platelet counts (79/79). Improvements were also observed in lymphocytes (47/79), leukocytes (35/79), and neutrophils (30/79). Statistical analysis demonstrated significant associations between empirical antibiotic administration and all inflammatory parameters (p = 0.001). Variability in leukocyte and neutrophil responses may reflect systemic inflammatory processes beyond infection. Empirical antibiotic administration in burn patients, predominantly adult males, resulted in significant improvements in inflammatory parameters, with platelet count as the most consistent indicator. However, interpretation should consider the patients’ overall clinical status.
Co-Authors Amalia, Riyanti Ardhianto, Denny Didik Hasmono Hamidu, La Ismayati, Dwi Lestari, Yovita Endah Masykuro, Nihayatul Muzammil, A. Novita Sari Oktafany Oktaviana, Rena Pulungan, Yulianasari Puspita, Okta Risanti, Yumna Dwi Suri, Nurma Suwartini Ulandari, Syaripah