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All Journal Jurnal Farmasi Udayana Jurnal Midpro Sainstech Farma: Jurnal Ilmu Kefarmasian SAINSTECH: Jurnal Penelitian dan Pengkajian Sains dan Teknologi Mestaka: Jurnal Pengabdian Kepada Masyarakat
Munawarohthus Sholikha
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences Other

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Journal : Sainstech Farma: Jurnal Ilmu Kefarmasian

 1 
Analisis Kandungan Logam Timbal (Pb), Besi (Fe) Dan Magnesium (Mg) Pada Pakan Ayam Ras Petelur Dengan Metode Spektrofotometri Serapan Atom (SSA) Sholikha, Munawarohthus; Natasya, Fauziah Cinta; Puspitasari, Lia
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 14 No 2 (2021): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v14i2.1014

Abstract

Pakan dibutuhkan oleh ayam ras petelur, namun dalam pakan tersebut dapat mengandung unsur logam seperti timbal, besi, magnesium, dan lain–lain. Hal ini akan berpengaruh terhadap produk ternak yang dihasilkan dari ayam tersebut. Jika unsur–unsur logam tidak terkontrol akan memberikan efek negatif untuk manusia yang mengonsumsi telur tersebut seperti kanker dan penyakit lainnya. Untuk mengetahui unsur–unsur logam yang terdapat di dalam pakan, dilakukan pengujian dengan metode Spektrofotometri Serapan Atom (SSA). Sampel uji diperoleh dari dua distributor berbeda yaitu sampel A dan sampel B yang terletak di daerah Jakarta. Dari pengujian tersebut didapatkan hasil, logam Pb (sampel A = 0,0276 mg/kg dan sampel B = Tidak Terdeteksi), logam Fe (sampel A = 134,79 mg/kg dan sampel B = 117,9 mg/kg), logam Mg (sampel A = 413,6 mg/kg dan sampel B = 363,7 mg/kg). Hasil dari pengujian menunjukkan bahwa pakan tersebut mengandung logam Pb tetapi masih di bawah nilai ambang batas, sedangkan kandungan logam Fe dan Mg nilainya berada di atas nilai ambang batas yang direkomendasikan oleh SNI 0,05 mg/kg.
Tyrosinase Enzyme Inhibition Activity Test by Ethanol Extract of Taro Leaf (Typhonium flagelliforme (Lodd.) Blume) In Vitro Sholikha, Munawarohthus; Wahyuningtyas, Wahyuningtyas; Puspitasari, Lia
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 1 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v16i1.1451

Abstract

Hyperpigmentation is an event that occurs due to excessive production of skin pigment. Skin color is strongly influenced by the presence of melanin, where the presence of melanin is strongly influenced by the enzyme tyrosinase. Taro leaf (Typhonium flagelliforme (Lodd.) Blume) are one of the plants have flavonoid compounds used as antioxidants and tyrosinase inhibitors. The aim of this study was to test the ethanol extract of taro leaf as a tyrosinase inhibitor. Taro leaf in this study were obtained through an extraction process using 96% ethanol solvent by maceration method. The thick ethanol extract of taro leaf was tested for phytochemical screening, total flavonoid levels, and tyrosinase inhibition test. The method used for tyrosinase inhibition test was enzymatic method in vitro. The results of this study indicated that there was a total flavonoid compound content of 0.7378% (b/b) and the inhibitor activity can be seen from the IC50 value for the diphenolation reaction (L-DOPA substrate) which was 13.307 mg/mL. This value was greater when compared with 0.093 mg/mL of phenolic acid, so that the ethanol extract of taro leaf has the potential to inhibit tyrosinase activity.
Sintesis Analog Kurkumin (2E,6E)-2-(4-Hidroksi-3-Metoksi-5-((Pirolidin)metil)benziliden) -6-(4-Metoksibenziliden)Sikloheksan-1-on Rahmawati, Nur; Fitriana, Adita Silvia; Sholikha, Munawarohthus
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 2 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v16i2.1578

Abstract

Curcumin is a potential compound to be developed. However, the clinical use of these compounds is limited due to their low stability and bioavailability. Therefore, to increase the pharmacological activity of curcumin, it is necessary to modify the chemical structure of curcumin. Curcumin analog compound (2E,6E)-2-(4-hydroxy-3-methoxy-5-((pyrrolidine)methyl)benzylidene)-6-(4-methoxybenzyliden)cyclohexane-1-on can be synthesized in 3 steps. Phase I, the reaction between p-methoxybenzaldehyde and cyclohexanone took place aldol condensation reaction with NaOH catalyst. Phase II, the Clasein-Schmidt reaction between compound 1 (the result of the synthesis of stage I) and vanillin involved dilute HCl as the catalyst. Phase III, reacting the results of the synthesis of phase II with Mannich pyrrolidine base by adapting the method used by Geschickter and Maeadow. Compound 3 as a result of purification was observed using Thin Layer Chromatography using Ethyl Acetate:Methanol (1:1) as an eluent to obtain Rf 0.46 and a melting range of 130-131 oC. The yield obtained was 51.52% with the characteristics of a reddish brown powder. This compound needs further identification using the Mass Spectrum and NMR.
Kepekaan Enterobacteriaceae Asal Cobek Batu Gado-Gado Terhadap Amoxicillin, Chloramphenicol, dan Tetracycline Hamida, Fathin; Ambarsari, Ratna; Djuhariah, Yayah Siti; Fahrudin, Fahri; Sholikha, Munawarohthus
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 17 No 2 (2024): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v17i2.1966

Abstract

Enterobacteriaceae are non-spore-forming Gram-negative bacteria that are widespread throughout the world. Most members of the Enterobacteriaceae are pathogenic bacteria in humans, animals and plants. Treatment of infections caused by Enterobacteriaceae is to use antibiotics. Enterobacteriaceae resistance to antibiotics has been widely reported in previous studies. Infections caused by antibiotic-resistant bacteria are more difficult to treated and endanger health. This bacteria can enter the body, one of the ways is through contaminated food such as gado-gado. Gado-gado is a ready-to-eat food made from various raw or partially boiled vegetables mixed with peanut sauce. Making peanut sauce is made directly without cooking using a stone mortar. Gado-gado is often found being sold on the side of the road in unhealthy hygiene and sanitation conditions. One of the unhealthy sanitation factors is using a stone mortar repeatedly without washing it. This provides an opportunity for contamination of the stone mortar and gado-gado itself. This study tested the susceptibility of Enterobacteriaceae isolates to the antibiotics amoxicillin, chloramphenicol, and tetracycline isolated from gado-gado stone mortars. Antibiotic susceptibility testing used the Kirby-Bauer disc diffusion method. Based on the antibiotic susceptibility test, it was found that three isolates, namely isolates CB1B (Klebsiella pneumoniae), CB3B (Serratia fonticola), and CB4A (Salmonella enterica) were resistant to amoxcillin, two isolates, namely CB1A (Proteus mirabilis) and CB2A (Enterobacter sp.) were intermediate. to amoxicillin, and one isolate, namely CB2B (Enterobacter sp.), was sensitive to amoxicillin. All Enterobacteriaceae isolates were sensitive to chloramphenicol and tetracycline in this study.
Co-Authors Adita Silvia Fitriana Ainun Wulandari Akhatik, Nurul Ambarsari, Ratna Andini, Issri Mila Nova Djuhariah, Yayah Siti Erwi Putri Setyaningsih Fahri Fahrudin, Fahri Fathin Hamida Febriani, Amelia H Herdini Herdini Herdini Jaya, Rendy Indra Kusuma, Ika Maruya Lia Puspitasari Mahfudza, A.R. Natasya, Fauziah Cinta Nur M, R. Nur Rahmawati Putri, Elvina Triana Rachmatiah, Tiah Risa Oktalia Sari Siswati Siswati Subaryanti, Subaryanti Syafriana, Vilya Teodhora, Teodhora Veryanti, Putu Rika Wahyuningtyas, Wahyuningtyas