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All Journal Biospecies Biology, Medicine, & Natural Product Chemistry Syntax Literate: Jurnal Ilmiah Indonesia Jambura Journal of Health Sciences and Research Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Prima Medika Sains Jurnal Kesehatan Tambusai Jurnal Locus Penelitian dan Pengabdian Buletin Kedokteran dan Kesehatan Prima Jurnal Indonesia Sosial Sains Eduvest - Journal of Universal Studies Journal of Pharmaceutical and Sciences.
Natali, Oliviti
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Perbandingan Efektivitas Ekstrak Kulit Jeruk Berastagi (Citrus Sinensis L.) Dengan Povidone-Iodine 10% Terhadap Penyembuhan Luka Sayat Pada Tikus Berdasarkan Jumlah Kolagen dan Lama Penyembuhan Luka Angin, Eka Lestari Br Perangin-; Natali, Oliviti; Lubis , Adhayani; Sumantri, Dinda Triana; Siregar, Yohana Putri Jelita
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 11 (2025): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i11.5072

Abstract

Penyembuhan luka merupakan proses biologis kompleks yang melibatkan pembentukan kolagen. Pemanfaatan bahan alami, seperti kulit jeruk Berastagi yang mengandung flavonoid, tanin, dan saponin, berpotensi mempercepat penyembuhan melalui efek anti-inflamasi, antioksidan, dan stimulasi kolagen. Penelitian ini bertujuan mengevaluasi efektivitas ekstrak etanol kulit jeruk Berastagi (EEKJ) terhadap pembentukan kolagen dan penyembuhan luka sayat pada tikus Wistar jantan, dibandingkan dengan povidone-iodine 10%. Desain penelitian menggunakan true experimental post test control group design dengan 5 kelompok, yaitu basis gel, povidone-iodine 10%, serta gel EEKJ konsentrasi 40%, 60%, dan 80%. Variabel yang diamati adalah jumlah kolagen dan persentase penyembuhan luka. Data dianalisis dengan One-Way ANOVA dan Post Hoc test (?=0,05). Hasil menunjukkan tidak terdapat perbedaan bermakna antara kelompok basis gel, povidone-iodine 10%, dan EEKJ terhadap jumlah kolagen maupun persentase penyembuhan luka. Namun, kelompok EEKJ konsentrasi 40% menunjukkan rerata jumlah kolagen tertinggi dan konsentrasi 60% menunjukkan rata-rata persentase penyembuhan luka tertinggi (45,50) dibandingkan 40% (43,69) dan 80% (40,29). Kesimpulannya, ekstrak kulit jeruk Berastagi mampu merangsang pembentukan kolagen dan mempercepat penyembuhan luka sayat, meskipun efektivitasnya tidak berbeda signifikan dengan povidone-iodine 10%. Penelitian lanjutan diperlukan dengan jumlah sampel lebih besar, variasi konsentrasi, serta uji klinis pada manusia. Penelitian ini memberikan kontribusi ilmiah dalam pemanfaatan limbah kulit jeruk sebagai agen penyembuh luka alami yang potensial dikembangkan sebagai sediaan topikal farmasi.
Efektivitas Ekstrak Kulit Jeruk Berastagi (Citrus Sinensis L.) Yang Diberikan Secara Topikal terhadap Kadar Serum C-reactive Protein pada Luka Sayat Tikus Jantan (Rattus Norvegicus) Siregar, Yohana Putri Jelita; Natali, Oliviti; Lubis, Adhayani; Sumantri , Dinda Triana; Perangin-Angin, Eka Lestari Br
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1159

Abstract

Introduction: Cutaneous wounds in male rats (Rattus norvegicus) are widely used as models for wound-healing research. C-reactive protein (CRP) is an inflammatory biomarker that increases in response to injury. Berastagi orange peel extract (Citrus sinensis L.) is known for its anti-inflammatory properties; however, its effectiveness in reducing serum CRP levels in cutaneous wounds has not been extensively studied. Objective: This study aimed to evaluate the effectiveness of topically administered Berastagi orange peel extract on serum CRP levels in male rats with cutaneous wounds. Methods: A total of 25 male rats were divided into three groups: control, treatment with orange peel extract, and treatment with a standard ointment. Wounds were inflicted on the rats' backs, and treatments were administered for a few days. Serum CRP levels were measured using the ELISA method. Results: Results indicated that the group receiving Berastagi orange peel extract exhibited a significant reduction in CRP levels compared to the control group (p < 0.05). The standard ointment group also showed a reduction, but not as effectively as the orange peel extract. Conclusion: Berastagi orange peel extract significantly reduces serum C-reactive protein levels in male rats with cutaneous wounds. These findings support the use of natural extracts as alternatives in wound healing therapy.
Comparison of The Effectiveness of Grape Seed (Vitis Vinifera) With Aloe Vera (Aloe Vera) in The Repair of Burns in Wistar Rats Based on Wound Diameter Veronica, Yashinta Maria; Natali, Oliviti; Djohan, Djohan
Eduvest - Journal of Universal Studies Vol. 4 No. 11 (2024): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v4i11.43692

Abstract

Burns are tissue damage or loss caused by contact with heat sources such as fire, hot water, chemicals, electricity and radiation. The grape plant has an activity of pharmacological effects, which are mainly present in its seeds and fruits. Grape seed extract containing proanthocyanidin can help wound healing by promoting neovascularization, extracellular matrix remodeling, fibrolastic cell migration and differentiation. Aloe vera leaves can be used to treat skin lesions, such as burns, irradiation damage and ischemic ulcers. In addition to being a hydrating and skin- protecting agent, this gel also has healing, analgesic, and anti-inflammatory activities because aloe vera contains vitamins C and E, essential amino acids, and polysaccharides that stimulate tissue growth and cell regeneration. The objective is to determine the effectivity of burn wound repair using grape seed extract and aloe vera. This research used 24 white rats weighing 150 to 200g that divided into 4 groups, positive control group, negative control group, 10% grape seed extract treatment group, and 10% aloe vera extract treatment group. This study used an experimental method with True Experimental design with Randomized Post-test only Control Group Design, by giving 10% concentration of grape seed extract and aloe vera extract with 10% concentration to rats that has been burnt. 
Antibacterial activity of ashitaba leaf extract against Streptococcus pneumoniae Hutabarat, Tommy Daniel Patar P.; Suandy, Suandy; Natali, Oliviti; Djuang, Michelle Hendriani; Akbar, Khainir; Oentari, Widyaningsih; Putri, Riri Rizan; Dalimunthe, Siti Aisyah
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7824

Abstract

Infection by Streptococcus pneumoniae represents a significant global health concern, necessitating the exploration of novel antimicrobial agents, particularly in light of escalating antibiotic resistance. This study aimed to identify the phytochemical constituents and to evaluate the antibacterial activity of an ethanol extract of Ashitaba leaves (Angelica keiskei) against S. pneumoniae. This experimental study employed a post-only control group design. Extraction was performed using ethanol via maceration, followed by qualitative phytochemical screening. Antibacterial activity was assessed using the disc diffusion method at concentrations of 50, 100, and 150 mg/mL, with ciprofloxacin as a positive control. Inhibition zone data were analysed using non-parametric statistical tests. Phytochemical screening indicated the presence of flavonoids, alkaloids, saponins, tannins, glycosides, and steroids/triterpenoids. The extract demonstrated antibacterial activity with mean inhibition zones of 16.57 mm at 50 mg/mL, 26.23 mm at 100 mg/mL, and 29.87 mm at 150 mg/mL. Statistical analysis revealed no significant difference in inhibition zones among the three extract concentrations, whereas all concentrations differed significantly from the positive control, ciprofloxacin (53.67 mm). It is concluded that the ethanol extract of Ashitaba leaves contains diverse bioactive compounds and exhibits significant in vitro antibacterial activity against S. pneumoniae, although its efficacy remains inferior to the synthetic antibiotic ciprofloxacin.
Co-Authors AA Sudharmawan, AA Adhayani, Adhayani Angie, Evelyn Angin, Eka Lestari Br Perangin- Arhamni, Ade Dalimunthe, Siti Aisyah Dewani, Yunita Djohan Djohan Djuang, Michelle Hendriani Ferdinanda, Fransiska Ginting, Dicky Owenta Girsang, Ermi Hutabarat, Tommy Daniel Patar P. Hutagalung, Caroline Febrina Jelita Siregar, Yohana Putri Karo, Mellinia Alpatri Br Khainir Akbar, Khainir Lubis , Adhayani Lubis, Adhayani Marpaung, Hans Hotma Haposan Masyitah Masyitah Mutia, Maya Sari Nasution, Sri Wahyun Nst, Bulan Ramadhani Oentari, Widyaningsih Panjaitan, Linda Perangin-Angin, Eka Lestari Br Putri, Riri Rizan Rajagukguk, Clara Terecia Rudi Chandra Salim, Susanto Sarumpaet, Elpina Siahaan, Debora Helena Siregar, Yohana Putri Jelita Suandy, Suandy Suhartina Suhartina, Suhartina Sumantri , Dinda Triana Sumantri, Dinda Triana Tarigan, Antje Irmella Veronica, Yashinta Maria Wika Hanida, Wika Yensuari, Yensuari