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All Journal Journal of Food and Pharmaceutical Science Jurnal Farmasi Klinik Indonesia Journal of Islamic Pharmacy Journal of Islamic Medicine Pharmaceutical Journal of Indonesia Keluwih: Jurnal Kesehatan dan Kedokteran Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Farmasis: Jurnal Sains Farmasi
Wirda Anggraini
Jurusan Farmasi, Fakultas Kedokteran Dan Ilmu Kesehatan, Universitas Islam Negeri Maulana Malik Ibrahim Malang, Malang, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Evaluasi Kualitatif Penggunaan Antibiotik pada Pasien Pneumonia RS “X’’ Di Malang Wirda Anggraini
KELUWIH: Jurnal Kesehatan dan Kedokteran Vol. 3 No. 1 (2021): Keluwih: Jurnal Kesehatan dan Kedokteran (December)
Publisher : Direktorat Penerbitan dan Publikasi Ilmiah, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/kesdok.V3i1.2887

Abstract

Abstract—Pneumonia was an inflammation that occurs in the lungs accompanied by exudation and consolidation of microorganisms. In Indonesia, the prevalence of pneumonia continues to increase. Treatment of pneumonia uses antibiotic therapy. The use of antibiotics needs to be controlled by evaluating the quality of antibiotic use to prevent negative effects that can occur on patients, such as antibiotic resistance. The purpose of this study was to determine the rationality of antibiotic use in pneumonia patients. This study did with an observational method with a cross-sectional design. The study was conducted in August-September 2019. Qualitative evaluations did with Gyssen method. The results of 35 medical record samples that fulfill the criteria showed that 13,24% of cases category 0; 10,29% of cases category I; 0% of cases category II C; 20,59% of cases in category II B; 2,94% of cases category II A; 0% of cases category III B; 0% of cases category III A; 0% of cases category IV D; 11,76% of cases category IV C; 2,94% of cases category IV B; 38,24% of cases category IV A; 0% of cases category V; 0% of cases category VI. Rational cases (category 0) were 13,24% and irrational cases (categories I-IV) were 86,76%.Keywords: antibiotic, evaluation, gyssen, pneumonia Abstrak—Pneumonia adalah peradangan yang terjadi pada paru-paru yang disertai dengan adanya eksudasi dan konsolidasi mikroorganisme. Di Indonesia, prevalensi kejadian pneumonia terus mengalami peningkatan. Pengobatan pneumonia menggunakan terapi antibiotik dan terapi suportif. Penggunaan antibiotik perlu dikendalikan dengan evaluasi kualitas penggunaan antibiotik untuk mencegah dampak negatif yang bisa terjadi pada pasien, salah satunya resistensi antibiotik. Tujuan penelitian ini adalah untuk mengetahui rasionalitas penggunaan antibiotik pada pasien pneumonia. Penelitian ini dilakukan dengan metode observasional dengan desain cross-sectional. Penelitian dilaksanakan pada bulan Agustus-September 2019. Evaluasi kualitatif dilakukan dengan menggunakan metode gyssen. Hasil evaluasi 35 sampel rekam medis yang memenuhi kriteria menunjukkan bahwa 13,24% kasus kategori 0; 10,29% kasus kategori I; 0% kasus kategori II C; 20,59% kasus kategori II B; 2,94% kasus kategori II A; 0% kasus kategori III B; 0% kategori III A; 0% kasus kategori IV D; 11,76% kasus yang masuk kategori IV C; 2,94% kasus kategori IV B; 38,24% kategori IV A; 0% kategori V; 0% kasus kategori VI. Kasus yang rasional (kategori 0) sebanyak 13,24% dan kasus yang tidak rasional (kategori I-IV) sebanyak 86,76%.Kata kunci: antibiotik, evaluasi, gyssen, pneumonia
Efek Neuroprotektif Fraksi Air Daun Semanggi (Marsilea crenata Presl.) secara In Vitro Burhan Ma'arif; Muslim, Menara; Riyanti, Anisa Eka; Guhir, Abdul Malik; Amalia, Dilla; Saidah, Nisfatul Lailatus; Anggraini, Wirda; Atmaja, Ria Ramadhani Dwi; Laswati, Hening; Agil, Mangestuti
FARMASIS: Jurnal Sains Farmasi Vol 2 No 1 (2021): Farmasis : Jurnal Sains Farmasi
Publisher : Universitas PGRI Adi Buana, Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36456/farmasis.v2i1.3537

Abstract

Background: Estrogen deficiency can trigger several diseases, one of which is neurodegenerative. Neurodegenerative begins with neuroinflammation, which triggers the activation of microglia cells resulting in a pro-inflammatory activity. Potential and relatively safe therapy to use to overcome it is by using phytoestrogen compounds. Marsilea crenata Presl. is a plant that contains phytoestrogens. Objective: The purpose of this study was to analyze the neuroprotective effect of the water fraction of Marsilea crenata Presl. leaves which was shown by inhibition of neuroinflammation and marked by increased levels of MHC II against HMC3 microglia cells. Methods: IFN-γ is induced into HMC3 microglia cells for 24 hours to cause inflammatory conditions. Marsilea crenata Presl. leaves water fraction was given at a dose of 62,5; 125; and 250 µg / ml. Analysis of the neuroprotective effect of HMC3 microglia cells using the ICC method with the aid of the CLSM instrument. Results: The results of this study indicate that the water fraction of Marsilea crenata Presl. leaves can reduce MHC II expression at concentrations of 125 and 250 μg / ml with values ​​of 465,748 and 460,884 AU at p less than 0,005. Conclusion: This study concludes that the water fraction of Marsilea crenata Presl. has neuroprotective activity shown at doses of 125 and 250 μg/ml which can reduce MHC II expression in HMC3 microglia cells induced by IFN-γ. The ED50 value which has a neuroprotective effect is at a dose of 0,582 μg/ml.  
Formulation and Evaluation of Halal Non-Aromatic Moisture and Protection Cream Preparations for Hajj and Umroh Pilgrims Annisa, Rahmi; Anggraini, Wirda; Purwaningsih, Fauziyah Eni; Salsabila, Dhia Fadhilah; Samah, Moh.Alfin; Mutiah, Roihatul
Journal of Islamic Medicine Vol 8, No 2 (2024): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2024
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v8i2.26427

Abstract

Background: Protective moisturizer cream can be used by Hajj and Umrah pilgrims.They can use sunscreen moisturizer cream as a moisturizer and sunscreen to protect their skin from exposure to the sun because it does not contain alcohol or certain fragrances. Objective: This research aims to determine the halalness of ingredients, the presence or absence of aromatic content, the suitability of physical characteristics, and the effectiveness of the SPF value of halal non-aromatic Sunscreen moisturizer cream preparations using pre-experimental design research methods. Methods: The physical characteristics were evaluated, including organoleptic, homogeneity, spreadability, adhesive power, pH, and viscosity. Results: The organoleptic test results show that the Sunscreen moisturizer cream preparation has a yellowish-white color, is scentless, and has a soft texture. Homogeneity testing shows that this preparation is homogeneous. The spreadability test value of the preparation is 6.50 cm; the sticking power value is 3.77 seconds; the pH value is 5.00; the viscosity value is 5.64 cPs. The research results also show that the preparation contains halal ingredients and does not contain fragrances. Halal non-aromatic sunscreen moisturizer cream. Formula SPF value 38.332 ± 1.526 with ultra protection type. Conclusion: All evaluations of the physical characteristics of the Sunscreen moisturizer cream preparation have met the requirements for a good cream preparation, except for the viscosity test. It contains halal ingredients and has ultraprotective protection against UV light. Keyword : Cream, Sunscreen, Moisturizer, Non Aromatic, Hajj Care
Co-Authors Abdul Hakim Abdul K. Jaelani Amalia, Dilla Anik Listiyana Arief Suryadinata Burhan Ma'arif Fauna Herawati Fidia Rizkiah Inayatilah Fina Luthfiana Firda Ludfiyah Guhir, Abdul Malik Hening Laswati Putra Herawati, Fauna Hidayah, Shofi Nurul Jaelani, Abdul K. Mangestuti Agil Muslim, Menara Nurwijayanti Purwaningsih, Fauziyah Eni Rahmi Annisa Ria Ramadhani Dwi Atmaja Rika Yulia Rika Yulia Riyanti, Anisa Eka Roihatul Mutiah Roihatul Mutiah Saidah, Nisfatul Lailatus Salsabila, Dhia Fadhilah Samah, Moh.Alfin Siti Maimunah Syahrir, Ach Tifany Maulida Candra Wiraningtias, Novia Beta Yen Yen Ari Indrawijaya