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All Journal Jurnal MIPA PHARMACON Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Acta Biochimica Indonesiana The Studies of Social Sciences Vivabio : Jurnal Pengabdian Multidisiplin Jurnal Perempuan dan Anak Indonesia Borneo Journal of Pharmacy
Datu, Olvie Syenni
Pharmacy Study Program, Faculty Of Mathematics And Natural Sciences, Sam Ratulangi University, Manado, North Sulawesi, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Immunology & microbiology Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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Journal : Jurnal MIPA

 1 
Pengaruh Pemberian Sari Buah Salak (Salacca zalacca) terhadap Profil lipid dan Berat Badan Tikus Model Hiperlipidemia dan Obesitasda Datu, Olvie Syenni; Lebang, Julianri Sari; Rumondor, Erladys Melindah
Jurnal MIPA Vol 11, No 1 (2022)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jm.v11i1.36530

Abstract

Cardiovaskular disease is the number one cause of death in the world, an estimated 17.9 million people die each year. Several risk factors that contribute to the occurrence of heart disease such as hypertension, diabetes mellitus, hyperlipidemia, and obesity. Snake Fruit is a fruit that is available in large quantities both in volume and variety. Snake Fruit is rich in antioxidants that can be used to treat hyperlipidemia and overweight. North Sulawesi is one of the centers of Snake Fruit production, especially in the southeast Minahasa area. This study aimed to test the effectiveness of Snake Fruit juice on the lipid profile of hyperlipidemic and obese rats induced by a high-fat diet in the form of used cooking oil, quail egg yolk and 0.01% PTU solution. The study used 5 groups, namely the negative control group was given aquadest, the positive control group was given simvastatin and the treatment group was given Snake Fruit juice with concentrations of 2%, 4% and 8%. The parameters observed in this study were body weight, lipid profile, and glucose profile. blood. The study showed that the administration of Snake Fruit juice had a significant effect on the lipid profile of rats for all parameters on the lipid profile and had a significant effect on weight loss and blood glucose levels where p < 0.05 and there was no significant difference between each treatment group in both lipid profile parameters. , body weight and blood glucose levels.
Efek Pemberian Ekstrak Buah Salak (Salacca zalacca) dalam menurunkan kadar glukosa darah pada tikus model Diabetes melitus Olvie Syenni Datu; Julianri Sari Lebang; Elly Juliana Suoth
Jurnal MIPA Vol. 12 No. 1 (2023)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jm.v12i1.44267

Abstract

Diabetes Mellitus is a chronic disease characterized by elevated blood glucose levels. Diabetes Mellitus is a global disease that affects 536.6 million people in the world and is predicted to increase to 643 million people in 2030 and 783.2 million people in 2045. Snake fruit is one of the fruits in North Sulawesi that has the potential to be developed. be an alternative to treatment. The aims of this study is was to examine the effect of snake fruit extract in rats with diabetes mellitus model. The study used 5 groups, negative control group was given NaCMC solution, the positive control group was given metformin and the treatment group was given snake fruit extract with concentrations of 10%, 20% and 40%. The parameters observed in this study were body weight and blood glucose profile. The study showed that the administration of snake fruit extract had a significant effect on blood glucose profiles and body weight with p < 0.05 and there were significant differences between each treatment group both in the glucose profile parameters and body weight of rats.
Perbandingan Aktivitas Analgesik Infusa Kelopak Bunga Rosella Varietas Merah dan Ungu pada Tikus Putih Julianri Sari Lebang; Jainer Pasca Siampa; Olvie Syenni Datu
Jurnal MIPA Vol. 13 No. 1 (2024): Artikel
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jm.v13i1.50482

Abstract

Data dunia menunjukkan 20% dari populasi dunia menderita nyeri kronis. Penggunaan antinyeri dalam jangka waktu panjang dapat menimbulkan efek samping pada saluran pencernaan dan ginjal. Kelopak bunga rosella diketahui memiliki banyak manfaat dalam pengobatan. Tujuan penelitian ini adalah untuk membandingkan aktivitas analgesik dari infusa kelopak bunga rosella merah dan ungu. Pengujian aktivitas dilakukan dengan metode geliat menggunakan 6 kelompok hewan yang terdiri dari 4 kelompok perlakuan yang diberi infusa rosella merah 25% dan 50%(P1 dan P2), infusa rosella ungu 25% dan 50% (P3 dan P4), kontrol negatif, dan kontrol positif. Asam asetat 2% (i.p) digunakan sebagai penginduksi nyeri. Hasil penelitian menunjukkan nilai rata-rata geliat yang paling rendah dan persen proteksi analgesik (PPA) yang paling tinggi ditunjukkan oleh kelompok P2. Uji statistic menggunakan ANOVA one way dan uji lanjut LSD menunjukkan tidak terdapat perbedaan signifikan nilai (PPA) antara kelompok P1, P3 dan P4, sedangkan kelompok P2 tidak berbeda signifikan dengan kelompok kontrol positif. Dapat disimpulkan bahwa aktivitas analgesik infusa rosella merah 50% lebih baik dibandingkan infusa rosella merah 25%, rosella ungu 25 dan 50%.
Co-Authors Adithya Yudistira Annisa Hamka Ciptanti Prakarsa Elly Suoth ERLADYS MELINDAH RUMONDOR, ERLADYS MELINDAH Fatimawali , Fatimawali Fatimawali . Gayatri Citraningtyas Imam Jayanto Irma Antasionasti Jainer Pasca Siampa Julianri Sari Lebang Julianri Sari Lebang Julianri Sari Lebang, Julianri Sari Khairuddin Lengkong, Cheisy Anastasya Gratia Lestari, Utami Sasmita Rundengan, Gerald Edward Sekeon, Crista Gretasia Siampa, Jainer Pasca Stevi Imanuela Yohanis Surya Sumantri Abdullah Tamahiwu, Natasya Ester Rebeca Trina Ekawati Tallei Utami Sasmita Lestari Widdhi Bodhi widdhi Bodhi Widya Astuty Lolo, Widya Astuty