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PENINGKATAN PENGETAHUAN MASYARAKAT TENTANG DEPRESI MELALUI EDUKASI Mahmudah, Nur; Putri, Refsya Azanti; Retinovaliani, Aviolena; Faj’riati, Nur Alfi Khoirul; A’dilah, Anis Afkar; Ningtiyas, Amelia Rizki; Riyadi, Eka Putri Widya Arsia; Findawan, Geofany Hargi; Fadhilla, Hana; Putri, Erika Arista; Meiliana, Sherin Isna; Hart, A’Ang Yuanita; Maharani, Maisa; Ayu, Rakyan Wening Puspa; Dewi, Sri Kumala; Hanifah, Zulfa Nur; Syahdiba, Natasya Maula; Ramadhani, Salsabila Putri; Sayekti, Nurul Cahyaning Nardi
Jurnal Pengabdian Masyarakat Medika Vol 2. No. 2, September 2022
Publisher : Universitas Muhamamdiyah Surakarta

ABSTRAK Pandemi COVID-19 merupakan stressor yang cukup berat bagi masyarakat, yang memicu kejadian gangguan jiwa. Indonesia mengalami peningkatan kasus gangguan jiwa sebanyak 2 kali lipat selama pandemi, baik berupa stres maupun depresi. Berdasarkan hal tersebut, diperlukan adanya informasi tentang gangguan jiwa, utamanya depresi pada masyarakat, sehingga diharapkan masyarakat memiliki pengetahuan tentang gejala penyakit tersebut dan mengetahui hal yang harus dilakukan jika memiliki gejala depresi. Tujuan kegiatan ini untuk memberikan edukasi kepada masyarakat tentang depresi terutama faktor risiko dan pengobatannya. Metode yang dilakukan berupa pemberian pretest, pemaparan materi dan post-test. Analisis nilai antara pretest dan post-test terdapat perbedaan signifikan (p<0,05). Kesimpulan kegiatan ini bahwa edukasi meningkatkan pengetahuan masyarakat tentang depresi. ABSTRACT The COVID-19 pandemic is a fairly heavy stressor for the community, which triggers the occurrence of mental disorders. Indonesia experienced a doubled cases of mental disorders during the pandemic, both of stress and depression. Based on this, it is necessary to provide information about mental disorders, especially depression to the public, so that people are expected to increase their knowledge about depression symptomps and know what to do if they have its. The purpose of this activity is to provide education to the public about depression, especially its risk factors and treatment. The method used is in the form of pretest, material presentation and post-test. After analyzing the values between the pretest and post-test there was a significant difference (p<0.05). We concluded that education increases public knowledge about depression.

Bacterial Profile and Antimicrobial Resistance Patterns of Pleural Empyema in Pekanbaru Hospitals Yovi, Indra; Safari, Dodi; Syah, Nur Afrainin; Anggraini, Dewi; Hanifah, Zulfa Nur; Shapira, Vanesya Zahrani; Elliyanti, Aisyah
Jurnal Respirologi Indonesia Vol 44, No 1 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i1.590

Background: Empyema is a problem worldwide due to its high incidence, mortality, and morbidity rates. So, administering antibiotics is mandatory to treat the disease. It should be sensitive to the causal microorganisms and avoid resistant ones for treatment efficacy. This research aimed to determine bacterial profile and antimicrobial resistance, which can be fundamental foundations for clinical practices in the treatment of patients, especially in Pekanbaru.Methods: This was a cross-sectional study from medical records at Arifin Achmad and Eka Hospitals from January 1, 2015, to December 31, 2022, including culture and antibiotic resistance test results with samples from pleural fluid and antibiotic susceptibility test using VITEK 2.0.Results: A total of 197 pleural fluid specimens were obtained. Gram-negative bacteria were found to be the most prevalent at 79.7%, namely Klebsiella pneumoniae (18.5%), Escherichia coli (12.0%), and Pseudomonas aeruginosa (11.0%). Gram-positive bacteria were found at 12.2%, the most common being Staphylococcus aureus (6.1%) and Enterococcus faecalis (2.0%). Antibiotic sensitivity tests for Gram-negative bacteria showed that amikacin and tigecycline were the most sensitive, and Gram-positive bacteria showed the most sensitivity to linezolid, tigecycline, and vancomycin. The resistance of Klebsiella pneumoniae and Escherichia coli to cephalosporins was 18.5% and 75.0%, respectively. The resistance of Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa to carbapenems was 8.0%, 13.0%, and 53.0%, respectively.Conclusion: Gram-negative is the most common microorganism found in pleural empyema. The resistance of multiresistant bacteria to antibiotics is high and requires supervision to apply appropriate antibiotic administration based on local antimicrobial patterns and the need to strengthen antimicrobial stewardship programs.

UJI AKTIVITAS SITOTOKSIK KOMBINASI DOKSORUBISIN DAN EKSTRAK ETANOL DAUN KEMANGI (Ocimum sanctum L.) TERHADAP SEL MCF-7 Hanifah, Zulfa Nur; Da’i, Muhammad
Usadha Journal of Pharmacy Vol. 1 No. 3 (2022): Agustus
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/ujp.v1i3.96

Doksorubisin merupakan antibiotik antrasiklin yang dianggap efektif sebagai salah satu agen kemoterapi antikanker dan banyak digunakan. Penggunaan doksorubisin sebagai agen kemoterapi dapat digunakan baik sebagai agen tunggal maupun kombinasi. Namun, penggunaan doksorubisin pada terapi kanker ternyata memberikan beberapa efek samping. Penelitian sebelumnya menunjukan bahwa ekstrak etanol daun kemangi (Ocimum sanctum L.) mempunyai efek sitotoksik terhadap sel MCF-7 dengan nilai IC50 sebesar 176,37 μg/mL. Kombinasi antara doksorubisin dan ekstrak tanaman telah terbukti memiliki potensi dalam meningkatkan efektivitas ekstrak dan sensitivitasnya terhadap sel MCF-7. Metode yang digunakan pada uji sitotoksisitas dan uji kombinasi adalah metode MTT-assay. Pada penelitian ini didapatkan nilai IC50 doksorubisin dan ekstrak etanol daun kemangi secara berturut-turut sebesar 3,58 µg/mL dan 721,36 µg/mL. Hal ini menunjukkan bahwa ekstrak etanol daun kemangi dalam penelitian ini tidak memiliki aktivitas sitotoksik. Kombinasi ekstrak etanol daun kemangi dan doksorubisin menunjukkan efek sinergisme kuat terhadap sel MCF-7 dengan nilai indeks kombinasi sebesar 0,121 pada konsentrasi optimal ekstrak-doksorubisin 360 μg/mL – 1 μg/mL(1/2 IC50 – 1/4 IC50) dan memiliki indeks kombinasi tertinggi 0,663 pada konsentrasi ekstrak-doksorubisin 90 μg/mL – 1 μg/mL (1/8 IC50 – 1/4 IC50). Hal ini menujukkan bahwa kombinasi doksorubisin dan ekstrak etanol daun kemangi memiliki potensi untuk dijadikan agen kokemoterapi.

Bacterial Profile and Antimicrobial Resistance Patterns of Pleural Empyema in Pekanbaru Hospitals Yovi, Indra; Safari, Dodi; Syah, Nur Afrainin; Anggraini, Dewi; Hanifah, Zulfa Nur; Shapira, Vanesya Zahrani; Elliyanti, Aisyah
Jurnal Respirologi Indonesia Vol 44 No 1 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i1.590

Background: Empyema is a problem worldwide due to its high incidence, mortality, and morbidity rates. So, administering antibiotics is mandatory to treat the disease. It should be sensitive to the causal microorganisms and avoid resistant ones for treatment efficacy. This research aimed to determine bacterial profile and antimicrobial resistance, which can be fundamental foundations for clinical practices in the treatment of patients, especially in Pekanbaru.Methods: This was a cross-sectional study from medical records at Arifin Achmad and Eka Hospitals from January 1, 2015, to December 31, 2022, including culture and antibiotic resistance test results with samples from pleural fluid and antibiotic susceptibility test using VITEK 2.0.Results: A total of 197 pleural fluid specimens were obtained. Gram-negative bacteria were found to be the most prevalent at 79.7%, namely Klebsiella pneumoniae (18.5%), Escherichia coli (12.0%), and Pseudomonas aeruginosa (11.0%). Gram-positive bacteria were found at 12.2%, the most common being Staphylococcus aureus (6.1%) and Enterococcus faecalis (2.0%). Antibiotic sensitivity tests for Gram-negative bacteria showed that amikacin and tigecycline were the most sensitive, and Gram-positive bacteria showed the most sensitivity to linezolid, tigecycline, and vancomycin. The resistance of Klebsiella pneumoniae and Escherichia coli to cephalosporins was 18.5% and 75.0%, respectively. The resistance of Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa to carbapenems was 8.0%, 13.0%, and 53.0%, respectively.Conclusion: Gram-negative is the most common microorganism found in pleural empyema. The resistance of multiresistant bacteria to antibiotics is high and requires supervision to apply appropriate antibiotic administration based on local antimicrobial patterns and the need to strengthen antimicrobial stewardship programs.

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