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All Journal Medula JK Unila (Jurnal Kedokteran Universitas Lampung) Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks
Putu Ristyaning Ayu
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Sindrom Obstructive Sleep Apnea William Bahagia; Putu Ristyaning Ayu
Medula Vol 9 No 4 (2020): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i4.238

Abstract

Obstructive Sleep Apnea (OSA) is a disorder and part of a complex sleep disorder breathing syndrome. OSA symptoms often occur althought it difficults to detect. If OSA does not get good management, it will cause long-term health problems. OSA is a condition of periodic upper airway obstruction during sleep that causes the breath to stop intermittently, either completely (apnea) or partial (hypoapnea). This condition is occurring in the upper respiratory tract (mainly in the oropharynx) resulting in decreased air flow. OSA symptoms are classified into night symptoms and daytime symptoms. Recurrent episodes of apnea, intermittent hypoxia and sleep fragmentation may affect organ function, especially the central nervous system and cardiovascular system, resulting in changes in metabolic balance. The gold standard for diagnosis of OSA is through a night sleep check with Polysomnography / PSG). The index used to determine the degree of mild-bad OSA is the Apnea-Hypoapnea Index (AHI), which counts the number of obstructive events per hour during sleep and the results of cardiorespiratory monitoring. Management of OSA consists of surgical therapy and non-surgical therapy. Positive airway pressure (PAP) is known to be the gold standard therapy for OSA. This article is a literature study to discuss pathophysiology, risk factors, signs and symptoms, to the handling and prevention of OSA.
Peran Insulin-like Growth Factor-1 dalam Patofisiologi Gangguan Pendengaran Anggita Dwi Paramitha; Tri Umiana Soleha; Putu Ristyaning Ayu
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.270

Abstract

Sensorineural hearing loss (SNHL) is considered a disease that cannot be treated due to irreversible nerve damage. SNHL occurs due to damage to the inner ear/cochlea namely hair cells and supporting cells (HCs and SCs). Hair cells that carry the sound into neurochemical damage are triggered by ROS. There are several factors that affect hearing loss. Insulin-like growth factor-I (IGF-I) belongs to the family of insulin polypeptides, which play a central role in embryonic development and adult nervous system homeostasis by endocrine, autocrine, and paracrine mechanisms. IGF-I is the basis for regulation of cochlear development, growth, and differentiation, and its mutation is related to hearing loss. Low IGF-I levels have been shown to correlate with various human syndromes that show a hearing loss.
Potensi Bit Merah (Beta vulgaris L.) sebagai Nefroprotektor dari Kerusakan Ginjal akibat Radikal Bebas Nabila Shafira; Putu Ristyaning Ayu; Susianti
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.277

Abstract

Every human being is born with a pair of kidneys located retroperitoneal in the body cavity. Kidney is an organ that filters blood and gets rid of the body’s metabolic waste. In addition, kidneys also play an important role in the excretion of drugs from the body, thus making it vulnerable to damage due to drugs and free radicals. in small amounts, free radicals can be converted into a non-toxic compound through the defence mechanism of endogenous antioxidants. However, when exposed to large amounts of free radicals, there will be an imbalance between the antioxidants produced and the antioxidants needed by the body. Overtime, the body will run out of antioxidants and free radicals will accumulate in the body. These free radicals wil form a covalent bond with the cell in the body especially in the proximal convoluted tubules of the kidneys and cause damage to the kidneys. This mechanism is called oxidative stress. Decreased kidney function can be assessed through blood urea and creatinine examination. Beetroot (Beta vulgaris L.) is a root plant that is generally used as vegetables. Beetroot is one of vegetables with the highest antioxidants content. Several studies have shown that beetroot extract has activity as a nephroprotector due to its abundant exogenous antioxidant contents. The antioxidant that are found in beetroots are flavonoids, betacyanins, betaxantins, ascorbic acidz, and carotenoids.
Pengaruh Jintan Hitam (Nigella sativa) Terhadap Sindrom Metabolik Pada Wanita Menopause Diwanti Aulia Hasanah; Sutarto; Putu Ristyaning Ayu; Selvi Rahmawati
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.281

Abstract

Menopause is permanently cessation of menstruation for at least 12 months in women with a median age of 51 years. The incidence of chronic diseases will be increased in menopause women, so that it affects their quality of life. Changes in estrogen levels during menopause are associated with an increase in body fat. This is an alarm sign for women's health because it causes an increase in blood pressure, insulin resistance and dyslipidemia. These changes can contribute to an increased risk of metabolic syndrome in menopausal women. Black cumin plant is a spice plant belonging to the Ranunculaceae family and grows in various regions of the world. Black cumin seeds and oils are usually used as traditional medicine for various diseases. The main bioactive substance in black cumin, thymoquinone, has a major influence in improving metabolic syndrome in menopausal women, especially in controlling lipid and blood sugar profiles. The mechanism of hypolipidemic action of N. sativa based on research caused by an increase in the regulation of LDL molecules through receptor-mediated endocytosis, and several other mechanisms. The hypoglycemic effect of N. sativa is by maintaining the integrity of pancreatic β cells, causing an increase in insulin levels.
Peran Albumin Glikat Pada Kontrol Glikemik dan Diagnosis Diabetes Mellitus Sharlene Sabrina; Putu Ristyaning Ayu; Iswandi Darwis
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.287

Abstract

Diabetes Mellitus or DM is a chronic metabolic syndrome, which is usually characterized by excess glycemic conditions or hyperglycemia. The incidence of diabetes is increasing rapidly in populations in Asia, especially in countries with fairly fast economic growth. At present, there are around 171-194 million people in the world who suffer from diabetes. Fructosamine, glycated albumin and HbA1c are glycate proteins used to evaluate glycemic control in diabetic patients. Albumin glycate (GA) has a much shorter half-life than erythrocytes, so glycemic albumin can reflect glycemic control on a short-term basis (around 2-3 weeks) compared to HbA1c. In addition, GA has faster and greater changes compared to HbA1c, so GA may be more useful for describing glycemic control. The concentration of albumin glycate can be determined in several ways, namely by using the colorimetric method with thiobarbituric acid, the enzymatic method with proteinase and ketamine oxidase, the HPLC chromatography method, and the mass spectrometry method. Several studies have concluded that there is a strong relationship between glycated albumin, HbA1c and fasting blood glucose so that glycated albumin can be used as a glycemic control tool for early detection of diabetes complications, aiding diagnosis of diabetes and assisting in the selection of adequate management for diabetes patients.
PENATALAKSANAAN HOLISTIK PADA PEREMPUAN USIA 73 TAHUN DENGAN SINDROMA METABOLIK Vicki Lusbiyanti Utami; Putu Ristyaning Ayu
Medula Vol 11 No 2 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i2.289

Abstract

Indonesia  dihadapkan  pada banyak masalah  kesehatan, salah satunya yaitu penyakit degeneratif. Penyakit degeneratif merupakan penyakit kronik menahun yang banyak mempengaruhi kualitas hidup serta produktivitas seseorang. Sindrom Metabolik (SM) merupakan kelainan metabolik kompleks.Komponen utama sindrom metabolik adalah obesitas, resistensi insulin, dislipidemia, dan hipertensi.Penyakit seperti hipertensi dan diabetes perlu dikelola secara komprehensif meliputi tatalaksana farmakologis dan non farmakologis.Menerapkan  pendekatan  dokter  keluarga  secara  holistik  dan  komprehensif dalam mendeteksi faktor risiko internal dan eksternal serta menyelesaikan masalah berbasis Evidence Based Medicine yang bersifat family-approached, patient-centered, dan communit oriented. Studi yang dilakukan adalah laporan kasus.Data primer diperoleh melalui anamnesis, pemeriksaan fisik dan kunjungan ke rumah.Data sekunder didapat dari rekam medis pasien.Pasien mengatakan tidak memiliki keluhan apapun.Pasien  mengatakan datang untuk memeriksakan kesehatannya serta membutuhkan surat rujukan ke RS tipe C untuk mendapatkan obat suntik terkait kencing manisnya. Pasien telah menderita kencing manis dan darah tinggi sejak ±7 tahun yang lalu, pasien mengetahui penyakitnya tersebut ketika melakukan skrining sebelum operasi Ca Servix di RSCM.  Pola makan pasien belum dapat dikontrol.Riwayat keluarga pasien yang terkena diabetes mellitus tidak ada, sedangkan riwayat darah tinggi ditemukan juga pada seluruh saudara kandung pasien dan ibu dari pasien serta suami pasien. Penegakan diagnosis dan penatalaksanaan pada pasien ini telah dilakukan secara holistik, patient centered, family approach dan community oriented berdasarkan beberapa teori dan penelitian terkini. Pada proses perubahan perilaku, pasien sudah mencapai tahap trial.
Indeks Trombosit Pada Penderita Preeklampsia di RSUD DR. H. Abdul Moeloek Provinsi Lampung Nurul Utami; Putu Ristyaning Ayu; Ratna Dewi Puspitasari; Risti Graharti
Jurnal Kedokteran Universitas Lampung Vol 2, No 2 (2018): Jk Unila
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v2i2.1944

Abstract

Preeklampsia pada kehamilan adalah kelainan malfungsi endotel pembuluh darah atau vaskular yang menyebar luas sehingga terjadi vasospasme setelah usia kehamilan 20 minggu. Preeklamsi mengakibatkan terjadinya penurunan perfusi organ dan pengaktifan endotel yang menimbulkan terjadinya hipertensi, edema, dan dijumpai proteinuria > 300 mg per 24 jam atau 30 mg/dl (+1 pada dipstik) dengan nilai sangat fluktuatif saat pengambilan urine sewaktu.1 Ukuran trombosit, ketika diukur sebagai mean platelet volume (MPV), merupakan indikator dari aktivitas trombosit. Trombosit yang berukuran lebih besar memiliki potensi protrombotik, aktivitas enzimatik dan metabolik yang lebih besar pula. 1 Iskemia plasenta akan menghasilkan radikal bebas yang menyebabkan terbentuknya peroksida lemak yang akan membentuk radikal toksik dan merusak sel endotel. Iskemia plasenta juga diikuti dengan lepasnya sejumlah faktor vasoaktif (TNF-α dan IL) yang mengganggu fungsi endotel, fungsi platelet dan mengubah keseimbangan antara vasokonstriksi dan vasodilatasi.2 Vasospasme yang terjadi juga menginduksi agegrasi platelet dan kerusakan endotel yang menambah konstribusi dalam mempertahankan disfungsi platelet dan memicu terpakainya platelet. Terjadinya trombositopenia yang merupakan tanda paling penting dari tingkat keparahan preeklampsia. Pada 50% kasus preeklampsia berhubungan dengan trombositopenia.Kata kunci: trombosit, preeklamsie, wanita hamil
Hubungan Antara Polip Serviks dengan Ancaman Abortus pada Kehamilan Muda Ratna Dewi Puspitasari; Putu Ristyaning Ayu; Nurul Utami; Risti Graharti
Jurnal Kedokteran Universitas Lampung Vol 2, No 2 (2018): Jk Unila
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v2i2.1954

Abstract

Polip merupakan lesi atau tumor padat jinak berupa adenoma maupun fibroadenoma yang tumbuh menonjol dan bertangkai, tumbuh di permukaan mukosa serviks (bagian endoserviks atau intramukosal serviks) dengan variasi eksternal atau regio vaginal serviks. Polip serviks paling banyak terjadi pada wanita usia reproduksi, namun yang paling rentan terhadap penyakit ini adalah perempuan usia 40 sampai 50 tahun. Polip serviks dapat ditemukan pada insiden yang memicu produksi hormon seperti pada wanita hamil.1Kelainan ginekologi yang sering diderita oleh wanita hamil dengan usia kehamilan muda adalah ancaman keguguran. Penegakan diagnosis ancaman abortus didapatkan dari anamnesis, seperti keluhan keluar darah dari kemaluan disertai nyeri perut ringan atau tidak sama sekali, dan usia kehamilan pasien < 20 minggu. Pada pemeriksaan inspekulo biasanya OUE tertutup, perdarahan dapat terlihat dari ostium, dan tidak ada kelainan pada serviks. Pada pemeriksaan dalam, OUE tertutup, tidak terdapat nyeri goyang serviks. Pada pemeriksaan tes kehamilan positif, dan pada pemeriksaan USG tampak janin masih hidup. 2 Infeksi vagina pada kehamilan berhubungan dengan terjadinya abortus atau partus sebelum waktunya sebanyak 2%. Namun untuk etiologi infeksi pada genitalia pasien harus dicari lebih lanjut dengan swab vagina dan pemeriksaan mikroskopis untuk mengetahui apakah infeksi ini disebabkan oleh bakteri, parasit ataukah jamur. Dugaan lain diakibatkan perubahan serviks akibat infeksi seperti polip serviks.Kata kunci: polip serviks, wanita hamil, abortus
Analisis Korelasi Jumlah Trombosit dengan Nilai Mean Platelet Volume to Platelet Count Ratio (MPR) pada Pasien Covid-19 Putu Ristyaning Ayu; Ridha Riano Fathunnisa
Medula Vol 13 No 1 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i1.567

Abstract

Coronavirus disease 2019 (Covid-19) is an infectious disease caused by SARS-CoV-2. The number of Covid-19 cases in Indonesia until November 2022 reached 6.7 million confirmed cases of Covid-19 and 160 thousand of them died. In treating Covid-19 patients quickly and accurately and reducing mortality from Covid-19, biomarkers are needed to predict patient mortality. Platelets, Mean Platelet Volume (MPV) and Mean Platelet Volume-To-Platelet Ratio (MPR) have been studied extensively and are thought to be used as predictors of the severity of Covid-19 patients. The design of this study was an observational analytic study with a cross-sectional approach which was carried out on 60 confirmed Covid-19 patients for the January-December 2021 period at Bandar Negara Husada Hospital. Based on the statistical analysis, the average platelet count was 260.5 and the MPR value was 0.04, and the results of the Pearson bivariate correlation analysis obtained r = 0.850 and p = 0.005. This study showed that there is a relationship between platelet count and MPR as a predictor of mortality and there is a difference between platelet count and MPR values in Covid-19 patients.
Miopia Ringan Pada Anak Zenith Puspitawati; Putu Ristyaning Ayu; Rani Himayani
Medula Vol 13 No 4.1 (2023): Medula - Edisi Spesial (Special Sense)
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i4.1.707

Abstract

Myopia is a serious health problem because its prevalence continues to increase worldwide. Myopia is a condition in which incoming light falls in front of the retina, causing blurred vision when looking at distant objects. In 2050 it is predicted that at least 49.8% of the world's population will suffer from high myopia of 9.8%. In children, refractive disorders, such as myopia, are often associated with vision care factors, however, several studies suggest that other factors have a significant relationship with the occurrence of myopia, namely genetic, environmental, gender, sleep duration, and economic status. This study aims to get an overview of mild myopia in children. The type of research is a literature review obtained from Text Books, Google Search, and Google Scholar. Found 7 literature. The results of the study found that there was no significant relationship between genetic variables and existing myopia. However, in another study, children with myopia parents had a higher prevalence of myopia. Factors that have a relationship with the incidence of myopia are environmental factors.
Co-Authors Anggita Dwi Paramitha Ari Irawan Diwanti Aulia Hasanah Evy Afriyani Iswandi Darwis Nabila Shafira Nurul Utami Oktoba, Zulpakor Rani Himayani Ratna Dewi Puspita Sari Ridha Riano Fathunnisa Risti Graharti Selvi Rahmawati Sharlene Sabrina Susianti Susianti Sutarto Tri Umiana Soleha Vicki Lusbiyanti Utami William Bahagia Zenith Puspitawati