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All Journal JURNAL FARMASIMED (JFM) International Journal of Health Sciences Usadha Parapemikir Jurnal Ilmiah Farmasi BIOCITY: Journal of Pharmacy Bioscience and Clinical Community Usadha Journal of Pharmacy Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Kunir: Jurnal Farmasi Indonesia (KJFI) BOHSEJ (Bhamada Occupational And Health Safety Environment Journal) Bhamada: Jurnal Ilmu dan Teknologi Kesehatan (E-Journal) JABI: Jurnal Abdimas Bhakti Indonesia
Listina, Osie
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Usadha

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Uji Efektivitas Antiinflamasi Ekstrak Etanol dan Fraksi Daun Ciplukan (Physalis angulata L.) Terhadap Mencit Putih Jantan (Mus musculus) Listina, Osie
Usadha Vol 3 No 1 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i1.8757

Abstract

Inflammation is a local protective response caused by tissue damage. Antiinflammatory drugs steroids and non steroids have many side effects so that there are many antiinflammatory development derived from natural materials, especially in plants.This study aimed to determine the anti-inflammatory effects of ethanol extract, N-hexane fraction and ethyl acetate fraction with doses of 600mg/kgBW, 1200mg/kgBW and 1800mg/kgBW. The method used was the production of udem induced with 1% carragenin subplantar. The study was conducted by administering carragenine as an inflammatory mediator on the feet of mice, then administering orally suspension Ethanol extract, N-hexane fraction and ethyl acetate fraction. Sodium CMC was as a negative control and diclofenac sodium was as a positive control. Measurements were taken every 30 minutes for 6 hours after induction of 1% carragenin. Based on the result of research, ethanol extract with dose of 600mg/kgBB had anti-inflammatory power of 48,43%, N-hexane fraction with dose 1200mg/kgBB had antiinflammatory power of 33,21% and ethyl acetate fraction with dose 1800mg/kgBB had anti inflammatory power equal to 50,08% and the most effective dose of anti inflammatory power of ethanol extract and ciplukan leaf fractionation at fraction of ethyl acetate 1800mg / kgBB with anti inflammatory value of 50,08%.
Uji Aktivitas Afrodisiaka Sediaan Tablet Effervescent Ekstrak Kombinasi Buah Pare (Momordica Charantia L.) Dan Bawang Putih (Allium Sativum L.) Pada Mencit Putih Jantan (Mus Musculus L.) Listina, Osie; Nurhidayati, Lailiana Garna; Fia, Nela Selfi Nur Okta
Usadha Vol 2 No 2 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i2.7467

Abstract

Aphrodisiacs are substances derived from food or medicine that can enhance sexual desire. This study aimed to evaluate the aphrodisiac activity of effervescent tablet formulations containing extracts of bitter melon (Momordica charantia L.) and garlic (Allium sativum L.), both individually and in combination, in male white mice (Mus musculus L.). The ICC method (Introduction, Climbing, Coitus) was applied to 25 male Wistar mice divided into five groups. Group I served as the negative control and received distilled water orally. Group II was administered an effervescent tablet solution containing bitter melon extract at a single dose of 980 mg/kg BW. Group III received an effervescent tablet solution containing garlic extract at a single dose of 150 mg/kg BW. Group IV was given a combination effervescent tablet solution at a ½:½ ratio (bitter melon extract 490 mg/kg BW and garlic extract 75 mg/kg BW). Group V received a combination effervescent tablet solution at a 1:1 ratio (bitter melon extract 980 mg/kg BW and garlic extract 150 mg/kg BW). Observations were conducted for 2 hours, recording the frequency of ICC behaviors. Data were analyzed using SPSS with ANOVA followed by Post Hoc tests. The results showed that all treatment groups exhibited significant differences in aphrodisiac activity, with the highest frequency observed in the 1:1 combination of bitter melon extract (980 mg/kg BW) and garlic extract (150 mg/kg BW) compared to other effervescent tablet formulations.
Formulasi dan Uji Fisik Ekstrak Biji Alpukat (Persea aericana Mill) dengan Cangkang Telur Sebagai Body Scrub Fahamsya, Arifina; Listina, Osie
Usadha Vol 2 No 2 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i2.7478

Abstract

Avocado seeds contain secondary metabolites such as alkaloids, flavonoids, saponins, tannins, and vitamin E, which are beneficial for skin care. A body scrub is a skin care preparation in the form of a liquid emulsion consisting of an oil phase and an aqueous phase, combined with abrasive particles that function to moisturize, cleanse skin pores, remove dead skin cells, and serve as a carrier for active compounds into the skin. This study aims to formulate a body scrub containing ethanol extract of avocado seeds that meets physical quality requirements and to determine its irritation potential. The ethanol extract of avocado seeds was obtained through maceration and remaceration methods. Four formulations were prepared: F0 (base), F1 (1%), F2 (5%), and F3 (10%). Physical evaluations included organoleptic testing, pH measurement, homogeneity, spreadability, adhesiveness, viscosity, and irritation testing. The results showed that the formulated body scrub met the physical quality requirements, with irritation scores ranging from 0.3 to 1.3, indicating very mild to mild irritation.
OPTIMASI EFEK ANALGETIK SIRUP EKSTRAK DAUN BELUNTAS (Pluchea Indica (L.) Less.) TERHADAP MENCIT JANTAN PUTIH (Mus Musculus) DENGAN METODE RANGSANG PANAS Listina, Osie
Usadha Vol 1 No 2 (2022): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Beluntas plants generally grow wild in dry areas and have enormous benefits in treatment such as eliminating body odor, increasing appetite, overcoming pain and reducing fever. Beluntas leaves contain flavonoids which help the process of relieving pain. Pain is an uncomfortable sensory and emotional feeling related to (threatening) tissue damage. This study aimed to determine whether there is an analgesic effect of beluntas leaves extract syrup. This study was experimental using 25 mice which were divided into 5 groups. The negative control group was given aquades, positive control group was given paracetamol, and 3 experimental groups were given beluntas leaves extract syrup, each with a dose of 150mg/kgBB, 300 mg/kgBB, and 600mg/kgBB. Testting of analgesic effect was conducted by giving pain to test animals, in the form of hot stimulus with temperature of 550C. The response of the mice observed was the licking of the feet and or jumping. Observations were made for 1 minute. Observations were made before giving the test substance, and then successively in the 30, 60, 90, and 120 minutes after administration of the test substance. The results showed the number of responses to pain stimuli in the group of mice given beluntas leaves extract syrup began to decline in the 30 minute and continued to give effect in the 60 minute. In the 90th minute the analgesic effect began to decline, but it still showed the analgesic effect.At the second and third concentrations (300mg/kgBW : 600mg/kgBW) syrup of beluntas leaf extract (Pluchea indica (L.) Less.) had the best analgesic effect.
Co-Authors Afina, Afina Agung Nur Cahyanta, Agung Nur Aisy, Syifa Rihadatul Alfiraza, Ery Nourika Andi Kamal M. Sallo Angkasa, Adelya Putri Apriliani, Isna Apriyani, Nala Firda Ayundari, Sukma Marifat Azam, Rizki Restiana Belangi, Siska Putri Desi Sri Rejeki Eko Prastyo Fahamsya, Arifina Fahamsya, Arini Fia, Nela Selfi Nur Okta Fitri Lestari, Fitri Garna, Lailiana Gautama, Tomy Sugiarto isti qomah Istriningsih, Endang Khasanah, Lutfatul Khoirunnisa, Dhea Ayu Larasati, Dwi Ajeng Maulinda, Yanda Rizqi Musrifah Musrifah, Musrifah Nida, Shofa Khoirun Nurhidayati, Lailiana Garna Oktiawati, Anisa Prabowo, Aditya Yulindra Agung Pramiastuti, Oktariani Purwatih, Eti Rizki Andita Noviar Sahalessy, Yona Subekti, Agung Tyas Suminar, Saka Utari Utari Wulandari, Prihastini Setyo Yulis, Dian Meiliani