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All Journal Jurnal Kesehatan Masyarakat Andalas (Andalas Journal of Public Health) Jurnal Kesehatan Andalas Journal of Midwifery Majalah Kedokteran Andalas Andalas obstetrics and gynecology journal Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Jurnal EduHealth Detector: Jurnal Inovasi Riset Ilmu Kesehatan
Elly Usman
Bagian Farmakologi FK Unand
Biochemistry, Genetics & Molecular Biology Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Journal of Midwifery

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Azithromycin and the Outcome of Treated COVID-19 Patients: A Hospital-Based Study Elly Usman
Journal of Midwifery Vol 7, No 1 (2022): Published on June 2022
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jom.7.1.76-81.2022

Abstract

COVID-19 is an infectious disease that has been declared a pandemic. Currently, there is no validated pharmacological treatment for use in COVID-19 disease and is still in the clinical trial stage. The aim of this study to determine the association of azithromycin and the outcome of treated COVID-19 patients. This study used a retrospective cohort.  The number of samples in this study were 40 subjects in each group of azithromycin and non-azithromycin. The research sample was all COVID-19 patients who were treated at Dr. M Djamil Hospital Padang with moderate and severe grades receiving treatment with azithromycin and non-azithromycin. The inclusion criteria in this study were moderate and severe COVID-19 patients and data related to research variables were complete and well-documented. Sampling technique with convenience sampling. Data analysis was performed using the Chi-square test. P < 0.05 was significant, and the data were analyzed using the SPSS version 21.0 program. The mortality of COVID-19 patients in patients receiving azithromycin therapy (80.0%) compared to non-azithromycin (85.0%). The results of the statistical test showed that there was no relationship of azithromycin administration with the outcome of COVID-19 patients (p>0.05), with OR (0.71, 95% CI 0.22-2.26). In this study, it is hoped that the decision on the use of azithromycin should consider the potential benefits and risks, evaluated that the possibility of the drug being effective is greater than the risk to the patient.
Correlation of ApoE Gene Polymorphism with Coronary Heart Disease Severity in Patients with Acute Coronary Syndrome Who Receive Statin Therapy, Padang, Indonesia Elly Usman; Gestina Aliska; Masrul Syafri
Journal of Midwifery Vol 7, No 1 (2022): Published on June 2022
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jom.7.1.1-7.2022

Abstract

Coronary Heart Disease (CHD) is still the most common cause of death. Ischemic heart disease causes more than 7 million (12.8%) deaths worldwide. It is estimated that 3,750,000 Indonesians have CHD. CHD is a disease with many risk factors. ApoE gene polymorphism is associated with atherosclerosis and plays a role in lipid metabolism, which is 2-16% affecting variability in LDL levels. This study aims to look at the relationship between ApoE gene polymorphism and the severity of coronary heart disease. Data regarding ApoE gene polymorphism was obtained using polymerase chain reaction (PCR). DNA was isolated from white blood cells using DNA purification kit. ApoE2, ApoE3, ApoE4 alleles were detected by DNA sequencing. Data on the severity of coronary heart disease were obtained from angiography and were calculated based on SYNTAX scores. In this study, ApoE was obtained with e2 allele frequencies (4.63%), e3 (78.70%), and e4 (16.67%) with E2 / 2 (0%), E2 / 3 (3.70%), E2 / 4 (5.56%), E3 / 3 (64.81%), E3 / 4 (24.07%), and E4 / 4 (1.85%). The relationship between the SYNTAX score and the ApoE genotype has no significant difference. ApoE3 / 4 genotype has the highest SYNTAX score and the e4 allele has the most influence on CHD despite the influence of statin therapy.
Co-Authors Ahmad Muhtar Ahmad Rafid Aisyah Ramadhini ALADIN ALADIN Almurdi Almurdi Amelin, Fitrisia Aziz Djamal Erlina Rustam Erly Erly Fadhila Aini Fenty Primadhani Gestina Aliska Gestina Aliska Herman, Deddy Iis Rahayu Ilmiawati, Ilmiawati Inez Amelinda Ismail Fajri Ivan Putra Siswanto Julizar Julizar Linosefa Linosefa Mahata, Liganda Endo Masrul Syafri Mohamad Reza Muhammad Gamal Eddin Nadjmir Nadjmir Nency Agustia Oea Khairsyaf Rahmatini . Rahmatul Firdaushty Rahmi Lestari Ramadani, Indah Rauza Sukma Rita Rizanda Machmud Rizky Erizka Siregar, Attahhal Fikrian Syadiq Syamel Muhammad Ulya Uti Fasrini Yanwirasti Yanwirasti Yusticia Katar