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Yufika, Amanda
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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Journal : Pediatric Sciences Journal

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Epicutaneous immunotherapy for peanut allergy treatment in pediatrics: A literature review Fadya, Vannisa; Safira, Siti Sarah; Nabila, Amira Qisthy; Yufika, Amanda
Pediatric Sciences Journal Vol. 6 No. 1 (2025): Available online : 1 June 2025
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v6i1.109

Abstract

Peanut allergy in children is a growing public health concern that significantly affects patients' quality of life. Although oral immunotherapy (OIT) has shown effectiveness in desensitizing allergic reactions, it is associated with a threefold increased risk of anaphylaxis compared to strict avoidance. As an alternative, epicutaneous immunotherapy (EPIT) has emerged as a promising therapy due to its favorable safety profile, ease of administration, and non-invasive nature. However, despite increasing interest in EPIT, there is still limited evidence assessing its efficacy and safety in pediatric populations. This literature review aims to summarize current findings on the mechanism of desensitization, clinical efficacy, safety, and impact on quality of life associated with EPIT in managing peanut allergy in children. Relevant articles were identified through database searches in PubMed, Cochrane, Science Direct, Scopus, and Google Scholar using Medical Subject Headings (MeSH) and keyword combinations such as "Epicutaneous Immunotherapy", "Peanut Allergy", and "Pediatric Allergy". EPIT works by delivering peanut allergens through a patch applied to intact skin. The allergen is taken up by Langerhans cells and presented to the immune system, triggering regulatory T-cell (Treg) responses that reduce allergic sensitivity. Viaskin© is the most clinically advanced EPIT delivery system currently available. Findings from clinical studies indicate that EPIT is effective in inducing desensitization, with a lower risk of systemic reactions compared to OIT. Furthermore, EPIT contributes to improved quality of life in children with peanut allergy. These results support EPIT as a promising therapeutic option for pediatric peanut allergy management.
Co-Authors Abbas, Kirellos Said Abdalla, Rashed YA. Abdeen, Ziad Abdul Malik Setiawan Abudurrahman, Muhammad F. Aburto, José TO. Acharya, Yogesh Adam, Rashed Y. Adejumo, Esther N. Akel, Kaitlyn B. Aloui , Khaoula Anak Agung Dewi Megawati, Anak Agung Dewi Anandu, Sunil Andika, Fina F. Andri Frediansyah, Andri Arab-Zozani, Morteza Babadi, Elham Bakhtiar Bakhtiar Balogun, Emmanuel O. Bondarenko, Anastasia Castillo-Briones, María F. Chandran, Deepak Dababseh, Deema Dahman, Nesrine Ben Hadj Dahman, Nesrine BH. Deeb, Dalia Durosinmi, Abiodun Elfrida Ratnawati Emad , Dina Emran, Talha B. Enitan , Seyi S. Enitan, Seyi S. Enitan, Seyi Samson Ezigbo, Eyiuche D. Fadya, Vannisa Fahriani, Marhami Fauzi Yusuf, Fauzi Ferjani, Manel Ferreto, Lirane ED. Firzan Nainu Gachabayov, Mahir Gunawan, Felicia A. Hafsi , Montacer Hafsi, Montacer Handayani, Yoshimi Haque , Md A. Haque, Md Ariful Harapan Harapan Husnah, Milda Ikram, Aamer Inostroza-Morales, Rocío B. Iqhrammullah, Muhammad Ismaeil, Mohajer IH. Ismail, Asma Y. Kacem, Wajdi Kakemam, Edris Khader, Yousef Khiri, Namareg ME. Kotfis, Katarzyna Koyanagi, Ai Kretchy, James-Paul Kurnia F. Jamil Kusuma, Hendrix I. Lazcano-Díaz, Sebastián A. Lemu, Yohannes K. Lestari, Lazulfa Inda Maidar, Maidar Malik, Najma I. Mamada, Sukamto S. Memish, Ziad A. Monib, Fatma A Monib, Fatma A. Mudatsir Mudatsir Müller, Ruth Mulya, Intan C. Nabila, Amira Qisthy Nur Wahyuniati, Nur Ordóñez-Aburto, José T. Panchawagh, Suhrud Parperis, Konstantinos R , Subramaniam R, Subramaniam Raad, Rawan Rademaker, Marius Ramadana, Rizki R. Ramadhan, Roy N. Rampengan, Derren DCH. Rampengan, Jade AH. Refin, Randa Y. Reza Maulana Rojas, Jorge ET. Rosiello, Dott F. Rosiello, Francesco Safira, Siti Sarah Sallam, Dina E. Sallam, Malik Sami, Farah S. Samsul Anwar Setiono, Steven Sharun, Khan Sirinam, Salin Smith, Lee Te, Haypheng Teyeb, Zeineb Torres-Roman, J. Smith Troncoso-Rojas, Jorge E. Ullah, Irfan Utomo, Prattama S. Vento, Sandro Wagner, Abram L. Wendt, Guilherme W. Wira Winardi, Wira Wiwik Handayani Yomi, Akele R.