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All Journal Farmaka Jurnal Farmasi Klinik Indonesia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Pharmacology and Clinical Pharmacy Research

Eli Halimah

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Author-ID : 1946687

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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REVIEW : BERBAGAI AKTIVITAS FARMAKOLOGI TANAMAN JOMBANG (Taraxacum officinale Webb.) NUR AZIZAH ALI; ELI HALIMAH
Farmaka Vol 18, No 1 (2020): Farmaka (Januari)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

ABSTRAKJombang (Taraxacum officinale Webb.) yang dikenal dengan dandelion merupakan tanaman yang sering digunakan sebagai tanaman herbal. Tanaman ini tersebar di daerah subtropis dan tropis termasuk Indonesia. Tanaman jombang sudah banyak digunakan oleh masyarakat sebagai rempah maupun untuk pengobatan yang khasiatnya sebagai antioksidan, mengobati penyakit hati, gangguan pencernaan dan gatal-gatal yang sudah digunakan secara empirik. Khasiat tersebut dapat terjadi karena terdapat kandungan senyawa utama seperti asam fenolat dan asam sikorat yang memiliki aktivitas farmakalogi dalam tanaman jombang. Review artikel ini dibuat dengan tujuan untuk memberikan informasi tentang aktivitas farmakologi tanaman jombang. Dari sumber data yang ditelaah, tanaman jombang memiliki aktivitas antioksidan, antifibrosis, hepatoprotektif, antijamur, antibakteri, antiinflamasi, antiinfluenza, antidepresan, antiproliferatif, dan meningkatkan pengosongan lambung. Dari berbagai aktivitas farmakologi tersebut, aktivitas antioksidan, antibakteri, dan antiproliferasi dari tanaman jombang berpotensi untuk dikembangkan lebih lanjut.Kata Kunci: jombang, Taraxacum officinale, pengobatan, aktivitas, farmakologi ABSTRACTJombang (Taraxacum officinale Webb.) what is known as dandelion is a plant that is often used as an herbal plant. This plant is spread in subtropical and tropical regions including Indonesia. Jombang plants have been widely used by the community as a spice for the treatment of its efficacy as an antioxidant, treatment of liver disease, digestive disorders and rubbing that have been used by empiricists. This property can occur because there are main ingredients such as phenolic acid and cycoric acid which have pharmacalogical activity in jombang plants. The review of this article was made with the aim to provide information about the pharmacological activity of jombang plants. From the sources of the data studied, the jombang plant has antioxidant activity, antifibrosis, hepatoprotective, antifungal, antimicroba, anti-inflammatory, antiinfluenza, antidepressant, antiproliferative, and increases gastric emptying. Of the various pharmacological activities, antioxidant, antimicrobe and antiproliferation of the jombang plant need to be further developed.Keywords: jombang, Taraxacum officinale treatment, activity, pharmacology

AKTIVITAS ANTIBAKTERI DARI EKSTRAK BERBAGAI SPESIES TUMBUHAN MANGROVE NIA KURNIASIH; Eli Halimah
Farmaka Vol 17, No 2 (2019): Farmaka (Agustus)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Penyakit infeksi merupakan penyakit yang prevalensinya cukup tinggi. Indonesia memiliki lautan yang luas yang didalamnya terdapat keanekaragaman hayati yang bermacam-macam salah satunya adalah tanaman mangrove yang memiliki berbagai macam spesies. Tanaman mangrove atau bakau dikenal sebagai tanaman yang hidup di area pesisir pantai dan digunakan sebagai tanaman yang menjaga area pantai agar tidak terjadi proses abrasi akibat ombak dari laut. Tanaman ini memiliki banyak manfaat seperti pencegah dan penyaring alami, tempat sumber makanan bagi biota laut, kayunya sebagai bahan bakar, serta sudah banyak digunakan secara empirik sebagai tanaman obat tradisional dan salah satunya sebagai antibakteri. Review artikel ini dilakukan untuk pengumpulan informasi mengenai aktivitas antibakteri dari beberapa jenis tanaman mangrove. Aktivitas antibakteri ini dilihat dari nilai Minimum Inhibitory Concentration (MIC) dan diameter zona hambat. Hasil pengujian antibakteri yang diperoleh berdasarkan parameter diameter zona hambat, spesies mangrove yang memiliki aktivitas antibakteri kuat (diameter zona hambat >20mm) yaitu ekstrak air eksokarp Bruguiera gymnorrhiza terhadap bakteri Delftia sp. menghasilkan zona hambat sebesar 23±0,55mm, ekstrak air batang Nypa fructicans terhadap bakteri Bacillus subtilis menghasilkan zona hambat 22,16±0,76mm, sedangkan ekstrak air daunnya terhadap Pseudomonas aeruginosa dan Klebsiella pneumonia masing-masing menghasilkan zona hambat sebesar 20,33±0,95mm dan 20,03±1,08mm, serta ekstrak metanol daun Ricinus communis terhadap Staphylococcus aureus menghasilkan zona hambat sebesar 20,7mm. Tanaman mangrove mempunyai potensi untuk dikembangkan sebagai antibakteri.Kata Kunci : Mangrove, infeksi, antibakteri

Terapi untuk Bell’s Palsy Berdasarkan Tingkat Keparahan Chintami Nurkholbiah; Eli Halimah
Farmaka Vol 14, No 2 (2016): Suplemen
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Bell’s palsy adalah kelumpuhan akut yang terjadi pada bagian saraf wajah yang tidak diketahui penyebabnya. Tujuan dari penulisan review ini yaitu untuk mengetahui terapi pada kasus Bell’s palsy berdasarkan Guideline dan tingkat keparahan. Metode yang digunakan yaitu dengan mencari beberapa jurnal ilmiah dan artikel ilmiah yang berkaitan dengan topik yang akan dibahas dalam tulisan ini. Berdasarkan beberapa hasil penelitian menunjukkan bahwa terapi untuk Bell’s palsy dengan tingkat keparahan ringan, sedang, dan berati lebih efektif ketika diberi terapi kombinasi yaitu obat kortikosteroid dengan obat antiviral dibandingkan dengan terapi tunggal yaitu pemberian obat kortikosteroid atau obat antiviral. Dan untuk terapi tunggal, pemberian obat kortikosteroid lebih baik dibandingkan dengan terapi obat antiviral saja.Kata kunci: Bell’s palsy, kortikosteroid, antiviral

REVIEW ARTIKEL: METODE DAN KARAKTERISASI NANOPARTIKEL TRANSFERSOM SEBAGAI PEMBAWA RUTE PENGHANTARAN TRANSDERMAL ALIFIA SYIFA PEBRIANTI; Eli Halimah
Farmaka Vol 19, No 2 (2021): Farmaka (Juli)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v19i2.27726

Transfersom merupakan salah satu vesikel pembawa yang pada komponennya ditambahkan surfaktan sehingga memiliki sifat yang ultra-fleksibel dan elastis. Dengan menggunakan transfersom, obat dapat berpenetrasi lebih baik ke dalam kulit meskipun terdapat penghalang dari lapisan kulit stratum korneum. Tujuan dari review ini adalah untuk menjelaskan metode apa saja yang dapat digunakan dalam pembuatan transfersom. Dalam membuat review artikel ini digunakan jurnal dan artikel hasil penelusuran di internet melalui website NCBI (dengan kategori yang dipilih adalah PubMed), science direct, dan google scholar yang telah dipublikasi dalam 10 tahun terakhir. Dari hasil pencarian, terdapat beberapa metode yang dapat digunakan untuk membuat transfersom, yaitu: thin film hydration/rotary evaporation-sonication, vortexing-sonication, reverse phase evaporation, injeksi etanol, protransfersome-transfersome, dan microfluids. Dari metode-metode tersebut, masing-masing metode memiliki karakteristik, kelebihan, dan kekurangannya masing-masing dalam pembuatan transfersom sehingga pemilihan metode untuk pembuatan transfersom yang dapat digunakan dapat disesuaikan dengan kebutuhan dan tujuan yang ingin dicapai. Metode thin film hydration sejauh ini paling banyak digunakan untuk mengembangkan transfersom dalam skala laboratorium.

IDENTIFIKASI PERSENTASE KELENGKAPAN RESEP DI SALAH SATU RUMAH SAKIT DI KOTA BANDUNG ALFIA NURSETIANI; ELI HALIMAH
Farmaka Vol 18, No 2 (2020): Farmaka (September)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v18i2.26204

ABSTRAKSemakin meningkatnya angka kesakitan dan penggunaan obat di rumah sakit, maka semakin bertambah pula angka permasalahan terkait obat jika penggunaannya tidak tepat. Salah satu cara untuk mencegah terjadinya permasalahan terkait obat adalah dengan melakukan pengkajian resep. Penelitian ini dilakukan untuk mengetahui pada aspek manakah yang memiliki persentase ketidaklengkapan atau kesalahan peresepan yang paling besar. Identifikasi kelengkapan resep tersebut dilakukan menggunakan metode observasi dengan aspek administrasi, aspek farmasetik, dan aspek klinis pada 60 resep yang terdiri dari 30 resep rawat jalan dan 30 resep rawat inap di salah satu rumah sakit di kota Bandung. Dari hasil penelitian didapatkan hasil persentase kesalahan peresepan pada aspek administrasi sebesar 19.44%, aspek farmasetik sebesar 20%, dan aspek klinis sebesar 16% pada 30 resep rawat jalan, sedangkan pada 30 resep rawat inap persentase kesalahan peresepan pada aspek administrasi sebesar 16.39%, aspek farmasetik sebesar 23.33%, dan aspek klinis sebesar 14.67%. Persentase ketidaklengkapan atau kesalahan peresepan terbesar terdapat pada aspek farmasetik, yaitu stabilitas obat dengan persentase sebesar 100%.Kata Kunci : Standar pelayanan kefarmasian, pengkajian resep, kelengkapan resep ABSTRACTThe increasing number of morbidity and drug use in hospitals, make the number of problems related to drugs has been increasing too. One way to prevent drug-related problems is to do a prescription screening. This research was conducted to find out which aspects had the greatest percentage of incompleteness or prescribing errors. Identification of the completeness of the prescription was carried out using observational methods with administrative aspects, pharmaceutical aspects, and clinical aspects in 60 prescriptions consisting of 30 outpatient prescriptions and 30 inpatient prescriptions at one of hospital in Bandung city. From the research results obtained the percentage of prescribing errors in administrative aspects of 19.44%, pharmaceutical aspects of 20%, and clinical aspects of 16% in 30 outpatient prescriptions, while in 30 prescriptions for prescription errors in administrative aspects was 16.39%, aspects pharmacetics at 23.33%, and clinical aspects at 14.67%. The biggest percentage of incompleteness or prescription errors is found in the pharmaceutical aspect, namely the stability of the drug with a percentage of 100%.Keywords : Pharmaceutical service standards, prescription screening, completeness of the prescription

Pola Peresepan Rawat Jalan: Studi Observasional Menggunakan Kriteria Prescribing Indicator WHO di Salah Satu Fasilitas Kesehatan Bandung Dika P. Destiani; Syahrul Naja; Aminah Nurhadiyah; Eli Halimah; Ellin Febrina
Indonesian Journal of Clinical Pharmacy Vol 5, No 3 (2016)
Publisher : Universitas Padjadjaran

Penelitian ini dilakukan sebagai tahap awal evaluasi peresepan obat di salah satu fasilitas kesehatan yang akan dilakukan berkala untuk meningkatkan kualitas pengobatan pasien dengan menggunakan lima indikator peresepan berdasarkan guideline World Health Organization (WHO) yaitu jumlah obat per lembar resep, penggunaan obat generik, antibiotik, obat injeksi, dan obat esensial. Pengumpulan data resep rawat jalan diambil secara retrospektif pada periode April 2015–Maret 2016 di salah satu fasilitas kesehatan di Bandung. Sebanyak 1.814 lembar resep dengan 3.886 obat yang termasuk kriteria inklusi, diperoleh rata-rata jumlah obat per lembar yaitu 2,13 obat. Penggunaan obat generik sebesar 57,47% dari 3.886 obat. Persentase penggunaan antibiotik sebesar 15,52% dan sediaan injeksi 0,41% dari 1.814 lembar resep, sedangkan penggunaan obat esensial sebesar 39,49% dari 3.886 obat yang diresepkan. Berdasarkan hasil tersebut penggunaan obat generik dan esensial masih sangat jauh dari standar WHO (100%) sedangkan penggunaan antibiotik dan obat injeksi memiliki nilai rendah dibandingkan dengan nilai rujukan World Health Organization. Kata kunci: Indikator peresepan, obat, WHO Prescribing of Outpatient: Observational Study Using WHO Prescribing Indicator in One of Health Care Facilities in Bandung This study was held to evaluate drug pattern in one of the health facilities in Bandung using five World Health Organization guideline for prescribing indicators, which include average number of drugs per encounter, percentage of drugs prescribed by generic name, percentage of encounters with an antibiotic, injection prescribed, and drugs prescribed from essential drugs list or formulary. Outpatient prescriptions were collected retrospectively from April 2015–March 2016. Average number of drugs per encounter 2.13 was gained by dividing 3,886 drugs with 1,814 prescriptions. Percentage of using generic drugs were 57.47%, antibiotics were 15.52 % and 0.41% for injections per encounters, whereas percentage of drugs prescribed from essential drugs list was 39.49%. The result showed that usage of generic and essential drugs were still far from WHO standard (100%) while the usage of antibiotics and injections were lower than World Health Organization recommendation.Keywords: Drug, prescribing indicators, WHO

Pharmaceutical Counseling Has a Positive Impact on Quality of Life of Hypertension Patients Gina Aulia; Eli Halimah; Keri Lestari
Pharmacology and Clinical Pharmacy Research Vol 3, No 1
Publisher : Universitas Padjadjaran, Indonesia

Pharmacists play a major role in educating patients regarding drug therapy, in order to achieve optimal health outcomes. The aim of this study was to investigate the effect of pharmaceutical counseling on quality of life (QoL) of hypertensive patients with renal impairment at one of public hospital in Bandung, Indonesia. This study used a prospective experimental design with pretest-posttest design for 2 months. Inclusion criteria in this study were hypertensive patients with renal impairment who received antihypertensive drugs, aged >18 years, and signed the informed consent. Exclusion criteria were patients who were not able to fill in the questionnaire, patients with end stage renal diseases, diabetes, and pregnant or lactating patients. Pharmaceutical counseling was given during 2 months of the therapy. Pharmaceutical counseling consisted of education on the appropriate use of drugs and disease management. Schedule of their own medication and leaflet containing educational information were given to the subjects. QoL was assessed using a previously validated Mini-Questionnaire of QoL in Arterial Hypertension (MINICHAL). The questionnaire consisted of 16 two dimensions questions, i.e., mental health and somatic manifestation. We found that the mean increase in mental health status (49.5±5.3) was higher than that of somatic dimension (32.7±3.6). Both dimensions had statistically significant improvement (P value <0.05). In conclusion, pharmaceutical counseling is beneficial to improve QoL of hypertension patients.Keywords: hypertension, renal impairment, quality of life

Performance Evaluation of Four Activated Partial Thromboplastin Time Reagents Peppi Z. Yuzaqi; Eli Halimah; Tatat Noviani
Pharmacology and Clinical Pharmacy Research Vol 3, No 2
Publisher : Universitas Padjadjaran, Indonesia

Activated Partial Thromboplastin Time (APTT) is a hematological examination to identify hemostatic abnormalities. This study aimed to compare the performance evaluation of four APTT reagents, i.e., CK Prest, Pathromtin SL, Actin SL, and Cephascreen. The methods used were photo optical, percent detection, and viscosity-based detection system (VDS). The analysis was performed on blood specimen of 43 subjects. The results indicated that the accuracy and precision in normal plasma control using C. K. Prest reagent in Coag-A-Mate® MTX II were d% -0.605 and CV% 2.252%, Pathromtin SL reagent in CA 560® (Sysmex®) were d% 6.9345 and CV%1.687, Actin FSL reagent in CA 560® (Sysmex®) were d% -1.51 and CV% 1.74, and Cephascreeen reagent in STA Compact® were d% 10.81 and CV% 1.60. The accuracy and precision in pathological plasma control using Pathromtin SL reagent in CA 560® (Sysmex®) were d% -1,11 and CV% 8.82, Cephascreen reagent in STA Compact® were d% 4.64 and CV% 2.72. The coefficient of correlation between C. K. Prest reagent and Pathromtin SL reagent was 0.880 with the regresion equation y=2.31x–33.70. The coefficient of correlation between C. K. Prest reagent and Actin FSL reagent was 0.986 with the regretion equation y=0.78x+2.93. The coefficient of correlation between C. K. Prest reagent and Cephascreen reagent was 0.987 with the regretion equation y=1.70x–3.97. In conclusion, the best precision was obtained from Cephascreen reagents in STA compact®devices for both normal and pathologic control plasma, with eligible accuracy.Keywords : Activated Partial Thromboplastin Time (APTT), Photo-optical, Viscosity-based Detection System (VDS)

Potential Nephrotoxicity of Lisinopril and Valsartan on Patients with Congestive Heart Failure Sarini Pani; Melisa I. Barliana; Eli Halimah; Venice Chaeriadi; Mally G. Sholih
Pharmacology and Clinical Pharmacy Research Vol 2, No 1
Publisher : Universitas Padjadjaran, Indonesia

Lisinopril (angiotensin converting enzyme inhibitor) and valsartan (angiotensin II receptorblocker) are the first-line treatment for patients with congestive heart failure (CHF). Thesetwo drugs potentially cause side effects on renal functions. However, limited informationwas available regarding the comparison of potential nephrotoxicity of these drugs in IndonesianCHF patients. This research was aimed to compare the potential nephrotoxicitybetween lisinopril and valsartan in outpatients with CHF at a hospital in Palu, Indonesia.This was an observational study conducted during April-May 2015. Potential nephrotoxicitywere assessed by measuring serum creatinin (SCr) and blood urea nitrogen (BUN). Datawere obtained from Cardiology Unit from a hospital in Palu, Indonesia. Statistical analysiswas conducted using T-test and Mann-Whitney test. The increasing trend of SCr and BUNwere observed in lisinopril-treated patients with the mean of increase were 21% and 59%,respectively. Relatively higher increase was observed in valsartan treatment group with 47%and 51% in SCr and BUN, respectively. The analysis showed that there were significant differencesin SCr level between lisinopril and valsartan groups (p=0.001), but the oppositeresults observed in BUN parameter (p=0.697). Therefore, valsartan was potentially morenephrotoxic than lisinopril based on the increase of SCr parameter. Thus, lisinopril is recommendedfor CHF patients who are particularly at high risks of having renal impairment.Keywords: lisinopril, valsartan, nephrotoxicity, congestive heart failure

Inhibitory Activity of Andrographolide and Andrograpanin on the Rate of PGH2 Formation Sri A. Sumiwi; Eli Halimah; Nyi M. Saptarini; Jutti Levita; As'ari Nawawi; Abdul Mutalib; Slamet Ibrahim
Pharmacology and Clinical Pharmacy Research Vol 1, No 3
Publisher : Universitas Padjadjaran, Indonesia

Cyclooxygenase (COX) or prostaglandin H2 synthase (PGHS) catalyzes the conversion of arachidonic acid into prostaglandins. Nonsteroidal anti-inflammatory drugs (NSAIDs) work by inhibiting both COX-1 and COX-2 isoforms, thus disturbing this reaction. In Indonesia, Andrographis paniculata (local name: sambiloto), is empirically used to reduce inflammation by consuming the herb tea of this plant. This work studied the inhibitory activity of andrographolide and andrograpanin, diterpenoids of the plant, on the rate of prostaglandin formation. Previous works have proven that andrographolide inhibited PGE2 production in LPS-induced human fibroblast cells. This study was performed by measuring the absorbance of TMPD (tetramethyl-p-phenyldiamine) oxidized by andrographolide and andrograpanin. Acetosal was used as a control drug. The rate of PGH2 formations on either COX-1 or COX- 2 was affected by andrographolide and andrograpanin. Andrographolide and andrograpanin interact longer with COX-1 than COX-2. Andrographolide shows weak inhibition on the rate of PGH2 formation, whilst andrograpanin might be further developed for potential antiinflammatory drugs.Keywords: Andrographis paniculata, anti-inflammatory, COX, cyclooxygenase, prostaglandin

Co-Authors Abdul Kholik Tasib Abdul Mutalib ALFIA NURSETIANI ALIFIA SYIFA PEBRIANTI Aminah Nurhadiyah As'ari Nawawi Budhi Prihartanto Chintami Nurkholbiah Dika P. Destiani Ellin Febrina Faizatun Maulida Gina Arifah Gina Aulia Irma Melyani Puspitasari Jutti Levita Keri Lestari Mally G. Sholih Melisa I. Barliana Ni Made Susilawati Nia Kurniasih NUR AZIZAH ALI Nyi M. Saptarini Peppi Z. Yuzaqi Rizky Abdulah Sarini Pani SITI SAIDAH Slamet Ibrahim Sri A. Sumiwi Sri Hartini Syahrul Naja Tatat Noviani Venice Chaeriadi

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