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All Journal Journal of Biomedicine and Translational Research Medica Hospitalia Diponegoro International Medical Journal (DIMJ) Cermin Dunia Kedokteran Neurona Seroja Husada: Jurnal Kesehatan Masyarakat
Suryawati, Herlina
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : medica hospitalia

 1 
OSA FAKTOR RISIKO KEJADIAN OBSTRUCTIVE SLEEP APNEA PADA PASIEN STROKE ISKEMIK: - Rosyidah, Nurul Uly; Mailasari Kusuma Dewi, Anna; Marliyawati, Dwi; Yunika, Kanti; Suryawati, Herlina; Budiarti, Rery
Medica Hospitalia : Journal of Clinical Medicine Vol. 9 No. 3 (2022): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v9i3.826

Abstract

LATAR BELAKANG: Sleep Disordered Breathing (SDB)  memiliki hubungan dua arah dengan stroke iskemik. SDB yang tidak diobati dapat menyebabkan stroke berulang. Penanganan SDB adalah kunci untuk preventif pada pasien stroke. TUJUAN: Menganalisis IMT, lingkar leher besar, deviasi septum, hipertrofi konka, hipertrofi tonsila palatina, makroglosia, dan obstruksi saluran nafas atas sebagai faktor risiko SDB pasien stroke iskemik. METODE: Penelitian observasional dengan desain cross sectional, pada 86 pasien stroke iskemik di Poli Neurologi dan THT-KL RSUP Kariadi Semarang bulan Desember 2021-Juli 2022. Data diperoleh melalui kuesioner, pemeriksaan fisik dan pemeriksaan nasolaringoskopi fleksibel. Analisis menggunakan uji chi-square dan uji regresi multivariat. HASIL: Didapatkan 86 subjek terdiri dari 42 laki-laki(48,8%) dan perempuan 44 (51,2%), usia rerata 54 th, dan 61 subjek (70,9%) stroke iskemik pertama. Septum deviasi (p= 0,020), hipertrofi konka inferior (p= 0,021), makroglosia (p= 0,012), hipertrofi tonsila palatina (p= 0,013), dan obstruksi saluran nafas atas (p= 0,035) merupakan faktor risiko SDB pada pasien stroke iskemik. Septum deviasi berisiko 6,1x, konka inferior hipertrofi berisiko 4,1x, dan hipertrofi tonsila palatina  berisiko 8,8x terhadap SDB pada pasien stroke iskemik. SIMPULAN: Septum deviasi, konka inferior hipertrofi, makroglossia, hipertrofi tonsila palatina, makroglosia, dan obstruksi saluran nafas atas merupakan faktor resiko terhadap SDB pasien stroke iskemik. Hipertrofi tonsila palatina merupakan faktor risiko yang paling dominan terhadap SDB pasien stroke iskemik. KATA KUNCI: SDB, faktor risiko, stroke iskemik, hipertrofi tonsila palatina, septum deviasi
Association Of Neuropathic Pain Improvement And hs-CRP Changes Among Trigeminal Neuralgia Patients Experienced Radiofrequency Ablation 60o and 65o Celcius: 6 months follow up Arlina, Yani; Budisulistyo, Trianggoro; Pudjonarko, Dwi; Tugasworo, Dodik; Suryawati, Herlina; Diah Pasmanasari, Elta
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.876

Abstract

INTRODUCTION: Trigeminal neuralgia (NT) is a neuropathic pain that involves the trigeminal nerve in the face. The first-line medical management of patients with NT is Carbamazepine (CBZ). Radiofrequency ablation (RFA) procedure is a minimally invasive procedure using a high-frequency current-generating device that produced heat ablate of C-fibers with effectiveness around 76% for 10 yeas follow-up. Inflammed trigeminal nerve (TG) or the branch(es) might be one of the underlying mechanisms unless vascular compression is a common etiology. The heat effects might be according to the temperature set up varies recently from 60°C to 95°C. METHOD: This observational study enrolled 75 severe NT subjects without satisfactory improvement of treatments, divided into 3 groups: analgesics prescription (Control), RFA 60, and RFA 65 Groups. The LANSS scores and hs-CRP levels were followed-up before (baseline), 2 weeks, 3, and 6 months experienced the treatments. Subjects ages in the range of 48.32 + 12.73 to 50.88 + 14.59 years old, and the duration of illness from 4.48 to 10.32 months. RESULT: The LANSS score >12 before treatments showed significance improvements (p<0.001), as in the Control (64% with neuropathic pain), RFA 60 (100% with neuropathic pain), and RFA 65 group (92% with nociceptive pain) at 2 weeks followed-up. At 3 and 6 months observed 100% subjects with nociceptive pain but without significancies. Even though the hs-CRP levels observed reduced for all groups, especially RFA 60 and RFA 65, but have no significances. CONCLUSION: The LANSS scores changes observed significant improvement in all groups, which mentioned if the neuropathic pain syndromes might be better under each treatment. The Hs-CRP levels improvement is better in the neuro ablation groups than analgesic drugs treatment. Even though the Hs-CRP are following of systemic nonspecific inflammation, NT is a focal inflammation.
The Wistar Rat Parietal Lobe Cell And Pain Perception Changes After Frequent Of Mobile Phone Electromagnetic Wave Expose Tamad, Fatiha Sri Utami; Budisulistyo, Trianggoro; Husni, Amin; Retnaningsih, Retnaningsih; Suryawati, Herlina; Suryadi, Suryadi
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.884

Abstract

Background: The increasing number of mobile phone users raises concerns about the effects. Mobile phone electromagnetic wave radiation harms pain perception due to granular cell changes in the cerebral parietal cortex. Objective: To determine the effect of exposure to electromagnetic waves mobile phone on pain perception due to changes in the granular cells of the cerebral parietal cortex Wistar rats. Methods: Experimental research using randomized posttest with control group design. Samples were 28 rats divided into 4 groups. The control group was not exposed, the treatment group was exposed to 2100 MHz electromagnetic waves for 2 hours/day with a distance of 3 cm for 15 days in treatment group 1, for 30 days in treatment group 2, and 45 days in treatment group 3. Measurement of pain onset using the hot method. Changes in pain threshold were taken from the difference in pain onset after exposure to before exposure. Granular cell changes in the cerebral parietal cortex were assessed from the total score with the provisions of normal cells (sumx0), hydropic degenerated cells (sumx1), and necrotic cells (sumx2). Results: The longer the exposure to mobile phones, the higher the pain threshold and the cerebral parietal cortex granular cell damage score. There was a significant difference in pain threshold and changes in cerebral parietal cortex granular cells between groups (p=0.000). There was a significant relationship between changes in the parietal cerebral cortex granular cells and pain threshold in Wistar rats exposed to electromagnetic waves (p=0.000). Conclusion: Exposure to mobile phone electromagnetic waves affects pain perception due to changes in the granular cells of the cerebral parietal cortex in wistar rats.
The Relationship Between Serum Folic Acid Levels With The Cognitive Function of The Elderly Hermanto, Hermanto; Muhartomo, Hexanto; Husni, Amin; Widiastuty, Maria Immaculata; Suryawati, Herlina; Wati, Arinta Puspita
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.891

Abstract

Background: Cognitive decline is a common condition that occurs in the elderly. One of the early indicators of senility is a decrease in cognitive function. Folic acid is thought to protect the arteries from damage because of homocysteine by converting homocysteine into cysteine and then excreted in the urine. Increased levels of homocysteine can interfere with vascular function and cause toxic effects on neurons thereby increasing the risk of cognitive decline. Objective: To determine the relationship between serum folic acid levels and cognitive function of the elderly. Method: Analytical descriptive research with a cross-sectional approach. The research subjects were the elderly who met the inclusion criteria and did not have exclusion criteria. The research was conducted from May to July 2022 at the Pucang Gading Nursing Home, Semarang. Serum folic acid levels were examined using the ELISA (Enzyme-linked immunosorbent assay) method. Cognitive function was assessed using the Indonesian version of the Montreal Cognitive Assessment (MoCA) simultaneously on the subject. Cognitive function is normal if the MoCA-INA value is ≥ 26 and it is said to be cognitive dysfunction if the MoCA-INA value is < 26. Data were analyzed using the Spearman test. Results are considered significant if the value of p <0.05.  Result: There is a strong positive correlation between serum folic acid levels and cognitive function in the elderly (r=0.914, p<0.001). There is a relationship between educational level and cognitive function (r=0.922, p<0.001) where higher education correlates with increased cognitive function in the elderly. Conclusion: There is a significant positive correlation between serum folic acid levels and cognitive function in the elderly
Co-Authors Alifiati Fitrikasari Amin Husni Ardhini, Rahmi Arinta Puspita Wati, Arinta Puspita Arlina, Yani Budiarti, Rery Budisulistyo, Trianggoro Daynuri, Riri Diah Pasmanasari, Elta Dodik Tugasworo Dwi Pudjonarko Endang Kustiowati Hamdani, Faishol Hartono, Jimmy Eko Budi Herlina, Sari Nafa Hermanto Hermanto Hexanto Muhartomo, Hexanto Kanti Yunika, Kanti Mailasari Kusuma Dewi, Anna Marliyawati, Dwi Minuljo, Tania Tedjo Priambada, Dody Puspitawati, Arinta Rakhmayanti, Rizky Retnaningsih Retnaningsih Rosyidah, Nurul Uly Soedarso, Mohamad Adi Suryadi Suryadi Tamad, Fatiha Sri Utami Tori, Marthin Widiastuty, Maria Immaculata