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All Journal Jurnal Ilmiah Poli Rekayasa BIO-SITE |BIOLOGI Sains Terapan THE JOURNAL OF MUHAMMADIYAH MEDICAL LABORATORY TECHNOLOGIST Jurnal Surya Medika Scripta Biologica Jurnal Biomedika Indonesian Journal of electronics, electromedical engineering, and medical informatics Science Midwifery BALABA (JURNAL LITBANG PENGENDALIAN PENYAKIT BERSUMBER BINATANG BANJARNEGARA) Pena Medika : Jurnal Kesehatan Bioscientist : Jurnal Ilmiah Biologi Teknika Prosiding Seminar Nasional Hasil-hasil Penelitian dan Pengabdian Pada Masyarakat Journal of Education Technology Information Social Sciences and Health Jurnal Pengabdian Teknik dan Sains (JPTS) Jurnal Biodiversitas dan Bioteknologi
Arif Mulyanto
Universitas Muhammadiyah Purwokerto
Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Evaluasi Jumlah Monosit, Jumlah Limfosit dan Kadar Anti Streptolysin-O pada Pasien Tonsilitis Anak Hanny Dwi Indah Nurcahyani; Dita Pratiwi Kusuma Wardani; Arif Mulyanto; Kurnia Rhitma Dhanti
Jurnal Biodiversitas dan Bioteknologi Vol 2 No 2 (2025): Biodiverse: Jurnal Biodiversitas dan Bioteknologi
Publisher : Jurnal Biodiversitas dan Bioteknologi

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Abstract

Tonsillitis is the inflammation of the tonsils that can occur in children, caused by the bacteria Streptococcus haemolyticus and Streptococcus pyogenes. Poor oral hygiene, physical exhaustion, and certain types of food are other risk factors for chronic tonsillitis. When bacteria enter the tonsil tissue, monocytes differentiate into macrophages that destroy foreign objects. Activated lymphocytes differentiate into plasma cells that produce ASO antibodies. This study aims to determine the relationship between the number of monocytes and lymphocytes and Anti-Streptolysin-O levels in pediatric tonsillitis patients. This study was an observational analytical study with a cross-sectional design conducted in July-August 2025 at Dr. R. Goeteng Taroenadibrata Purbalingga Regional General Hospital by measuring the number of monocytes and lymphocytes using a hematology analyzer and Anti-Streptolysin-O levels using the latex agglutination method. The sample size for this study was 32 pediatric tonsillitis patients using accidental sampling. The relationship between monocyte and lymphocyte counts and ASO levels was analyzed using Spearman's rho correlation test. The results of the Spearman's rho correlation test showed that there was no correlation between the number of monocytes and ASO levels (p=0.637, r=0.087) or between the number of lymphocytes and ASO levels (p=0.412, r=-0.150). There was no correlation between the number of monocytes and lymphocytes and ASO levels in pediatric tonsillitis patients. More research is needed on inflammatory markers such as HsCRP, Procalcitonin (PCT) and Interleukin 6 (IL-6).
Evaluasi Jumlah Leukosit, Jumlah Netrofil, dan Kadar Anti Streptolysin O pada Pasien Tonsilitis Anak Citra Nadia Salsabila; Dita Pratiwi Kusuma Wardani; Arif Mulyanto; Defi Nurul Hayati
Jurnal Biodiversitas dan Bioteknologi Vol 2 No 2 (2025): Biodiverse: Jurnal Biodiversitas dan Bioteknologi
Publisher : Jurnal Biodiversitas dan Bioteknologi

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Abstract

Tonsillitis is a common global disease that most frequently affects children, particularly those aged 5–9 years. The primary cause of tonsillitis is infection of the tonsils by Streptococcus ?-hemolyticus Group A bacteria. Leukocytes play a key role in fighting infections, while neutrophils, as the main cells involved in acute inflammation, destroy bacteria through phagocytosis. This study aimed to determine the correlation between leukocyte and neutrophil counts and Anti-Streptolysin O (ASO) levels in children with tonsillitis. This research employed a cross-sectional design involving 32 pediatric tonsillitis patients, both inpatients and outpatients, at Dr. R. Goeteng Taroenadibrata Regional Hospital, Purbalingga. ASO levels were measured using the latex agglutination method, while hematological parameters—total leukocyte and neutrophil counts—were measured using a hematology analyzer based on the flow cytometry method. Data on the correlation between leukocyte and neutrophil counts and ASO levels were analyzed using Spearman’s rho correlation test. The results showed no significant correlation between leukocyte count and ASO level (p = 0.424, r = 0.146), and no correlation between neutrophil count and ASO level (p = 0.653, r = 0.083). There was no significant correlation between leukocyte and neutrophil counts and ASO levels in children with tonsillitis. Further studies are recommended using ASO measurement methods such as ELISA or turbidimetry, as well as additional inflammatory markers including Interleukin-1 (IL-1), Interferon-? (IFN-?), and Tumor Necrosis Factor-? (TNF-?).
Association Between Hygiene Level Among Diabetic Ulcer Patients and the Incidence of Methicillin-Resistant Staphylococcus aureus (MRSA) Infection Windy Lestari; Kurniawan; Arif Mulyanto; Farida Dwi Handayani
Bioscientist : Jurnal Ilmiah Biologi Vol. 14 No. 3 (2026): September
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v14i3.22019

Abstract

This study aimed to analyze the association between hygiene level and the incidence of Methicillin-Resistant Staphylococcus aureus (MRSA) infection in diabetic ulcers. An analytical observational study with a cross-sectional approach was conducted. The study included 20 patients with diabetic ulcers at RSUD Prof. Dr. Margono Soekarjo Purwokerto, selected using an accidental sampling technique. Bacterial identification was performed through culture on Mannitol Salt Agar (MSA), Gram staining, biochemical tests, and antibiotic susceptibility testing using the disk diffusion method. MRSA identification was determined based on cefoxitin susceptibility testing. Hygiene levels were assessed using an observation checklist developed based on wound care principles and WHO guidelines. Data were analyzed using Fisher’s Exact test with a significance level of p < 0.05. Among the 20 patients with diabetic ulcers, MRSA infection was identified in 17 patients (85%), while 3 patients (15%) were not infected with MRSA. In the group with good hygiene practices, 2 patients (10%) were infected with MRSA and 3 patients (15%) were not infected, whereas among patients with poor hygiene practices, 15 patients (75%) were infected with MRSA. Statistical analysis revealed a significant association between hygiene level and MRSA infection incidence (p = 0.009). These findings indicate that hygiene practices in diabetic ulcer care are associated with the occurrence of MRSA infection among patients with diabetic ulcers.
Association Between Procalcitonin and Lymphocyte Counts Post-Cupping Therapy in Patients With Diabetes Mellitus Nadia Rizqi Aulia; Dita Pratiwi Kusuma Wardani; Uli Mas’uliyah Indarwati; Arif Mulyanto; Kurnia Ritma Dhanti
Journal of Education Technology Information Social Sciences and Health Vol. 5 No. 2 (2026): September 2026
Publisher : CV. Rayyan Dwi Bharata

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57235/jetish.v5i2.9060

Abstract

Diabetes mellitus (DM) is a long-term metabolic condition that arises when the pancreas fails to produce insulin properly, typically marked by blood glucose readings above the normal threshold of 200 mg/dL. This condition activates an inflammatory response within the body, and procalcitonin is among the biomarkers used to detect such inflammation in DM patients. Beyond this marker, hematological parameters, particularly lymphocyte counts, can also serve as useful indicators. Persistent hyperglycemia experienced by DM patients can give rise to systemic inflammation, which in turn alters both the quantity and function of lymphocytes. Cupping therapy is believed to help improve blood circulation and reduce blood glucose levels in patients with DM. This study aimed to determine the correlation between procalcitonin levels and lymphocyte counts in patients with DM after undergoing cupping therapy. This study employed q quasi-experimental method with a one-group posttest-only design. The study involved 22 patients with type 2 diabetes melitus who underwent wet cupping therapy at Griya Bekam Lebah Emas Banyumas. Procaltionin levels and lymphocyte counts were analyzed using the Spearman Rho correlation test. The result of the Spearman Rho correlation test showed a p-velue of 0.257 and an r-value of 0.253. Based on these results, no significant correlation was found between procalcitonin levels and lymphocyte counts in DM patients post cupping therapy.
Co-Authors Abdul Latif Ade Rusman Aisyah Sabila Rosyada Alfato Yusnar Kharismasyah Amalia Ovi Mustika Seno Annisa Gallela Anjani Citra Nadia Salsabila Danu Tirta Nadi Defi Nurul Hayati Dhanti, Kurnia Ritma Dini Nur Afifah Dita Pratiwi Kusuma Wardani Ermi Susi Yanti Evi Nurhayati Farid Ishartomo Farida Dwi Handayani Fatiatun Fatiatun Fitri Paramitha Annisa gema romadhona Hanny Dwi Indah Nurcahyani Ikhsan Mujahid Isnaeni Rofiqoch Istianah - Iwan Setiawan Jumrianto Jumrianto Kurnia Rhitma Dhanti Kurniawan Kurniawan - Kurniawan Kusnanto Mukti Wibowo Linda Wijaya Linda Wijayanti Minto Rahaju N. Prasath Nadia Ega Haliza NADIA RIZQI AULIA Nur An-Nuha Muniroh Presillia Grisviani Grisviani Regawa Bayu Pamungkas Retno Sulistyowati Ridho Muktiadi Royan - Royan Royan Rum Sapundani Samuel Surya Brilianto santosa, Arif Prashadi SUDARSONO, TANTRI ANALISAWATI Supriyadi Supriyadi Syafira Dian Ergiana Tantri Analisawati Sudarsono Tantri Analisawati Sudarsono Tantri Analisawati Sudarsono Tyas Ulfah Khasanah Uli Mas’uliyah Indarwati Windy Lestari