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All Journal Jurnal SOLMA Indonesian Journal of Police Studies Jurnal Kesehatan Tambusai Muhammadiyah Medical Journal Jurnal Ilmiah Pangan Halal Indonesian Journal of Biomedicine and Clinical Sciences Sanus Medical Journal Annales Bogorienses
Budiman, Muhamad Arif
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Sanus Medical Journal

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Synergistic Anti-inflammatory Activity of Tinospora crispa L. and Zingiber officinale: A BSA Assay Study Dewi, Sari Puspita; Kurnia, Achdi; Permata Sari, Shinta Dewi; Budiman, Muhamad Arif
Sanus Medical Journal Vol. 7 No. 1 (2025)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v7i1.20514

Abstract

Ginger rhizome (Zingiber officinale) and Tinospora crispa L. (Tinospora crispa L.) extracts contain various active compounds that have the potential to be anti-inflammatory agents. This study aims to evaluate the anti-inflammatory activity of ginger rhizome and Tinospora crispa L. leaf extracts, both singly and in combination, using the BSA test method. Extraction was carried out using the maceration method with 70% ethanol solvent. Anti-inflammatory activity tests were carried out in vitro at 75, 100, and 150 μg/mL concentrations by measuring the extract's ability to prevent heat-induced BSA denaturation. The yield of Tinospora crispa L. extract reached 41.39% and that of ginger extract 25.63%. The combination of 150 μg/mL extracts showed the highest anti- inflammatory activity (96.82%) of all the extract test samples. In comparison, the lowest anti-inflammatory activity was found in 75 μg/mL ginger extract, at 89.21%. Statistical tests showed a significant difference between the 75 μg/mL ginger extract and the 150 μg/mL combination (p=0.047). The combination of ginger and Tinospora crispa extract has the potential to be developed as a natural anti-inflammatory agent.
Co-Authors Alleandra, Tasya Ayu Risa Putri, Made Dawami, Rido Elfirta, Rizki Rabeca Ferdian, Pamungkas Rizki Gogo Harahap, Roito Elmina Handayani, Tri Hadi Harahap, Roito Elmina Gogo Hasni Hasni Herjuno Ari Nugroho, Herjuno Ari Husein, Faiza Jamaluddin Ahmad Kantri, Wafa Afrodita Kurnia, Achdi Madiastuti, Septi Mangkuanom, Arwin Saleh Muhammad Rifqi Nanang, Fitry Rahayu NG, Ignatius Yansen Noli Novidahlia Nurhayati Nurhayati Permata Sari, Shinta Dewi Pudyastuti, Erlina Qonsolanisota, Gitrif Sari Puspita Dewi, Sari Puspita Sari, Shinta Dewi Sari, Shinta Dewi Permata Siti Elkana Nauli Sri Suciati Ningsih Syabani, Ines Nur Trimawanti, Wening Vera Lusiana, Mika Wartika Rosa Farida