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Wienaldi, Wienaldi
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Pengaruh Ekstrak Buah Pala (Myrisca Fragrans Houtt) Terhadap Fungsi Pankreas Dan Gambaran Hispatologi Pankreas Tikus Putih Galur Wistar Jantan Yang Mengalami Diabetes Melitus Widhiasi, Lia Kristiani; Wienaldi, Wienaldi; Suandy, Suandy
JURNAL PENELITIAN PENDIDIKAN, PSIKOLOGI DAN KESEHATAN (J-P3K) Vol 6, No 1 (2025): J-P3K
Publisher : Yayasan Mata Pena Madani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51849/j-p3k.v6i1.613

Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak buah pala (Myristica fragrans Houtt) terhadap fungsi pankreas dan gambaran histopatologi pankreas pada tikus putih galur Wistar jantan yang mengalami diabetes melitus. Diabetes melitus dapat menyebabkan kerusakan pada pankreas yang berpengaruh terhadap fungsi insulin dan metabolisme tubuh. Dalam penelitian ini, tikus diabetes diberi perlakuan dengan ekstrak buah pala pada dosis tertentu selama periode tertentu. Fungsi pankreas diukur melalui kadar glukosa darah, sedangkan gambaran histopatologi pankreas dianalisis menggunakan preparat jaringan. Hasil penelitian menunjukkan bahwa ekstrak buah pala dapat meningkatkan fungsi pankreas dengan menurunkan kadar glukosa darah dan memperbaiki kondisi histopatologi pankreas yang rusak akibat diabetes melitus. Temuan ini menunjukkan bahwa ekstrak buah pala berpotensi sebagai terapi tambahan untuk memperbaiki kerusakan pankreas pada penderita diabetes melitus.
Perilaku penggunaan APD dan kecelakaan kerja pada pekerja pabrik kelapa sawit PT. Padasa Enam Utama Kalianta Satu Sinurat, Buenita; Siregar, Santy Deasy; Oetari, Widyaningsih; Pardianto, Gede; Wienaldi, Wienaldi; Sidabutar, Mitra Juniaty
Buletin Kedokteran & Kesehatan Prima Vol. 1 No. 2 (2022): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v1i2.2817

Abstract

Keselamatan dan kesehatan kerja merupakan suatu pemikiran dan upaya untuk menjamin keutuhan dan kesempurnaan baik jasmani maupun rohani pekerja dan dengan keselamatan dan kesehatan kerja maka para pihak diharapkan dapat melakukan pekerjaan dengan aman dan nyaman. APD adalah seperangkat alat yang digunakan oleh tenaga kerja untuk melindungi seluruh atau sebagian tubuhnya terhadap kemungkinan adanya potensi bahaya di tempat kerja atau kecelakaan kerja. Adapun tujuan dari penelitian ini adalah untuk mengetahui Hubungan Perilaku Penggunaan APD dengan Kecelakaan Kerja pada Pekerja Pabrik Kelapa Sawit PT. Padasa Enam Utama Kalianta Satu, Kec. Kabun, Riau. Jenis penelitian ini adalah kuantitatif dengan desain deskriptif. Populasi penelitian ini adalah seluruh pekerja yang berkerja di Pabrik Kelapa Sawit dengan jumlah 140 orang dan sampel sebanyak 50 orang. Pengumpulan data dilakukan dengan menggunakan kuesioner tentang pengetahuan dan sikap para perkerja saat di tempat kerja. Analisis data yang digunakan dalam penelitian ini adalah analisis univariate dan bivariate menggunakan uji Chi-Square. Hasil penelitian didapatkan bahwa terdapat 2 faktor yang memiliki hubungan yang bermakna dengan Kecelakaan Kerja pada Pekerja Pabrik Kelapa Sawit PT. Padasa Enam Utama Kalianta Satu, Kec. Kabun, Riau yaitu pengetahuan (p=0.023) dan sikap (p=0.019). Diharapkan perusahaan menyediakan training (pelatihan) kepada pekerja untuk meningkatkan pengetahuan para pekerja dan juga diharapkan perusahaan membentuk tim untuk memonitor kedisplinan pekerja dalam kepatuhan penggunaan APD sehingga dapat mengurangi resiko terjadinya kecelakaan kerja.
The relationship between anemia and quality of life in chronic kidney disease patients undergoing hemodialysis at Royal Prima Hospital Manalu, Angelia Tesalonika Mawarni; Suhartina, Suhartina; Wienaldi, Wienaldi
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 2 (2024): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i2.5689

Abstract

This study aimed to investigate the relationship between anemia and quality of life in patients with chronic renal failure undergoing hemodialysis at Royal Prima Hospital. An analytical observational design using a cross-sectional approach was used. Data were collected from pre-existing medical records, and quality of life was assessed using a modified WHOQOL-BREF questionnaire that evaluates various aspects of life using a 5-point Likert scale. The chi-square test was used to determine the significance of the relationship between anemia status and quality of life among patients. A study of 51 hemodialysis patients at Royal Prima Hospital showed a high prevalence of anemia, with 86.3% of patients showing hemoglobin levels below the normal range. Although most patients (92.2%) were prescribed Sangobion, an iron supplement, many patients remained anemic, indicating a potential problem in terms of treatment efficacy or compliance. The duration of hemodialysis varied among the participants, with most undergoing treatment for more than 24 months, while the others were on hemodialysis for less than 24 months. About 92.2% reported a moderate quality of life, while only 7.8% experienced a poor quality of life. Statistical analysis showed no significant difference in the quality of life between patients with and without anemia (p=0.495), indicating that anemia may not have a direct impact on the overall quality of life for this patient population. In conclusion, although anemia is prevalent in hemodialysis patients at Royal Prima Hospital, its association with quality of life appears to be limited based on the findings of this study. Future research should focus on understanding the causes of anemia in this population and developing targeted strategies to improve the hematological status and overall quality of life of patients undergoing hemodialysis.
Prevalence of chronic obstructive pulmonary disease among TB patients at Royal Prima Hospital Cristoffel, Abraham; Wienaldi, Wienaldi; Suandy, Suandy
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 2 (2024): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i2.6308

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is a respiratory disease characterized by a reduction in lung capacity and is the third leading cause of death worldwide. COPD is a complex disease involving various environmental and genetic factors. This study aimed to determine the prevalence of COPD among TB patients at Royal Prima Hospital in Medan. This was a retrospective descriptive study with a cross-sectional design. The population of this study was all outpatient TB medical records at Royal Prima Hospital in Medan. Purposive sampling was used, resulting in a sample size of 68 individuals. Data was analyzed univariately using descriptive statistics presented in frequency distribution tables and percentages. The results showed that most COPD patients at Royal Prima Hospital were elderly (73.5%), male (85.3%), employed (64.7%), had a junior high school education (47.1%), had suffered from COPD for less than 10 years (70.3%), and were active smokers (63.2%). Most COPD patients were categorized as having moderate disease (39.7%). It is hoped that Royal Prima Hospital will continue to develop prevention programs for Chronic Obstructive Pulmonary Disease to reduce the number of cases, and that COPD patients who frequently visit healthcare facilities will receive instructions on self-care management for their long-term condition to reduce disease severity.
Faktor yang Mempengaruhi Kejadian Stunting pada Balita Umur 24-60 Bulan di Desa Dusun Bagot Raja Purba, Greace Hasianna; Wienaldi, Wienaldi; Fachrial, Edy
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i10.62339

Abstract

Stunting merupakan salah satu masalah gizi kronis yang masih tinggi di Indonesia dan menjadi prioritas nasinal dalam bidang kesehatan, Kondisi ini terjadi akibat kekurangan giji dalam waktu yang lama, infeksi berulang, serta pola asuh dan lingkungan yang kurang mendukung. Stunting berdampak pada pertumbuhan fisik, perkembangan kognitif, dan produktivitas anak di masa depan. Berdasarkan data Riset Kesehatan Dasar (Riskesdas) tahun 2018, prevalens stunting di indonesia mencapai 30,7% angka ini masih di atas ambang batas yang ditetapkan WHO yaitu 20%. Penelitian ini bertujuan untuk mengetahui faktor faktor yang mempengaruhi kejadian stunting pada balita usia 24-60 Bulan di Desa Dusun Bagot Raja, Kecamatan Purba, Kabupaten Simalungun. Penelitian ini menggunakan metode kuantitatif dengan desain cross-sectional. Populasi penelitian adalah seluruh balita usia 24-60 bulan di Desa Dusun Bagot Raja sebanyak 41 responden yang diambil dengan teknik total sampling. Data dikumpulkan melalui wawancara menggunakan kuisioner dan dianalisis dengan Chi-Square menggunakan program SPSS. Variabel independen dalam penelitian ini meliputi berat badan lahir, asupan energi, pemberian ASI eksklusif, pola asuh, pendapatan keluarga, dan keragaman pangan Hasil penelitian menunjukkan bahwa prevalensi stunting di Desa Dusun Bagot Raja sebesar 63%. Anaisis bivariat menunjukkan adanya hubungan yang signifikan antara kejadian stunting dengan berat badan lahir (p= 0,011), asupan energi (p=0,009),pemberian ASI eksklusif (p=0,003), pendapatan keluarga (p=0,001), dan kergaman pangan (p=0,001). Sementara itu pola asuh tidak menunjukkan hubungan yang signifikan (p=0,082). Faktor yang paling dominan mempengaruhi kejadian stunting adalah pendapatan keluarga dan keragaman pangan Tingginya angka stunting di Desa Dusun Bagot Raja dipengaruhi oleh rendahnya pendapatan keluarga. Kurangnya keragaman pangan, aupan energi yang tidak terpenuhi, riwayar berat badan lahir rendah, dan pemberian ASI ekskusif yang tidak optimal. Upaya pencegahan perlu difokuskan pada peningkatan gizi keluarga, edukasi pola makan, gizi seimbang, serta pemberdayaan ekonomi masyarakat untuk meningkatkan kesejahteraan keluarga.
Analysis of Patient Satisfaction and Loyalty Mediated by Reputation and Conduct of Public Hospital Staff Government of North Sumatra Province Nasution, Sri Lestari Ramadhani; Sitompul, Fernades; Wienaldi, Wienaldi; Girsang, Ermi
Poltekita : Jurnal Ilmu Kesehatan Vol. 17 No. 4 (2024): February
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v17i4.3482

Abstract

This research investigates the pivotal role of hospitals in healthcare, categorizing them into general and specialized facilities based on resources and capabilities. Focusing on North Sumatra, the study explores the significance of hospital conditions in influencing patients' choices, particularly in a competitive healthcare landscape driven by responsiveness to quality information. Employing a quantitative approach with non-probability sampling, the research follows a positivist philosophy to examine the connection and influence between independent and dependent variables. Conducted at the General Government Hospital in North Sumatra, the study spans from a preliminary survey in September 2023 to November 2023, with data collection ongoing and results to be presented in a seminar. The analysis reveals a substantial impact of Patient Satisfaction (PS) on Patient Loyalty (PL) (coefficient = 0.581), supported by a t-statistic value of 5.572 (>1.96) and a p-value of 0.000 (<0.05). PS also significantly influences Hospital Staff Behavior (HSB) (coefficient = 0.280, t-statistic = 2.630, p-value = 0.009 < 0.05) and Hospital Reputation (HR) (coefficient = 0.450, t-statistic = 4.789, p-value = 0.000 < 0.05). Hospital Staff (HS) demonstrates a notable influence (coefficient = 0.101) on PL, though the relationship is not statistically significant (t-statistic = 1.520, p-value = 0.129 > 0.05). Similarly, HR influences PL (coefficient = 0.124), but the relationship is not statistically significant (t-statistic = 1.402, p-value = 0.161 > 0.05). Furthermore, PS exhibits a mediated influence on PL through HSB (coefficient = 0.028, t-statistic = 1.221, p-value = 0.223 > 0.05) and through HR (coefficient = 0.056, t-statistic = 1.269, p-value = 0.205 > 0.05). These findings underscore the critical role of patient satisfaction in shaping loyalty, highlighting the mediating effects of Hospital Staff Behavior and Hospital Reputation. Understanding these dynamics is crucial for promoting healthcare competition and enhancing care quality in the North Sumatra region.
Effectiveness Test of Topical Application of Coffee Bean Extract in Accelerating the Wound Healing Process of Incised Wounds on the Dorsal Area of White Rats (Rattus norvegicus) Wistar Strain Chandra, Dody; Nasution, Sri Wahyuni; Wienaldi, Wienaldi
Jurnal EduHealth Vol. 14 No. 04 (2023): Jurnal eduHealt, 2023, December
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This study aimed to evaluate the effectiveness of the topical application of coffee bean extract (Coffea) in accelerating the wound healing process of cut wounds on the backs of Wistar strain white rats (Rattus norvegicus). The research was conducted using an experimental design with a completely randomized design (CRD) consisting of four treatment groups, namely the negative control group (receiving base ointment), the positive control group (receiving antibiotic ointment), and two treatment groups receiving coffee bean extract at concentrations of 1% and 2%. A total of 20 Wistar-strain white rats were used as the research subjects. Cut wounds were created on the backs of the rats using sterile sharp instruments. After the formation of the cut wounds, the treatments were applied topically to the wound area according to the assigned treatment groups. Observations were made periodically for 14 days, and the parameters observed included wound healing time, presence of secondary infection, inflammation, and scar formation. The study showed that topical application of coffee bean extract at concentrations of 1% and 2% significantly accelerated the wound healing process in the Wistar strain white rats. The wound healing time in the treatment groups receiving 1% and 2% coffee bean extract was significantly faster compared to the negative control group (p < 0.05). Still, it did not differ significantly from the positive control group (p > 0.05). Furthermore, the treatment groups receiving coffee bean extract also exhibited a significant reduction in inflammation and secondary infection compared to the negative control group. However, there was no significant difference in scar formation between the treatment and control groups. In conclusion, topical application of 1% and 2% coffee bean extract effectively accelerated the wound healing process of cut wounds on the backs of Wistar strain white rats. This study provides insights into the potential use of coffee bean extract as an alternative therapy for wound healing. However, further research is needed to evaluate the mechanisms of action and possible side effects associated with using coffee bean extract.
Comparison of the Effectiveness of Dermapen Using Trambosit Plasma and Scar Serum Dermapen Actions on Scar Acne Areas on the Skin Surface of Wistar Female Rats (Rattus Norvegicus) Riza Al Djoefri, Mohamad; Wienaldi, Wienaldi; Chailur, Muhammad; Marthin Simbolon, Boyke
Jurnal EduHealth Vol. 14 No. 04 (2023): Jurnal eduHealt, 2023, December
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This study aimed to analyze and compare the effectiveness of the action of dermapen using plasma from platelets with the movement of dermapen using scar serum on pockmarked areas on the skin surface of female Wistar rats (Rattus norvegicus). The results of wound observations based on the period (days) with an average healing time of 10.4 days and 12 days needed by each mouse to close the wound in the PRP dermapen group were faster than the serum scar group. This can be explained by the PRP content containing growth factors important for wound healing and tissue regeneration, thus accelerating healing. Meanwhile, scar serum contains concentrates that are useful for nourishing and moisturizing the skin, which can easily penetrate the deepest layers of the skin, thereby accelerating skin regeneration. Further microscopic studies, such as histopathological studies, are needed to examine the number of fibroblasts.
Bakteri Endofit Pinang Sebagai Penghasil Antioksidan dan Inhibitor α-Glukosidase Balkis, Tiara; Fachrial , Edy; Wienaldi, Wienaldi
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1090

Abstract

Introduction: Diabetes mellitus is a chronic metabolic disorder with a high global prevalence and serious complications. The prediabetes stage is a critical target for prevention, often managed with α-glucosidase inhibitors. However, synthetic drugs such as acarbose are frequently associated with gastrointestinal side effects, highlighting the need for safer alternatives. Endophytic microbes from medicinal plants, including areca nut (Areca catechu), have the potential to produce bioactive compounds with antioxidant and antidiabetic activities. Objective: This study aimed to explore endophytic bacteria from fresh areca nut seeds as a source of metabolites with antioxidant and α-glucosidase inhibitory activity. Methods: Fresh areca nut seeds were sterilized using the surface sterilization method, followed by endophytic bacterial isolation and Gram staining. Cultures were fermented in Nutrient Broth, and supernatants were obtained by centrifugation. Antioxidant activity was assessed using the DPPH method, while α-glucosidase inhibition was tested in vitro with p-nitrophenyl α-D-glucopyranoside as substrate. Acarbose served as the positive control. Results: Seven Gram-negative, rod-shaped endophytic isolates (BP1-BP7) were obtained. Isolate BP1 exhibited the highest antioxidant activity with 45.7% inhibition. Furthermore, the BP1 supernatant demonstrated potent α-glucosidase inhibitory activity up to 93,6%, comparable to that of acarbose (91%). Conclusion: Endophytic bacteria from areca nut seeds possess dual bioactivity as antioxidants and α-glucosidase inhibitors, suggesting their potential as sustainable alternative antidiabetic agents worthy of further investigation.
Hubungan Kualitas Tidur dengan Indeks Massa Tubuh (IMT) di Fakultas Kedokteran Universitas Prima Indonesia Angkatan Tahun 2022 Mahani, Yensielia; Wienaldi, Wienaldi; Fachrial, Edy
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i11.62564

Abstract

Kualitas tidur yang buruk dapat memengaruhi keseimbangan metabolik tubuh dan berdampak pada perubahan Indeks Massa Tubuh (IMT). Mahasiswa kedokteran merupakan kelompok yang rentan mengalami gangguan tidur akibat beban akademik yang tinggi dan pola hidup tidak teratur. Penelitian ini bertujuan untuk mengetahui hubungan antara kualitas tidur dengan Indeks Massa Tubuh (IMT) pada mahasiswa Fakultas Kedokteran Universitas Prima Indonesia angkatan tahun 2022. Jenis penelitian ini adalah kuantitatif dengan metode analitik cross-sectional. Data dikumpulkan melalui kuesioner Pittsburgh Sleep Quality Index (PSQI) untuk menilai kualitas tidur serta pengukuran berat dan tinggi badan untuk menentukan IMT. Jumlah sampel sebanyak 178 mahasiswa yang dipilih dengan metode total sampling. Analisis data dilakukan menggunakan uji Chi-Square dan uji Cramer’s V dengan bantuan program SPSS. Hasil penelitian menunjukkan bahwa 94 responden (52,8%) memiliki kualitas tidur baik dan 84 responden (47,2%) memiliki kualitas tidur buruk. Mayoritas responden memiliki IMT normal sebanyak 113 orang (63,5%), sedangkan 29 orang (16,3%) tergolong obesitas. Uji Chi-Square menghasilkan nilai p < 0,001 yang menunjukkan adanya hubungan signifikan antara kualitas tidur dengan IMT, dengan kekuatan hubungan sedang (Cramer’s V = 0,492). Kesimpulan penelitian ini adalah semakin buruk kualitas tidur seseorang, semakin tinggi kecenderungan mengalami peningkatan IMT.
Co-Authors Adrian Adrian Afni Kartika, Ajeng Angnes, Odri Aulia, Hilda Rafni Balkis, Tiara Chailur, Muhammad Chandra, Dody Cristoffel, Abraham Cui, Zhan Davin, Radhitya Qowiyyul Edy Fachrial Elisabeth Elisabeth Fioni, Fioni Ginting, Chrismis Novalinda Girsang, Ermi Hati Harefa, Lurusan Jonathan Samuel Gultom, Andre Lestari Nasution, Sri Liena, Liena Linfeng, Gao Mahani, Yensielia Manalu, Angelia Tesalonika Mawarni Marthin Simbolon, Boyke Napiah Nasution, Ali Nazar Syahputri, Iskandar Oetari, Widyaningsih Pardianto, Gede Purba, Greace Hasianna Riza Al Djoefri, Mohamad Santy Deasy Siregar Sari Mutia, Maya Selviana Barus, Shella Sidabutar, Mitra Juniaty Sinurat, Buenita Siregar, Hernita Sitompul, Fernades Sri Lestari Ramadhani Nasution Suandy, Suandy Suhartina Suhartina, Suhartina Widhiasi, Lia Kristiani Willim, Devannie Alberta