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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Farmasi Indonesia Indian Journal of Forensic Medicine & Toxicology Poltekita: Jurnal Pengabdian Masyarakat Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Komunitas Farmasi Nasional Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Ratna Widyasari
Akademi Farmasi Yarsi Pontianak
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health

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Aktivitas Mukolitik Ekstrak Etanol Kulit Buah Jeruk Sambal (Citrus amblycarpa (Hassk.) Ochse) Secara In Vitro DINA YUSPITA SARI; Sanitasari; Ratna Widyasari
Jurnal Komunitas Farmasi Nasional Vol. 2 No. 2 (2022): Jurnal Komunitas Farmasi Nasional
Publisher : Akademi Farmasi Yarsi Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

An in vitro study of the mucolytic activity of the ethanol extract of limau citrus peel (Citrus amblycarpa (Hassk.) Ochse) has been carried out. This study aims to prove the mucolytic activity of the ethanol extract of limau citrus peel in vitro and determine the appropriate concentration. The mucolytic activity was tested using a Brookfield viscometer with 5 treatments and 3 repetitions every 15 minutes for 1 hour with different concentrations, namely: positive control (0.2% Acetylcysteine), negative control (0.5% Na-CMC), and ethanol extract of limau citrus peel with concentrations of: 1.6%, 2.1%, and 2.6%. The results of this study show that the percentage of mucolytic activity in extracts with concentrations of 1.6%, 2.1%, and 2.6% were 4.108%, 9.906%, and 16.952%. The results indicate that the three extract concentrations provide mucolytic activity.
Morphology Analysis of Hair Photoinduced and Chemical Damaged After Treatment with Sappan Wood (Caesalpinia sappan L.) Hair Tonic using SEM Dina Yuspita Sari; Ratna Widyasari; Indri Astuti
Borneo Journal of Pharmacy Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i4.4652

Abstract

Exposure to sunlight for a long time and repeatedly can also cause chemical and physical damage to human hair. Clinically, microscopic analysis using a scanning electron microscope (SEM) can assess hair damage by identifying the characteristic morphology of hair damage. This study aims to analyze the morphology of damaged hair chemically induced using 3% H2O2 and photoinduced UVB radiation before and after applying sappan wood (Caesalpinia sappan) hair tonic. The active ingredients used were ethanol extract, ethanol fraction, and chloroform-methanol fraction of C. sappan, which contains an antioxidant compound. Caesalpinia sappan simplicia was macerated using 96% ethanol and then partitioned using n-hexane. The ethanol fraction was then applied using vacuum column chromatography using chloroform : methanol (5 : 1) as eluent. The extracts and fractions were then formulated into hair tonic preparations. For SEM analysis, hair samples were coated with a sputter gold coater machine and divided into five treatments: undamaged hair, damaged hair with 3% H2O2 and UVB rays as a positive control, and treatment I, II, and III, in which the hair was damaged with 3% H2O2 and UVB rays respectively, then FI, FII, and FIII were applied, respectively (2000x magnification). Damaged hair with UVB induction shows moderate damage, and 3% H2O2 shows moderate to severe damage. The results in the treatment group show that the three hair tonics coated the hair cuticle, indicating an interaction with the hair fiber, and modified the cuticle by coating the cuticle.
Uji Toksisitas Akut Ekstrak Metanol Kulit Buah Jeruk Sambal (Citrus microcarpa Bunge) Terhadap Larva Artemia salina L. Dengan Metode Brine Shrimp Lethality Test (BSLT) Ratna Widyasari; Dina Yuspitasari; Wilda Wildaniah; Rosi Cahayuni Wahida
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 3 No 1 (2018)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v3i1.64

Abstract

Tanaman jeruk sambal (Citrus microcarpa Bunge) merupakan salah satu tanaman yang banyak terdapat di Kalimantan Barat. Kulit buah jeruk sambal mempunyai aktivitas antioksidan kuat dan aktivitas antimikroba, hal ini berkaitan erat dengan kandungan senyawa metabolit sekunder yaitu flavonoid, alkaloid dan polifenol, dimana senyawa ini berpotensi sitotoksik. Tujuan dari penelitian ini adalah untuk mengetahui apakah ekstrak metanol kulit jeruk sambal bersifat sitotoksik dengan metode Brine Shrimp Lethality Test (BSLT) dan mengetahui nilai LC50 yang dihasilkan. Penelitian eksperimental ini menggunakan ekstrak metanol kulit jeruk sambal dengan pembagian konsentrasi 1000 µg/ml, 750 µg/ml, 500 µg/ml, 250 µg/ml, 100 µg/ml, dan 0 µg/ml dimana pada masing-masing konsentrasi diletakkan 10 ekor larva Artemia salina L. Data kematian larva dikumpulkan dan dianalisis dengan metode analisis probit. Berdasarkan hasil dari analisis regresi linier menunjukkan nilai LC50 dari ekstrak metanol kulit jeruk sambal adalah 234,42 µg/ml.. Hasil penelitian ini menunjukan bahwa ekstrak metanol kulit jeruk sambal bersifat sitotoksik yang ditunjukkan dengan harga LC50 < 1000 µg/ml.
PENETAPAN KADAR FLAVONOID TOTAL EKSTRAK METANOL KULIT JERUK SAMBAL SECARA SPEKTROFOTOMETRI UV-VISIBEL RATNA WIDYASARI; Fadli Fadli; Sri Handayani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 4 No 2 (2020)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v4i2.129

Abstract

Jeruk Sambal (Citrus microcarpa Bunge) seringnya dimanfaatkan sebagai tanaman obat tradisional di Kalimantan Barat, seperti antioksidan dan antibakteri dikarenakan adanya senyawa flavonoid dan polifenol. Penelitian ini bertujuan untuk menentukan kadar flavonoid total dari ekstrak metanol kulit jeruk sambal. Penentuan kadar flavonoid total menggunakan metode spektrofotometri UV-Visibel dengan kuersetin sebagai pembanding. Pengukuran panjang gelombang maksimum kuersetin dilakukan pada panjang gelombang 380 nm – 780 nm dan diperoleh panjang gelombang maksimum kuersetin pada 432 nm. Kadar flavonoid total dihitung dengan persamaan regresi linear y = 0,0068 x + 0,1132 dengan koefisien relasi R2 = 0.9712 yang diperoleh dari kurva kalibrasi kuersetin. Hasil skrining fitokimia menunjukkan kulit jeruk sambal mengandung flavonoid dengan kadar flavonoid total sebesar 0,3324 mg/g.Kata kunci:  Kulit Jeruk Sambal, Penetapan Kadar, Flavonoid, Spektrofotometri UV-Visibel
Co-Authors Arief Priyo Nugroho Asep Kusnali Athiah Masykuroh Dina Yuspita Sari Dina Yuspita Sari Dina Yuspitasari Diyan Effendi Fadli Fadli Fadli Fadli Fenny Oktaviyeni Indri Astuti Irfan Ardani Justicia, Adhisty Kharisma Pinda Hutajulu Puspita, Weni Ratika Ratiningsih Rivo Maghfirandi Rosi Cahayuni Wahida Sanitasari Siti Maimunah Sri Handayani Wilda Wildaniah Winda Tahuhiddah Zulfa Auliyati Agustina