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All Journal Jurnal Neutrino : jurnal fisika dan aplikasinya Jurnal Pendidikan Fisika Indonesia Jurnal Spektra Jurnal SOLMA Spektra: Jurnal Fisika dan Aplikasinya Manuju : Malahayati Nursing Journal JURNAL METEOROLOGI DAN GEOFISIKA Jurnal Abdi Masyarakat Indonesia PROSIDING SEMINAR NASIONAL FISIKA (E-JOURNAL) Journal of Global Pharma Technology Indonesian Journal of Electronics, Electromedical Engineering, and Medical Informatics Journal of The Physical Society of Indonesia
Umiatin, Umiatin
Program Studi Fisika, FMIPA, Universitas Negeri Jakarta, Indonesia
Aerospace Engineering Humanities Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Other

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Journal : Journal of Global Pharma Technology

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Expression of Adipocyte Binding Protein-2 (AP-2) on the Adipogenic Differentiation of Mesenchymal Stem Cell after Pulsed Electromagnetic Field (PEMF) Exposure Umiatin U
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Obesity is a health condition that can cause serious health problems in developing countries such as Indonesia and still a major health concern worldwide. Obesity increasing the risk of a number of pathological disorders including certain cancers, heart disease, stroke, and diabetes. It has been reported that Pulsed Electromagnetic Field (PEMF) have an inhibitory effect on adipogenesis of MSCs. However, it is not clear if this effect is direct or indirect. Various genes are involved in the development of obesity include adipocyte binding protein 2 (AP-2) which is associated with inflammation and the metabolic syndrome. In the present study, we investigated the effect of PEMF exposure with frequency 75 Hz and magnetic field 2 mT on the adipogenic differentiation of mesenchymal stem cells (MSCs). In the present study we used the MSCs second passage. The cells were stimulated by PEMF of 75 Hz/2mT for 14 days 10 in/day. The relative expression of AP-2 was measured on days 2, 4, 7 and 14 by using quantitative reverse transcription polymerase chain reaction (qRT-PCR) method. The PEMF significantly inhibited adipogenic differentiation by down regulating the expression of AP-2 on days 2, 4 and 7. This result indicated that PEMF exposure may have potent effect to inhibit adipogenic differentiation. Keywords: Pulsed electromagnetic field, Adipogenic, Mesenchymal Stem Cells, AP-2
Co-Authors Abidin, Muhammad Adini, Muhammad Hifdzi Ahmad Zatnika Purwalaksana, Ahmad Zatnika Al Farizy, Firnas Aldaciptarisa, Aldaciptarisa Aulia Rachma, Lu'luunnisa Bedy Purnama Bestari Laksmi Arafahnti Bunga Falana, Isfasona Cecep E Rustana Danang Trihatmoko, Danang Delila Septiani Dwi Putri Desnita Dwi Anita Suryandari Endang Wijaya Erick Kurniawan Erlina Erlina Erlina Erlina Esmar Budi Esmar Budi Esmar Budi Esmar Budi Fadli Handoyo Farhan Yusuf Fariani Hermin Febrian Zulmi Firmanul Catur Wibowo Fitri Sakinah Futri Wulandari Futri Wulandari Futri Wulandari, Futri Hadi Nasbey Hadi Nugrahaningsih, Tritiyatma Halimah, Nova Nur Haris Suhendar Hayatining Suci Abdilah Heru Prasetio I Made Astra I Made Astra I. M. Astra Ifa, Rista Putri Nur Istantia Chantika, Kinanti Ita Herawati Kartika, Irma Kurniadewi, Fera Leni Andayani Luluk Yunaini M. Jannah Michael Setiyanto Silambi Mitra Djamal Muhammad Nurdin Muhammad Reza Faisal, Muhammad Reza Muhammad Ridho Pratama Mutiara Pratama Nabila Amalia Dewi Nadya Hidayatie Novita Fitriani Nur Indah Arahman Rahim Nurhayadi, Muktiningsih Nurul Fadillah Octaviany, Sheila Nurul Mahilda Puji Sari Putri Fajriani, Fathya Putri, Pinkan Amanda Putria, Sarah Febriyana Riandini Riandini Ridho Akbar Bintoro Rizky Yusuf Halomoan Salsa Ghina Khairunisa Saputro, Setyo Wahyu Sastra Kusuma Wijaya Septiani, Elsa Shallu Fidhah Ariyanti Siti Aisyah Solechah Sri Rahayu Taryudi Taryudi Taryudi, Taryudi Tesa Apriyanti Tora Oktaviana Tritiyatma Hadi Nugrahaningsih Widia Bela Oktaviani Widyaningrum Indrasari Yolanda Natasya Mega Stella