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All Journal Biotropika Panrita Abdi - Jurnal Pengabdian pada Masyarakat Medica Hospitalia Indonesian Journal of Health Science Indonesian Journal of Life Sciences Jurnal Ilmiah Pengabdian Masyarakat Bidang Kesehatan SEGARA : Jurnal Pengabdian Kepada Masyarakat Jurnal Sains Biomedis Journal of World Future Medicine, Health and Nursing Altius: Jurnal Ilmu Olahraga dan Kesehatan
Afifa Radhina
Department Of Physiology, Faculty Of Medicine, Universitas Pembangunan Veteran Jakarta, Jakarta, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary Other

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Effectiveness of Mesenchymal Stem Cells and Their Derivatives in Modulating Oxidative Stress in Neurodegenerative Diseases: A Structured Narrative Review Niken Rahmah Ghanny; Putu Erma Pradnyani; Assyafiya Salwa; Herera Rahajeng; Afifa Radhina; Bunga Anggreini Sari; Ichwan Baihaki
Indonesian Journal of Life Sciences 2026: IJLS Vol 08 No.01
Publisher : Universitas Bio Scientia Internasional Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v8i01.297

Abstract

Background: Oxidative stress plays a critical role in the development and progression of neurodegenerative diseases such as Parkinson’s disease (PD), Alzheimer’s disease (AD), and amyotrophic lateral sclerosis (ALS). Mesenchymal stem cells (MSCs) and their derivatives have emerged as promising therapeutic strategies due to their antioxidant, anti-inflammatory, and neuroprotective properties. Objective: This review evaluated the effectiveness of MSC-based interventions in modulating oxidative stress in neurodegenerative disease models. Methods: A structured narrative review search was conducted following PRISMA 2020 guidelines using PubMed and Scopus databases for studies published between 2020 and 2025, with the last search in December 2025. Results: 33 studies met the inclusion criteria, primarily involving Parkinson’s and Alzheimer’s disease models. Overall, MSC-based therapies reduced oxidative stress markers, enhanced antioxidant defenses, activated the Nrf2/HO-1 pathway, improved mitochondrial function, and reduced neuroinflammation in experimental neurodegenerative disease models.
Pathogenicity and characteristics of Blastocystis subtypes Nurul Ain; Afifa Radhina; Mike Permata Sari
Indonesian Journal of Health Science Vol 6 No 4 (2026)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v6i4.1698

Abstract

Blastocystis sp., an intestinal protozoan widely distributed in the human gastrointestinal tract, exhibits a global presence, with prevalence varying by region and generally higher in developing countries compared to developed ones. In Indonesia, reported prevalence varies considerably by region and study population, ranging from approximately 34% to 72% in several regional studies. This protozoan is water-borne and primarily transmitted through cysts via the fecal-oral route. Factors such as poor hygiene, immigration, travel to tropical developing countries, contact with animals, and consumption of contaminated food or water elevate the risk of infection. The pathogenesis in humans remains unclear, as infections may either manifest symptoms or remain asymptomatic, partly due to diagnostic limitations and variation in virulence across subtypes. This review aims to elucidate the characteristics and pathogenicity of Blastocystis sp. subtypes, particularly ST3, which is frequently dominant in symptomatic patients, and to discuss ongoing controversies in the literature.
Beyond BMI in Community Health Promotion: An Integrated Anthropometric, Physiological, and Functional Screening Approach among Urban Women in East Jakarta, Indonesia Ichwan Baihaki; Taufiq Fredrik Pasiak; Afifa Radhina; Assyafiya Salwa; Bunga Anggreini Sari; Fransiskus Samuel Renaldi; Herera Rahajeng; Muhammad Fadhil; Niken Rahmah Ghanny; Ria Apriliani
Jurnal Ilmiah Pengabdian Masyarakat Bidang Kesehatan (Abdigermas) Vol. 4 No. 2 (2026): Jurnal Ilmiah Pengabdian Kepada Masyarakat Bidang Kesehatan (Abdigermas)
Publisher : CV Media Inti Teknologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58723/abdigermas.v4i2.750

Abstract

Background: Community-based preventive screening is important for reducing non-communicable disease risk among adult women, particularly those who influence household health practices. However, screening activities frequently emphasize Body Mass Index (BMI), although BMI alone may not adequately describe central adiposity, elevated blood pressure, and functional health indicators. This community service article aimed to describe the implementation of health education and integrated screening involving anthropometric, physiological, and functional measurements among female guardians at Yayasan Tarbiyatul Yatim, East Jakarta, Indonesia.Aims: This study aimed to (1) implement a community-based health education and screening program for adult female participants, (2) assess anthropometric, physiological, and functional health indicators including blood pressure, BMI, waist circumference, and hand grip strength, and (3) identify the prevalence of potential cardiometabolic and functional risk markers beyond BMI.Methods: This activity was implemented on January 8, 2026 using a preventive-promotive community service framework with descriptive program evaluation. Thirty-two adult female participants joined health education, screening, and individual consultation. The community service dataset included blood pressure, pulse, oxygen saturation, body temperature, body weight, height, BMI, waist circumference, hand grip strength, health history, lifestyle profile, and current complaints. Data were analyzed descriptively using frequency, percentage, mean, median, standard deviation, and range.Result: The participants had a mean age of 49.8 years. Mean systolic and diastolic blood pressure were 129.2 mmHg and 78.8 mmHg, respectively. Mean BMI was 24.9 kg/m²; 16/32 participants (50.0%) were categorized as normal, 9/32 (28.1%) overweight, 4/32 (12.5%) obese, and 3/32 (9.4%) underweight. Mean waist circumference was 97.7 cm, and 29/32 participants (90.6%) had waist circumference >80 cm. Mean hand grip strength was 16.5 kg, and 21/32 participants (65.6%) had values <18 kg.Conclusion: Integrated screening beyond BMI is feasible in community service settings and can help identify potential cardiometabolic and functional risk indicators that require counseling or referral. Future activities should include documented repeat measurements for abnormal findings, structured pretest-posttest educational evaluation, biochemical testing, and referral follow-up.
HISTOPATHOLOGICAL IMAGE OF THE NUMBER OF NEURONS IN THE BRAIN OF MICE (MUS MUSCULUS) INDUCED BY LEAD HEAVY METAL Herera Rahajeng; Eka Sri Haryati; Ichwan Baihaki; Niken Rahmah Ghanny; Afifa Radhina; Assyafiya Salwa; Fransiskus Samuel Renaldi
Journal of World Future Medicine, Health and Nursing Vol. 4 No. 2 (2026)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/health.v4i2.3677

Abstract

Lead is a known heavy metal from human history to date for various uses, abuses and toxicities. Lead poisoning has been recognized as one of the most serious environmental health issues worldwide, especially children living in developing countries. Lead can damage or affect the organs of the body, among others, the nervous system, kidneys, reproductive system, and heart, as well as disturbances in the brain so that intellectual and mental disorders in the brain. This study aims to see the effect of lead on the number of neurons in the hippocampus in mice experimental animals. The mice used amounted to 10 tails and divided into two for the control group and the treatment group. The control group, each of which was 5 tails, was then given unbleached drinking water while the treatment group was given drinking water mixed with acetate with concentration of 1000ppm for 17 days in adlibitum. The observations were taken from each of the 5 fields of view on each preparation with a magnification of 40x. The calculation of the number of neuron cells is then analyzed descriptive statistics and different test. The result showed that control group with mean ± SD were 127,6 ± 7,9, and for treatment group that was 80,0 ± 20,9. T independent test result showed p = 0,001 (p <0,05) which means that there was a significant difference between control and treatment group. The conclusion of this research is the existence of neuron cell damage in mice that get treatment. By showing the number of neurons less than the control mice. Suggestion to develop this research hence need to continue research to find neuro protector compound specially from lead work in brain.
Peningkatan Kesadaran Masyarakat tentang LBP dan Kecemasan di Lingkungan Masjid Al-Muhajirin, Pangkalan Jati, Depok Niken Rahmah Ghanny; Riri Oktavani Banjarnahor; Afifa Radhina; Herera Rahajeng
Segara : Jurnal Pengabdian Kepada Masyarakat Vol 3 No 2 (2025): Vol. 3 No. 2 (2025): SEGARA : Jurnal Pengabdian Kepada Masyarakat
Publisher : Fakultas Kedokteran UPN "Veteran" Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/segara.v3i2.12531

Abstract

Nyeri punggung bawah atau low back pain (LBP) merupakan masalah kesehatan masyarakat dengan karakteristik penyakit berupa durasi penyakit yang lama. Studi menunjukkan bahwa pasien dengan LBP sering mengalami kecemasan akibat dari gejala nyeri yang berkepanjangan. Tingkat prevalensi LBP di Indonesia sebesar 44,29% pada pra-lansia dan lansia, dengan faktor psikologis termasuk kecemasan dan stress yang diidentifikasi sebagai faktor resiko signifikan dalam kronisitas nyeri. Kondisi LBP dan kecemasan bersifat dua arah: kecemasan dapat memperburuk persepsi nyeri, sementara nyeri presisten dapat meningkatkan gejala kecemasan. Resiko terjadinya kondisi tersebut dipengaruhi oleh faktor genetik, faktor psikososial, dan lingkungan. Kegiatan pengabdian masyarakat yang dilakukan oleh Fakultas Kedokteran Universitas Pembangunan Nasional Veteran Jakarta (FK UPNVJ) bertujuan untuk meningkatkan kesadaran masyarakat mengenai hubungan antara LBP dan kecemasan. Pelaksanaan kegiatan berupa penyampaian materi edukasi melalui metode ceramah dan pengisian kuesioner. Kegiatan dilakukan di lingkungan Masjid Al-Muhajirin, Pangkalan Jati, Depok, dengan jumlah sasaran sebanyak 42 peserta. Berdasarkan hasil pemeriksaan peserta, sebanyak 57,1% warga mempunyai keluhan LBP dan sebanyak 2,3% mengalami nyeri intensitas berat sekali disertai kecemasan. Hasil menunjukkan adanya kasus LBP pada masyarakat lingkungan Masjid Al-Muhajirin, Pangkalan Jati, Depok. Kegiatan edukasi LBP dan keterkaitannya dengan kecemasan berhasil meningkatkan kesadaran masyarakat tentang hubungan bidireksional antara LBP dan kecemasan, ditandai dengan antusiasme dan respons positif peserta. Kegiatan ini efektif sebagai langkah awal dalam meningkatkan kesadaran masyarakat tentang pentingnya pendekatan holistik terhadap LBP yang mencakup aspek psikologis. Mengingat tingginya prevalensi LBP dan gangguan kecemasan di Indonesia, maka diperlukan program edukasi berkelanjutan untuk mendukung pencegahan dan deteksi dini penyakit tersebut
Energy System Contributions to Sports Performance: A Systematic Review Afifa Radhina; Niken Rahmah Ghanny; Herera Rahajeng; Assyafiya Salwa; Ichwan Baihaki; Bunga Anggreini Sari; Fransiskus Samuel Renaldi
Altius: Jurnal Ilmu Olahraga dan Kesehatan Vol. 15 No. 1 (2026): Altius: Jurnal Ilmu Olahraga dan Kesehatan
Publisher : Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/altius.v15i1.203

Abstract

Understanding how the body produces and utilizes energy during exercise is key to enhancing athletic performance and refining training strategies. This systematic review analyzes recent studies on the contributions of the phosphagen (ATP-PCr), glycolytic (anaerobic), and oxidative (aerobic) energy systems in various sports. The review follows PRISMA 2020 guidelines and includes studies published between 2020 and 2025, selected from Scopus, PubMed, Google Scholar, and Web of Science. Energy system contributions were evaluated using markers such as oxygen uptake, substrate utilization, blood lactate levels, and ATP turnover rates. The review finds that in high-intensity, short-duration events like the 100m sprint, the phosphagen system accounts for 70%, while glycolytic and oxidative systems contribute 25% and 5%, respectively. In endurance events such as marathons, oxidative metabolism dominates, contributing 85–95% of total energy. Sports with mixed intensity, such as soccer and basketball, show dynamic contributions, with oxidative metabolism at 50–60%, phosphagen at 20–30%, and glycolytic at 15–25%. These results highlight the importance of sport-specific training to optimize energy system interactions and performance.
Co-Authors Amalia Shari Arianto, Steven Assyafiya Salwa Assyafiya Salwa Assyafiya Salwa Bunga Anggreini Sari Cityta Putri Kwarta Eka Sri Haryati Erma Pradnyani, Putu Herera Rahajeng Ichwan Baihaki Indriani, Narita Insani Fitrahulil Jannah Jannah, Insani Fitrahulil Muhammad Fadhil Muhammad Fadhil Niken Rahmah Ghanny Niken Rahmah Ghanny Niken Rahmah Ghanny Niken Rahmah Ghanny Niken Rahmah Ghanny Nisa Kartika Komara Nurul Ain Pararawendy Indarjo Privia Muliamarshanti Rahajeng, Herera Renaldi, Fransiskus Samuel Ria Apriliani Riri Oktavani Banjarnahor SARI, MIKE PERMATA Shari, Amalia Steven Arianto Taufiq Fredrik Pasiak