Article Per Year (5 Year)
p-Index From 2021 - 2026
2.63
P-Index
This Author published in this journals
All Journal JURNAL FARMASIMED (JFM) Jurnal Kesehatan Ilmiah Indonesia / Indonesian Health Scientific Journal Jurnal Pengabdian Masyarakat Aufa (JPMA) Jurnal Pengmas Kestra (JPK) Indonesian Journal of Science and Pharmacy
Harahap, Hasni Yaturramadhan
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

Published : 14 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 4 Documents
Search
Journal : JURNAL FARMASIMED (JFM)

 1 
Test of the Anti-Inflammatory Effectiveness of Ethanol Extract Gel Preparation of Sabrang Onion Bulb (Eleutherine bulbosa) on Incisional Wounds in Wistar Rats Harahap, Hasni Yaturramadhan; Syarifuddin, Shofian; Cahya, Cucu Arum Dwi; Br Sinaga, Irma Suryani Kristina
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2317

Abstract

Background: The use of medicinal plants is increasingly widespread among the community, especially due to their properties in healing various diseases. One of the developing medicinal plants is bawang sabrang (Eleutherine bulbosa), which has been proven to accelerate the healing process of wounds. Objective: To evaluate the effectiveness of administering gel extract from bawang dayak tubers on the healing process of incised wounds in rats. The test subjects used were 25 male rats. Incisions measuring 2 cm were made on the backs of the rats using a surgical knife. Method: Laboratory experimental study with a Completely Randomized Design (CRD) consisting of five treatments: one positive control (bioplacenton gel), one negative control (gel base), and three graduated concentrations of gel extract, namely 5%, 10%, and 15%. Treatments were administered twice daily for 14 days. Results: Measurement of wound diameter showed that the gel extract of bawang sabrang at a concentration of 15% and the positive control provided a more effective healing effect compared to the gel extract at concentrations of 5%, 10%, and the negative control (gel base). Conclusion: Ethanol extract of bawang sabrang is effective as a gel for healing incised wounds in rats at a concentration of 15%. The physical properties of the gel show a characteristic aroma and a golden red color, homogenous without grains or lumps, a pH of 4.9, and a spreadability of 5 cm.Keywords: Bawang sabrang tuber, Anti-inflammatory, rats, Edema.
Formulation and Evaluation of Body Lotion Preparation from Ethanol Extract of Avocado Leaves (Persea americana Mill.) as Antioxidant with DPPH Method Simanjuntak, Putri Nuraimun; Herlina , Herlina; Aritonang, Barita; Harahap, Hasni Yaturramadhan
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/hf00qs72

Abstract

Skin damage is a common problem that can affect appearance and health. Excessive exposure to free radicals from UV rays is one of the main causes of skin damage, the use of body lotions containing natural antioxidant compounds is very important to protect the skin from these effects. Avocado leaves (Persea americana Mill.) have been known to contain antioxidant chemicals that are good for skin protection, one of which is flavonoids. The purpose of this study was to determine whether avocado leaf body lotion preparations can function as antioxidants and to develop body lotion preparations that meet the evaluation test requirements. The research stages included the preparation of simple drugs, the preparation of avocado leaf extract, the test of antioxidant functional groups with UV-Vis and FTIR spectroscopy, the preparation of avocado leaf ethanol extract body lotion, the evaluation of body lotion preparations, and the testing of antioxidant activity of body lotions using the DPPH method. The results of the phytochemical analysis revealed the presence of tannins, alkaloids, saponins, and flavonoids. Avocado leaf extract body lotion was formulated in four concentration variations (0%, 2%, 4%, and 6%). All formulas meet SNI, with a pH of 7 and a spreadability of between 5-7 cm. Antioxidant activity tests showed a decreasing IC50 value with increasing extract concentration: 12.4643 µg/mL (2%), 4.6300 µg/mL (4%), and 1.1065 µg/mL (6%), which are categorized as very strong. The formulation with a concentration of 6% showed stronger activity. The conclusion of this study indicates that lotion made from avocado leaf extract has the potential as a skin care product with very strong antioxidant capabilities.
The Potential of Durian (Durio zibethinus) Fruit Peel Extract on Blood Pressure, SOD, and hsCRP Levels in Male Wistar Rats Harahap, Hasni Yaturramadhan; Pranata, Chandra
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/6fhzjm83

Abstract

Hypertension remains a major global health problem and is recognized as a leading risk factor for cardiovascular disease. Its pathogenesis involves complex mechanisms, particularly oxidative stress and chronic inflammation. An imbalance between free radical production and endogenous antioxidant defense, especially the enzyme Superoxide Dismutase (SOD), leads to endothelial dysfunction and elevated blood pressure. In parallel, inflammatory mediators such as interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) play important roles in the progression of hypertension. Although conventional therapies are effective, they are often associated with side effects and long-term costs, prompting interest in alternative treatments derived from natural resources. Durian peel (Durio zibethinus), usually considered waste, is rich in bioactive compounds such as flavonoids, alkaloids, tannins, and saponins with potential antioxidant and anti-inflammatory effects. This study employed a true experimental design with a post-test control group using male Wistar rats induced with hypertension by L-NAME administration. Animals were randomized into five groups: negative control, positive control (captopril), and three treatment groups with different extract doses. Assessments included blood pressure measurement, SOD activity, IL-6, and hs-CRP levels. Results demonstrated that durian peel extract contained an average flavonoid level of 16.27 mg QE/g with moderate antioxidant activity (IC50 88.90 µg/mL). The highest dose (800 mg/kgBW) reduced blood pressure by 14.2 ± 3.90 mmHg, approaching the effect of captopril (15.03 ± 6.30 mmHg). Moreover, SOD activity increased, IL-6 levels declined at medium to high doses, and hs-CRP levels decreased significantly, nearly comparable to the positive control. In conclusion, durian peel extract shows potential as an antihypertensive agent through mechanisms involving enhanced antioxidant defense and reduced systemic inflammation.
Effectiveness Test of a 96% Ethanolic Extract Cream of Sambung Nyawa Leaves (Gynura procumbens L.) on Incision Wounds in Male White Rats Pranata, Chandra; Harahap, Hasni Yaturramadhan; Herlina, Herlina; Silitonga, Anissa Jelita
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/fh42gn18

Abstract

Background: A major challenge in wound care is the high risk of infection and the relatively prolonged healing process. Synthetic antiseptics such as povidone iodine remain widely used as first-line therapy; however, prolonged use has been reported to cause adverse effects, including tissue irritation and the potential to delay epithelialization under certain conditions. Therefore, alternative therapies that are safer, more effective, and accessible to the community are needed. One promising approach involves the use of traditional medicinal plants known to possess antiseptic, anti-inflammatory, astringent, and antibacterial properties. Sambung Nyawa leaves (Gynura procumbens L.) have been empirically used in Indonesia to treat various health conditions, including skin wounds. This study aimed to evaluate the wound healing effect of an ethanol extract cream of Sambung Nyawa leaves and to determine the most effective concentration for incision wound healing. Methods: A true experimental method with a post-test only control group design was employed. The study subjects were male white rats (Rattus norvegicus) with standardized incision wounds. The animals were treated with Sambung Nyawa leaf extract cream at concentrations of 5%, 10%, and 20%, along with a positive control group (povidone iodine) and a negative control group. The observed parameter was wound diameter following treatment. Results: The findings indicated that the 20% cream concentration demonstrated the fastest healing time, followed by the 10% and 5% concentrations, the positive control, and the negative control. Differences in wound diameter among treatment groups suggest that Sambung Nyawa leaf extract has the potential to accelerate the wound healing process. Conclusion: Cream formulations containing 5%, 10%, and 20% extract exhibited effectiveness relatively comparable to povidone iodine, indicating their potential for development as a natural alternative therapy for incision wounds.
Co-Authors Aritonang, Barita Br Sinaga, Irma Suryani Kristina Cahya, Cucu Arum Dwi Debi Meilani Dicky Yuswardi Wiratma Diningsih, Ayus Harahap, Cory Linda Futri Harahap, Yanna Wari Herlina , Herlina Herlina Herlina Karnirius Harefa NURUL HIDAYAH Pranata, Chandra Rotua Sumihar Sitorus Silitonga, Anissa Jelita Simanjuntak, Putri Nuraimun Syarifuddin, Shofian Widyaningsih, Fadlilah