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All Journal Pharmaciana: Jurnal Kefarmasian JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Riset Kefarmasian Indonesia Jurnal Ilmiah Medicamento Jurnal Pengabdian Masyarakat Asia Jurnal Pengabdian kepada Masyarakat Pharmaceutical And Biomedical Sciences Journal (PBSJ) Usadha Journal of Pharmacy Borneo Journal of Pharmacy
Nyoman Budiartha Siada
Universitas Mahasaraswati Denpasar
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Penggunaan Antibiotik dan Resistensi Escherichia coli and Klebsiella pneumoniae: Studi Ekologikal Lima Tahun di Sebuah Rumah Sakit Umum Daerah Sanjaya, Dwi Arymbhi; Meriyani, Herleeyana; Juanita, Rr. Asih; Siada, Nyoman Budiartha; Mahaputra, Yudistira; Kamalia, Made Gek Adisti
Jurnal Ilmiah Medicamento Vol 11 No 2 (2025): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i2.11156

Abstract

Antibiotic resistance is a growing global health threat, partly driven by high antibiotic consumption. The World Health Organization (WHO) has identified critical-priority bacteria, including Escherichia coli and Klebsiella pneumoniae, due to their increasing resistance to multiple antibiotics. This study aimed to evaluate the correlation between antibiotic consumption and resistance rates in Escherichia coli and Klebsiella pneumoniae. This ecological study was conducted at a Regional Hospital in Indonesia based on retrospective inpatient data from January 2019 to December 2023. The population in this study is all data on systemic antibiotic consumption based on the J01 category of the Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) classification system and antibiogram from inpatient databases. Pearson and Spearman’s rank correlation analyses were performed to examine the associations between systemic antibiotic consumption levels and the percentage of Escherichia coli and Klebsiella pneumoniae resistance to other antibiotics. The most frequently used antibiotics were cefixime (305.664 DDD/100 bed-days), levofloxacin (139.552 DDD/100 bed-days), and ceftriaxone (109.805 DDD/100 bed-days). A strong and statistically significant correlation was observed between doxycycline consumption and Escherichia coli resistance to meropenem (r=0.894; p=0.041). Moreover, consumption levels of cefazolin, ceftazidime, cefepime, and ciprofloxacin were correlated with Escherichia coli resistance to ceftriaxone (p<0.05), while cefoperazone use demonstrated a very strong and statistically significant correlation with Escherichia coli resistance to ampicillin-sulbactam (r=0.952; p=0.012). Conversely, no significant correlation was found between antibiotic consumption and resistance in Klebsiella pneumoniae, suggesting that alternative factors such as intrinsic resistance mechanisms, mobile genetic elements, and environmental reservoirs may influence resistance development.
Antibiotic consumption and resistance: a 3-years ecological study for four critical groups of bacteria in a general regional hospital Sanjaya, Dwi Arymbhi; Siada, Nyoman Budiartha; Juanita, Rr Asih; Mahaputra, I Putu Yudistira; Kamalia, Made Gek Adisti; Meriyani, Herleeyana
Pharmaciana Vol. 14 No. 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.27321

Abstract

Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae are the most critical groups of multi-drug resistant (MDR) bacteria that cause a threat in hospitals. This study identified the trend of antibiotic consumption, antibiotic resistance pattern, and the relationship between antibiotic consumption and antibiotic resistance in a critical group of bacteria in a general regional hospital. This ecological study was based on retrospective data from inpatient databases in a general regional hospital over three years (2017-2019). The trend for annual antibiotic consumption over 2017-2019 was defined as defined daily doses/100 bed-days. The relationship between total antibiotic consumption and the percentage of antibiotic resistance among four isolated critical bacteria was explored in time series analysis and linear regression. The most frequently used antibiotic was ampicillin (220.33 DDD/100 bed-days), ciprofloxacin (126.86 DDD/100 bed-days), and ampicillin-sulbactam (126.34 DDD/100 bed-days). There was a significant relationship between antibiotic consumption (ampicillin, ampicillin-sulbactam, ceftazidime, gentamicin, amikacin, and ciprofloxacin) in DDD/100 bed-days and antibiotic resistance in E. coli, K. pneumoniae, and P. aeruginosa (p<0.05) but not statically significant in A. baumannii (p=0.062). The annual usage fluctuated or remained stable, with no statistically significant trends change. The relationship between antibiotic consumption and antibiotic resistance was significant in three out of four critical groups of bacteria.
The Impact of EG and DEG Cases on Sales of Over-The-Counter Syrup Mendra, Ni Nyoman Yudianti; Antari, Ni Putu Udayana; Siada, Nyoman Budiartha; Marwati, I Gusti Ayu
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 2 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.32013

Abstract

The Indonesian Food and Drug Authority (BPOM) investigated and listed safe and unsafe syrup products in response to the contamination of Ethylene Glycol (EG) and Diethylene Glycol (DEG), causing Acute Kidney Injury in pediatric patients. Unsafe products were recalled and removed from distribution, leading to uncertainty and panic among the public and significantly impacting over-the-counter syrup sales in several pharmacies. This retrospective observational study assessed the impact of EG and DEG contamination on the sales of over-the-counter syrup in Pharmacy X in South Denpasar. Data from three months before (August to October 18th, 2022) and three months following the official instruction was published (October 19th, 2022 to December 2022) were analyzed using Wilcoxon test. The findings reveal a staggering decline in the sales of over-the-counter syrup by 35,03% (p-value of 0.03). Moreover, there was a notable increase of prescriptions in powder forms. The contamination cases caused panic, resulting in changes in behavior and consumption patterns. Despite the availability of safety information on an official website, public hesitance toward syrup products persists, indicating the need to implement a more effective strategy to address misinformation and restore public trust. Each individual must be responsible for educating the public during crises to prevent the spread of misinformation, ultimately restoring trust and normal consumer behavior. Furthermore, efficient stock management should be implemented to anticipate potential health crises in the future proactively.
POLA PERESEPAN OBAT ANTIHIPERTENSI DI POLI RAWAT JALAN RUMAH SAKIT “X” DI BALI PERIODE TAHUN 2022 Mendra, Ni Nyoman Yudianti; Puspasari, I Gusti Ayu; Siada, Nyoman Budiartha
Usadha Journal of Pharmacy Vol. 3 No. 2 (2024): Mei
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/ujp.v3i2.311

Abstract

Hipertensi merupakan salah satu penyakit kronis dengan tingkat kejadian yang tinggi dan beresiko menyebabkan komplikasi. Pengobatan dan peresepan obat yang rasional diperlukan untuk mengontrol tekanan darah pasien serta mencegah terjadinya komplikasi. Penelitian ini bertujuan untuk mengetahui pola peresepan dan rasionalitas terapi antihipertensi pada pasien rawat jalan di salah satu rumah sakit umum di Bali tahun 2022 dengan BPJS sebagai jaminan asuransi kesehatan. Penelitian ini merupakan penelitian deskriptif dengan pengambilan data secara retrospektif dimana teknik pengambilan sampelnya menggunakan purposive sampling. Kriteria inklusi dalam penelitian ini meliputi pasien hipertensi dengan dan tanpa komorbid, telah menjalani pengobatan minimal 3 bulan terapi pada periode Januari - Desember 2022. Rasionalitas terapi meliputi tepat obat, tepat pasien, tepat dosis, dan tepat interval waktu pemberian yang dinilai berdasarkan pedoman JNC 8 dan Konsensus Penatalaksanaan Hipertensi Tahun 2021. Berdasarkan data dari 368 pasien rawat jalan, antihipertensi yang diresepkan meliputi Angiotensin receptor blocker (ARB) dengan persentase 64,13%; Calsium Channel Blocker (CCB) 59,51%; Angiotensin Converting Enzim Inhibitor (ACEI) 16,85%; Beta Blocker 15,22% dan diuretik sebesar 0,81%. Pada hasil evaluasi peresepan obat antihipertensi diperoleh tepat obat sebanyak 98,64%, tepat pasien sebanyak 96,74%, tepat dosis sebanyak 100%, dan tepat interval waktu pemberian sebanyak 100%.
OPTIMASI KOMBINASI COCOA BUTTER DAN MILK BUTTER SEBAGAI BASIS BODY BUTTER EKSTRAK ETANOL DAUN JAMBU BIJI (Psidium guajava Linn) Suradnyana, I Gede Made; Mahardika, I Komang Gede; Siada, Nyoman Budiartha
Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 2 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i2.242

Abstract

Guava leaf extract is known to contain flavonoids, a class of flavone compounds that have very strong antioxidant activity. The antioxidant activity of guava leaf ethanol extract as measured by the DPPH method showed an IC50 value of 72 µg/ml. Body butter preparations have a better ability to nourish and maintain skin moisture because they contain high oil components. Cocoa butter and milk butter are the bases that are widely used in body butter formulas and are able to maintain skin health. This study aims to determine the area of optimum composition of the combination of cocoa butter and milk butter in body butter preparations of guava leaf ethanol extract (Psidium guajava L.). This study used a factorial design with two factors, namely cocoa butter and milk butter and two levels, namely 2% and 4% for cocoa butter and 2% and 15% for milk butter. The observed responses were pH and spreadibility with data analysis using Design Expert and SPSS software. Based on the results of the research, the optimum area for the combination of cocoa butter and milk butter with the pH equation is Y = 6.00000 – 1.77504(X1) – 4.73345 (X2) + 1.8336(X1X2) and the dispersion equation is Y = 3 ,77692+0,366667(X1) – 0,005128(X2) + 0.033333(X1X2). The optimal composition area of cocoa butter and milk butter has been validated on the combination of 3% cocoa butter and 8,5% milk butter.
The Association between Resistance of Sepsis-Inducing Bacteria to First-Line Antibiotics and Sepsis Outcome: A Retrospective Cross-Sectional Study Meriyani, Herleeyana; Sanjaya, Dwi Arymbhi; Juanita, Rr. Asih; Siada, Nyoman Budiartha; Yudiartha, I Wayan Maysa; Suryawan, Kadek
Jurnal Ilmiah Medicamento Vol 12 No 1 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i1.13597

Abstract

Background: Sepsis is a significant infectious disease linked to high mortality rates. Several bacterial pathogens that cause sepsis have shown resistance to first-line antibiotics. This resistance in sepsis-causing bacteria to initial antibiotic agents threatens treatment success, elevating mortality risk, healthcare costs, and prolonged hospital stays.Objective: This study aimed to investigate the relationship between the resistance of sepsis-causing bacteria to first-line antibiotics and sepsis treatment outcomes.Methods: This cross-sectional study was a single-center retrospective study. Data were collected from sepsis patients admitted to the intensive care unit of a general hospital in Bali between 2022 and 2023. The patients included in this study were those with a positive bacterial infection, as provided in the culture result. Therapy outcomes were evaluated based on discharge status: improved or unimproved (deceased). The resistance of sepsis-causing bacteria to first-line antibiotics, including fluoroquinolones, third- and fourth-generation cephalosporins, piperacillin-tazobactam, and vancomycin, was assessed through blood cultures. The relationship between antibiotic resistance and therapy outcomes was analyzed using the Gamma correlation coefficient. This study included 57 of 108 sepsis patients, primarily male (57.89%) and older than 60 years (57.89%).Results: A strong, significant positive correlation was observed between the resistance of sepsis-causing bacteria to third-generation cephalosporins and therapy outcomes (p=0.001; r=0.637). In contrast, resistance to fluoroquinolones (p=0.108; r=0.387), fourth-generation cephalosporins (p=0.377; r=-0.199), piperacillin-tazobactam (p=0.816; r=-0.060), and vancomycin (p=0.911; r=0.030) did not significantly impact therapy outcomes. The outcome of sepsis therapy is associated with resistance of sepsis-causing bacteria to third-generation cephalosporins but not to fluoroquinolones, fourth-generation cephalosporins, piperacillin-tazobactam, or vancomycin. This study uses a relatively small sample size, which precludes subgroup analyses.Conclusion: Non-significant findings for some antibiotics may reflect insufficient power; further study is needed to assess the correlation between resistance of sepsis-causing bacteria to fluoroquinolones, fourth-generation cephalosporins, piperacillin-tazobactam, and vancomycin.
Evaluasi Pemberian Terapi pada Pasien Demam Berdarah Dengue di Rumah Sakit Umum Provinsi Bali Sanjaya, Dwi Arymbhi; Meriyani, Herleeyana; Juanita, Rr Asih; Siada, Nyoman Budiartha; Ambara Damayanti, Made Elvenia; Noviani, Lusy
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 1 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i1.78958

Abstract

Sekitar 50-100 juta jiwa terjangkit demam berdarah dengue (DBD) setiap tahunnya dengan jumlah kematian mencapai 20.000 hingga 40.000 juta jiwa per tahun menurut World Health Organization (WHO). Provinsi Bali menduduki peringkat ke-3 dengan Incidence Rate (IR) DBD tertinggi pada tahun 2021 yaitu 59,8 per 100.000 penduduk. Penyakit DBD biasanya disertai dengan komplikasi dan penyakit penyerta yang dapat mengakibatkan peningkatan morbiditas dan mortalitas. Penelitian ini bertujuan mengetahui gambaran perbaikan klinis yang diamati dari parameter hematologi (leukosit, hemoglobin, hematokrit, dan trombosit) pada pasien DBD dengan komplikasi dan penyakit penyerta. Penelitian ini merupakan penelitian observasional dengan pendekatan cross-sectional yang dilakukan di rumah sakit umum Provinsi Bali. Pengambilan data dilakukan secara retrospektif yaitu data yang diperoleh dari bulan Januari 2020 hingga Desember 2021. Lima puluh tiga sampel pada penelitian diambil menggunakan teknik total sampling. Efektivitas penatalaksanaan DBD dengan komplikasi dan penyakit penyerta pada hari pertama, hari ketiga, dan hari kelima dianalisis menggunakan uji Cochran dengan post-hoc McNemar. Pasien DBD dengan komplikasi dan penyakit penyerta pada penelitian ini sejumlah 53 orang dengan 66% laki-laki dan 34% perempuan dengan rata-rata lama rawat inap yaitu 6,0 hari. Ringer laktat dan parasetamol merupakan jenis terapi yang paling banyak digunakan dalam penatalaksanaan DBD. Penatalaksanaan pasien DBD dengan komplikasi dan penyakit penyerta di rumah sakit umum Provinsi Bali pada tahun 2020-2021 menunjukan peningkatan trombosit dan leukosit yang signifikan sejak hari ketiga hingga hari kelima (p<0,05). 
Evaluasi Rasionalitas Pengobatan Pasien Dengue Hemorrhagic Fever dengan Komplikasi dan Komorbiditas di Rumah Sakit “X” Provinsi Bali Juanita, Rr Asih; Meriyani, Herleeyana; Sanjaya, Dwi Arymbhi; Siada, Nyoman Budiartha; Prascitasari, Nyoman Ayu
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 2 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i2.92941

Abstract

Penggunaan obat pada pasien Dengue Hemorrhagic Fever (DHF) dengan komplikasi dan komorbiditas perlu mendapat perhatian khusus untuk menghindari kejadian Drug Related Problems (DRPs) yang dapat memengaruhi luaran klinis. Penelitian ini bertujuan untuk mengevaluasi rasionalitas pengobatan pada pasien DHF dengan komplikasi dan komorbiditas di Rumah Sakit “X” Provinsi Bali. Jenis penelitian yang digunakan adalah observasional dengan rancangan cross-sectional. Data rekam medis pasien dikumpulkan secara retrospektif tahun 2020-2021. Penilaian rasionalitas pengobatan dilakukan dengan analisis DRPs menggunakan instrumen Pharmaceutical Care Network Europe Association (PCNE) versi 9.1. Luaran klinis dianalisis berdasarkan nilai trombosit, hematokrit, leukosit, dan hemoglobin. Analisis hubungan rasionalitas pengobatan terhadap luaran klinis dilakukan menggunakan uji Chi-square. Dari total 115 pasien yang memenuhi kriteria penelitian, terjadi DRPs pada 33% pasien dan 67% tidak terjadi DRPs. DRPs yang terjadi yaitu P3.2 Unclear problem/complaint (51%); P1.2 Effect of drug treatment not optimal (28%); P1.3 Untreated symptoms or indication (13%); serta P3.1 Unnecessary drug-treatment (8%). Rasionalitas pengobatan tidak berhubungan dengan luaran klinis pasien DHF dengan komplikasi dan komorbiditas di Rumah Sakit “X” Provinsi Bali (p>0,05).
Evaluasi Kesesuaian Antibiotik berdasarkan Metode Gyssens pada Peresepan Pasien Covid-19 disertai Koinfeksi Pneumonia di Rumah Sakit “X” Kota Denpasar Juanita, Rr Asih; Siada, Nyoman Budiartha; Sanjaya, Dwi Arymbhi; Meriyani, Herleeyana; Wulandari, Ni Putu Nadya Kirana
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 3 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i3.78815

Abstract

Koinfeksi bakteri penyebab pneumonia pada individu dengan Covid-19 berpotensi memperburuk kondisi klinis serta meningkatkan risiko morbiditas dan mortalitas apabila tidak memperoleh penanganan yang adekuat.Terapi antibiotik yang diberikan harus sesuai dengan derajat keparahan pneumonia yang diukur dengan skor Pneumonia Severity Index (PSI). Ketidaktepatan terapi antibiotik dapat meningkatkan risiko terjadinya resistensi. Oleh karena itu, evaluasi penggunaan antibiotik sangat penting dilakukan untuk meminimalkan risiko ketidaktepatan terapi yang dapat menyebabkan terjadinya resistensi bakteri terhadap antibiotik. Namun, penelitian mengenai evaluasi kesesuaian antibiotik pada peresepan pasien Covid-19 disertai koinfeksi pneumonia masih terbatas. Penelitian ini dilakukan dengan tujuan untuk mengevaluasi kesesuaian antibiotik pada peresepan pasien Covid-19 disertai koinfeksi pneumonia di Rumah Sakit “X” Kota Denpasar. Penelitian dilakukan menggunakan desain cross sectional dengan pendekatan retrospektif. Data penelitian dikumpulkan dari rekam medis pasien kemudian dievaluasi secara kualitatif menggunakan metode gyssens, secara kuantitatif dengan Prescribed Daily Dose (PDD), serta hubungan kesesuaian penggunaan antibiotik dengan perbaikan derajat keparahan dianalisis secara statistik menggunakan uji Fisher. Evaluasi kesesuaian antibiotik secara kualitatif menunjukkan sebesar 87% termasuk kategori IVA (ada alternatif antibiotik yang lebih efektif), 3% kategori IIIA (penggunaan antibiotik terlalu lama), dan 10% kategori 0 (penggunaan antibiotik tepat). Hasil evaluasi secara kuantitatif menunjukkan nilai PDD yaitu cefepime (6 gram/hari); cefotaxime (4,2 gram/hari); cefuroxime, ceftazidime, cefoperazone + sulbactam (3 gram/hari); cefoperazone (2,67 gram/hari); ceftriaxone (1 gram/hari); levofloxacin (0,75 gram/hari), azithromycin (0,5 gram/hari), dan moxifloxacin (0,4 gram/hari).Kesesuaian penggunaan antibiotik tidak memiliki hubungan terhadap perbaikan derajat keparahan pasien Covid-19 disertai koinfeksi pneumonia (p = 1,000).
Kajian Literatur: Study Design Dalam Farmakoepidemiologi Untuk Mengetahui Resistensi Bakteri Terhadap Antibiotik Meriyani, Herleeyana; Sanjaya, Dwi Arymbhi; Juanita, Rr Asih; Siada, Nyoman Budiartha
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 8, No 1 (2023)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v8i1.61651

Abstract

Penelitian terkait resistensi bakteri terhadap antibiotik dapat dilakukan dengan berbagai study design. Study design merupakan salah satu titik kritis dalam penelitian resistensi bakteri terhadap antibiotik. Penelitian ini bertujuan untuk memberikan gambaran kelebihan dan kekurangan dari study design yang digunakan dalam penelitian farmakoepidemiologi tentang resistensi bakteri terhadap antibiotik. Pencarian literatur dilakukan secara elektronik untuk artikel yang dipublikasikan tahun 2011 hingga 30 Juni 2021 pada basis data EBSCO, Plos One, Proquest, PubMed, ScienceDirect, dan Google Scholar. Kriteria inklusi meliputi original article dengan desain cohort (prospective dan retrospective), case control, cross-sectional dan ecological study; memiliki Digital Object Identifier (DOI); dipublikasi 10 tahun terakhir; serta mengunakan Bahasa Inggris. Artikel dalam bentuk review, tidak merupakan full text, dan artikel dengan jumlah sampel penelitian yang tidak jelas tidak disertakan dalam kajian ini. Artikel yang terkumpul dari 6 database sejumlah 209 artikel (EBSCO 45 artikel, Plos One 42 artikel, ProQuest 32 artikel, PubMed 68 artikel, ScienceDirect 19 artikel dan Google Scholar 3 artikel). Duplikasi artikel dieksklusi (29 artikel). Artikel tidak memenuhi kriteria inklusi (86 artikel), 64 artikel tidak relavan dengan tujuan penelitian, sehingga diperoleh 30 artikel dalam studi ini. Rancangan penelitian pada penelitian ini yaitu case-control (2 artikel), cohort-prospective (14 artikel), cohort-retrospective (5 artikel), cross-sectional (8 artikel) dan ecological study (1 artikel). Masing-masing rancangan memiliki kelebihan dan kekurangannya masing-masing. Pemilihan desain studi dalam penelitian resistensi bakteri terhadap antibiotik dilakukan sesuai dengan tujuan penelitian, jenis paparan yang diamati, jenis outcome serta tipe penelitian (comparative, correlative study) serta ketersediaan sumber daya dalam melakukan penelitian resistensi bakteri terhadap antibiotik.
Co-Authors Agung Ari Chandra Wibawa Ambara Damayanti, Made Elvenia Chusna, Nurul Debby Juliadi Dewa Ayu Ika Pramitha Dwi Arymbhi Sanjaya Gde Nyoman Astika Herleeyana Meriyani I Gede Made Suradnyana I Gusti Ayu Puspasari I Komang Gede Mahardika I Putu Yudistira Mahaputra Kamalia, Made Gek Adisti Ketupapa, Florentina Gabriela Ketut Agus Adrianta Made Gek Adisti Kamalia Mahaputra, I Putu Yudistira Mahaputra, Yudistira Mahardika, I Komang Gede Marwati, I Gusti Ayu Mendra, Ni Nyoman Yudianti Meriyani, Herleeyana Ni Made Dharma Shantini Suena Ni Made Sukma Sanjiwani Ni Nyoman Yudianti Mendra Ni Putu Udayana Antari Noviani, Lusy Prascitasari, Nyoman Ayu Puspasari, I Gusti Ayu Putu Sukma Purnamasari RR. Asih Juanita Suradnyana, I Gede Made Suryawan, Kadek Triska Ananda Rahayu Wulandari, Ni Putu Nadya Kirana Yudiartha, I Wayan Maysa